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Nachhaltige und zukunftsfähige Mobilität in Städten kann langfristig nur durch die aktive Partizipation ihrer Bürger und Institutionen erreicht werden. Betriebliches Mobilitätsmanagement (BMM) kann dabei einen positiven Beitrag im Hinblick auf Umwelt, Gesundheit und Kosten leisten. Die vorliegende Arbeit beschäftigt sich mit der Wahrnehmung gesundheitlicher und finanzieller Wertschöpfungsaspekte des BMM. Im Rahmen des Forschungsprojekts Betriebe lösen Verkehrsprobleme werden Mobilitätsverhalten und Maßnahmen der Betrieblichen Gesundheitsförderung (BFG) in Bonner Betrieben untersucht. Folgenden Aspekten wird besondere Beachtung geschenkt: Bedeutung Betrieblicher Gesundheitsförderung in Bonner Betrieben, Mobilitätsverhalten von Arbeitnehmern auf dem Weg zur Dienststelle, Wahrnehmung eines unmittelbaren Zusammenhangs zwischen körperlicher Aktivität und Gesundheit bzw. krankheitsbedingter Kosten und Umsatzeinbußen durch Bewegungsmangel. Die Analyse resultiert auf der Basis einer schriftlichen Befragung von 178 Unternehmen, einer Online-Umfrage von 1.341 Mitarbeitern aus 14 Unternehmen sowie auf persönlichen Interviews mit 22 Betriebsleitern bzw. Mobilitäts- und Gesundheitsbeauftragten. Die Ergebnisse der Studie machen sowohl Handlungsbedarf als auch Optimierungspotentiale im Bereich BMM auf Betriebsseite deutlich. Kostensimulationen zeigen darüber hinaus auf, dass durch die Implementierung von BGF-Maßnahmen, explizit der Förderung von Bewegung, auf betriebs- und volkswirtschaftlicher Seite beachtliche Kosten im Gesundheitsbereich eingespart sowie höhere Gewinne im Unternehmen erzielt werden können.
Temperature Dependency of Morphological Structure of Thermoplastic Polyurethane using WAXS and SAXS
(2016)
Polyurethanes achieved an exceptional position among the most important organic polymers due to their highly specific technological application areas. Polyurethanes represent a polyaddition product of isocyanate and diols. In terms of their enormous industrial importance, the chemistry of isocyanates has been extensively studied.
UX-Professionals stehen vor der Aufgabe ihre Fertigkeiten und Kenntnisse kontinuierlich auszubauen. Eine Möglichkeit dies zu tun sind Communities of Practice, also Gemeinschaften von Personen mit ähnlichen Aufgaben und Schwerpunkten sowie einem gemeinsamen Interesse an Lösungen. Sie agieren weitgehend selbstorganisiert und dienen dem Austausch und der gegenseitigen Unterstützung. So entstehen ein gemeinsamer Wissensschatz sowie ein Netzwerk zwischen allen UX-Interessierten. Der Aufbau einer Community of Practice für UX-Professionals wurde in einem mittelständigen Unternehmen über 18 Monate begleitet und ausgewertet. Die Ergebnisse führten zu Handlungsempfehlungen, um Hindernisse beim Aufbau zu reduzieren und einen Mehrwert für alle Beteiligten herbeizuführen.
Recessive mutations in the MPV17 gene cause mitochondrial DNA depletion syndrome, a fatal infantile genetic liver disease in humans. Loss of function in mice leads to glomerulosclerosis and sensineural deafness accompanied with mitochondrial DNA depletion. Mutations in the yeast homolog Sym1, and in the zebra fish homolog tra cause interesting, but not obviously related phenotypes, although the human gene can complement the yeast Sym1 mutation. The MPV17 protein is a hydrophobic membrane protein of 176 amino acids and unknown function. Initially localised in murine peroxisomes, it was later reported to be a mitochondrial inner membrane protein in humans and in yeast. To resolve this contradiction we tested two new mouse monoclonal antibodies directed against the human MPV17 protein in Western blots and immunohistochemistry on human U2OS cells. One of these monoclonal antibodies showed specific reactivity to a protein of 20 kD absent in MPV17 negative mouse cells. Immunofluorescence studies revealed colocalisation with peroxisomal, endosomal and lysosomal markers, but not with mitochondria. This data reveal a novel connection between a possible peroxisomal/endosomal/lysosomal function and mitochondrial DNA depletion.
