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Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria

  • The non-filarial and non-communicable disease podoconiosis affects around 4 million people and is characterized by severe leg lymphedema accompanied with painful intermittent acute inflammatory episodes, called acute dermatolymphangioadenitis (ADLA) attacks. Risk factors have been associated with the disease but the mechanisms of pathophysiology remain uncertain. Lymphedema can lead to skin lesions, which can serve as entry points for bacteria that may cause ADLA attacks leading to progression of the lymphedema. However, the microbiome of the skin of affected legs from podoconiosis individuals remains unclear. Thus, we analysed the skin microbiome of podoconiosis legs using next generation sequencing. We revealed a positive correlation between increasing lymphedema severity and non-commensal anaerobic bacteria, especially Anaerococcus provencensis, as well as a negative correlation with the presence of Corynebacterium, a constituent of normal skin flora. Disease symptoms were generally linked to higher microbial diversity and richness, which deviated from the normal composition of the skin. These findings show an association of distinct bacterial taxa with lymphedema stages, highlighting the important role of bacteria for the pathogenesis of podoconiosis and might enable a selection of better treatment regimens to manage ADLA attacks and disease progression.

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Metadaten
Document Type:Article
Language:English
Author:Claudio Neidhöfer, Derick Lekealem Nkwetta, Bangsi Rose Fuen, Njodzeka Flora Yenban, Nancielle Mbiatong, Gordon Takop Nchanji, Patricia Korir, Nina Wetzig, Martin Sieber, Ralf Thiele, Marijo Parcina, Ute Klarmann-Schulz, Achim Hoerauf, Samuel Wanji, Manuel Ritter
Parent Title (English):Scientific Reports
Volume:13
Issue:1
Article Number:13785
Number of pages:9
ISSN:2045-2322
URN:urn:nbn:de:hbz:1044-opus-75099
DOI:https://doi.org/10.1038/s41598-023-40765-7
PMID:https://pubmed.ncbi.nlm.nih.gov/37612446
Publisher:Springer Nature
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2023/08/23
Copyright:© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License.
Funding:This study was part of the TAKeOFF project which is funded by the German Federal Ministry of Education and Research (BMBF) [01KA1611, 01KA2027, and 01KA2113A]. AH is additionally supported by the DFG under Germany’s Excellence Strategy-EXC2151-390873048. SW is the Senior Fellow Plus of the European Developing Clinical Trial Partnership (EDCTP2).
Keyword:Bacteria, Anaerobic; Elephantiasis; Humans; Leg; Lymphedema; Skin
Departments, institutes and facilities:Fachbereich Informatik
Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2023/09/13
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International