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Nur maximal ein Fünftel aller Menschen in Deutschland, die Maschinen entwickeln, technische Innovationen vorantreiben, optimieren oder reparieren, sind weiblich. Der Anteil von Frauen in technischen Berufen liegt derzeit bei etwa 20 Prozent (1). Vergleichbar niedrig ist auch die Zahl der Journalistinnen, die sich technischen Themen verschrieben haben. Technik und auch der Technikjournalismus sind hierzulande immer noch Männerdomänen.
Machine learning and neural networks are now ubiquitous in sonar perception, but it lags behind the computer vision field due to the lack of data and pre-trained models specifically for sonar images. In this paper we present the Marine Debris Turntable dataset and produce pre-trained neural networks trained on this dataset, meant to fill the gap of missing pre-trained models for sonar images. We train Resnet 20, MobileNets, DenseNet121, SqueezeNet, MiniXception, and an Autoencoder, over several input image sizes, from 32 x 32 to 96 x 96, on the Marine Debris turntable dataset. We evaluate these models using transfer learning for low-shot classification in the Marine Debris Watertank and another dataset captured using a Gemini 720i sonar. Our results show that in both datasets the pre-trained models produce good features that allow good classification accuracy with low samples (10-30 samples per class). The Gemini dataset validates that the features transfer to other kinds of sonar sensors. We expect that the community benefits from the public release of our pre-trained models and the turntable dataset.
The rapid increase in solar photovoltaic (PV) installations worldwide has resulted in the electricity grid becoming increasingly dependent on atmospheric conditions, thus requiring more accurate forecasts of incoming solar irradiance. In this context, measured data from PV systems are a valuable source of information about the optical properties of the atmosphere, in particular the cloud optical depth (COD). This work reports first results from an inversion algorithm developed to infer global, direct and diffuse irradiance as well as atmospheric optical properties from PV power measurements, with the goal of assimilating this information into numerical weather prediction (NWP) models.
In den Atmosphärenwissenschaften spielt die Strahlungsbilanz der Erde eine wichtige Rolle für unser Verständnis des Klimasystems. Hier liefern ausgereifte Satellitenprodukte dekadische Klimazeitreihen mit einer so hohen Genauigkeit, dass z.B. Änderungen im Zusammenhang mit dem Klimawandel detektiert werden können. Dies gilt insbesondere auch für die solaren Strahlungsflüsse an der Erdoberfläche. Beim Vergleich dieser Satellitenprodukte mit instantanen Beobachtungen der Strahlung am Erdboden sind jedoch oft erhebliche Abweichungen feststellbar, die hauptsächlich durch kleinskalige Variabilität in der räumlichen Struktur von Wolken und ihrer Strahlungswirkung verursacht werden. Hier ist auch zu bedenken, dass Bodenbeobachtungen fast einer Punktmessung entsprechen, während Satellitenpixel eine Fläche in der Größenordnung von Quadratkilometern abtasten.
West Africa has a great potential for the application of solar energy systems, as it combines high levels of solar irradiance with a lack of energy production. Southern West Africa is a region with a very high aerosol load. Urbanization, uncontrolled fires, traffic as well as power plants and oil rigs lead to increasing anthropogenic emissions. The naturally circulating north winds bring mineral dust from the Sahel and Sahara and monsoons - sea salt and other oceanic compounds from the south. The EU-funded Dynamics-Aerosol-Chemistry-Cloud Interactions in West Africa (DACCIWA) project (2014–2018), dlivered the most complete dataset of the atmosphere over the region to date. In our study, we use in-situ measured optical properties of aerosols from the airborne campaign over the Gulf of Guinea and inland, and from ground measurements in coastal cities.
The aim of this study was to investigate employees’ self-reported creativity before and after vacation and to examine the impact of recovery experiences (detachment, relaxation, mastery, meaning, autonomy, affiliation) on changes in creativity. The DRAMMA model of Newman et al. provides the theoretical background of our approach. Longitudinal data was assessed with four repeated measurements. The study encompassed data from 274 white-collar workers. Analyses showed that employees subjectively perceive their creativity to benefit not immediately after their vacation but 2 weeks later. Detachment was significantly related to lower creativity within persons, while mastery experiences explained differences in creativity between persons. This study provides a detailed picture of changes in creativity around vacations.
In this study, we investigate the thermo-mechanical relaxation and crystallization behavior of polyethylene using mesoscale molecular dynamics simulations. Our models specifically mimic constraints that occur in real-life polymer processing: After strong uniaxial stretching of the melt, we quench and release the polymer chains at different loading conditions. These conditions allow for free or hindered shrinkage, respectively. We present the shrinkage and swelling behavior as well as the crystallization kinetics over up to 600 ns simulation time. We are able to precisely evaluate how the interplay of chain length, temperature, local entanglements and orientation of chain segments influences crystallization and relaxation behavior. From our models, we determine the temperature dependent crystallization rate of polyethylene, including crystallization onset temperature.
Introduction: Chronic pain is a frequent severe disease and often associated with anxiety, depression, insomnia, disability, and reduced quality of life. This maladaptive condition is further characterized by sensory loss, hyperalgesia, and allodynia. Blue light has been hypothesized to modulate sensory neurons and thereby influence nociception.
Objectives: Here, we compared the effects of blue light vs red light and thermal control on pain sensation in a human experimental pain model.
Methods: Pain, hyperalgesia, and allodynia were induced in 30 healthy volunteers through high-density transcutaneous electrical stimulation. Subsequently, blue light, red light, or thermal control treatment was applied in a cross-over design. The nonvisual effects of the respective light treatments were examined using a well-established quantitative sensory testing protocol. Somatosensory parameters as well as pain intensity and quality were scored.
Results: Blue light substantially reduced spontaneous pain as assessed by numeric rating scale pain scoring. Similarly, pain quality was significantly altered as assessed by the German counterpart of the McGill Pain Questionnaire. Furthermore, blue light showed antihyperalgesic, antiallodynic, and antihypesthesic effects in contrast to red light or thermal control treatment.
Conclusion: Blue-light phototherapy ameliorates pain intensity and quality in a human experimental pain model and reveals antihyperalgesic, antiallodynic, and antihypesthesic effects. Therefore, blue-light phototherapy may be a novel approach to treat pain in multiple conditions.
In the research project "MetPVNet", both, the forecast-based operation management in distribution grids and as well as the forecasts of the feed-in of PV-power from decentralized plants could be improved on the basis of satellite data and numerical weather forecasts. Based on a detailed network analyses for a real medium-voltage grid area, it was shown that both – the integration of forecast data based on satellite and weather data and the improvement of subsequent day forecasts based on numerical weather models – have a significant added value for forecast-based congestion management or redispatch and reactive power management in the distribution grid. Furthermore, forecast improvements for the forecast model of the German Weather Service were achieved by assimilating visible satellite imagery, and cloud and radiation products from satellites were improved, thus improving the database for short-term forecasting as well as for assimilation. In addition, several methods have been developed that will enable forecast improvement in the future, especially for weather situations with high cloud induced variability and high forecast errors. This article summarizes the most important project results.
Zur Förderung einer freien und offenen Wissenschaft fördert und unterstützt die Hochschule Bonn-Rhein-Sieg den ungehinderten Zugang zu wissenschaftlicher Arbeit. Um die wissenschaftlichen Ergebnisse der Forschenden an der H-BRS einer breiten Öffentlichkeit zugänglich zu machen, wird die Möglichkeit gefördert, wissenschaftliche Arbeiten Open Access zu publizieren. Dadurch lassen sich diese ohne Zugriffsbeschränkungen nutzen und sind international sichtbar.
Polymer fibers with liquid crystals (LCs) in the core have potential as autonomous sensors of airborne volatile organic compounds (VOCs), with a high surface-to-volume ratio enabling fast and sensitive response and an attractive non-woven textile form factor. We demonstrate their ability to continuously and quantitatively measure the concentration of toluene, cyclohexane, and isopropanol as representative VOCs, via the impact of each VOC on the LC birefringence. The response is fully reversible and repeatable over several cycles, the response time can be as low as seconds, and high sensitivity is achieved when the operating temperature is near the LC-isotropic transition temperature. We propose that a broad operating temperature range can be realized by combining fibers with different LC mixtures, yielding autonomous VOC sensors suitable for integration in apparel or in furniture that can compete with existing consumer-grade electronic VOC sensors in terms of sensitivity and response speed.
For several decades, farmers have been mixing rock powders with livestock slurry to reduce its NH3 emissions and increase its nutrient content. However, mixing rock powders with slurry is controversial, and there is currently no scientific evidence for its effects on NH3 and greenhouse gas (GHG) emissions or on changes in its nutrient content due to element release from rock powders. The major aim of this study was therefore to analyse the effects of mixing two commercially established rock powders with cattle slurry on NH3, CO2, N2O and CH4 emissions, and on nutrient release over a course of 46 days. We found that rock powders did not significantly affect CO2 emission rates. NH3 and N2O emission rates did not differ significantly up until the end of the trial, when the emission rates of the rock powder treatments significantly increased for NH3 and significantly decreased for N2O, respectively, which coincided with a reduction of the slurry crust. Cumulative NH3 emissions did not, however, differ significantly between treatments. Unexpected and significant increases in CH4 emission rates occurred for the rock powder treatments. Rock powders increased the macro- and micronutrient content of the slurry. The conflicting results are discussed and future research directions are proposed.
Object-Based Trace Model for Automatic Indicator Computation in the Human Learning Environments
(2021)
This paper proposes a traces model in the form of an object or class model (in the UML sense) which allows the automatic calculation of indicators of various kinds and independently of the computer environment for human learning (CEHL). The model is based on the establishment of a trace-based system that encompasses all the logic of traces collecting and indicators calculation. It is im-plemented in the form of a trace database. It is an important contribution in the field of the exploitation of the traces of apprenticeship in a CEHL because it pro-vides a general formalism for modeling the traces and allowing the calculation of several indicators at the same time. Also, with the inclusion of calculated indica-tors as potential learning traces, our model provides a formalism for classifying the various indicators in the form of inheritance relationships, which promotes the reuse of indicators already calculated. Economically, the model can allow organi-zations with different learning platforms to invest only in one traces Management System. At the social level, it can allow a better sharing of trace databases be-tween the various research institutions in the field of CEHL.
This study intends to contribute to the discourse on social protection and crime. The study assessed social protection as a tool for crime prevention, with bias to Owerri municipal local government area of Imo state, Nigeria as a case study. The study employed a qualitative approach which allowed the researcher to explore experiences and perspectives of selected participants. Purposive sampling was considered appropriate for the defined population. In-depth interview and focus group discussion (FGD) served as data collection instruments. A review of available literature, reports, newspaper publications, reports, and various internet sources were exhaustively utilised to gather secondary data.
The study revealed that social protection possesses the potential to prevent crime. The study informed that certain intervention programmes established by the government helped in decreasing crime incidences in the area under study. In addition, the study revealed that social protection enhances wellbeing, empowers people, promotes better living conditions, imbues a sense of belonging and inclusiveness, promotes social stability and does not lead to dependency. However, the study revealed that social protection alone is incapable of eradicating crime.