Diese Theorie-Einführung hat konsequent praktische Anwendungen im Blick. Seien es Workflow-Systeme, Web Services, Verschlüsselung von Informationen, Authentifizierungsprotokolle oder selbstfahrende Autos - all diese Technologien haben enge Bezüge zu den theoretischen Grundlagen der Informatik. So trägt das Buch dazu bei, dass Studierende die Grundlagen der Theoretischen Informatik nicht nur verstehen, sondern auch anwenden können, um effektiv und produktiv an informationstechnischen Problemlösungen mitwirken zu können. Wegen seiner speziellen inhaltlichen und didaktischen Qualität ist das Buch neben dem Einsatz in der Lehre auch für das Selbststudium geeignet.
Background: Falls are common in older adults and can result in serious injuries. Due to demographic changes, falls and related healthcare costs are likely to increase over the next years. Participation and motivation of older adults in fall prevention measures remain a challenge. The iStoppFalls project developed an information and communication technology (ICT)-based system for older adults to use at home in order to reduce common fall risk factors such as impaired balance and muscle weakness. The system aims at increasing older adults’ motivation to participate in ICT-based fall prevention measures. This article reports on usability, user-experience and user-acceptance aspects affecting the use of the iStoppFalls system by older adults.
Methods: In the course of a 16-week international multicenter study, 153 community-dwelling older adults aged 65+ participated in the iStoppFalls randomized controlled trial, of which half used the system in their home to exercise and assess their risk of falling. During the study, 60 participants completed questionnaires regarding the usability, user experience and user acceptance of the iStoppFalls system. Usability was measured with the System Usability Scale (SUS). For user experience the Physical Activity Enjoyment Scale (PACES) was applied. User acceptance was assessed with the Dynamic Acceptance Model for the Re-evaluation of Technologies (DART). To collect more detailed data on usability, user experience and user acceptance, additional qualitative interviews and observations were conducted with participants.
Results: Participants evaluated the usability of the system with an overall score of 62 (Standard Deviation, SD 15.58) out of 100, which suggests good usability. Most users enjoyed the iStoppFalls games and assessments, as shown by the overall PACES score of 31 (SD 8.03). With a score of 0.87 (SD 0.26), user acceptance results showed that participants accepted the iStoppFalls system for use in their own home. Interview data suggested that certain factors such as motivation, complexity or graphical design were different for gender and age.
Conclusions: The results suggest that the iStoppFalls system has good usability, user experience and user acceptance. It will be important to take these along with factors such as motivation, gender and age into consideration when designing and further developing ICT-based fall prevention systems.
With the rising interest in vehicular communication systems many proposals for secure vehicle-to-vehicle commu- nication were made in recent years. Also, several standard- ization activities concerning the security and privacy measures in these communication systems were initiated in Europe and in US. Here, we discuss some limitations for secure vehicle- to-infrastructure communication in the existing standards of the European Telecommunications Standards Institute. Next, a vulnerability analysis for roadside stations on one side and security and privacy requirements for roadside stations on the other side are given. Afterwards, a proposal for a multi-domain public key architecture for intelligent transport systems, which considers the necessities of road infrastructure authorities and vehicle manufacturers, is introduced. The domains of the public key infrastructure are cryptographically linked based on local trust lists. In addition, a crypto agility concept is suggested, which takes adaptation of key length and cryptographic algorithms during PKI operation into account.
A deployment of the Vehicle-to-Vehicle communication technology according to ETSI is in preparation in Europe. Currently, a Public Key Infrastructure policy for Intelligent Transport Systems in Europe is in discussion to enable V2V communication. This policy set aside two classes of keys and certificates for ITS vehicle stations: long term authentication keys and pseudonymous keys and certificates. We show that from our point of view the periodic sent Cooperative Awareness Messages with extensive data have technical limitations and together with the pseudonym concept cause privacy problems.
