Proteolytic ENaC activation in health and disease—a complicated puzzle
- The epithelial sodium channel (ENaC) is a heterotrimeric ion channel that plays a key role in sodium and water homeostasis in tetrapod vertebrates. In the aldosterone-sensitive distal nephron, hormonally controlled ENaC expression matches dietary sodium intake to its excretion. Furthermore, ENaC mediates sodium absorption across the epithelia of the colon, sweat ducts, reproductive tract, and lung. ENaC is a constitutively active ion channel and its expression, membrane abundance, and open probability (PO) are controlled by multiple intracellular and extracellular mediators and mechanisms [9]. Aberrant ENaC regulation is associated with severe human diseases, including hypertension, cystic fibrosis, pulmonary edema, pseudohypoaldosteronism type 1, and nephrotic syndrome [9].
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| Document Type: | Article |
|---|---|
| Language: | English |
| Author: | Mike Althaus, Rene Yufenyuy Lawong |
| Parent Title (English): | Pflügers Archiv: European Journal of Physiology |
| Volume: | 474 |
| Issue: | 2 |
| First Page: | 177 |
| Last Page: | 179 |
| ISSN: | 1432-2013 |
| URN: | urn:nbn:de:hbz:1044-opus-60084 |
| DOI: | https://doi.org/10.1007/s00424-021-02644-w |
| PMID: | https://pubmed.ncbi.nlm.nih.gov/34799769 |
| Publisher: | Springer |
| Publishing Institution: | Hochschule Bonn-Rhein-Sieg |
| Date of first publication: | 2021/11/20 |
| Copyright: | © The Author(s) 2021 |
| Funding Information: | Open Access funding enabled and organized by Projekt DEAL. |
| Note: | This article is a commentary to the original article https://doi.org/10.1007/s00424-021- 02639-7 |
| Departments, institutes and facilities: | Fachbereich Angewandte Naturwissenschaften |
| Institut für funktionale Gen-Analytik (IFGA) | |
| Dewey Decimal Classification (DDC): | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 571 Physiologie und verwandte Themen |
| Open access funding: | Hochschule Bonn-Rhein-Sieg / Hochschul- und Kreisbibliothek / Open-Access-Förderung durch das Projekt DEAL |
| Hochschule Bonn-Rhein-Sieg / Hochschul- und Kreisbibliothek / Open-Access-Förderung durch das Projekt DEAL / Springer 2021 | |
| Entry in this database: | 2021/11/24 |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
