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Mitochondrial Regulation of Cell-Death

  • Mitochondria are much studied organelles, investigated for decades for their vital role as powerhouses of the cell and for the evolutionary history concealed in the mitochondrial genome. To this day, research on mitochondria is still yielding fascinating new information. Over the past two decades a large body of evidence has been accumulated showing these structures, which are at the heart of metabolic processes sustaining life, at same time containing the seeds of cellular self-destruction. This chapter describes the death-inducing proteins that are released from mitochondria, the mechanisms of release, as well as how release is regulated. Finally, phytochemicals that affect the release of lethal mitochondrial proteins are discussed.

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Document Type:Part of a Book
Author:Richard Jäger, Howard O. Fearnhead
Parent Title (English):Chandra (Ed.): Mitochondria as targets for phytochemicals in cancer prevention and therapy
First Page:33
Last Page:60
Place of publication:New York, NY
Date of first publication:2013/12/10
Keyword:BcL-2 family; Mitochondrial apoptogens; Mitochondrial outer membrane permeabilization (MOMP); Programmed cell death
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2016/03/03