We propose an artificial slime mould model (ASMM) inspired by the plasmodium of Physarum polucephalum (P. polucephalum). ASMM consists of plural slimes, and each slime shares energy via a tube with neighboring slimes. Outer slimes sense their environment and conform to it. Outer slimes periodically transmit information about their surrounding environment via a contraction wave to inner slimes. Thus, ASMM shows how slimes can sense a better environment even if that environment is not adjacent to the slimes. The slimes subsequently can move in the direction of an attractant.
In der Ergebnisdarstellung der Reha-QM-Outcome Studie der DRV Baden-Württemberg und des Qualitätsverbunds Gesundheit konnte gezeigt werden, dass Kliniken eines Verbundes, die ein gemeinsames, auf aktivem Benchmarking und Von-Einander-Lernen gegründetes Qualitätsmanagement (Basis QMS Reha®) anwenden, ein Jahr nach der Reha etwas bessere Ergebnisse in relevanten Outcome-Parametern (u. a. subjektiver Reha-Nutzen, geleistete Rentenversicherungsbeiträge) erzielen als der Durchschnitt der Kliniken (Toepler et al., 2015). Der vorliegende Beitrag stellt die verbundinterne Analyse der Studienergebnisse dar und geht der Frage nach, welche QM-Elemente einen positiven Einfluss auf die Outcome-Parameter ausüben.
Wireless sensor networks are widely used in a variety of fields including industrial environments. In case of a clustered network the location of cluster head affects the reliability of the network operation. Finding of the optimum location of the cluster head, therefore, is critical for the design of a network. This paper discusses the optimisation approach, based on the brute force algorithm, in the context of topology optimisation of a cluster structure centralised wireless sensor network. Two examples are given to verify the approach that demonstrate the implementation of the brute force algorithm to find an optimum location of the cluster head.
Cognitive robotics aims at understanding biological processes, though it has also the potential to improve future robotics systems. Here we show how a biologically inspired model of motor control with neural fields can be augmented with additional components such that it is able to solve a basic robotics task, that of obstacle avoidance. While obstacle avoidance is a well researched area, the focus here is on the extensibility of a biologically inspired framework. This work demonstrates how easily the biological inspired system can be used to adapt to new tasks. This flexibility is thought to be a major hallmark of biological agents.
The work at hand outlines a recording setup for capturing hand and finger movements of musicians. The focus is on a series of baseline experiments on the detectability of coloured markers under different lighting conditions. With the goal of capturing and recording hand and finger movements of musicians in mind, requirements for such a system and existing approaches are analysed and compared. The results of the experiments and the analysis of related work show that the envisioned setup is suited for the expected scenario.
Within qualitative interviews we examine attitudes towards driverless cars in order to investigate new mobility services and explore the impact of such services on everyday mobility. We identified three main issues that we would like to discuss in the workshop: (I) Designing beyond a driver-centric approach; (II) Developing mobility services for cars which drive themselves; and (III) Exploring self-driving practices.
Marketing und Recht kompakt
(2016)
"Marketing und Recht - was soll das denn?" So oder ähnlich wird der eine oder andere auf den Titel des vorliegenden Buches spontan reagieren. Das verwundert nicht, ist die Buch-Landschaft doch vor allem dadurch geprägt, dass Marketing-Werke und Abhandlungen zu marketingrelevanten Rechtsthemen am Büchermarkt stets "getrennt marschieren". Wer Marketingkonzepte entwirft, Vorhaben im Rahmen der Marketingforschung durchführen will oder beabsichtigt, Entscheidungen im Rahmen des Marketings zu treffen, sollte unseres Erachtens möglichst frühzeitig die gängigen "juristischen Fallstricke" erkennen und in seinen Überlegungen berücksichtigen.
Design of an Active Multispectral SWIR Camera System for Skin Detection and Face Verification
(2016)
Biometric face recognition is becoming more frequently used in different application scenarios. However, spoofing attacks with facial disguises are still a serious problem for state of the art face recognition algorithms. This work proposes an approach to face verification based on spectral signatures of material surfaces in the short wave infrared (SWIR) range. They allow distinguishing authentic human skin reliably from other materials, independent of the skin type. We present the design of an active SWIR imaging system that acquires four-band multispectral image stacks in real-time. The system uses pulsed small band illumination, which allows for fast image acquisition and high spectral resolution and renders it widely independent of ambient light. After extracting the spectral signatures from the acquired images, detected faces can be verified or rejected by classifying the material as "skin" or "no-skin". The approach is extensively evaluated with respect to both acquisition and classification performance. In addition, we present a database containing RGB and multispectral SWIR face images, as well as spectrometer measurements of a variety of subjects, which is used to evaluate our approach and will be made available to the research community by the time this work is published.