Der Öffentliche Gesundheitsdienst (ÖGD) übernimmt eine wichtige Funktion in Sachen Bevölkerungsgesundheit und wird häufig, neben ambulanter und stationärer Versorgung, als ‚dritte Säule‘ im deutschen Gesundheitswesen beschrieben. Diese sprachlich gleichwertige Positionierung spiegelt sich allerdings in der Realität nicht wider, im Vergleich ist seine Stellung eher schwach. In der Frage, welche Ursachen hierfür vorliegen, könnte eine Hypothese lauten, dass ein diffuses Aufgabenprofil einen negativen Einfluss auf seine Stellung ausübt. Um diesen möglichen Einfluss näher zu untersuchen, lautet die Forschungsfrage: „Wie lässt sich die Stellung des ÖGD innerhalb des deutschen Gesundheitswesens anhand seines Aufgabenprofils aus kontingenztheoretischer Perspektive erklären?“.
Zu deren Beantwortung wird zunächst die Ausgestaltung der aktuellen Aufgabenprofile erhoben und verglichen. Anschließend untersucht die Arbeit mit Hilfe der organisationssoziologischen Kontingenztheorie, welche situativen Einflussfaktoren sich möglicherweise auf Aufgabenprofil und damit auch die Stellung des ÖGD ausgewirkt haben. Im Ergebnis zeigt sich, dass Veränderungen in den Aufgaben teilweise recht deutlich in Verbindung gebracht werden können mit Veränderungen der Organisationssituation, auch lässt sich ein Zusammenhang zwischen Aufgabenprofil und Stellung vermuten. Soll dem ÖGD in Zukunft wieder eine stärkere Bedeutung zukommen, so ist es neben einer gewissen Vereinheitlichung der Aufgabenprofile von großer Bedeutung, ihm wieder exklusive Aufgaben zuzusprechen. Diese könnten insbesondere in den Bereichen Planung, Koordination und Steuerung, Datengewinnung und aufbereitung oder darin liegen, sich wieder verstärkt auf Bevölkerungsgruppen zu fokussieren, welche nicht durch andere Bereiche abgedeckt werden. Hierfür müssen die nötigen Ressourcen zur Verfügung stehen: Neben den bereits beschlossenen Unterstützungsleistungen gilt es insbesondere in Bezug auf die personelle Ausstattung, den ÖGD langfristig attraktiv zu gestalten. Dazu kann eine aufgewertete Stellung sowie eine verbesserte Situation in den einzelnen Behörden einen großen Teil beitragen.
Many people do not consume as much healthy food as recommended. Nudging has been identified as a promising intervention strategy to increase the consumption of healthy food. The present study analyzed the effects of three body shape nudges (thin, thick, or Giacometti artwork) on food ordering and assessed the mediating role of being aware of the nudge. Students (686) and employees (218) of a German university participated in an online experimental study. After randomization, participants visited a realistic online cafeteria and composed a meal for themselves. Under experimental conditions, participants were exposed to one out of three nudges while choosing dishes: (1) thin body shape, (2) thick body shape, and (3) the Giacometti artwork nudge. The Giacometti nudge resulted in more orders for salad among employees. The thin and thick body shape nudges did not change dish orders. Awareness of the nudge mediated the numbers of calories ordered when using the Giacometti or thin body shape nudges. These findings provide useful insights for health interventions in occupational and public health sectors using nudges. Our study contributes to the research on the Giacometti nudge by showing its effectiveness when participants are aware (it is effective under conditions where it is consciously perceived).
Cancer is a complex disease where resistance to therapies and relapses often pose a serious clinical challenge. The scenario is even more complicated when the cancer type itself is heterogeneous in nature, e.g., lymphoma, a cancer of the lymphocytes which constitutes more than 70 different subtypes. Indeed, the treatment options continue to expand in lymphomas. Herein, we provide insights into lymphoma-specific clinical trials based on cytokine-induced killer (CIK) cell therapy and other pre-clinical lymphoma models where CIK cells have been used along with other synergetic tumor-targeting immune modules to improve their therapeutic potential. From a broader perspective, we will highlight that CIK cell therapy has potential, and in this rapidly evolving landscape of cancer therapies its optimization (as a personalized therapeutic approach) will be beneficial in lymphomas.
Damit nachhaltiger Konsum möglich ist, müssen Verbraucherinnen und Verbraucher die Nachhaltigkeit von Produkten angemessen einschätzen können. Ausgehend von der Annahme, dass Greenwashing-Slogans solche Einschätzungen möglicherweise behindern, untersucht dieses zweiteilige quantitative Online-Experiment Schlussfolgerungen von Verbraucherinnen und Verbrauchern, die statische Werbeanzeigen betrachteten. Dabei wurden konkrete, d.h. quantifizierte Umweltaussagen mit vagen Botschaften (Greenwashing-Kondition) bezüglich eines fiktiven TV-Produktes bzw. TV-Herstellers verglichen. Ein Drittel der jungen und gebildeten Stichprobe (N = 163) zog nach Ansicht einer Produktanzeige, die den geringen Stromverbrauch des „Omro UHD-Fernsehers“ bewarb, den Schluss, dass weitere, in der Werbung nicht beobachtbare Umweltmerkmale eher wahrscheinlich als unwahrscheinlich sind. Unternehmensanzeigen zur Energieeffizienz der Produktion von „Nextvision“ entlockten diese Schlussfolgerung sogar 73 Prozent der Probanden. Vage und konkrete Behauptungen unterschieden sich hinsichtlich dieser sog. Halo-Effekte kaum. Dazu berechnete Indizes korrelierten signifikant positiv mit der eingeschätzten Produktqualität, was für die Wirksamkeit eines Gesamteindruckes (General Impression Halos) spricht. Dies galt insbesondere für vage Botschaften. Sie eignen sich daher besonders für Werbetreibende, weil Anzeigen in der Regel nur für kurze Zeit Aufmerksamkeit erhalten. Verbraucherinnen und Verbrauchern kann auf Basis der Ergebnisse geraten werden, stärker auf die theoretische Überprüfbarkeit von Werbeslogans zu achten.
An der Hochschule Bonn-Rhein-Sieg fand am Donnerstag, den 23.9.21 das erste Verbraucherforum für Verbraucherinformatik statt. Im Rahmen der Online-Tagesveranstaltung diskutierten mehr als 30 Teilnehmer:innen über Themen und Ideen rund um den Bereich Verbraucherdatenschutz. Dabei kamen sowohl Beiträge aus der Informatik, den Verbraucher- und Sozialwissenschaften sowie auch der regulatorischen Perspektive zur Sprache. Der folgende Beitrag stellt den Hintergrund der Veranstaltung dar und berichtet über Inhalte der Vorträge sowie Anknüpfungspunkte für die weitere Konstituierung der Verbraucherinformatik. Veranstalter waren das Institut für Verbraucherinformatik an der H-BRS in Zusammenarbeit mit dem Lehrstuhl IT-Sicherheit der Universität Siegen sowie dem Kompetenzzentrum Verbraucherforschung NRW der Verbraucherzentrale NRW e. V. mit Förderung des Bundesministeriums der Justiz und für Verbraucherschutz.
An der Hochschule Bonn-Rhein-Sieg fand am Donnerstag, den 23.9.21 das erste Verbraucherforum für Verbraucherinformatik statt. Im Rahmen der Online-Tagesveranstaltung diskutierten mehr als 30 Teilnehmer:innen über Themen und Ideen rund um den Bereich Verbraucherdatenschutz. Dabei kamen sowohl Beiträge aus der Informatik, den Verbraucher- und Sozialwissenschaften sowie auch der regulatorischen Perspektive zur Sprache. Der folgende Beitrag stellt den Hintergrund der Veranstaltung dar und berichtet über Inhalte der Vorträge sowie Anknüpfungspunkte für die weitere Konstituierung der Verbraucherinformatik. Veranstalter waren das Institut für Verbraucherinformatik an der H-BRS in Zusammenarbeit mit dem Lehrstuhl IT-Sicherheit der Universität Siegen sowie dem Kompetenzzentrum Verbraucherforschung NRW der Verbraucherzentrale NRW e. V. mit Förderung des Bundesministeriums der Justiz und für Verbraucherschutz.
Die Blockchain-Technologie ist einer der großen Innovationstreiber der letzten Jahre. Mit einer zugrundeliegenden Blockchain-Technologie ist auch der Betrieb von verteilten Anwendungen, sogenannter Decentralized Applications (DApps), bereits technisch umsetzbar. Dieser Beitrag verfolgt das Ziel, Gestaltungsmöglichkeiten der digitalen Verbraucherteilhabe an Blockchain-Anwendungen zu untersuchen. Hierzu enthält der Beitrag eine Einführung in die digitale Verbraucherteilhabe und die technischen Grundlagen und Eigenschaften der Blockchain-Technologie, einschließlich darauf basierender DApps. Abschließend werden technische, ethisch-organisatorische, rechtliche und sonstige Anforderungsbereiche für die Umsetzung von digitaler Verbraucherteilhabe in Blockchain-Anwendungen adressiert.
Background: Atypical myopathy (AM), an acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in horses, induce changes in mitochondrial metabolism. Only few veterinary laboratories offer diagnostic testing for this disease. Inborn and acquired MADD exist in humans, therefore determination of organic acids (OA) in urine and acylcarnitines (AC) in blood by assays available in medical laboratories can serve as AM diagnostics. The evolution of OA and AC profiles in surviving horses is unreported.
Methods: AC profiles using electrospray ionization tandem mass spectrometry (ESI-MS/MS) and OA in urine using gas chromatography mass spectrometry (GC–MS) were determined in dried blot spots (DBS, n = 7) and urine samples (n = 5) of horses with AM (n = 7) at disease presentation and in longitudinal samples from 3/4 survivors and compared to DBS (n = 16) and urine samples (n = 7) from control horses using the Wilcoxon test.
Results: All short- (C2-C5) and medium-chain (C6-C12) AC in blood differed significantly (p < 0.008) between horses with AM and controls, except for C5:1 (p = 0.45) and C5OH + C4DC (p = 0.06). In AM survivors the AC concentrations decreased over time but were still partially elevated after 7 days. 14/62 (23%) of OA differed significantly between horses with AM and control horses. Concentrations of ethylmalonic acid, 2-hydroxyglutaric acid and the acylglycines (butyryl-, valeryl-, and hexanoylglycine) were highly elevated in the urine of all horses with AM at the day of disease presentation. In AM survivors, concentrations of those metabolites were initially lower and decreased during remission to approach normalization after 7 days.
Conclusion: OA and AC profiling by specialized human medical laboratories was used to diagnose AM in horses. Elevation of specific metabolites were still evident several days after disease presentation, allowing diagnosis via analysis of samples from convalescent animals.
