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Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation

  • Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation.

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Document Type:Article
Author:Werner Götz, Edda Tobiasch, Steffen Witzleben, Margit Schulze
Parent Title (English):Pharmaceutics
Article Number:117
Number of pages:27
Place of publication:Basel
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2019/03/12
Copyright:© 2019 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Funding Information:Funding: Financial support was given by the BMBF project, Hybrid-KEM (FKZ 13FH569IX6).
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für Technik, Ressourcenschonung und Energieeffizienz (TREE)
Projects:IngenieurNachwuchs 2015: PersoImplant - Personalisierte zellbesiedelte Implantate für Knochendefekte mit 'kritischer Größe' (DE/BMBF/03FH019IX5,13FH019IX5)
IngenieurNachwuchs 2016: Hybrid-KEM - Entwicklung neuer Hybride auf Phosphat/Silicat/Agarose-Basis als KnochenErsatzMaterial mit Release-Funktion für Bisphosphonat-Wirkstoffe (DE/BMBF/13FH569IX6)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2019/03/28
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International