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Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins

  • The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a pharmacological tool compound for investigation of specific functions of the mentioned enzymes in vitro. Herein, the rational design, organic synthesis and quantitative structure-activity-relationships are described extensively.

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Metadaten
Document Type:Doctoral Thesis
Language:English
Author:Christian Breuer
Number of pages:VIII, 294
URL:https://nbn-resolving.org/urn:nbn:de:hbz:5-57228
Handle:https://hdl.handle.net/20.500.11811/8266
Referee:Michael G├╝tschow, Gerd Bendas
Date of exam:2020/01/10
Contributing Corporation:Rheinische Friedrich-Wilhelms-Universit├Ąt Bonn
Date of first publication:2020/02/07
Embargo Date:2021/02/15
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Graduierteninstitut
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2020/05/08