Cultivation of perennials such as Miscanthus x giganteus Greef et Deuter (Mis) combines the provision of ecosystem services and the generation of additional carbon sources for farming. The potential of Mis based fertilisers, regarding immobilisation of inorganic nitrogen (N) and build-up of soil organic matter (SOM), was tested in a field trial. Therefore, a crop rotation of winter barley (Hordeum vulgare L.), mustard (Sinapis alba L.) as catch crop, sugar beet (Beta vulgaris L.) and winter wheat (Triticum aestivum L.) was set up. The tested treatments were a mixture of Cattle Slurry (CS) and Mis, a mixture of CS and Wheat Straw (CS–WS), Cattle Manure (CM) from Mis shredded bedding, CM from WS shredded bedding, a pure CS, Urea Ammonium Nitrate (UAN) and a treatment without any N applied (NoN). When the carbon-rich fertilisers (both mixtures and manures) were applied to cereals, they led to a slight N immobilisation compared to pure CS, whereas differences were mostly not significant. Furthermore, Mis fertilisers were at least as efficient as WS-based organic fertilisers in inducing a contribution of SOM build-up and in reducing inorganic N before winter and thus preventing N losses, whereas differences were mostly not significant.
Suitability of Current Sensors for the Measurement of Switching Currents in Power Semiconductors
(2021)
This paper investigates the impact of current sensors on the measurement of transient currents in fast-switching power semiconductors in a double pulse test (DPT environment. We review previous research that assesses the influence of current sensors on a DPT circuit through mathematical modeling. The developed selection aids can be used to identify suitable current sensors for transient current measurements of fast-switching power semiconductors and to estimate the error introduced by their insertion into the DPT circuit. Afterwards, this analysis is extended by including further elements from real DPT applications to increase the consistency of the error estimation with practical situations and setups. Both methods are compared and their individual advantages and drawbacks are discussed. Finally, a recommendation on when to use which method is derived.
Frequently the main purpose of domestic artifacts equipped with smart sensors is to hide technology, like previous examples of a Smart Mirror show. However, current Smart Homes often fail to provide meaningful IoT applications for all residents’ needs. To design beyond efficiency and productivity, we propose to realize the potential of the traditional artifact for calm and engaging experiences. Therefore, we followed a design case study approach with 22 participants in total. After an initial focus group, we conducted a diary study to examine home routines and developed a conceptual design. The evaluation of our mid-fidelity prototype shows, that we need to study carefully the practices of the residents to leverage the physical material of the artifact to fit the routines. Our Smart Mirror, enhanced by digital qualities, supports meaningful activities and makes the bathroom more appealing. Thereby, we discuss domestic technology design beyond automation.
With the debates on climate change and sustainability, a reduction of the share of cars in the modal split has become increasingly prevalent in both public and academic discourse. Besides some motivational approaches, there is a lack of ICT artifacts that successfully raise the ability of consumers to adopt sustainable mobility patterns. To further understand the requirements and the design of these artifacts within everyday mobility adopted a practice-lens. This lens is helpful to get a broader perspective on the use of ICT artifacts along consumers’ transformational journey towards sustainable mobility practices. Based on 12 retrospective interviews with car-free mobility consumers, we argue that artifacts should not be viewed as ’magic-bullet’ solutions but should accompany the complex transformation of practices in multifaceted ways. Moreover, we highlight in particular the difficulties of appropriating shared infrastructures and aligning own practices with them. This opens up a design space to provide more support for these kinds of material-interactions, to provide access to consumption infrastructures and make them usable, rather than leaving consumers alone with increased motivation.
Recent publications propose concepts of systems that integrate the various services and data sources of everyday food practices. However, this research does not go beyond the conceptualization of such systems. Therefore, there is a deficit in understanding how to combine different services and data sources and which design challenges arise from building integrated Household Information Systems. In this paper, we probed the design of an Integrated Household Information System with 13 participants. The results point towards more personalization, automatization of storage administration and enabling flexible artifact ecologies. Our paper contributes to understanding the design and usage of Integrated Household Information Systems, as a new class of information systems for HCI research.
Die digitale Transformation verändert die internationale Kooperation der Hochschulen massiv. Über die Möglichkeiten der virtuellen Mobilität hinaus entstehen neue Themenfelder, die internationale Lern- und Lehrerlebnisse mit digitaler Unterstützung verändern, ergänzen oder neu ermöglichen. Dazu sind im Bereich der Förderung der Internationalisierung (DAAD, Erasmus+, BMBF u.a.) Projekte und Förderformate entstanden, die Digitalisierung und Internationalisierung kombinieren und die neuen Themenstellungen adressieren, z.B. didaktische Formate, administrative Prozesse (auch im Kontext OZG und DSGVO), virtuelle und hybride Mobilität, internationale Projekt- und Teamformate sowie schlussendlich auch Inhalte, die internationale, interkulturelle und interdisziplinäre Kompetenzen mit digitalen Kompetenzen verbinden. Der vorgeschlagene Workshop soll entsprechende Projekte zusammenbringen und die Themen strukturieren, um einen Überblick der Entwicklungen zu schaffen und somit einen Beitrag zur Definition des Themenfelds „Digitalisierung & Internationalisierung“ zu leisten.
Background: Staurosporine-dependent single and collective cell migration patterns of breast carcinoma cells MDA-MB-231, MCF-7, and SK-BR-3 were analysed to characterise the presence of drug-dependent migration promoting and inhibiting yin-yang effects. Methods: Migration patterns of various breast cancer cells after staurosporine treatment were investigated using Western blot, cell toxicity assays, single and collective cell migration assays, and video time-lapse. Statistical analyses were performed with Kruskal–Wallis and Fligner–Killeen tests. Results: Application of staurosporine induced the migration of single MCF-7 cells but inhibited collective cell migration. With the exception of low-density SK-BR-3 cells, staurosporine induced the generation of immobile flattened giant cells. Video time-lapse analysis revealed that within the borderline of cell collectives, staurosporine reduced the velocity of individual MDA-MB-231 and SK-BR-3, but not of MCF-7 cells. In individual MCF-7 cells, mainly the directionality of migration became disturbed, which led to an increased migration rate parallel to the borderline, and hereby to an inhibition of the migration of the cell collective as a total. Moreover, the application of staurosporine led to a transient activation of ERK1/2 in all cell lines. Conclusion: Dependent on the context (single versus collective cells), a drug may induce opposite effects in the same cell line.
The synthesis and characterization of a new class of 1,2,4-oxadiazolylpyridinium as a cationic scaffold for fluorinated ionic liquid crystals is herein described. A series of 12 fluorinated heterocyclic salts based on a 1,2,4-oxadiazole moiety, connected through its C(5) or C(3) to an N-alkylpyridinium unit and a perfluoroheptyl chain, differing in the length of the alkyl chain and counterions, has been synthesized. As counterions iodide, bromide and bis(trifluoromethane)sulfonimide have been considered. The synthesis, structure, and liquid crystalline properties of these compounds are discussed on the basis of the tuned structural variables. The thermotropic properties of this series of salts have been investigated by differential scanning calorimetry and polarized optical microscopy. The results showed the existence of an enantiotropic mesomorphic smectic liquid crystalline phase for six bis(trifluoromethane)sulfonimide salts.
Die Implementierung strategischer Erfolgsfaktoren rückt zunehmend in den Fokus kleiner und mittelständischer Unternehmen. Vor dem Hintergrund des überdurchschnittlichen Erfolgs sogenannter Hidden Champions (HC) stellt sich unter einer praxisorientierten Perspektive die Frage, welche Bedeutung mittelständische Unternehmen grundsätzlich den von Hermann Simon identifizierten Erfolgsprinzipien für HC für den Unternehmenserfolg zumessen. Die empirische Studie analysierte dazu die Bedeutung dieser Erfolgsfaktoren für mittelständische Unternehmen und untersuchte, ob Bedeutungsunterschiede zwischen erfolgreichen und weniger erfolgreichen Unternehmen der Stichprobe existieren. Im Rahmen einer explorativen, multivariaten Datenanalyse konnten außerdem zwei Cluster, die „Internationalen Innovatoren“ und die „Nationalen Traditionalisten“, im Datensatz identifiziert werden, die sich hinreichend in der Bedeutungszumessung der Erfolgsfaktoren voneinander unterschieden.
Animal models are often needed in cancer research but some research questions may be answered with other models, e.g., 3D replicas of patient-specific data, as these mirror the anatomy in more detail. We, therefore, developed a simple eight-step process to fabricate a 3D replica from computer tomography (CT) data using solely open access software and described the method in detail. For evaluation, we performed experiments regarding endoscopic tumor treatment with magnetic nanoparticles by magnetic hyperthermia and local drug release. For this, the magnetic nanoparticles need to be accumulated at the tumor site via a magnetic field trap. Using the developed eight-step process, we printed a replica of a locally advanced pancreatic cancer and used it to find the best position for the magnetic field trap. In addition, we described a method to hold these magnetic field traps stably in place. The results are highly important for the development of endoscopic tumor treatment with magnetic nanoparticles as the handling and the stable positioning of the magnetic field trap at the stomach wall in close proximity to the pancreatic tumor could be defined and practiced. Finally, the detailed description of the workflow and use of open access software allows for a wide range of possible uses.
The molecular weight properties of lignins are one of the key elements that need to be analyzed for a successful industrial application of these promising biopolymers. In this study, the use of 1H NMR as well as diffusion-ordered spectroscopy (DOSY NMR), combined with multivariate regression methods, was investigated for the determination of the molecular weight (Mw and Mn) and the polydispersity of organosolv lignins (n = 53, Miscanthus x giganteus, Paulownia tomentosa, and Silphium perfoliatum). The suitability of the models was demonstrated by cross validation (CV) as well as by an independent validation set of samples from different biomass origins (beech wood and wheat straw). CV errors of ca. 7–9 and 14–16% were achieved for all parameters with the models from the 1H NMR spectra and the DOSY NMR data, respectively. The prediction errors for the validation samples were in a similar range for the partial least squares model from the 1H NMR data and for a multiple linear regression using the DOSY NMR data. The results indicate the usefulness of NMR measurements combined with multivariate regression methods as a potential alternative to more time-consuming methods such as gel permeation chromatography.
Der Einsatz von Remote-Laboren in ingenieurwissenschaftlichen Studiengängen ermöglicht Studierenden an einigen Hochschulen die ortsunabhängige Nutzung von Laboren, Maschinen und Robotern. Remote-Labore eignen sich in besonderer Weise dafür, den digitalisierungsbedingten Anforderungen und dem Qualifikationsbedarf aus Wirtschaft und Industrie zu begegnen. Die Onlinebedienung von Laboren bietet viele Ansatzpunkte für den Erwerb digitaler Kompetenzen, wie beispielsweise das Sammeln und Analysieren von Big Data, das Entwickeln geeigneter Schnittstellen für den Onlinezugriff oder den korrekten Einsatz zur Verfügung stehender softwarebasierter Messtechnik. Auch während der Coronapandemie im Sommersemester 2020, als der reguläre Zugang zu Laboren aufgrund der Kontaktbeschränkungen nicht erlaubt war, ermöglichten Remote-Labore den Studierenden praktische Erfahrungen. Jedoch stellen nicht nur die didaktischen, sondern auch die technischen und organisatorischen Aspekte ingenieurwissenschaftliche Studiengänge bei der Umsetzung von Remote-Laboren vor anspruchsvolle Aufgaben. Der nachfolgende Beitrag greift diese Aspekte auf und beschreibt anhand ausgewählter Beispiele, wie die Umsetzung und Integration von Remote-Laboren in Studium und Lehre gelingen kann, aber auch welche Herausforderungen nach wie vor bestehen.
