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This study deals with the in-situ detection of volume fractions of melt in labradorite and basalt at 0.3 GPa pressure and temperatures ranging from 400–1500 °C. Methods used were frequency dependent electrical conductivity (EC) and energy dispersive X-ray diffraction (EDX). These techniques allowed melt fraction determination under in-situ pressure and temperature conditions, while optical analysis (SEM) was performed on quenched samples. EC allowed detecting melt frac- tions as low as 0.03 due to changes in dielectric properties. Increasing melt fractions caused the formerly isolated melt bubbles to interconnect along grain boundaries, thus increasing the bulk conductivity. Electrical conductivity thus provides a measure for both, the formation of melt (dielectric property) and the degree of interconnection of melt (bulk conductivity). Energy dispersive X-ray diffraction experiments (EDX) provided an additional measure for the volume fraction of melt. EDX diffraction data were used to calculate the volume fraction of melt on the basis of the peak to background ratio. In a final step the experimental data (SEM, EC, EDX) were compared with geometric models of melt distribution, namely the Archie-, cube-, tube-, Hashin-Shtrikman HS + and HS - model. The electrical "polarisability" data closely fit the HS + model, while bulk conductivity data were found to be less sensitive for melt fraction detection.
Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases
(2017)
ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. As few ETV6-RUNX1 carriers develop precursor B cell acute lymphocytic leukemia (pB-ALL), the underlying genetic basis for development of full-blown leukemia remains to be identified, but the appearance of leukemia cases in time-space clusters keeps infection as a potential causal factor. Here we present in vivo genetic evidence mechanistically connecting preleukemic ETV6-RUNX1 expression in hematopoetic stem cells/peripheral cells (HSC/PC) and postnatal infections for human-like pB-ALL. In our model, ETV6-RUNX1 conferred a low risk of developing pB-ALL after exposure to common pathogens, corroborating the low incidence observed in humans. Murine preleukemic ETV6-RUNX1 pro/preB cells showed high Rag1/2 expression, known for human ETV6-RUNX1 pB-ALL. Murine and human ETV6-RUNX1 pB-ALL revealed recurrent genomic alterations, with a relevant proportion affecting genes of the lysine demethylase (KDM) family. KDM5C loss-of-function resulted in increased levels of H3K4me3, which co-precipitated with RAG2 in a human cell line model, laying the molecular basis for recombination activity. We conclude that alterations of KDM family members represent a disease-driving mechanism and an explanation for RAG off-target cleavage observed in humans. Our results explain the genetic basis for clonal evolution of an ETV6-RUNX1 preleukemic clone to pB-ALL after infection exposure and offer the possibility of novel therapeutic approaches.
In today’s business, culture plays a vital role or to a high degree influences the attitude, perception and decision making process of an individual. Culture is an unavoidable state of rules and regulations that defines people’s daily life in a particular environment or society. There are plenty examples of business failures or stagnation or failure of joint ventures, on account of the management's inability to recognize cross-cultural challenges and tackle them appropriately.
OpenDaylight (ODL) is a commercial, collaborative, open-source platform to accelerate the adoption and innovation of Software Defined Networking (SDN) and Network Function Visualization. This paper describes the novel ODL architecture in a simplified way to grasp a better understanding of such architecture. ODL architecture intends to foster new innovation and accelerate adoption of programming the network. The innovation of Model-Driven Service Abstraction Layer (MD-SAL) in the architecture leads to developing models for automatic management and configuration of the networks. MD-SAL provides ODL with the ability to support any protocol talking to the network elements as well as any network application. The flexibility inherent in ODL architecture could enable ODL to shape the next generation networks.
This study sought to determine the relationship between entrepreneurial education and youth employability and economic development in Kenya. A descriptive cross sectional design was used to collect data, with the main data collection instrument being a semi structured questionnaire. The population of the study comprised the micro, small and medium scale enterprises in Nairobi, Kenya. Out of the 100 questionnaires issued, 93 were completed and returned giving a response rate of 93%. Descriptive analysis (means and standard deviations ) and inferential analysis was used to analyze the data. Regression and correlation analysis was done to test the hypotheses. It was found that several indicators of entrepreneurial education had a significantly positive influence on youth employability. For example, entrepreneurial education enhances opportunity recognition as an indicator of entrepreneurial education was statistically significantly correlated with the statement that entrepreneurship endeavor is an employment alternative as an indicator of youth employability (r = 331**, P = 0.01). Similarly, the statement that entrepreneurial education sharpens competitiveness had a significantly positive influence on the statement that entrepreneurship endevour is an employment alternative (r =.313** P = 0.01). The overall model for entrepreneurial education and youth employability had an R Square value of 0.151, and an F value of 3.086, (p = 0.013 < 0.05), indicating that the influence is significant at the 0.05 level. The study found that most indicators of youth employability had a significantly positive correlation with indicators of economic development. It was found that there was a significant positive correlation between entrepreneurial education enhances new product and service development and entrepreneurial education reduces youth unemployment (r =0.304**, P = 0.01), while entrepreneurial education enhances new product and service development also has a positive correlation with entrepreneurial education reduces youth unemployment (.304** , P = 0.01). The overall model for youth employability and economic development had an R square value of .087 and F value of 2.103, p =0.87 > 0.05, indication that although youth employability is responsible for 8.7% of economic development, the effect is not statistically significant. The implication for this is that entrepreneurial education should be encouraged as a way of enhancing entrepreneurial thinking among the youth, so that they can use this to venture into self employment. However, this study did not find a significant direct link between youth employability and economic development, and this can only be implied. We suggest increased government support for entrepreneurship training and for closer industry university collaboration and partnerships in order to accelerate economic development.