Scientists and engineers are using a distributed system Remote Component Environment (RCE) to design and simulate complex systems like airplanes, ships and satellites. During the simulation, RCE executes local and remote code. Remote code is classified as untrusted code. The execution of remote code comprises potential security risks for the host system of RCE. Additionally, RCE provides full access to system resources. The objective of this thesis is to implement a sandbox prototype to reduce the vulnerability of RCE during the execution of remote code.
Diese Arbeit präsentiert eine Methode zur zuverlässigen Personendetektion für die Absicherung des Arbeitsbereichs von Industrierobotern. Hierzu wird ein im Nahinfrarotbereich (NIR) arbeitendes aktives Kamerasystem eingesetzt, das durch erweiterte und robuste Hauterkennungseigenschaften besonders dazu geeignet ist, zwischen verschiedensten Materialoberflächen und menschlicher Haut zu unterscheiden. So soll zum einen die Erkennungsleistung gegenüber handelsüblichen, im visuellen Bereich arbeitenden RGB-Kamerasystemen gesteigert werden und gleichzeitig eine „intelligente“ Form des Mutings realisiert werden. Die im Rahmen des Projekts „Sichere Personendetektion im Arbeitsbereich von Industrierobotern durch ein aktives NIR-Kamerasystem (SPAI)“ entwickelte und hier vorgestellte Methode erreicht in einer ersten Variante eine pixelweise Personenerkennungsrate von ca. 98,16%.
Supported by their large size and high resolution, display walls suit well for different collaboration types. However, in order to foster instead of impede collaboration processes, interaction techniques need to be carefully designed, taking into regard the possibilities and limitations of the display size, and their effects on human perception and performance. In this paper we investigate the impact of visual distractors (which, for instance, might be caused by other collaborators' input) in peripheral vision on short-term memory and attention. The distractors occur frequently when multiple users collaborate in large wall display systems and may draw attention away from the main task, as such potentially affecting performance and cognitive load. Yet, the effect of these distractors is hardly understood. Gaining a better understanding thus may provide valuable input for designing more effective user interfaces. In this article, we report on two interrelated studies that investigated the effect of distractors. Depending on when the distractor is inserted in the task performance sequence, as well as the location of the distractor, user performance can be disturbed: we will show that distractors may not affect short term memory, but do have an effect on attention. We will closely look into the effects, and identify future directions to design more effective interfaces.
Effects of Workspace Awareness and Territoriality in Environments with Large, Shared Displays
(2016)
Synchronous cooperative work of multiple collaborators in large, high-resolution display systems comprises such psychological phenomena like workspace awareness and human territoriality. The phenomena and interplay between them can cause a significant impact on human-human and human-environment interaction. In a non-digital environment humans rely on their own physical abilities, utilities, and social protocols to control those phenomena (e.g. close eyes, or use earplugs to reduce workspace awareness; rotate oneself towards collaborators to increase workspace awareness). Digital environments, on the other hand, provide us with a possibility to ease, automate, and unify control processes, thus taking off that burden from users. Yet, we have to understand first, what effects workspace awareness and territoriality have within a collaborative environment. The aim of this doctoral thesis is to investigate effects of workspace awareness and territoriality on users and interaction processes in mixed-focus scenarios of various collaborative settings.
The design of future materials for biotechnological applications via deposition of molecules on surfaces will require not only exquisite control of the deposition procedure, but of equal importance will be our ability to predict the shapes and stability of individual molecules on various surfaces. Furthermore, one will need to be able to predict the structure patterns generated during the self-organization of whole layers of (bio)molecules on the surface. In this review, we present an overview over the current state of the art regarding the prediction and clarification of structures of biomolecules on surfaces using theoretical and computational methods.