John V. Pavlik: Journalism in the Age of Virtual Reality: How Experiential Media are Transforming News
New York: Columbia UP 2019, 284 S., ISBN 9780231184496, GBP 25,-
Karen Fowler-Watt, Stephen Jukes (Hg.): New Journalisms: Rethinking Practice, Theory and Pedagogy
London, New York: Routledge 2020, 198 S., ISBN 9781138596757, GBP 34,99
Intimate swabs taken for examination in sexual assault cases typically yield mixtures of sperm and epithelial cell types. While powerful, differential extraction protocols to overcome such cell type mixtures by separate lysis of epithelial cells and spermatozoa can still prove ineffective, in particular if only few sperm cells are present or if swabs contain sperm from more than one individual leading to complex low level DNA mixtures. A means to avoid such mixtures consists in the analysis of single micromanipulated sperm cells. However, the quantity of DNA from single sperm cells is not sufficient for conventional STR analysis. Here, we describe a simple method for micromanipulating individual sperm cells from intimate swabs and show that whole genome amplification can generate sufficient amounts of DNA from single cells for subsequent DNA profiling. We recovered over 80% of alleles of haploid autosomal STR profiles from the majority of individual sperm cells. Furthermore, we demonstrate that in mixtures of sperm from two contributors, Y-STR and X-STR profiles of individual sperm cells can be used to sort the haploid autosomal profiles to develop the diploid consensus STR profiles of the individual donors. Finally, by analysing single sperm cells from mock sexual assault swabs with one or two sperm donors, we showed that our protocols enabled the identification of the unknown male contributors.
Different analyses and feasibility studies have been conducted on the plant extracts of thyme (Thymus vulgaris), European horse chestnut (Aesculus hippocastanum), Nordmann fir (Abies nordmanniana), and snowdrop (Galanthus elwesii) to evaluate bio‐based alternatives to common petrol‐based stabilisers. For this purpose, in this study, plant extracts were incorporated into poly‐lactic acid films (PLA) at different concentrations. The films’ UV absorbance and migration into packed food was analysed via photometric assays (ABTS radical cation scavenging capacity assay, β‐carotene assay) and GC–MS analysis. Furthermore, the synergistic antioxidant effects of various combinations of extracts and isolated active compounds were determined. This way, antioxidant effects can be increased, allowing for a highly effective use of resources. All extracts were successfully incorporated into PLA films and showed notable photoabsorbing effects, while no migration risk was observed. Depending on extract combinations, high synergistic effects of up to 726% can be utilised to improve the effectiveness of bio‐based extracts. This applies particularly to tomato paste and Aesculus hippocastanum extracts, which overall show high synergistic and antioxidant effects in combination with each other and with isolated active compounds. The study shows that it is possible to create safe bio‐based antioxidant films which show even improved properties when using highlighted target combinations.
The ability to discriminate between different ionic species, termed ion selectivity, is a key feature of ion channels and forms the basis for their physiological function. Members of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily of trimeric ion channels are typically sodium selective, but to a surprisingly variable degree. While acid-sensing ion channels (ASICs) are weakly sodium selective (sodium:potassium ratio ∼10:1), ENaCs show a remarkably high preference for sodium over potassium (>500:1). This discrepancy may be expected to originate from differences in the pore-lining second transmembrane segment (M2). However, these show a relatively high degree of sequence conservation between ASICs and ENaCs, and previous functional and structural studies could not unequivocally establish that differences in M2 alone can account for the disparate degrees of ion selectivity. By contrast, surprisingly little is known about the contributions of the first transmembrane segment (M1) and the preceding pre-M1 region. In this study, we used conventional and noncanonical amino acid-based mutagenesis in combination with a variety of electrophysiological approaches to show that the pre-M1 and M1 regions of mASIC1a channels are major determinants of ion selectivity. Mutational investigations of the corresponding regions in hENaC show that these regions contribute less to ion selectivity, despite affecting ion conductance. In conclusion, our work suggests that the remarkably different degrees of sodium selectivity in ASICs and ENaCs are achieved through different mechanisms. These results further highlight how M1 and pre-M1 are likely to differentially affect pore structure in these related channels.
Anhand detaillierter Netzanalysen für ein reales Mittelspannungsnetzgebiet konnte gezeigt werden, dass sowohl die Einbindung von Prognosedaten auf Basis von Satelliten und Wetterdaten, als auch die Verbesserung von Folgetagsprognosen auf der Basis numerischer Wettermodelle einen deutlichen Mehrwert für ein prognosebasiertes Engpassmanagement bzw. Redispatch und Blindleistungsmanagement im Verteilnetz aufweisen. Auch Kurzfristprognosen auf der Basis von Satellitendaten haben einen positiven Effekt. Ein weiterer wichtiger Mehrwert des Projektes ist auch die Rückmeldung der kritischen Prognosesituationen aus Sicht der Anwendungsfälle, so dass wie bereits im Projekt gezeigt und darüber hinaus, Prognosen zielgerichteter auf die Anwendung im Verteilnetzbetrieb ausgelegt und optimiert werden können.
Weiterhin konnten Prognoseverbesserungen für das Vorhersagemodell des Deutschen Wetterdienstes durch die Assimilation von sichtbaren Satellitenbildern erreicht werden. Darüber hinaus wurden Wolken- und Strahlungsprodukte aus Satelliten verbessert und somit die Datenbasis für die Kurzfristprognose als auch für die Assimilation.
Darüber hinaus wurden verschiedene Methoden entwickelt, die zukünftig zu einer weiteren Prognoseverbesserung, insbesondere für Wettersituationen mit hohen Prognosefehlern, führen könnten. Solche Situationen wurden aus Sicht des Netzbetriebs und mithilfe von satellitenbasierten Analysen der Gesamtwetterlage für die Perioden der MetPVNet Messkampagnen identifiziert. Hierbei handelte es sich insbesondere um Situationen mit starker oder stark wechselhafter Bewölkung.
Für die MetPVNet Messkampagnen wurde auf der Basis eines Trainingsdatensatzes und in Abhängigkeit der Variabilitätsklasse die Abweichung der bodennahen Einstrahlung von Satellitendaten oder von Strahlungsprognosen quantifiziert. Diese Art der Informationen bietet zukünftig die Möglichkeit zur Bewertung der Prognosegüte.
Risk-based authentication (RBA) aims to strengthen password-based authentication rather than replacing it. RBA does this by monitoring and recording additional features during the login process. If feature values at login time differ significantly from those observed before, RBA requests an additional proof of identification. Although RBA is recommended in the NIST digital identity guidelines, it has so far been used almost exclusively by major online services. This is partly due to a lack of open knowledge and implementations that would allow any service provider to roll out RBA protection to its users. To close this gap, we provide a first in-depth analysis of RBA characteristics in a practical deployment. We observed N=780 users with 247 unique features on a real-world online service for over 1.8 years. Based on our collected data set, we provide (i) a behavior analysis of two RBA implementations that were apparently used by major online services in the wild, (ii) a benchmark of the features to extract a subset that is most suitable for RBA use, (iii) a new feature that has not been used in RBA before, and (iv) factors which have a significant effect on RBA performance. Our results show that RBA needs to be carefully tailored to each online service, as even small configuration adjustments can greatly impact RBA's security and usability properties. We provide insights on the selection of features, their weightings, and the risk classification in order to benefit from RBA after a minimum number of login attempts.
Cytokine-induced killer (CIK) cells are an ex vivo expanded heterogeneous cell population with an enriched NK-T phenotype (CD3+CD56+). Due to the convenient and relatively inexpensive expansion capability, together with low incidence of graft versus host disease (GVHD) in allogeneic cancer patients, CIK cells are a promising candidate for immunotherapy. It is well known that natural killer group 2D (NKG2D) plays an important role in CIK cell-mediated antitumor activity; however, it remains unclear whether its engagement alone is sufficient or if it requires additional co-stimulatory signals to activate the CIK cells. Likewise, the role of 2B4 has not yet been identified in CIK cells. Herein, we investigated the individual and cumulative contribution of NKG2D and 2B4 in the activation of CIK cells. Our analysis suggests that (a) NKG2D (not 2B4) is implicated in CIK cell (especially CD3+CD56+ subset)-mediated cytotoxicity, IFN-γ secretion, E/T conjugate formation, and degranulation; (b) NKG2D alone is adequate enough to induce degranulation, IFN-γ secretion, and LFA-1 activation in CIK cells, while 2B4 only provides limited synergy with NKG2D (e.g., in LFA-1 activation); and (c) NKG2D was unable to costimulate CD3. Collectively, we conclude that NKG2D engagement alone suffices to activate CIK cells, thereby strengthening the idea that targeting the NKG2D axis is a promising approach to improve CIK cell therapy for cancer patients. Furthermore, CIK cells exhibit similarities to classical invariant natural killer (iNKT) cells with deficiencies in 2B4 stimulation and in the costimulation of CD3 with NKG2D. In addition, based on the current data, the divergence in receptor function between CIK cells and NK (or T) cells can be assumed, pointing to the possibility that molecular modifications (e.g., using chimeric antigen receptor technology) on CIK cells may need to be customized and optimized to maximize their functional potential.
The clear-sky radiative effect of aerosol–radiation interactions is of relevance for our understanding of the climate system. The influence of aerosol on the surface energy budget is of high interest for the renewable energy sector. In this study, the radiative effect is investigated in particular with respect to seasonal and regional variations for the region of Germany and the year 2015 at the surface and top of atmosphere using two complementary approaches.
First, an ensemble of clear-sky models which explicitly consider aerosols is utilized to retrieve the aerosol optical depth and the surface direct radiative effect of aerosols by means of a clear-sky fitting technique. For this, short-wave broadband irradiance measurements in the absence of clouds are used as a basis. A clear-sky detection algorithm is used to identify cloud-free observations. Considered are measurements of the short-wave broadband global and diffuse horizontal irradiance with shaded and unshaded pyranometers at 25 stations across Germany within the observational network of the German Weather Service (DWD). The clear-sky models used are the Modified MAC model (MMAC), the Meteorological Radiation Model (MRM) v6.1, the Meteorological–Statistical solar radiation model (METSTAT), the European Solar Radiation Atlas (ESRA), Heliosat-1, the Center for Environment and Man solar radiation model (CEM), and the simplified Solis model. The definition of aerosol and atmospheric characteristics of the models are examined in detail for their suitability for this approach.
