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This study deals with the in-situ detection of volume fractions of melt in labradorite and basalt at 0.3 GPa pressure and temperatures ranging from 400–1500 °C. Methods used were frequency dependent electrical conductivity (EC) and energy dispersive X-ray diffraction (EDX). These techniques allowed melt fraction determination under in-situ pressure and temperature conditions, while optical analysis (SEM) was performed on quenched samples. EC allowed detecting melt frac- tions as low as 0.03 due to changes in dielectric properties. Increasing melt fractions caused the formerly isolated melt bubbles to interconnect along grain boundaries, thus increasing the bulk conductivity. Electrical conductivity thus provides a measure for both, the formation of melt (dielectric property) and the degree of interconnection of melt (bulk conductivity). Energy dispersive X-ray diffraction experiments (EDX) provided an additional measure for the volume fraction of melt. EDX diffraction data were used to calculate the volume fraction of melt on the basis of the peak to background ratio. In a final step the experimental data (SEM, EC, EDX) were compared with geometric models of melt distribution, namely the Archie-, cube-, tube-, Hashin-Shtrikman HS + and HS - model. The electrical "polarisability" data closely fit the HS + model, while bulk conductivity data were found to be less sensitive for melt fraction detection.
Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases
(2017)
ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. As few ETV6-RUNX1 carriers develop precursor B cell acute lymphocytic leukemia (pB-ALL), the underlying genetic basis for development of full-blown leukemia remains to be identified, but the appearance of leukemia cases in time-space clusters keeps infection as a potential causal factor. Here we present in vivo genetic evidence mechanistically connecting preleukemic ETV6-RUNX1 expression in hematopoetic stem cells/peripheral cells (HSC/PC) and postnatal infections for human-like pB-ALL. In our model, ETV6-RUNX1 conferred a low risk of developing pB-ALL after exposure to common pathogens, corroborating the low incidence observed in humans. Murine preleukemic ETV6-RUNX1 pro/preB cells showed high Rag1/2 expression, known for human ETV6-RUNX1 pB-ALL. Murine and human ETV6-RUNX1 pB-ALL revealed recurrent genomic alterations, with a relevant proportion affecting genes of the lysine demethylase (KDM) family. KDM5C loss-of-function resulted in increased levels of H3K4me3, which co-precipitated with RAG2 in a human cell line model, laying the molecular basis for recombination activity. We conclude that alterations of KDM family members represent a disease-driving mechanism and an explanation for RAG off-target cleavage observed in humans. Our results explain the genetic basis for clonal evolution of an ETV6-RUNX1 preleukemic clone to pB-ALL after infection exposure and offer the possibility of novel therapeutic approaches.
In today’s business, culture plays a vital role or to a high degree influences the attitude, perception and decision making process of an individual. Culture is an unavoidable state of rules and regulations that defines people’s daily life in a particular environment or society. There are plenty examples of business failures or stagnation or failure of joint ventures, on account of the management's inability to recognize cross-cultural challenges and tackle them appropriately.
Sie leiten ein heterogenes oder agiles Team und merken, dass Sie bisherige Führungsgrundsätze überdenken müssen? In diesem Spotlight erfahren Sie, wie Sie mit dem Wandel zur Agilität und mit Diversity in Ihrem Team umgehen können. Sie erhalten Unterstützung beim Thema Delegieren oder wenn Sie sich mit widersprüchlichen Führungszielen konfrontiert sehen. Außerdem zeigen Ihnen unsere Autoren mit direkt einsetzbaren Tipps, wie Sie wertschätzend führen sowie für Verbindlichkeit und ein gemeinsames Verständnis im Projektteam sorgen.
OpenDaylight (ODL) is a commercial, collaborative, open-source platform to accelerate the adoption and innovation of Software Defined Networking (SDN) and Network Function Visualization. This paper describes the novel ODL architecture in a simplified way to grasp a better understanding of such architecture. ODL architecture intends to foster new innovation and accelerate adoption of programming the network. The innovation of Model-Driven Service Abstraction Layer (MD-SAL) in the architecture leads to developing models for automatic management and configuration of the networks. MD-SAL provides ODL with the ability to support any protocol talking to the network elements as well as any network application. The flexibility inherent in ODL architecture could enable ODL to shape the next generation networks.
This study sought to determine the relationship between entrepreneurial education and youth employability and economic development in Kenya. A descriptive cross sectional design was used to collect data, with the main data collection instrument being a semi structured questionnaire. The population of the study comprised the micro, small and medium scale enterprises in Nairobi, Kenya. Out of the 100 questionnaires issued, 93 were completed and returned giving a response rate of 93%. Descriptive analysis (means and standard deviations ) and inferential analysis was used to analyze the data. Regression and correlation analysis was done to test the hypotheses. It was found that several indicators of entrepreneurial education had a significantly positive influence on youth employability. For example, entrepreneurial education enhances opportunity recognition as an indicator of entrepreneurial education was statistically significantly correlated with the statement that entrepreneurship endeavor is an employment alternative as an indicator of youth employability (r = 331**, P = 0.01). Similarly, the statement that entrepreneurial education sharpens competitiveness had a significantly positive influence on the statement that entrepreneurship endevour is an employment alternative (r =.313** P = 0.01). The overall model for entrepreneurial education and youth employability had an R Square value of 0.151, and an F value of 3.086, (p = 0.013 < 0.05), indicating that the influence is significant at the 0.05 level. The study found that most indicators of youth employability had a significantly positive correlation with indicators of economic development. It was found that there was a significant positive correlation between entrepreneurial education enhances new product and service development and entrepreneurial education reduces youth unemployment (r =0.304**, P = 0.01), while entrepreneurial education enhances new product and service development also has a positive correlation with entrepreneurial education reduces youth unemployment (.304** , P = 0.01). The overall model for youth employability and economic development had an R square value of .087 and F value of 2.103, p =0.87 > 0.05, indication that although youth employability is responsible for 8.7% of economic development, the effect is not statistically significant. The implication for this is that entrepreneurial education should be encouraged as a way of enhancing entrepreneurial thinking among the youth, so that they can use this to venture into self employment. However, this study did not find a significant direct link between youth employability and economic development, and this can only be implied. We suggest increased government support for entrepreneurship training and for closer industry university collaboration and partnerships in order to accelerate economic development.