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Rate dependent tack behavior of silicone-based pressure sensitive adhesives for transdermal therapeutic systems

  • Transdermal therapeutic systems (TTS) represent an up-to-day medication applied to human skin, which consists of a drug-containing pressure-sensitive adhesive (PSA) and a flexible backing layer. The development of a reliable TTS requires precise knowledge of the viscoelastic tack behavior of PSA in terms of adhesion and detaching. Tailoring of a PSA can be achieved by altering the resin content or modifying the chemical properties of the macromolecules. In this study, three different resin content of two silicone-based PSA – non-amine compatible, and less tack, amine-compatible – were investigated with the help of recently developed RheoTack method to characterize the retraction speed dependent tack behavior for various geometries of the testing rods. The obtained force-retraction displacement-curves clearly depict the effect of the chemical structure as well as the resin content. Decreasing the resin content shifts the start of fibril fracture to larger deformations states and significantly enhances the stretchability of the fibrils. To compare various rod geometries precisely, the force-retraction displacement curves were normalized to account for effective contact areas. The flat and spherical rods led to completely different failure and tack behaviors. Furthermore, the adhesion formation between TTS with flexible backing layers and rods during the dwell phase happens in a different manner compared to rigid plates, in particular for flat rods, where maximum compression stresses occur at the edges and not uniformly over the cross-section. Thus, the approach to follow ASTM D2949 has to be reconsidered for tests of these materials.

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Metadaten
Document Type:Preprint
Language:English
Author:Michael Meurer, Gatien Kamsu Fogain, Esther Ramakers van Dorp, Christian Dresbach, Bernhard Möginger, Berenika Hausnerova
Number of pages:16
DOI:https://doi.org/10.21203/rs.3.rs-3010924/v1
Publisher:Research Square
Date of first publication:2023/06/08
Copyright:This work is licensed under a CC BY 4.0 License.
Funding:This study was also supported by the German Ministry of Education and Research. Grant No.: 03FH039PX5. The author B.H. acknowledges the Ministry of Education, Youth and Sports of the Czech Republic, DKRVO (RP/CPS/2022/003). The author M.M. also thanks the Graduate Institute Bonn-Rhein-Sieg University of Applied Sciences for supporting this work by granting a scholarship.
Note:
The datasets generated during and/or analysed during the current study are available in the Zenodo open repository maintained by https://doi.org/10.5281/zenodo.5603015.
Keyword:adhesion; force-retraction displacement-curve; pressure sensitive adhesive; tack; transdermal therapeutic systems
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für Technik, Ressourcenschonung und Energieeffizienz (TREE)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 53 Physik / 531 Klassische Mechanik; Festkörpermechanik
Entry in this database:2023/06/16
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International