Second, the radiative effect is estimated using explicit radiative transfer simulations with inputs on the meteorological state of the atmosphere, trace gases and aerosol from the Copernicus Atmosphere Monitoring Service (CAMS) reanalysis. The aerosol optical properties (aerosol optical depth, Ångström exponent, single scattering albedo and asymmetry parameter) are first evaluated with AERONET direct sun and inversion products. The largest inconsistency is found for the aerosol absorption, which is overestimated by about 0.03 or about 30 % by the CAMS reanalysis. Compared to the DWD observational network, the simulated global, direct and diffuse irradiances show reasonable agreement within the measurement uncertainty. The radiative kernel method is used to estimate the resulting uncertainty and bias of the simulated direct radiative effect. The uncertainty is estimated to −1.5 ± 7.7 and 0.6 ± 3.5 W m−2 at the surface and top of atmosphere, respectively, while the annual-mean biases at the surface, top of atmosphere and total atmosphere are −10.6, −6.5 and 4.1 W m−2, respectively.
The retrieval of the aerosol radiative effect with the clear-sky models shows a high level of agreement with the radiative transfer simulations, with an RMSE of 5.8 W m−2 and a correlation of 0.75. The annual mean of the REari at the surface for the 25 DWD stations shows a value of −12.8 ± 5 W m−2 as the average over the clear-sky models, compared to −11 W m−2 from the radiative transfer simulations. Since all models assume a fixed aerosol characterization, the annual cycle of the aerosol radiation effect cannot be reproduced. Out of this set of clear-sky models, the largest level of agreement is shown by the ESRA and MRM v6.1 models.
Mebendazole Mediates Proteasomal Degradation of GLI Transcription Factors in Acute Myeloid Leukemia
(2021)
The prognosis of elderly AML patients is still poor due to chemotherapy resistance. The Hedgehog (HH) pathway is important for leukemic transformation because of aberrant activation of GLI transcription factors. MBZ is a well-tolerated anthelmintic that exhibits strong antitumor effects. Herein, we show that MBZ induced strong, dose-dependent anti-leukemic effects on AML cells, including the sensitization of AML cells to chemotherapy with cytarabine. MBZ strongly reduced intracellular protein levels of GLI1/GLI2 transcription factors. Consequently, MBZ reduced the GLI promoter activity as observed in luciferase-based reporter assays in AML cell lines. Further analysis revealed that MBZ mediates its anti-leukemic effects by promoting the proteasomal degradation of GLI transcription factors via inhibition of HSP70/90 chaperone activity. Extensive molecular dynamics simulations were performed on the MBZ-HSP90 complex, showing a stable binding interaction at the ATP binding site. Importantly, two patients with refractory AML were treated with MBZ in an off-label setting and MBZ effectively reduced the GLI signaling activity in a modified plasma inhibitory assay, resulting in a decrease in peripheral blood blast counts in one patient. Our data prove that MBZ is an effective GLI inhibitor that should be evaluated in combination to conventional chemotherapy in the clinical setting.
Over the last decades, different kinds of design guides have been created to maintain consistency and usability in interactive system development. However, in the case of spatial applications, practitioners from research and industry either have difficulty finding them or perceive such guides as lacking relevance, practicability, and applicability. This paper presents the current state of scientific research and industry practice by investigating currently used design recommendations for mixed reality (MR) system development. We analyzed and compared 875 design recommendations for MR applications elicited from 89 scientific papers and documentation from six industry practitioners in a literature review. In doing so, we identified differences regarding four key topics: Focus on unique MR design challenges, abstraction regarding devices and ecosystems, level of detail and abstraction of content, and covered topics. Based on that,we contribute to the MR design research by providing three factors for perceived irrelevance and six main implications for design recommendations that are applicable in scientific and industry practice.
This study investigates the effects of four multifunctional chain-extending cross-linkers (CECL) on the processability, mechanical performance, and structure of polybutylene adipate terephthalate (PBAT) and polylactic acid (PLA) blends produced using film blowing technology. The newly developed reference compound (M·VERA® B5029) and the CECL modified blends are characterized with respect to the initial properties and the corresponding properties after aging at 50 °C for 1 and 2 months. The tensile strength, seal strength, and melt volume rate (MVR) are markedly changed after thermal aging, whereas the storage modulus, elongation at the break, and tear resistance remain constant. The degradation of the polymer chains and crosslinking with increased and decreased MVR, respectively, is examined thoroughly with differential scanning calorimetry (DSC), with the results indicating that the CECL-modified blends do not generally endure thermo-oxidation over time. Further, DSC measurements of 25 µm and 100 µm films reveal that film blowing pronouncedly changes the structures of the compounds. These findings are also confirmed by dynamic mechanical analysis, with the conclusion that tris(2,4-di-tert-butylphenyl)phosphite barely affects the glass transition temperature, while with the other changes in CECL are seen. Cross-linking is found for aromatic polycarbodiimide and poly(4,4-dicyclohexylmethanecarbodiimide) CECL after melting of granules and films, although overall the most synergetic effect of the CECL is shown by 1,3-phenylenebisoxazoline.
Aim: To understand how transcriptional factors Pdr1 and Pdr3, belonging to the pleiotropic drug resistance system, are activated, and regulated after introducing chemical toxins to the cell in the model organism Saccharomyces cerevisiae.
Methods: Series of molecular methods were applied using different strains of S. cerevisiae over-expressing proteins of interest as a eukaryotic cell model. The chemical stress introduced to the cell is represented by menadione. Results were obtained performing protein detection and analysis. Additionally, the regulation of the DNA binding of the transcriptional activators after stimulation is quantified using chromatin immunoprecipitation, employing epitope-tagged factors and real-time qPCR.
Results: Our results indicated higher expression levels of the Pdr1 transcriptional factor, compared to its homologous Pdr3 after treatment with menadione. The yeast-cell defence system was tested against various organic solvents to exclude the possibility of their presence potentially affecting the results. The results indicate that Pdr1 is most abundant after 30 minutes from the beginning of the treatment, compared with 240 minutes after the treatment when the function of the transcription factor is faded. It appears that Pdr1 binding to the PDR5 and SNQ2 promoters, which are both activated by Pdr1, peaks around the same time, or more precisely after 40 minutes from the start of the treatment.
Conclusion: The tendency of Pdr1 reduction after its activation by menadione is detected. One possibility is that Pdr1, after recognizing the xenobiotic menadione, is removed by a degradation mechanism. Given the fact that Pdr1 directly binds the xenobiotic molecule, its destruction might help the cells to remove toxic levels of menadione. It is possible that overexpressing the part of Pdr1 which recognizes menadione alone was sufficient to detoxify and hence produce a tolerance towards menadione.
When users in virtual reality cannot physically walk and self-motions are instead only visually simulated, spatial updating is often impaired. In this paper, we report on a study that investigated if HeadJoystick, an embodied leaning-based flying interface, could improve performance in a 3D navigational search task that relies on maintaining situational awareness and spatial updating in VR. We compared it to Gamepad, a standard flying interface. For both interfaces, participants were seated on a swivel chair and controlled simulated rotations by physically rotating. They either leaned (forward/backward, right/left, up/down) or used the Gamepad thumbsticks for simulated translation. In a gamified 3D navigational search task, participants had to find eight balls within 5 min. Those balls were hidden amongst 16 randomly positioned boxes in a dark environment devoid of any landmarks. Compared to the Gamepad, participants collected more balls using the HeadJoystick. It also minimized the distance travelled, motion sickness, and mental task demand. Moreover, the HeadJoystick was rated better in terms of ease of use, controllability, learnability, overall usability, and self-motion perception. However, participants rated HeadJoystick could be more physically fatiguing after a long use. Overall, participants felt more engaged with HeadJoystick, enjoyed it more, and preferred it. Together, this provides evidence that leaning-based interfaces like HeadJoystick can provide an affordable and effective alternative for flying in VR and potentially telepresence drones.
The year 2020 was dominated by the Corona pandemic, which abruptly changed everyday life at the university. Bonn-Rhein-Sieg University of Applied Sciences (H-BRS) succeeded not only in maintaining operations under these difficult circumstances, but also in enriching them with new ideas and insights. This difficult year 2020 has opened up new perspectives, especially for teaching, but also for research and administration. This annual report, to which we have given the motto "Walking - knowing the point of view, taking direction, showing attitude", tells of this. It shows which paths the H-BRS has taken in the past year. Some routes were rocky, and some slopes could only be overcome with combined efforts. Often, however, new terrain was opened up. The aim was always to find answers to the multi-layered, complex questions of our time - whether with regard to digitalisation, climate change or the social responsibility of science.
Advocates of autonomous driving predict that the occupation of taxi driver could be made obsolete by shared autonomous vehicles (SAV) in the long term. Conducting interviews with German taxi drivers, we investigate how they perceive the changes caused by advancing automation for the future of their business. Our study contributes insights into how the work of taxi drivers could change given the advent of autonomous driving: While the task of driving could be taken over by SAVs for standard trips, taxi drivers are certain that other areas of their work such as providing supplementary services and assistance to passengers would constitute a limit to such forms of automation, but probably involving a shifting role for the taxi drivers, one which focuses on the sociality of the work. Our findings illustrate how taxi drivers see the future of their work, suggesting design implications for tools that take various forms of assistance into account, and demonstrating how important it is to consider taxi drivers in the co-design of future taxis and SAV services.
The epithelial sodium channel (ENaC) plays a key role in salt and water homeostasis in tetrapod vertebrates. There are four ENaC subunits (α, β, γ, δ), forming heterotrimeric αβγ- or δβγ-ENaCs. While the physiology of αβγ-ENaC is well understood, for decades the field has stalled with respect to δβγ-ENaC due to the lack of mammalian model organisms. The SCNN1D gene coding for δ-ENaC was previously believed to be absent in rodents, hindering studies using standard laboratory animals. We analysed all currently available rodent genomes and discovered that SCNN1D is present in rodents but was independently lost in five rodent lineages, including the Muridae (mice and rats). The independent loss of SCNN1D in rodent lineages may be constrained by phylogeny and taxon-specific adaptation to dry habitats, however habitat aridity does not provide a selection pressure for maintenance of SCNN1D across Rodentia. A fusion of two exons coding for a structurally flexible region in the extracellular domain of δ-ENaC appeared in the Hystricognathi (a group that includes guinea pigs). This conserved pattern evolved at least 41 Ma ago and represents a new autapomorphic feature for this clade. Exon fusion does not impair functionality of guinea pig (Cavia porcellus) δβγ-ENaC expressed in Xenopus oocytes. Electrophysiological characterisation at the whole-cell and single-channel level revealed conserved biophysical features and mechanisms controlling guinea pig αβγ- and δβγ-ENaC function as compared to human orthologues. Guinea pigs therefore represent commercially available mammalian model animals that will help shed light on the physiological function of δ-ENaC.
Risk-based authentication (RBA) extends authentication mechanisms to make them more robust against account takeover attacks, such as those using stolen passwords. RBA is recommended by NIST and NCSC to strengthen password-based authentication, and is already used by major online services. Also, users consider RBA to be more usable than two-factor authentication and just as secure. However, users currently obtain RBA's high security and usability benefits at the cost of exposing potentially sensitive personal data (e.g., IP address or browser information). This conflicts with user privacy and requires to consider user rights regarding the processing of personal data. We outline potential privacy challenges regarding different attacker models and propose improvements to balance privacy in RBA systems. To estimate the properties of the privacy-preserving RBA enhancements in practical environments, we evaluated a subset of them with long-term data from 780 users of a real-world online service. Our results show the potential to increase privacy in RBA solutions. However, it is limited to certain parameters that should guide RBA design to protect privacy. We outline research directions that need to be considered to achieve a widespread adoption of privacy preserving RBA with high user acceptance.
