Volltext-Downloads (blau) und Frontdoor-Views (grau)

Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins

  • The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a pharmacological tool compound for investigation of specific functions of the mentioned enzymes in vitro. Herein, the rational design, organic synthesis and quantitative structure-activity-relationships are described extensively.

Export metadata

Additional Services

Search Google Scholar Check availability


Show usage statistics
Document Type:Doctoral Thesis
Author:Christian Breuer
Number of pages:VIII, 294
Referee:Michael G├╝tschow, Gerd Bendas
Date of exam:2020/01/10
Contributing Corporation:Rheinische Friedrich-Wilhelms-Universit├Ąt Bonn
Date of first publication:2020/02/07
Embargo Date:2021/02/15
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2020/05/08