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Vegetables as a vehicle for antimicrobial resistance (vAMR): An agroecosystem exploration from the One Health perspective in India

  • Introduction: Antimicrobial resistance (AMR) has emerged as one of the leading threats to public health. AMR possesses a multidimensional challenge that has social, economic, and environmental dimensions that encompass the food production system, influencing human and animal health. The One Health approach highlights the inextricable linkage and interdependence between the health of people, animals, agriculture, and the environment. Antibiotic use in any of these One Health areas can potentially impact the health of other areas. There is a dearth of evidence on AMR from the natural environment, such as the plant-based agriculture sector. Antibiotics, antibiotic-resistant bacteria (ARB), and related AMR genes (ARGs) are assumed to present in the natural environment and disseminate resistance to fresh produce/vegetables and thus to human health upon consumption. Therefore, this study aims to investigate the role of vegetables in the spread of AMR through an agroecosystem exploration from a One Health perspective in Ahmedabad, India. Protocol: The present study will be executed in Ahmedabad, located in Gujarat state in the Western part of India, by adopting a mixed-method approach. First, a systematic review will be conducted to document the prevalence of ARB and ARGs on fresh produce in South Asia. Second, agriculture farmland surveys will be used to collect the general farming practices and the data on common vegetables consumed raw by the households in Ahmedabad. Third, vegetable and soil samples will be collected from the selected agriculture farms and analyzed for the presence or absence of ARB and ARGs using standard microbiological and molecular methods. Discussion: The analysis will help to understand the spread of ARB/ARGs through the agroecosystem. This is anticipated to provide an insight into the current state of ARB/ARGs contamination of fresh produce/vegetables and will assist in identifying the relevant strategies for effectively controlling and preventing the spread of AMR.

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Document Type:Preprint
Author:Pachillu Kalpana, Timo Falkenberg, Sandul Yasobant, Deepak Saxena, Christiane Schreiber
Parent Title (English):F1000Research
Article Number:316
Number of pages:12
Date of first publication:2023/03/22
Copyright:© 2023 Kalpana P et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Funding:This work was supported by the University of Bonn, the University of Applied Sciences Bonn-Rhein-Sieg, and the Ministry of Culture and Science of North Rhine-Westphalia, Germany, through the Forschungskolleg “One Health and Urban Transformation”.
Projects:NRW Forschungskolleg One Health and Urban Transformation
Dewey Decimal Classification (DDC):3 Sozialwissenschaften / 36 Soziale Probleme, Sozialdienste / 360 Soziale Probleme und Sozialdienste; Verbände
Entry in this database:2023/04/18