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Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo

  • The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50% during the first stage and increased cell survival 70% during the second stage. Complete loss of Bax reduced apoptosis by 20% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo.

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Metadaten
Document Type:Article
Language:English
Parent Title (English):Cancer Res. (Cancer research)
Volume:59
Issue:11
First Page:2541
Last Page:2545
ISSN:1538-7445
URL:http://cancerres.aacrjournals.org/content/59/11/2541
Publisher:American Association for Cancer Research
Date of first publication:1999/06/01
Departments, institutes and facilities:Institut für funktionale Gen-Analytik (IfGA)
Dewey Decimal Classification (DDC):600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2018/07/14