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Proteolytic ENaC activation in health and disease—a complicated puzzle

  • The epithelial sodium channel (ENaC) is a heterotrimeric ion channel that plays a key role in sodium and water homeostasis in tetrapod vertebrates. In the aldosterone-sensitive distal nephron, hormonally controlled ENaC expression matches dietary sodium intake to its excretion. Furthermore, ENaC mediates sodium absorption across the epithelia of the colon, sweat ducts, reproductive tract, and lung. ENaC is a constitutively active ion channel and its expression, membrane abundance, and open probability (PO) are controlled by multiple intracellular and extracellular mediators and mechanisms [9]. Aberrant ENaC regulation is associated with severe human diseases, including hypertension, cystic fibrosis, pulmonary edema, pseudohypoaldosteronism type 1, and nephrotic syndrome [9].

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Document Type:Article
Author:Mike Althaus, Rene Yufenyuy Lawong
Parent Title (English):Pflügers Archiv: European Journal of Physiology
First Page:177
Last Page:179
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2021/11/20
Copyright:© The Author(s) 2021
Funding Information:Open Access funding enabled and organized by Projekt DEAL.
This article is a commentary to the original article https://doi.org/10.1007/s00424-021- 02639-7
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 571 Physiologie und verwandte Themen
Open access funding:Hochschule Bonn-Rhein-Sieg / Hochschul- und Kreisbibliothek / Open-Access-Förderung durch das Projekt DEAL
Hochschule Bonn-Rhein-Sieg / Hochschul- und Kreisbibliothek / Open-Access-Förderung durch das Projekt DEAL / Springer 2021
Entry in this database:2021/11/24
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International