Das Jahr 2020 stand unter dem Eindruck der Corona-Pandemie, die den Hochschulalltag schlagartig verändert hat. Daraus ergaben sich für vor allem für die Lehre, die Forschung und die Verwaltung Herausforderungen, aber auch neue Perspektiven. "Wir haben dabei viel für die Hochschule der Zukunft gelernt, etwa wie Digitalisierung den Hochschulalltag verändern wird", so Hochschulpräsident Hartmut Ihne in seinem Vorwort zum Jahresbericht. "Vor allem aber haben wir gelernt, dass wir die Solidarität aller mit allen brauchen."
Der Jahresbericht stellt zahlreiche Beispiele für gelungene Gemeinschaftsleistungen heraus - ob es nun um den Umgang mit der Corona-Pandemie, Projekte zur Energiewende und zum Klimaschutz, Coaching für internationale Studierende oder den Erfolg des Hacker-Teams beim internationalen Wettbewerb "Hack-a-Sat" geht.
Auf mehr als 80 Seiten bietet die Broschüre einen Überblick über die wichtigsten Themen aus den Gebieten Forschung, Lehre, Studium und Kooperation. Abgerundet wird der Jahresbericht durch Daten, Fakten und Personalien.
Im Interview sprechen zudem Hartmut Ihne und Bonns Oberbürgermeisterin Katja Dörner über die Bewältigung des Klimawandels. Dabei geht es vor allem um die Frage, wie der durch die Corona-Pandemie intensiver gewordene Dialog zwischen Wissenschaft und Politik zu einem schnelleren Handeln beitragen kann.
In contrast to the German power supply, the energy supply in many West African countries is very unstable. Frequent power outages are not uncommon. Especially for critical infrastructures, such as hospitals, a stable power supply is vital. To compensate for the power outages, diesel generators are often used. In the future, these systems will increasingly be supplemented by PV systems and storage, so that the generator will have to be used less or not at all when needed. For the design and operation of such systems, it is necessary to better understand the atmospheric variability of PV power generation. For example, there are large variations between rainy and dry seasons, between days with high and low dust levels - caused by sandstorms (harmattan) or urban air pollution.
In view of the rapid growth of solar power installations worldwide, accurate forecasts of photovoltaic (PV) power generation are becoming increasingly indispensable for the overall stability of the electricity grid. In the context of household energy storage systems, PV power forecasts contribute towards intelligent energy management and control of PV-battery systems, in particular so that self-sufficiency and battery lifetime are maximised. Typical battery control algorithms require day-ahead forecasts of PV power generation, and in most cases a combination of statistical methods and numerical weather prediction (NWP) models are employed. The latter are however often inaccurate, both due to deficiencies in model physics as well as an insufficient description of irradiance variability.
The future of work
(2021)
Driven by the exponential increase in the computational power of machines, data digitalization and scientific advancement in robotics and automation, the current wave of technological change is seemingly unprecedented in speed and scale. It transforms manufacturing and businesses making them more flexible, decentralized and efficient (Lasi et al. 2014). Even though technological change is nothing new, some argue that it is different this time. The new technologies have not only the potential to substitute labor (Nomaler and Verspagen 2018), they also change the way people work. The trend towards new forms of employment is no longer a marginal phenomenon.
The changing world poses many challenges to public policies, including social policies – among them social protection policies, which are the main focus of this handbook. Here, in this part of the handbook, we take on a number of these challenges: demographic changes and their interaction with social protection policies; roles of social protection in coping with the consequences of the COVID-19 pandemic (both topics discussed in Chapter 39 and 43 by Woodall); the challenges of globalisation (discussed in Chapter 40 by Betz) and the limitations it imposes on state sovereignty and its ability to decide on the size of publicly funded programmes, in particular social protection; challenges to labour markets and social effective protection coverage posed by automation and digitalisation of businesses (discussed in Chapter 41 by Gassmann) and, last but not least, potential roles of social protection in facilitating population’s adjustments to climate change (discussed in Chapter 42 by Malerba).
Policy analysis is the cornerstone of evidence-based policy making.1 It identifies the problems, informs programme design, supports the monitoring of policy implementation and is needed to evaluate programme impacts (Scott 2005). Rigorous and credible policy evidence is necessary to ensure the transparency and accountability of policy decisions, to secure political and public support and, hence, the allocation of financial resources. Sound policy analysis helps design effective and efficient programmes, thereby maximizing programme impact.
In recent years, the basic income grant (BIG) discourse has gained attention worldwide as a potential policy option in social protection as testified by recent public debates, ongoing pilot projects, campaigning efforts,1 policy measures during Covid-19 and the surge in academic research. A BIG refers to regular cash transfers paid to all members of society irrespective of their socio-economic status, their capacity or willingness to participate in the labour market or having to meet pre-determined conditions (Offe 2008; Van Parijs 1995, 2003; Wright 2004, 2006). Despite the recent hype around BIG, Iran is the only country worldwide with a scaled-up BIG (Tabatabai 2011, 2012). Other programmes have never gone beyond pilot programmes. This raises the question why this is the case.
With the roll out of social protection programmes to national scale, questions about implementation and delivery move more and more into the centre of debate (e.g. UNDP 2020; UNDP and UNCDF 2014; Kramon 2019). This concerns in particular the local level, where key processes of implementation are taking place, but where at the same time institutional, operational and financial capacities are often the weakest. While social protection programmes are usually based on a clearly defined set of operational rules and regulations – usually set out in a programme manual – in practice these processes often tend to look quite different. Although many social protection programmes have explicitly excluded traditional authorities from playing an active role in programme delivery, there is ample evidence from across countries that in many local contexts, these ‘informal institutions’ continue to play an important role in the delivery of social protection programmes.
Public preferences
(2021)
For reforms to be acceptable and sustainable in the long run, they should be aligned with public preferences. ‘Preferences’ is a technical term used in social sciences or humanities including for example disciplines such as economics, philosophy or psychology. Broadly speaking, preferences refer to an individual’s judgements on liking one alternative more than others. More specifically, preferences are ‘subjective comparative evaluations, in the form of “Agent prefers X to Y”’ (Hansson and Grüne-Yanoff 2018). Here, we are particularly interested in people’s policy preferences concerning social protection, an area which deserves more attention in policy debates and research.
Designing a social protection system is of course not only a technical exercise but a very political affair. A systems approach to social protection is shaped by the political elites and the respective coalitions of change, the political institutions as well as the political system of a country. This explains why also seemingly similar countries in terms of their risk profile, poverty situation and economic situation can adopt very different social protection systems or make very different progress with respect to social protection expansion. Not only are the established welfare states of the Global North but also the nascent social protection systems in the Global South a testimony of this variety.
While there is a standard set of instruments that can be used in social protection systems, this needs to be adapted and combined in different ways in order to serve different groups in society best. The needs of a young person who is just starting life and should not be trapped from birth in unfavourable socio-economic conditions are different from the social protection requirements of a retired person who has finished the active part of life and requires income and care security for an indefinite time period.
Social budgeting
(2021)
At the beginning of 2020 with the globally spreading pandemic of COVID-19 and all its social and economic consequences, the importance of having comprehensive, universal and effective social protection systems became once again – like during all the major economic and social crises before – very clear (Gentilini et al. 2020; Chapter 43 of this volume). Countries with strong social protection systems, although needing to enhance many benefit provisions and extend coverage to reach those in non-standard forms of employment, still were coping better with the pandemic and had better chances of cushioning the resulting economic downturn. However, we know from past experience that after the crisis is over, austerity measures may focus again on limiting social expenditure under all kinds of excuses.
Actors
(2021)
Social protection is for many international organizations a state’s affair.1 While the state definitely plays an important role, the state is by far not the only actor and there is no predefined institutional arrangement of how social protection should be implemented. An exclusive focus on the state would therefore be short-sighted when assessing and comparing the performance of social protection systems. It is hence important to understand the mix of actors involved, the type of contribution they can make to social protection and their modes of cooperation. This contribution will therefore first sketch out the role and interplay of the main actors in social protection and then challenge some of the common assumptions made around how roles are best allocated in the social protection system concerning the providers of informal social protection, the private sector, civil society organizations (CSO) as well as international actors.
Social services
(2021)
People are usually exposed to multiple economic and social risks, including discrimination, abuse, violence and social exclusion. While material support has a positive impact on the reduction of social risks and aspects of exclusion (WHO 2019), some situations require concrete, personal and guiding support on an individual basis. This type of service is commonly referred to as social services (Trukeschitz 2006).
The idea of a basic income grant (BIG) is not new and there are ongoing debates internationally as well as nationally in low- and middle-income countries just like in high-income countries of a BIG as a social protection policy option. The challenge is that there are different conceptualisations, which conflates and muddles the understanding. In the context of social assistance provision, a universal basic income grant (UBIG) is often compared and contrasted against targeted cash transfers (CTs). This case study systematically presents the arguments for targeted CTs and UBIGs. The value of the case study is that it systematically brings together these arguments, highlighting the variations in UBIG applications, including the evidence and actual impact of UBIG experiments. The structure of the case study is as follows: Section 2 simultaneously contrasts and compares the arguments for targeted CTs and UBIG. Section 3 discusses UBIG experiments, as well as presenting the evidence on the application of the UBIG idea, and Section 4 concludes.
Social transfers
(2021)
Social transfers are on the rise in the Global South but they have also been in the centre of discussion in the Global North as an attractive instrument to buffer new risks and uncertainties in a changing world. They have experienced a dramatic change since the beginning of the new century, starting off as a revolutionary programmatic intervention in countries such as Mexico and Brazil or as a fledgling pilot programme in countries such as Zambia, Kenya and Malawi. They have now become a standard intervention across the globe, a truly global social policy as Hickey and Seekings (2019, 249) coined it. This global trend has been facilitated by donors’ strive to move away from ever recurring humanitarian actions, by increased pressure on donors to show aid effectiveness with the money finally reaching the most vulnerable as well as by international concerted actions such as the United Nations initiative of a global social protection floor.
While social protection has become an important policy field in many low- and middle-income countries (LICs and MICs), 55 per cent of the world’s population are still not even covered by one social protection benefit, with 87 per cent of people uncovered in Sub-Saharan Africa and 61 per cent in Asia and the Pacific (ILO 2017). Next to undercoverage, there are other factors that lower the efficiency, effectiveness and social justice of social protection in many countries, such as the lack of a joint vision and policy strategy, fragmented social protection programmes, duplication of administrative systems and efforts and irrational prioritisation in spending. These all call for a stronger systems approach to social protection. This handbook is therefore dedicated to social protection systems, highlighting the relevance but also the challenges that are related to a harmonised and coordinated approach across different social protection instruments, institutions, actors and delivery mechanisms. It takes the reader through all possible aspects of social protection systems.