This paper presents implementation results of several side channel countermeasures for protecting the scalar multiplication of ECC (Elliptic Curve Cryptography) implemented on an ARM Cortex M3 processor that is used in security sensitive wireless sensor nodes. Our implementation was done for the ECC curves P-256, brainpool256r1, and Ed25519. Investigated countermeasures include Double-And-Add Always, Montgomery Ladder, Scalar Randomization, Randomized Scalar Splitting, Coordinate Randomization, and Randomized Sliding Window. Practical side channel tests for SEMA (Simple Electromagnetic Analysis) and MESD (Multiple Exponent, Single Data) are included. Though more advanced side channel attacks are not evaluated, yet, our results show that an appropriate level of resistance against the most relevant attacks can be reached.
Fault-Channel Watermarks
(2016)
We examined the cytotoxic effects of chaetocin on clear cell renal cell carcinoma (ccRCC) cells and the possibility to combine the effects of chaetocin with the effects of cytokine-induced killer cells (CIK) assayed by MTT assay and FACS analysis. Chaetocin is a thiodioxopiperazine produced by fungi belonging to the chaetomiaceae family. In 2007, it was first reported that chaetocin shows potent and selective ex vivo anti-cancer activity by inducing reactive oxygen species. CIK cells are generated from CD3+/CD56- T lymphocytes with double negative CD4-/CD8- phenotype that are isolated from human blood. The addition of distinct interleukins and antibodies results in the generation of CIK cells that are able to specifically target and destroy renal carcinoma cells. The results of this research state that the anti-ccRCC activity of chaetocin is weak and does not show a high grade of selectivity on clear cell renal cell carcinoma cells. Although the CIK cells show a high grade of selective anti-ccRCC activity, this effect could not be improved by the addition of chaetocin. So chaetocin seems to be no suitable agent for specific targeting ccRCC cells or for the combination therapy with CIK cells in renal cancer.
We present a new multi-pixel high resolution (R ≳ 107) spectrometer for the Stratospheric Observatory for Far-Infrared Astronomy (SOFIA). The receiver uses 2 × 7-pixel subarrays in orthogonal polarization, each in an hexagonal array around a central pixel. We present the first results for this new instrument after commissioning campaigns in May and December 2015 and after science observations performed in May 2016. The receiver is designed to ultimately cover the full 1.8−2.5 THz frequency range but in its first implementation, the observing range was limited to observations of the [CII] line at 1.9 THz in 2015 and extended to 1.83−2.07 THz in 2016. The instrument sensitivities are state-of-the-art and the first scientific observations performed shortly after the commissioning confirm that the time efficiency for large scale imaging is improved by more than an order of magnitude as compared to single pixel receivers. An example of large scale mapping around the Horsehead Nebula is presented here illustrating this improvement. The array has been added to SOFIA’s instrument suite already for ongoing observing cycle 4.
In this paper, several blocking techniques are applied to matrices that do not have a strong blocked structure. The aim is to efficiently use vectorization with current CPUs, even for matrices without an explicit block structure on nonzero elements. Different approaches are known to find fixed or variable sized blocks of nonzero elements in a matrix. We present a new matrix format for 2D rectangular blocks of variable size, allowing fill-ins per block of explicit zero values up to a user definable threshold. We give a heuristic to detect such 2D blocks in a sparse matrix. The performance of a Sparse Matrix Vector Multiplication for chosen block formats is measured and compared. Results show that the benefit of blocking formats depend – as to be expected – on the structure of the matrix and that variable sized block formats can have advantages over fixed size formats.
In this paper, a set of micro-benchmarks is proposed to determine basic performance parameters of single-node mainstream hardware architectures for High Performance Computing. Performance parameters of recent processors, including those of accelerators, are determined. The investigated systems are Intel server processor architectures and the two accelerator lines Intel Xeon Phi and Nvidia graphic processors. Additionally, the performance impact of thread mapping on multiprocessors and Intel Xeon Phi is shown. The results show similarities for some parameters between all architectures, but significant differences for others.
SDN and WMN evolved to be sophisticated technologies used in a variety of applications. However, a combined approach called wmSDN has not been widely addressed in the research community. Our idea in this field consists of WiFi-based point-to-point links managed by the OpenFlow protocol. We investigate two different issues regarding this idea. First, which WiFi operational mode is suitable in an OpenFlow managed broadcast domain? Second, does the performance decrease compared with other routing or switching principles? Therefore, we set up a real-world testbed and a suitable simulation environment. Unlike previous work, we show that it is possible to use WiFi links without conducting MAC address rewriting at each hop by utilizing the 4-address-mode.
