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The osteogenic differentiation of bone chip-derived mesenchymal stem cells is controlled via specific receptor signaling

  • Mesenchymal stem cells (MSCs) are an attractive cell source for Regenerative Dentistry in particular due to their ability to differentiate towards osteoblasts, among other lineages. Tooth and jaw bone loss are frequent sequelae of traumatic and pathological conditions in both the young and the elderly and must be met by appropriate prosthetic replacements. For successful osseointegration of the dental implant a sufficient bone level is necessary. Besides the utilization of bone autografts or synthetic biomaterials, medical research is more and more focused on the utilization of MSCs. Compared to cells obtained from liposuction material, ectomesenchymal stem cells derived from the head area e.g. out of dental follicles or particulate, non-vascularized bone chips show a higher differentiation potential towards osteoblasts.

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Document Type:Article
Author:C. Kaebisch, J.K. Gorski, Y.A. Issa, M. Winter, E. Tobiasch
Parent Title (English):Journal of Biological Research
First Page:87
Publisher:PAGEPress Publications
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2015/03/19
86th SIBS National Congress, Palermo, Italy, 24-25 October 2013
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2020/03/11
Licence (German):License LogoCreative Commons - CC BY-NC - Namensnennung-Nicht kommerziell 3.0