Refine
H-BRS Bibliography
- yes (4917) (remove)
Departments, institutes and facilities
- Fachbereich Wirtschaftswissenschaften (1243)
- Fachbereich Informatik (1148)
- Fachbereich Angewandte Naturwissenschaften (766)
- Fachbereich Ingenieurwissenschaften und Kommunikation (636)
- Institut für Technik, Ressourcenschonung und Energieeffizienz (TREE) (480)
- Präsidium (403)
- Fachbereich Sozialpolitik und Soziale Sicherung (402)
- Institute of Visual Computing (IVC) (313)
- Institut für funktionale Gen-Analytik (IFGA) (241)
- Internationales Zentrum für Nachhaltige Entwicklung (IZNE) (195)
Document Type
- Article (1603)
- Conference Object (1119)
- Part of a Book (690)
- Part of Periodical (410)
- Book (monograph, edited volume) (370)
- Report (145)
- Preprint (88)
- Working Paper (87)
- Contribution to a Periodical (83)
- Doctoral Thesis (70)
Year of publication
Keywords
- Lehrbuch (85)
- Deutschland (27)
- Nachhaltigkeit (27)
- Controlling (23)
- Unternehmen (23)
- Digitalisierung (17)
- Management (17)
- Betriebswirtschaftslehre (16)
- Machine Learning (16)
- Corporate Social Responsibility (15)
Fünfte Ordnung zur Änderung der Beitragsordnung des Studierendenwerks Bonn vom 24. August 2015
(2015)
Fünfte Ordnung über die Änderung der Grundordnung der Hochschule Bonn-Rhein-Sieg vom 18.03.2015
(2015)
Vierte Ordnung über die Änderung der Grundordnung der Hochschule Bonn-Rhein-Sieg vom 16.10.2014
(2014)
Dritte Ordnung über die Änderung der Grundordnung der Hochschule Bonn-Rhein-Sieg vom 21.11.2013
(2014)
Satzung der Fachschaft Wirtschaftswissenschaften der Hochschule Bonn-Rhein-Sieg vom 24.04.2013
(2013)
Satzung der Fachschaft Wirtschaftswissenschaften der Hochschule Bonn-Rhein-Sieg vom 26.04.2012
(2012)
Satzung des Institutes für Sicherheitsforschung der Hochschule Bonn-Rhein-Sieg vom 16.02.2012
(2012)
Selection Performance and Reliability of Eye and Head Gaze Tracking Under Varying Light Conditions
(2024)
Is It Really You Who Forgot the Password? When Account Recovery Meets Risk-Based Authentication
(2024)
Introduction: A multitude of findings from cell cultures and animal studies are available to support the anti-cancer properties of cannabidiol (CBD). Since CBD acts on multiple molecular targets, its clinical adaptation, especially in combination with cancer immunotherapy regimen remains a serious concern.
Methods: Considering this, we extensively studied the effect of CBD on the cytokine-induced killer (CIK) cell immunotherapy approach using multiple non-small cell lung cancer (NSCLC) cells harboring diverse genotypes.
Results: Our analysis showed that, a) The Transient Receptor Potential Cation Channel Subfamily V Member 2 (TRPV2) channel was intracellularly expressed both in NSCLC cells and CIK cells. b) A synergistic effect of CIK combined with CBD, resulted in a significant increase in tumor lysis and Interferon gamma (IFN-g) production. c) CBD had a preference to elevate the CD25+CD69+ population and the CD62L_CD45RA+terminal effector memory (EMRA) population in NKT-CIK cells, suggesting early-stage activation and effector memory differentiation in CD3+CD56+ CIK cells. Of interest, we observed that CBD enhanced the calcium influx, which was mediated by the TRPV2 channel and elevated phosphor-Extracellular signal-Regulated Kinase (p-ERK) expression directly in CIK cells, whereas ERK selective inhibitor FR180204 inhibited the increasing cytotoxic CIK ability induced by CBD. Further examinations revealed that CBD induced DNA double-strand breaks via upregulation of histone H2AX phosphorylation in NSCLC cells and the migration and invasion ability of NSCLC cells suppressed by CBD were rescued using the TRPV2 antagonist (Tranilast) in the absence of CIK cells. We further investigated the epigenetic effects of this synergy and found that adding CBD to CIK cells decreased the Long Interspersed Nuclear Element-1 (LINE-1) mRNA expression and the global DNA methylation level in NSCLC cells carrying KRAS mutation. We further investigated the epigenetic effects of this synergy and found that adding CBD to CIK cells decreased the Long Interspersed Nuclear Element-1 (LINE-1) mRNA expression and the global DNA methylation level in NSCLC cells carrying KRAS mutation.
Conclusions: Taken together, CBD holds a great potential for treating NSCLC with CIK cell immunotherapy. In addition, we utilized NSCLC with different driver mutations to investigate the efficacy of CBD. Our findings might provide evidence for CBD-personized treatment with NSCLC patients.