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Long-term retention of gadolinium in the skin of rodents following the administration of gadolinium-based contrast agents

  • Several publications suggest a potential association between the administration of Gadolinium-based contrast agents (GBCAs) and the onset of a rare but serious disease, Nephrogenic Systemic Fibrosis (NSF). The aim of this study was to determine the elimination time-course of Gadolinium (Gd) from skin tissue after application of GBCAs in rats. Seven different marketed GBCAs were injected on five consecutive days at a dose of 2.5 mmol/kg bodyweight into the tail vein of Han-Wistar rats and the Gd concentrations were determined by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in skin biopsies taken at various time-points up to a year after the last injection. Most of the administered Gd was eliminated from the skin within a time-period of about 2 months. However, the repeated administration of linear GBCAs resulted in long-term retention of a small portion of the administered Gd in the skin tissue of rats, with substantially higher values observed in animals treated with non-ionic linear agents than in those that received ionic linear GBCAs. Following treatment with macrocyclic GBCAs, Gd values in the skin were in the same range as observed in the controls from day 24 post-injection onwards. In summary, we observed a correlation between the complex stability of GBCAs and the amount of residual Gd in the skin up to a year after application of GBCAs.

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Metadaten
Document Type:Article
Language:English
Author:Hubertus Pietsch, Philipp Lengsfeld, Gregor Jost, Thomas Frenzel, Joachim Hütter, Martin A. Sieber
Parent Title (English):European Radiology
Volume:19
Issue:6
First Page:1417
Last Page:1424
ISSN:0938-7994
DOI:https://doi.org/10.1007/s00330-008-1259-4
PMID:https://pubmed.ncbi.nlm.nih.gov/19169690
Publisher:Springer
Date of first publication:2009/01/24
Copyright:(c) The Author(s) 2009. This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License
Departments, institutes and facilities:Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2018/08/08
Licence (German):License LogoCreative Commons - CC BY-NC - Namensnennung-Nicht kommerziell 3.0