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Analysis of nine nitrosamines relevant to occupational safety by ion mobility spectroscopy and preliminary gas chromatographic separation

  • Nitrosamines have been identified as a probable human carcinogen and thus are of high concern in many manufacturing industries and various matrices (for example pharmaceutical, cosmetic and food products, workplace air or potable- and wastewater). This study aims to analyse nine nitrosamines relevant in the field of occupational safety using a gas chromatography-drift tube ion mobility spectrometry (GC-DT-IMS) system. To do this, single nitrosamine standards as well as a standard mix, each at 0.1 g/L, were introduced via liquid injection. A GC-DT-IMS method capable of separating the nitrosamine signals according to retention time (first dimension) and drift time (second dimension) in 10 min was developed. The system shows excellent selectivity as each nitrosamine gives two signals pertaining to monomer and dimer in the second dimension. For the first time, reduced ion mobility values for nitrosamines were determined, ranging from 1.18 to 2.03 cm2s−1V−1. The high selectivity of the GC-DT-IMS method could provide a definite advantage for monitoring nitrosamines in different manufacturing industries and consumer products.

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Metadaten
Document Type:Article
Language:English
Author:Jana Hinz, Tessema F. Mekonnen, Jonas Bergrath, Savanna Sewell, Yannic Schneck, Michaela Wirtz, Ursula Telgheder
Parent Title (English):Journal of Chromatography Open
Volume:4
Article Number:100102
Number of pages:7
ISSN:2772-3917
URN:urn:nbn:de:hbz:1044-opus-75166
DOI:https://doi.org/10.1016/j.jcoa.2023.100102
Publisher:Elsevier
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2023/08/26
Copyright:© 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
Funding:This research was funded by the German Social Accident Insurance (Deutsche Gesetzliche Unfallversicherung, DGUV), Grant No. FP0461.
Keyword:Carcinogenic; Drift tube; Gas chromatography; Ion mobility spectrometer; Nitrosamine; Occupational safety
Departments, institutes and facilities:Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 66 Chemische Verfahrenstechnik / 660 Chemische Verfahrenstechnik
Open access funding:Hochschule Bonn-Rhein-Sieg / Publikationsfonds / 2022 ff
Deutsche Forschungsgemeinschaft / DFG Förderung Open Access Publikationskosten 2023 - 2025
Entry in this database:2023/09/15
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International