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In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca: Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase

  • Balanites aegyptiaca (Balanitaceae) is a widely grown desert plant with multiuse potential. In the present paper, a crude extract from B. aegyptiaca seeds equivalent to a ratio of 1 : 2000 seeds to the extract was screened for antiplasmodial activity. The determined IC(50) value for the chloroquine-susceptible Plasmodium falciparum NF54 strain was 68.26 μg/μL ± 3.5. Analysis of the extract by gas chromatography-mass spectrometry detected 6-phenyl-2(H)-1,2,4-triazin-5-one oxime, an inhibitor of the parasitic M18 Aspartyl Aminopeptidase as one of the compounds which is responsible for the in vitro antiplasmodial activity. The crude plant extract had a K(i) of 2.35 μg/μL and showed a dose-dependent response. After depletion of the compound, a significantly lower inhibition was determined with a K(i) of 4.8 μg/μL. Moreover, two phenolic compounds, that is, 2,6-di-tert-butyl-phenol and 2,4-di-tert-butyl-phenol, with determined IC(50) values of 50.29 μM ± 3 and 47.82 μM ± 2.5, respectively, were detected. These compounds may contribute to the in vitro antimalarial activity due to their antioxidative properties. In an in vivo experiment, treatment of BALB/c mice with the aqueous Balanite extract did not lead to eradication of the parasites, although a reduced parasitemia at day 12 p.i. was observed.

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Metadaten
Document Type:Article
Language:English
Author:Peter Kusch, Susanne Deininger, Sabine Specht, Rudeka Maniako, Stefanie Haubrich, Tanja Pommerening, Paul Kong Thoo Lin, Achim Hoerauf, Annette Kaiser
Parent Title (English):Journal of Parasitology Research
Volume:2011
Article Number:368692
Number of pages:9
ISSN:2090-0031
ISSN:2090-0023
URN:urn:nbn:de:hbz:1044-opus-8527
DOI:https://doi.org/10.1155/2011/368692
PMID:https://pubmed.ncbi.nlm.nih.gov/21687598
Publisher:Hindawi
Place of publication:London
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2011/05/25
Copyright:© 2011 Peter Kusch et al. This is an open access article distributed under the Creative Commons Attribution License.
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2015/04/02
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 3.0