Access to affordable energy - for basic needs as well as for national economic development - is a crucial concern for developing countries. Access to modern and sustainable energy services in rural areas, where the majority of the population is living in poverty, is a particularly urgent challenge, and one which has been recognized as crucial within the global development agenda.
The current dominant development model, focused on achieving macro-economic growth, gives priority to large-scale or centralized energy infrastructures for national growth or for meeting the urban demand. Rural areas of poorer countries are often at a disadvantage in terms of access to all types of services – roads, health facilities, markets, information and clean water. The high cost of providing these services in remote areas has led to new approaches being tried, based on self-help and the private sector rather than traditional government-led solutions. The missing access to electricity is primarily the reason for the poor operational environment of entrepreneurship especially in rural areas of developing countries, which poses many barriers to their development and limits their competitiveness. Energy services for household, agriculture and production serve as best examples as sectors exposed to enable entrepreneurship by productive use of renewable energy.
This paper describes the line-up, the challenges and the outcome of a development project in rural Ethiopia to support entrepreneurship based on the usage of renewable energy, in this case mainly photo-voltaic technology. In particular, this study tries to show up key features which are required to enable sustainable energy access and foster implementation challenges of developed business models in practice. Based on this experience, the paper discusses implications and lessons learned for a further development.
The non-farm sector is critical for the socio-economic development of Ghana especially the rural poor. Literature suggest that people engage in non-farm enterprises as a way out of poverty or a survival strategy, perhaps as a substitute for the landless. This paper analyses the determinants of individual participation in non-farm enterprises and the intensity of participation. The paper uses EGC/ISSER Socio-Economic Panel Survey data collected in 2009. The paper estimated the determinants of participation using a probit model and then estimated the intensity of participation using a truncated regression model. The results indicate that majority of women (about 73%) are engaged in non-farm enterprises in rural Ghana. The study found that females tended to participate more in non-farm self-employment and are less likely to participate in non-farm wage employment. The results further showed that individual characteristics such as the gender of the individual, being head of a household, being the spouse of a household head, having formal education, age of the individual, having access to credit, possessing a mobile phone, per capita landing holding and ownership of livestock influenced the participation of individuals in self-and wage employment. Results from truncated regression model for self-employed enterprises showed that having access to mobile phones, owning more livestock and electricity are important in determining the intensity of participation in self-employed enterprises. For wage-employment, being a household head, spouse of household head, having access to mobile phone and owning more livestock increased the number of days working on wage employment. Education is relevant for employment in the non-farm sector especially wage-employment. Government should play a lead role in making formal education accessible to the rural people. Deliberate policies should focus on addressing critical factors such as access to credit, mobile phone, electricity and education which are relevant for increasing participation intensity in rural enterprises.
Over the past decades, growing trends in social media, e-literacy and globalisation have led to the increased use of electrical and electronic equipment (EEE) in offices, schools, homes, hospitals and other institutions. Although, there are more efforts at introducing diversity, innovation and increased use of EEE, there had been limited effort at managing the end?of?life of these electronic devices. Evidence from previous research showed that the management of the end of life of electronic waste is highly dominated by Micro, Small and Medium Sized Enterprises (MSMEs) in the informal sector who employ more crude technology in their operations. This exploratory study therefore, sought to examine the activities of corporate bodies and MSMEs (formal and informal) in the e-waste sector in the Accra and Kumasi Metropolitan Areas in Ghana. Data was collected via questionnaires and interview from randomly selected respondents in the two metropolises. Results reveal that even though corporate institutions import a lot of electrical and electronic equipment, they do not have any policies on disposal of the e-waste generated. Thus, a high percentage of the e-waste generated is processed by the informal sector. The implications of the results are that policy makers and other stakeholders should encourage MSMEs to formalize their activities, support investment and green business development as well as funding and training for MSMEs operating in the sector.
Small and Medium Enterprises (SMEs) are engine of economy both for developed and developing countries. They play a significant role in income generation, job creation, poverty reduction and reducing income inequality. In Burundi, key stakeholders such as policy-makers as well as other international and national actors have made more effort to develop the segment of SMEs. Indeed, many start-ups have been created but are however, exposed to several challenges in their business operations. This paper aimed at investigating main critical barriers to SMEs growth and development in Burundi. The research was based upon a sample survey of small firms in Burundi and 314 small enterprises were surveyed. Rural start-ups’ critical barriers identified are mainly poor management, lack of access to market flow, lack of working capital, inadequate qualified workforce and low selling prices. On the other hand, five severe obstacles for urban SMEs identified are insecurity, access to financing, macroeconomic situation, lack of customers and unfair competition. A better understanding of all these barriers that SMEs are facing is useful to set up best strategies susceptible to increase their growth.
Entrepreneurship education serves a conduit for new venture creation as it provides the knowledge and skills needed to increase the self-efficacy of individuals to start and run new businesses and to grow existing ones. This study, therefore, sought to assess the relationship between the approaches to the teaching of entrepreneur-ship and entrepreneurial intention on a cohort of 292 respondents consisting of students who have studied entrepreneurship in three selected Universities. A structured questionnaire was used to obtain data randomly from students. The canonical correlation results indicate that education for and through entrepreneurship is the best approach to promoting entrepreneurial intensity among University students, if the aim of teaching entrepreneur-ship is to promote start-up activities. The findings provide valuable insights for institutions of higher learning and policy makers in Ghana with respect to the appropriate methodologies to be adopted in the teaching of entrepreneurship in our universities.