WiFi-based Long Distance (WiLD) networks have emerged as a promising alternative technology approach for providing Internet in rural areas. An important factor in network planning of these wireless networks is estimating the path loss. In this work, we present various propagation models we found suitable for point-to-point (P2P) operation in the WiFi frequency bands. We conducted outdoor experiments with commercial offthe- shelf (COTS) hardware in our testbed made of 7 different long-distance links ranging from 450 m to 10.3 km and a mobile measurement station. We found that for short links with omni-directional antennas ground-reflection is a measurable phenomenon. For longer links, we show that either FSPL or the Longley-Rice model provides accurate results for certain links. We conclude that a good site survey is needed to exclude influences not included in the propagation models.
WiFi-based Long Distance (WiLD) networks have emerged as a promising alternative approach for Internet in rural areas. However, the MAC layer, which is based on the IEEE802.11 standard, comprises contiguous stations in a cell and is spatially restricted to a few hundred meters at most. In this work, we summarize efforts by different researchers to use IEEE802.11 over long-distances. In addition, we introduce WiLDToken, our solution to optimizing the throughput and fairness and reducing the delay on WiLD links. Compared to previous alternative MAC layers protocols for WiLD, our focus is on optimizing a single link in a multi-radio multi-channel mesh. We implement our protocol in the ns-3 network simulator and show thatWiLDToken is superior to an adapted version of the Distributed Coordination Function (DCF) for different link distances. We find that the throughput on a single link is close to the physical data-rate without a major decrease over longer distances.
The analysis of Δ9-tetrahydrocannabinol (THC) and its metabolites 11-hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH) from blood serum is a routine task in forensic toxicology laboratories. For examination of consumption habits, the concentration of the phase I metabolite THC-COOH is used. Recommendations for interpretation of analysis values in medical-psychological assessments (regranting of driver’s licenses, Germany) include threshold values for the free, unconjugated THC-COOH. Using a fully automated two-step liquid-liquid extraction, THC, 11-OH-THC, and free, unconjugated THC-COOH were extracted from blood serum, silylated with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA), and analyzed by GC/MS. The automation was carried out by an x-y-z sample robot equipped with modules for shaking, centrifugation, and solvent evaporation. This method was based on a previously developed manual sample preparation method. Validation guidelines of the Society of Toxicological and Forensic Chemistry (GTFCh) were fulfilled for both methods, at which the focus of this article is the automated one. Limits of detection and quantification for THC were 0.3 and 0.6 μg/L, for 11-OH-THC were 0.1 and 0.8 μg/L, and for THC-COOH were 0.3 and 1.1 μg/L, when extracting only 0.5 mL of blood serum. Therefore, the required limit of quantification for THC of 1 μg/L in driving under the influence of cannabis cases in Germany (and other countries) can be reached and the method can be employed in that context. Real and external control samples were analyzed, and a round robin test was passed successfully. To date, the method is employed in the Institute of Legal Medicine in Giessen, Germany, in daily routine. Automation helps in avoiding errors during sample preparation and reduces the workload of the laboratory personnel. Due to its flexibility, the analysis system can be employed for other liquid-liquid extractions as well. To the best of our knowledge, this is the first publication on a comprehensively automated classical liquid-liquid extraction workflow in the field of forensic toxicological analysis.
Domestic Robotics
(2016)
Die für den deutschen Glücks- und Gewinnspielmarkt derzeit geltenden rechtlichen und ordnungspolitischen Rahmenbedingungen führen dazu, dass sich der nicht-regulierte Markt deutlich zu Lasten des regulierten Marktes ausweitet, was negative volkswirtschaftliche und soziale Effekte zur Folge hat. Ziel der Politik sollte es sein, einen möglichst großen Teil des bis dato nicht-regulierten Marktes (Grau- und Schwarzmarkt) in einen geregelten Rahmen zu überführen.
