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Introduction: Antimicrobial resistance (AMR) has emerged as one of the leading threats to public health. AMR possesses a multidimensional challenge that has social, economic, and environmental dimensions that encompass the food production system, influencing human and animal health. The One Health approach highlights the inextricable linkage and interdependence between the health of people, animals, agriculture, and the environment. Antibiotic use in any of these One Health areas can potentially impact the health of other areas. There is a dearth of evidence on AMR from the natural environment, such as the plant-based agriculture sector. Antibiotics, antibiotic-resistant bacteria (ARB), and related AMR genes (ARGs) are assumed to present in the natural environment and disseminate resistance to fresh produce/vegetables and thus to human health upon consumption. Therefore, this study aims to investigate the role of vegetables in the spread of AMR through an agroecosystem exploration from a One Health perspective in Ahmedabad, India.
Protocol: The present study will be executed in Ahmedabad, located in Gujarat state in the Western part of India, by adopting a mixed-method approach. First, a systematic review will be conducted to document the prevalence of ARB and ARGs on fresh produce in South Asia. Second, agriculture farmland surveys will be used to collect the general farming practices and the data on common vegetables consumed raw by the households in Ahmedabad. Third, vegetable and soil samples will be collected from the selected agriculture farms and analyzed for the presence or absence of ARB and ARGs using standard microbiological and molecular methods.
Discussion: The analysis will help to understand the spread of ARB/ARGs through the agroecosystem. This is anticipated to provide an insight into the current state of ARB/ARGs contamination of fresh produce/vegetables and will assist in identifying the relevant strategies for effectively controlling and preventing the spread of AMR.
KPI-EDGAR: A Novel Dataset and Accompanying Metric for Relation Extraction from Financial Documents
(2023)
Jahresbericht 2022
(2023)
Voraussehen heißt, Visionen für die Zukunft zu entwickeln und verantwortungsvoll mitzugestalten und dies im engen Austausch zwischen angewandter Wissenschaft, Gesellschaft und Wirtschaft. Das ist der Hochschule Bonn-Rhein-Sieg ein wichtiges Anliegen. Die H-BRS hat in Lehre, Forschung und Transfer neue Wege beschritten und Akzente gesetzt – zum Beispiel auf den Gebieten Nachhaltigkeit, Energiewende oder Cybersecurity. Der Jahresbericht 2022/23 bietet einen Überblick über die wichtigsten Themen aus den Gebieten Forschung, Lehre, Studium und Kooperation.
Dieses Buch wurde im Rahmen eines Wirtschaftsinformatik-Projektes an der Hochschule Bonn-Rhein-Sieg unter Aufsicht von Prof. Dr. Alexandra Kees geschrieben. Ziel des Projektes war die Erstellung eines Funktionsreferenzmodells für Enterprise Resource Planning (ERP-) Software, welches in Form eines Buches veröffentlicht werden sollte. Die Studierenden haben für das Projekt jeweils verschiedene Teilbereiche, die in einem ERP-System gewöhnlich Anwendung finden, zugeteilt bekommen. In diesem Teil wird der Bereich Lagerverwaltung näher betrachtet.
RELA haploinsufficiency is a recently described autoinflammatory condition presenting with intermittent fevers and mucocutaneous ulcerations. The RELA gene encodes the p65 protein, one of five NF-κB family transcription factors. As RELA is an essential regulator of mucosal homeostasis, haploinsufficiency leads to decreased NF-κB signaling which promotes TNF-driven mucosal apoptosis with impaired epithelial recovery. Thus far, only eight cases have been reported in the literature. Here, we report four families with three novel and one previously described pathogenic variant in RELA. These four families included 23 affected individuals for which genetic testing was available in 16. Almost half of these patients had been previously diagnosed with more common rheumatologic entities (such as Behcet's Disease; BD) prior to the discovery of their pathogenic RELA variants. The most common clinical features were orogenital ulcers, rash, joint inflammation, and fever. The least common were conjunctivitis and recurrent infections. Clinical variability was remarkable even among familial cases, and incomplete penetrance was observed. Patients in our series were treated with a variety of medications, and benefit was observed with glucocorticoids, colchicine, and TNF inhibitors. Altogether, our work adds to the current literature and doubles the number of reported cases with RELA-Associated Inflammatory Disease (RAID). It reaffirms the central importance of the NF-κB pathway in immunity and inflammation, as well as the important regulatory role of RELA in mucosal homeostasis. RELA associated inflammatory disease should be considered in all patients with BD, particularly those with early onset and/or with a strong family history.
Das Konzept von Purpose, Travelling und Connectivity: Drei Säulen der Organisation und Leadership
(2023)
Geschäftsprozess-Management
(2023)