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New roles for old enzymes: killer caspases as the engine of cell behavior changes

  • It has become increasingly clear that caspases, far from being merely cell death effectors, have a much wider range of functions within the cell. These functions are as diverse as signal transduction and cytoskeletal remodeling, and caspases are now known to have an essential role in cell proliferation, migration, and differentiation. There is also evidence that apoptotic cells themselves can direct the behavior of nearby cells through the caspase-dependent secretion of paracrine signaling factors. In some processes, including the differentiation of skeletal muscle myoblasts, both caspase activation in differentiating cells as well as signaling from apoptotic cells has been reported. Here, we review the non-apoptotic outcomes of caspase activity in a range of different model systems and attempt to integrate this knowledge.

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Metadaten
Document Type:Article
Language:English
Author:Patrick F. Connolly, Richard Jäger, Howard O. Fearnhead
Parent Title (English):Frontiers in Physiology
Volume:5
Article Number:149
Number of pages:10
ISSN:1664-042X
URN:urn:nbn:de:hbz:1044-opus-13374
DOI:https://doi.org/10.3389/fphys.2014.00149
PMID:https://pubmed.ncbi.nlm.nih.gov/24795644
Publisher:Frontiers Media
Place of publication:Lausanne
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2014/04/16
Copyright:Copyright © 2014 Connolly, Jäger and Fearnhead. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Keyword:apoptosis; caspase; differentiation; myogenesis; non-apoptotic roles; proliferation
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 571 Physiologie und verwandte Themen
Entry in this database:2015/04/02
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 3.0