Diese etablierte Formelsammlung enthält und erklärt mathematische Formeln die in den Wirtschaftswissenschaften unbedingt notwendig sind. Das Verständnis der Formeln und deren praktische Anwendung werden durch nützliche Hilfen und Beispiele sinnvoll unterstützt. Damit ist das Buch ein unverzichtbares Tool für Studierende; es eignet sich aber auch als Nachschlagewerk für Verantwortliche aus Wirtschaft, Politik und Lehre.
Das gewerbliche Geldspiel steht bereits seit längerer Zeit in der öffentlichen Kritik. Dabei wird zum Teil ein grundsätzliches Verbot, zumindest jedoch eine qualitative Beschneidung und quantitative Zurückdrängung des Spielangebots, das bereits derzeit relativ hoch reguliert ist, gefordert. Die Sechste und Siebte Verordnung zur Änderung der Spielverordnung haben eine Reihe von Verschärfungen gebracht, u.a. die Beschränkung der Anzahl zulässiger Spielgeräte in Gaststätten von derzeit bis zu drei auf zwei Geräte.
Companies often have difficulties determining which criteria to base their investment decisions in different countries on. When considering direct foreign investment several risk indices are available. The PCI (Peren-Clement-Index) in its original form was developed in 1998. Its further refinement improves the PCI in three major ways: First, it offers a dynamic adjustment of criteria and consideration of recent changes in the international environment. Second, it provides business specificities of a company or its industrial sector to be considered in addition to macroeconomic aspects by a two-dimensional presentation, which ensures a customized assessment. Third, the PCI allows for consolidating investment decisions by combining a resource-orientated with a market-oriented view. The PCI allows, unlike other indices, a customized and company-specific strategic planning process. Ultimately companies must take up both perspectives in the context of an international investment decision. The use of risk indices in corporate planning for assessing global investments decision creates a fundamentally new of risk assessment.
The megatrends towards both a digital and a usership economy have changed entire markets in the past and will continue to do so over the next decades. In this work, we outline what this change means for possible futures of the mobility sector, taking the combination of trends in both economies into account. Using a sys-tematic, scenario-based trend analysis, we draft four general future scenarios and adapt the two most relevant scenarios to the automotive sector. Our findings show that combing the trends from both economies provides new insights that have often been neglected in literature because of an isolated view on digital technology only. However, service concepts such as self-driving car sharing or self-driving taxis have a great impact at various levels including microeconomic (e.g., service and product design, business models) and macroeconomic (e.g., with regard to ecological, economical, and social impacts). We give a brief outline of these issues and show which business mo dels could be successful in the most likely future scenarios, before we frame strategic implications for today’s automobile manufacturers.
Mobilitäts- und Nachhaltigkeitsforscher sehen sich bei der Erforschung des Mobilitätsverhaltens von Personen mit einer bunten Palette an Erhebungsmethoden konfrontiert. Erweitert wird diese Vielfalt in der letzten Zeit durch die Möglichkeit, dieses Verhalten direkt über die Smartphones der Probanden zu erfassen. Um die Auswahl geeigneter Methoden zu erleichtern, liefert die vorliegende Literaturstudie einen detaillierten Überblick zu Fragestellungen, Daten und Erhebungsmethoden, die im Bereich der Mobilitätsforschung zur Erfassung von Alltagsmobilität eingesetzt werden.
Beta-ketothiolase deficiency, also known as mitochondrial acetoacetyl-CoA thiolase (T2) deficiency, is an autosomal recessive disease caused by mutations in the acetylCoA acetyltransferase 1 (ACAT1) gene. A German T2deficient patient that developed a severe ketoacidotic episode at the age of 11 months, was revealed to be a compound heterozygote of a previously reported null mutation, c.472A>G (p.N158D) and a novel mutation, c.949G>A (p.D317N), in ACAT1. The c.949G>A mutation was suspected to cause aberrant splicing as it is located within an exonic splicing enhancer sequence (c. 947CTGACGC) that is a potential binding site for serine/argininerich splicing factor 1. A mutation in this sequence, c.951C>T, results in exon 10 skipping. A minigene construct was synthesized that included exon 9truncated intron 9exon 10truncated intron 10exon 11, and the splicing of this minigene revealed that the c.949G>A mutant construct caused exon 10 skipping in a proportion of the transcripts. Furthermore, additional substitution of G for C at the first nucleotide of exon 10 (c.941G>C) abolished the effect of the c.949G>A mutation. Transient expression analysis of the c.949G>A mutant cDNA revealed no residual T2 activity in the mutated D317N enzyme. Therefore, c.949G>A (D317N) is a pathogenic missense mutation, and diminishes the effect of an exonic splicing enhancer and causes exon 10 skipping. The present study demonstrates that a missense mutation, or even a synonymous substitution, may disrupt enzyme function by interference with splicing.
