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Targeting Prostate Cancer with a Combination of WNT Inhibitors and a Bi-functional Peptide

  • BACKGROUND/AIM: Prostate cancer is the most common cancer in the Western world. A bi-functional peptide was combined with wingless-related integration site (WNT) inhibitors to determine if there is an additive therapeutic effect when they are used against prostate cancer, since their efficacy has already been proven when used alone. MATERIALS AND METHODS: A bi-functional peptide (TP-LYT) was designed with a target domain (LTVSPWY) and a lytic domain (KLAKLAK)2, and a second peptide with the same lytic domain but a random sequence instead of the target domain was used as a negative control. Two different WNT inhibitors were used, ethacrynic acid and ciclopiroxolamine. They were tested on prostate cancer cells using the WST-8 assay. RESULTS: A synergistic effect of peptides and WNT inhibitors was demonstrated, increasing the toxicity against cancer cells. CONCLUSION: Our findings potentially allow safer treatment since lower concentrations of WNT inhibitors can be used in combination with this bi-functional peptide.

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Metadaten
Document Type:Article
Language:English
Parent Title (English):Anticancer Res. (Anticancer Research)
Volume:37
Issue:2
First Page:555
Last Page:559
ISSN:0250-7005
DOI:https://doi.org/10.21873/anticanres.11348
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=28179301
Publisher:The International Institute of Anticancer Research
Publication year:2017
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IfGA)
Dewey Decimal Classification (DDC):600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2017/02/14