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Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

  • Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.

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Document Type:Article
Author:Markus Witzler, Dominik Büchner, Sarah Hani Shoushrah, Patrick Babczyk, Juliana Baranova, Steffen Witzleben, Edda Tobiasch, Margit Schulze
Parent Title (English):Biomolecules
Article Number:840
Number of pages:26
Place of publication:Basel
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2019/12/06
Copyright:© 2019 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license.
Funding Information:This work was funded by the German Federal Ministry of Education and Research (BMBF) programs Ingenieur Nachwuchs 2015: PersoImplant (grant no. 13FH019IX5), Ingenieur Nachwuchs 2016: HybridKEM (grant no. 13FH569IX6), and the Ministry of Culture and Science of the German State of North Rhine-Westphalia (MKW NRW) program FH Zeit für Forschung 2016: “TestMedgO” (grant no. 1609FHZ027).
Keyword:angiogenesis; bone tissue engineering; composites; osteogenesis; polysaccharide; stem cells
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für Technik, Ressourcenschonung und Energieeffizienz (TREE)
Projects:IngenieurNachwuchs 2015: PersoImplant - Personalisierte zellbesiedelte Implantate für Knochendefekte mit 'kritischer Größe' (DE/BMBF/03FH019IX5,13FH019IX5)
IngenieurNachwuchs 2016: Hybrid-KEM - Entwicklung neuer Hybride auf Phosphat/Silicat/Agarose-Basis als KnochenErsatzMaterial mit Release-Funktion für Bisphosphonat-Wirkstoffe (DE/BMBF/13FH569IX6)
TestMedgO - Testung eines neuen potentiellen Medikamentes gegen Osteoporose (NRW/MKW/1609FHZ027)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 572 Biochemie
Entry in this database:2019/12/11
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International