Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
- The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a pharmacological tool compound for investigation of specific functions of the mentioned enzymes in vitro. Herein, the rational design, organic synthesis and quantitative structure-activity-relationships are described extensively.
| Document Type: | Doctoral Thesis |
|---|---|
| Language: | English |
| Author: | Christian Breuer |
| Number of pages: | VIII, 294 |
| URL: | https://nbn-resolving.org/urn:nbn:de:hbz:5-57228 |
| Handle: | https://hdl.handle.net/20.500.11811/8266 |
| Referee: | Michael Gütschow, Gerd Bendas |
| Publisher: | Universitäts- und Landesbibliothek Bonn |
| Date of exam: | 2020/01/10 |
| Contributing Corporation: | Rheinische Friedrich-Wilhelms-Universität Bonn |
| Date of first publication: | 2020/02/07 |
| Embargo Date: | 2021/02/15 |
| Departments, institutes and facilities: | Fachbereich Angewandte Naturwissenschaften |
| Graduierteninstitut | |
| Dewey Decimal Classification (DDC): | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
| Entry in this database: | 2020/05/08 |
