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Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?

  • With increasing life expectancy, demands for dental tissue and whole-tooth regeneration are becoming more significant. Despite great progress in medicine, including regenerative therapies, the complex structure of dental tissues introduces several challenges to the field of regenerative dentistry. Interdisciplinary efforts from cellular biologists, material scientists, and clinical odontologists are being made to establish strategies and find the solutions for dental tissue regeneration and/or whole-tooth regeneration. In recent years, many significant discoveries were done regarding signaling pathways and factors shaping calcified tissue genesis, including those of tooth. Novel biocompatible scaffolds and polymer-based drug release systems are under development and may soon result in clinically applicable biomaterials with the potential to modulate signaling cascades involved in dental tissue genesis and regeneration. Approaches for whole-tooth regeneration utilizing adult stem cells, induced pluripotent stem cells, or tooth germ cells transplantation are emerging as promising alternatives to overcome existing in vitro tissue generation hurdles. In this interdisciplinary review, most recent advances in cellular signaling guiding dental tissue genesis, novel functionalized scaffolds and drug release material, various odontogenic cell sources, and methods for tooth regeneration are discussed thus providing a multi-faceted, up-to-date, and illustrative overview on the tooth regeneration matter, alongside hints for future directions in the challenging field of regenerative dentistry.

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Document Type:Article
Author:Juliana Baranova, Dominik Büchner, Werner Götz, Margit Schulze, Edda Tobiasch
Parent Title (English):International Journal of Molecular Sciences
Article Number:4031
Number of pages:34
Place of publication:Basel
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2020/06/04
Copyright:© 2020 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Funding Information:This article was supported by the Bundesministerium für Bildung und Forschung (BMBF) FHprofUnt to E.T., FKZ: 13FH012PB2; EFRE co-financed NRW Ziel 2: “Regionale Wettbewerbsfähigkeit und Beschäftigung”, 2007–2013, Ministerium für Innovation, Wissenschaft und Forschung (MIWF) NRW FH-Extra to E.T., FKZ: z1112fh012; DAAD PPP Vigoni to E.T., FKZ: 314-vigoni-dr and FKZ: 54669218; BMBF-AIF to E.T., FKZ: 1720X06; BMBF IngenieurNachwuchs to E.T., FKZ: 13FH019IX5; MIWF NRW FH Zeit für Forschung to E.T., FKZ 005-1703-0017. BMBF IngenieurNachwuchs to S.W.; FKZ: 13FH569IX6; and National Council for Scientific and Technological Development of Brazil (Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq, Brasil) under “Cotas do Programa de Pós-Graduação” No. 142137/2019-7 to J.B.
Keyword:amelogenesis; cementogenesis; dentinogenesis; dentogenesis; drug release materials; odontogenic cells; scaffolds; stem cells; whole-tooth regeneration
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Projects:IngenieurNachwuchs 2015: PersoImplant - Personalisierte zellbesiedelte Implantate für Knochendefekte mit 'kritischer Größe' (DE/BMBF/03FH019IX5,13FH019IX5)
IngenieurNachwuchs 2016: Hybrid-KEM - Entwicklung neuer Hybride auf Phosphat/Silicat/Agarose-Basis als KnochenErsatzMaterial mit Release-Funktion für Bisphosphonat-Wirkstoffe (DE/BMBF/13FH569IX6)
Untersuchung des Einflusses ausdifferenzierender Adipozyten bei der Pathogenese des Diabetes mellitus Typ 2 (AdiPaD) (DE/BMBF/1720X06;1320X06)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 617 Chirurgie, Medizin nach Körperregion, Zahnmedizin, Augenheilkunde, Ohrenheilkunde, Audiologie
Entry in this database:2020/06/06
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International