Turbulent compressible flows are traditionally simulated using explicit time integrators applied to discretized versions of the Navier-Stokes equations. However, the associated Courant-Friedrichs-Lewy condition severely restricts the maximum time-step size. Exploiting the Lagrangian nature of the Boltzmann equation’s material derivative, we now introduce a feasible three-dimensional semi-Lagrangian lattice Boltzmann method (SLLBM), which circumvents this restriction. While many lattice Boltzmann methods for compressible flows were restricted to two dimensions due to the enormous number of discrete velocities in three dimensions, the SLLBM uses only 45 discrete velocities. Based on compressible Taylor-Green vortex simulations we show that the new method accurately captures shocks or shocklets as well as turbulence in 3D without utilizing additional filtering or stabilizing techniques other than the filtering introduced by the interpolation, even when the time-step sizes are up to two orders of magnitude larger compared to simulations in the literature. Our new method therefore enables researchers to study compressible turbulent flows by a fully explicit scheme, whose range of admissible time-step sizes is dictated by physics rather than spatial discretization.
New communication technologies are changing the way we work and communicate with people around the world. Given this reality, students in Higher Education (HE) worldwide need to develop knowledge in their area of study as well as attitudes and values that will enable them to be responsible and ethical global citizens in the workforce they will soon enter, regardless of the degree. Different institutional and country-specific requirements are important factors when developing an international Virtual Exchange (VE) program. Digital learning environments such as ProGlobe – Promoting the Global Exchange of Ideas on Sustainable Goals, Practices, and Cultural Diversity – offer a platform for collaborating with diverse students around the world to share and reflect on ideas on sustainable practices. Students work together virtually on a joint interdisciplinary project that aims to create knowledge and foster cultural diversity. This project was successfully integrated into each country’s course syllabus through a common global theme; sustainability. The focus of this paper is to present multi-disciplinary perspectives on the opportunities and challenges in implementing a VE project in HE. Furthermore, it will present the challenges that country coordinators dealt with when planning and implementing their project. Given the disparity found in each course syllabus, project coordinators uniquely handled the project goal, approach, and assessment for their specific course and program. Not only did the students and faculty gain valuable insight into different aspects of collaboration when working in interdisciplinary HE projects, they also reflected on their own impact on the environment and learned to listen to how people in different countries deal with environmental issues. This approach provided students with meaningful intercultural experiences that helped them link ideas and concepts about a global issue through the lens of their own discipline as well as other disciplines worldwide.
Because the robust and rapid determination of spoilage microorganisms is becoming increasingly important in industry, the use of IR microspectroscopy, and the establishment of robust and versatile chemometric models for data processing and classification, is gaining importance. To further improve the chemometric models, bacterial stress responses were induced, to study the effect on the IR spectra and to improve the chemometric model. Thus, in this work, nine important food-relevant microorganisms were subjected to eight stress conditions, besides the regular culturing as a reference. Spectral changes compared to normal growth conditions without stressors were found in the spectral regions of 900–1500 cm−1 and 1500–1700 cm−1. These differences might stem from changes in the protein secondary structure, exopolymer production, and concentration of nucleic acids, lipids, and polysaccharides. As a result, a model for the discrimination of the studied microorganisms at the genus, species and strain level was established, with an accuracy of 96.6%. This was achieved despite the inclusion of various stress conditions and times after incubation of the bacteria. In addition, a model was developed for each individual microorganism, to separate each stress condition or regular treatment with 100% accuracy.
Target meaning representations for semantic parsing tasks are often based on programming or query languages, such as SQL, and can be formalized by a context-free grammar. Assuming a priori knowledge of the target domain, such grammars can be exploited to enforce syntactical constraints when predicting logical forms. To that end, we assess how syntactical parsers can be integrated into modern encoder-decoder frameworks. Specifically, we implement an attentional SEQ2SEQ model that uses an LR parser to maintain syntactically valid sequences throughout the decoding procedure. Compared to other approaches to grammar-guided decoding that modify the underlying neural network architecture or attempt to derive full parse trees, our approach is conceptually simpler, adds less computational overhead during inference and integrates seamlessly with current SEQ2SEQ frameworks. We present preliminary evaluation results against a recurrent SEQ2SEQ baseline on GEOQUERY and ATIS and demonstrate improved performance while enforcing grammatical constraints.
Since stationary self-checkout is widely introduced and well understood, previous research barely examined newer generations of smartphone-based Scan&Go. Especially from a design perspective, we know little about the factors contributing to the adoption of Scan&Go solutions and how design enables consumers to take full advantage of this development rather than being burdened with using complex and unenjoyable systems. To understand the influencing factors and the design from a consumer perspective, we conducted a mixed-methods study where we triangulated data of an online survey with 103 participants and a qualitative study with 20 participants. Based on the results, our study presents a refined and nuanced understanding of technology as well as infrastructure-related factors that influence adoption. Moreover, we present several implications for designing and implementing of Scan&Go in retail environments.
Hektor Haarkötter und Filiz Kalmuk, zwei Kommunikationswissenschaftler*innen der Hochschule Bonn-Rhein-Sieg, haben die Medienseiten der überregionalen Printausgaben der SZ, FAZ und taz sowie der Regionalzeitungen WAZ, Tagesspiegel und Kölner Stadt-Anzeiger analysiert. Insgesamt wurden über 2000 Medienartikel untersucht. In Interviews mit verantwortlichen Medienredakteur*innen wichtiger Printorgane wurden Objektivität, Ausgewogenheit und Themenvielfalt der aktuellen Medienberichterstattung diskutiert.
Der Medienjournalismus deutscher Tageszeitungen zeichnet sich durch eine überwiegend sachliche Berichterstattung aus. Festgestellt wurde ein ausgeglichener Mix von ,harten‘ medienpolitischen Themen einerseits und ,weichen‘ Unterhaltungsthemen andererseits. Politische Parteien werden im Medienjournalismus nicht verzerrt dargestellt; über die „Systemkonkurrenz“ der öffentlich-rechtlichen Medien berichten die privatwirtschaftlich organisierten Zeitungen fair und ausgewogen.
Die Studie über „Medienjournalismus in Deutschland“ identifiziert aber auch Schwachstellen. Die dringend gebotene Reflexion über die gesellschaftlichen Folgen der Medienumwälzungen kommt zu kurz. Veränderungen durch die Digitalisierung und die Europäisierung der Medien-Landschaft spielen eine untergeordnete Rolle, für Belange des Hörfunks zeigt er zu wenig Interesse.
A qualitative study of Machine Learning practices and engineering challenges in Earth Observation
(2021)
Machine Learning (ML) is ubiquitously on the advance. Like many domains, Earth Observation (EO) also increasingly relies on ML applications, where ML methods are applied to process vast amounts of heterogeneous and continuous data streams to answer socially and environmentally relevant questions. However, developing such ML- based EO systems remains challenging: Development processes and employed workflows are often barely structured and poorly reported. The application of ML methods and techniques is considered to be opaque and the lack of transparency is contradictory to the responsible development of ML-based EO applications. To improve this situation a better understanding of the current practices and engineering-related challenges in developing ML-based EO applications is required. In this paper, we report observations from an exploratory study where five experts shared their view on ML engineering in semi-structured interviews. We analysed these interviews with coding techniques as often applied in the domain of empirical software engineering. The interviews provide informative insights into the practical development of ML applications and reveal several engineering challenges. In addition, interviewees participated in a novel workflow sketching task, which provided a tangible reflection of implicit processes. Overall, the results confirm a gap between theoretical conceptions and real practices in ML development even though workflows were sketched abstractly as textbook-like. The results pave the way for a large-scale investigation on requirements for ML engineering in EO.
The clear-sky radiative effect of aerosol-radiation interactions is of relevance for our understanding of the climate system. The influence of aerosol on the surface energy budget is of high interest for the renewable energy sector. In this study, the radiative effect is investigated in particular with respect to seasonal and regional variations for the region of Germany and the year 2015 at the surface and top of atmosphere using two complementary approaches.
First, an ensemble of clear-sky models which explicitly consider aerosols is utilized to retrieve the aerosol optical depth and the surface direct radiative effect of aerosols by means of a clear sky fitting technique. For this, short-wave broadband irradiance measurements in the absence of clouds are used as a basis. A clear sky detection algorithm is used to identify cloud free observations. Considered are measurements of the shortwave broadband global and diffuse horizontal irradiance with shaded and unshaded pyranometers at 25 stations across Germany within the observational network of the German Weather Service (DWD). Clear sky models used are MMAC, MRMv6.1, METSTAT, ESRA, Heliosat-1, CEM and the simplified Solis model. The definition of aerosol and atmospheric characteristics of the models are examined in detail for their suitability for this approach.
Second, the radiative effect is estimated using explicit radiative transfer simulations with inputs on the meteorological state of the atmosphere, trace-gases and aerosol from CAMS reanalysis. The aerosol optical properties (aerosol optical depth, Ångström exponent, single scattering albedo and assymetrie parameter) are first evaluated with AERONET direct sun and inversion products. The largest inconsistency is found for the aerosol absorption, which is overestimated by about 0.03 or about 30 % by the CAMS reanalysis. Compared to the DWD observational network, the simulated global, direct and diffuse irradiances show reasonable agreement within the measurement uncertainty. The radiative kernel method is used to estimate the resulting uncertainty and bias of the simulated direct radiative effect. The uncertainty is estimated to −1.5 ± 7.7 and 0.6 ± 3.5 W m−2 at the surface and top of atmosphere, respectively, while the annual-mean biases at the surface, top of atmosphere and total atmosphere are −10.6, −6.5 and 4.1 W m−2, respectively.
The retrieval of the aerosol radiative effect with the clear sky models shows a high level of agreement with the radiative transfer simulations, with an RMSE of 5.8 W m−2 and a correlation of 0.75. The annual mean of the REari at the surface for the 25 DWD stations shows a value of −12.8 ± 5 W m−2 as average over the clear sky models, compared to −11 W m−2 from the radiative transfer simulations. Since all models assume a fixed aerosol characterisation, the annual cycle of the aerosol radiation effect cannot be reproduced. Out of this set of clear sky models, the largest level of agreement is shown by the ESRA and MRMv6.1 models.
An der H-BRS, einer Hochschule für Angewandte Wissenschaften mit ca. 9.000 Studierenden, wurde die OER-Kultur bewusst als Teil der Strategie zur Digitalisierung der Lehre in drei Schritten etabliert: (1) Gemeinsame Strategiebildung als Teil eines partizipativ erarbeiteten Hochschulentwicklungsplans: Verankerung von OER in der Digitalisierungsstrategie. (2) Basierend auf der Vernetzung der Expertinnen und Experten erfolgreiche Einwerbung von OER-Projekten, die exemplarisch vorgestellt werden. (3) Dauerhafte strategische Verankerung, basierend auf kontinuierlicher interner und externer Netzwerkarbeit, Etablierung von digitalen Austauschplattformen für die Lehrenden, Transfer des OER-Gedankens (Kooperation, Austausch, Mehrfachnutzen) auf die Hochschuldidaktik sowie regelmäßige Ausschreibungen von Fördermaßnahmen.