Informations- und Kommunikationstechnologie (IKT) in den Bereichen Smart Home und Smart Living ist durch die zunehmende Vernetzung des häuslichen Anwendungsfelds mit der Digitalisierung des Stromnetzes, alternativen Möglichkeiten der Energiegewinnung und -speicherung und neuer Mobilitätskonzepte geprägt und zu einem unverzichtbaren Bestandteil privaten wie unternehmerischen Handelns geworden.
Falls and their consequences are arguably most important events for transition from independent living to institutional care for older adults. Information and communication technology (ICT)-based support of fall prevention and fall risk assessment under the control of the user has a tremendous potential to, over time, prevent falls and reduce associated harm and costs. Our research uses participative design and a persuasive health approach to allow for seamless integration of an ICT-based fall prevention system into older adults’ everyday life. Based on a 6-month field study with 12 participants, we present qualitative results regarding the system use and provide insights into attitudes and practices of older adults concerning fall prevention and ICT-supported self-management of health. Our study demonstrates how it can lead to positive aspects of embodiment and health literacy through continuous monitoring of personal results, improved technical confidence, and quality of life. Implications are provided for designing similar systems.
Return to Work (RTW) stellt ein wesentliches Outcomekriterium für die Abbildung der Effektivität medizinischer Rehabilitationsmaßnahmen dar. Dabei hängt die Höhe der RTW-Quote u. a. von Messmethode, Messzeitpunkt und Stichprobe ab (Streibelt, Egner, 2012). RTW wird häufig mit dem bloßen Status der Erwerbstätigkeit oder Arbeitsfähigkeit gleichgesetzt, wobei kritisiert werden kann, dass dabei der Aspekt einer dauerhaften beruflichen Wiedereingliederung zu wenig Berücksichtigung findet.
Die Ergebnisqualität medizinischer Rehabilitationsleistungen wird häufig über „Patient Reported Outcomes“ (PROs) gemessen. Die Bedeutung von PROs für die Nutzenbeurteilung von therapeutischen Interventionen wird häufig unterschätzt (Brettschneider et al., 2011; Calvert et al., 2013). Es wird untersucht, inwieweit sich PROs in „harten“ Endpunkten wie z. B. Beitragszahlungen der Versicherten in die Sozialversicherung widerspiegeln.
The development of advanced robotic systems is challenging as expertise from multiple domains needs to be integrated conceptually and technically. Model-driven engineering promises an efficient and flexible approach for developing robotics applications that copes with this challenge. Domain-specific modeling allows to describe robotics concerns with concepts and notations closer to the respective problem domain. This raises the level of abstraction and results in models that are easier to understand and validate. Furthermore, model-driven engineering allows to increase the level of automation, e.g. through code generation, and to bridge the gap between modeling and implementation. The anticipated results are improved efficiency and quality of the robotics systems engineering process. Within this contribution, we survey the available literature on domain-specific modeling and languages that target core robotics concerns. In total 137 publications were identified that comply with a set of defined criteria, which we consider essential for contributions in this field. With the presented survey, we provide an overview on the state-of-the-art of domain-specific modeling approaches in robotics. The surveyed publications are investigated from the perspective of users and developers of model-based approaches in robotics along a set of quantitative and qualitative research questions. The presented quantitative analysis clearly indicates the rising popularity of applying domain-specific modeling approaches to robotics in the academic community. Beyond this statistical analysis, we map the selected publications to a defined set of robotics subdomains and typical development phases in robotic systems engineering as reference for potential users. Furthermore, we analyze these contributions from a language engineering viewpoint and discuss aspects such as the methods and tools used for their implementation as well as their documentation status, platform integration, typical use cases and the evaluation strategies used for validation of the proposed approaches. Finally, we conclude with recommendations for discussion in the model-driven engineering and robotics community based on the insights gained in this survey.