Cultivation of Miscanthus x giganteus L. (Mis) with annual harvest of biomass could provide an additional C source for farmers. To test the potential of Mis-C for immobilizing inorganic N from slurry or manure and as a C source for soil organic matter build-up in comparison to wheat (Triticum aestivum L.) straw (WS), a greenhouse experiment was performed. Pot experiments with ryegrass (Lolium perenne L.) were set up to investigate the N dynamics of two organic fertilisers based on Mis at Campus Klein-Altendorf, Germany. The two fertilisers, a mixture of cattle slurry and Mis as well as cattle manure from Mis-bedding material resulted in a slightly higher N immobilisation. Especially at the 1st and 2nd harvest, they were partly significantly different compared with the WS treatments. The fertilisers based on Mis resulted in a slightly higher microbial biomass C and microbial biomass N and thus can be identified as an additional C source to prevent nitrogen losses and for the build-up of soil organic matter (SOM) in the long-term.
Software developers build complex systems using plenty of third-party libraries. Documentation is key to understand and use the functionality provided via the libraries’ APIs. Therefore, functionality is the main focus of contemporary API documentation, while cross-cutting concerns such as security are almost never considered at all, especially when the API itself does not provide security features. Documentations of JavaScript libraries for use in web applications, e.g., do not specify how to add or adapt a Content Security Policy (CSP) to mitigate content injection attacks like Cross-Site Scripting (XSS). This is unfortunate, as security-relevant API documentation might have an influence on secure coding practices and prevailing major vulnerabilities such as XSS. For the first time, we study the effects of integrating security-relevant information in non-security API documentation. For this purpose, we took CSP as an exemplary study object and extended the official Google Maps JavaScript API documentation with security-relevant CSP information in three distinct manners. Then, we evaluated the usage of these variations in a between-group eye-tracking lab study involving N=49 participants. Our observations suggest: (1) Developers are focused on elements with code examples. They mostly skim the documentation while searching for a quick solution to their programming task. This finding gives further evidence to results of related studies. (2) The location where CSP-related code examples are placed in non-security API documentation significantly impacts the time it takes to find this security-relevant information. In particular, the study results showed that the proximity to functional-related code examples in documentation is a decisive factor. (3) Examples significantly help to produce secure CSP solutions. (4) Developers have additional information needs that our approach cannot meet.
Overall, our study contributes to a first understanding of the impact of security-relevant information in non-security API documentation on CSP implementation. Although further research is required, our findings emphasize that API producers should take responsibility for adequately documenting security aspects and thus supporting the sensibility and training of developers to implement secure systems. This responsibility also holds in seemingly non-security relevant contexts.
The modern concept of the evolution of Mars assumes that life could potentially have originated on the planet Mars, possibly during the end of the late heavy bombardment, and could then be transferred to other planets. Since then, physical and chemical conditions on Mars changed and now strongly limit the presence of terrestrial-like life forms. These adverse conditions include scarcity of liquid water (although brine solutions may exist), low temperature and atmospheric pressure, and cosmic radiation. Ionizing radiation is very important among these life-constraining factors because it damages DNA and other cellular components, particularly in liquid conditions where radiation-induced reactive oxidants diffuse freely. Here, we investigated the impact of high doses (up to 2 kGy) of densely-ionizing (197.6 keV/µm), space-relevant iron ions (corresponding on the irradiation that reach the uppermost layer of the Mars subsurface) on the survival of an extremophilic terrestrial organism-Cryomyces antarcticus-in liquid medium and under atmospheric conditions, through different techniques. Results showed that it survived in a metabolically active state when subjected to high doses of Fe ions and was able to repair eventual DNA damages. It implies that some terrestrial life forms can withstand prolonged exposure to space-relevant ion radiation.
3-Hydroxyisobutyrate Dehydrogenase (HIBADH) deficiency - a novel disorder of valine metabolism
(2021)
3-Hydroxyisobutyric acid (3HiB) is an intermediate in the degradation of the branched-chain amino acid valine. Disorders in valine degradation can lead to 3HiB accumulation and its excretion in the urine. This article describes the first two patients with a new metabolic disorder, 3-hydroxyisobutyrate dehydrogenase (HIBADH) deficiency, its phenotype and its treatment with a low-valine diet. The detected mutation in the HIBADH gene leads to nonsense-mediated mRNA decay of the mutant allele and to a complete loss-of-function of the enzyme. Under strict adherence to a low-valine diet a rapid decrease of 3HiB excretion in the urine was observed. Due to limited patient numbers and intrafamilial differences in phenotype with one affected and one unaffected individual, the clinical phenotype of HIBADH deficiency needs further evaluation.
Although work events can be regarded as pivotal elements of organizational life, only a few studies have examined how positive and negative events relate to and combine to affect work engagement over time. Theory suggests that, to better understand how current events affect work engagement (WE), we have to account for recent events that have preceded these current events. We present competing theoretical views on how recent and current work events may affect employees (e.g., getting used to a high frequency of negative events or becoming more sensitive to negative events). Although the occurrence of events implies discrete changes in the experience of work, prior research has not considered whether work events actually accumulate to sustained mid-term changes in WE. To address these gaps in the literature, we conducted a week-level longitudinal study across a period of 15 consecutive weeks among 135 employees, which yielded 849 weekly observations. While positive events were associated with higher levels of WE within the same week, negative events were not. Our results support neither satiation nor sensitization processes. However, a high frequency of negative events in the preceding week amplified the beneficial effects of positive events on WE in the current week. Growth curve analyses show that the benefits of positive events accumulate to sustain high levels of WE. WE dissipates in the absence of a continuous experience of positive events. Our study adds a temporal component by highlighting that positive events affect work engagement, particularly in light of recent negative events. Our study informs research that has taken a feature-oriented perspective on the dynamic interplay of job demands and resources.
Science Track FrOSCon 2018
(2021)
Open Innovation
(2021)
Der Begriff Open Innovation steht für die Öffnung von unternehmensinternen Innovationsprozessen für sogenannte „externe Quellen“. Zu diesen externen Quellen zählen beispielsweise Lieferanten, Partner, Experten aus Forschungseinrichtungen und insbeson-dere auch Kunden. Diese werden gezielt in die Innovationsentwicklung integriert, sei es als Informations- und Ideenquelle bzw. als Impulsgeber für die Innovationsentwicklung. Daneben existieren auch tiefere Integrationsmöglichkeiten, die eine direkte Partizipation an der Innovationsentwicklung ermöglichen.
Less is Often More: Header Whitelisting as Semantic Gap Mitigation in HTTP-Based Software Systems
(2021)
The web is the most wide-spread digital system in the world and is used for many crucial applications. This makes web application security extremely important and, although there are already many security measures, new vulnerabilities are constantly being discovered. One reason for some of the recent discoveries lies in the presence of intermediate systems—e.g. caches, message routers, and load balancers—on the way between a client and a web application server. The implementations of such intermediaries may interpret HTTP messages differently, which leads to a semantically different understanding of the same message. This so-called semantic gap can cause weaknesses in the entire HTTP message processing chain.
In this paper we introduce the header whitelisting (HWL) approach to address the semantic gap in HTTP message processing pipelines. The basic idea is to normalize and reduce an HTTP request header to the minimum required fields using a whitelist before processing it in an intermediary or on the server, and then restore the original request for the next hop. Our results show that HWL can avoid misinterpretations of HTTP messages in the different components and thus prevent many attacks rooted in a semantic gap including request smuggling, cache poisoning, and authentication bypass.
XML Signature Wrapping (XSW) has been a relevant threat to web services for 15 years until today. Using the Personal Health Record (PHR), which is currently under development in Germany, we investigate a current SOAP-based web services system as a case study. In doing so, we highlight several deficiencies in defending against XSW. Using this real-world contemporary example as motivation, we introduce a guideline for more secure XML signature processing that provides practitioners with easier access to the effective countermeasures identified in the current state of research.
Dental stem cells have been isolated from the medical waste of various dental tissues. They have been characterized by numerous markers, which are evaluated herein and differentiated into multiple cell types. They can also be used to generate cell lines and iPSCs for long-term in vitro research. Methods for utilizing these stem cells including cellular systems such as organoids or cell sheets, cell-free systems such as exosomes, and scaffold-based approaches with and without drug release concepts are reported in this review and presented with new pictures for clarification. These in vitro applications can be deployed in disease modeling and subsequent pharmaceutical research and also pave the way for tissue regeneration. The main focus herein is on the potential of dental stem cells for hard tissue regeneration, especially bone, by evaluating their potential for osteogenesis and angiogenesis, and the regulation of these two processes by growth factors and environmental stimulators. Current in vitro and in vivo publications show numerous benefits of using dental stem cells for research purposes and hard tissue regeneration. However, only a few clinical trials currently exist. The goal of this review is to pinpoint this imbalance and encourage scientists to pick up this research and proceed one step further to translation.
Der Hochschulentwicklungsplan (HEP) 3 der Hochschule Bonn-Rhein-Sieg beschreibt die strategischen Schwerpunkte der Hochschulentwicklung für die Jahre 2021 bis 2025. Er steht insbesondere unter den Leitbegriffen "Nachhaltigkeit und gesellschaftliche Verantwortung, Digitalisierung, Internationalisierung und Diversität".
The promotion of sustainable packaging is part of the European Green Deal and plays a key role in the EU’s social and political strategy. One option is the use of renewable resources and biomass waste as raw materials for polymer production. Lignocellulose biomass from annual and perennial industrial crops and agricultural residues are a major source of polysaccharides, proteins, and lignin and can also be used to obtain plant-based extracts and essential oils. Therefore, these biomasses are considered as potential substitute for fossil-based resources. Here, the status quo of bio-based polymers is discussed and evaluated in terms of properties related to packaging applications such as gas and water vapor permeability as well as mechanical properties. So far, their practical use is still restricted due to lower performance in fundamental packaging functions that directly influence food quality and safety, the length of shelf life, and thus the amount of food waste. Besides bio-based polymers, this review focuses on plant extracts as active packaging agents. Incorporating extracts of herbs, flowers, trees, and their fruits is inevitable to achieve desired material properties that are capable to prolong the food shelf life. Finally, the adoption potential of packaging based on polymers from renewable resources is discussed from a bioeconomy perspective.
Intersectoral collaborations are an integral component of the prevention and control of diseases in a complex health system. On the one hand, One Health (OH) is promoting the establishment of intersectoral collaborations for prevention at the human-animal-environment interface. On the other hand, operationalising OH can only be realized through intersectoral collaborations.
This work contributes to broadening the knowledge of the process for operationalising OH by analysing the governance structures behind different initiatives that tackle health problems at the human-animal-environment interface. The cases taken as examples for the analysis are the control and response to rabies and avian influenza under “classical OH”, and the management of floods and droughts for insights into “extended OH”. Data from Ghana and India were collected and compared to identify the key elements that enable ISC for OH.
Despite the case studies being heterogeneous in terms of their geographic, economic, social, cultural, and historical contexts, strong similarities were identified on how intersectoral collaborations in OH were initiated, managed, and taken to scale.
The actions documented for rabies prevention and control were historically based on one sector being the leader and implementer of activities, while avian influenza management relied more on intersectoral collaborations with clearly defined sectoral responsibilities. The management of the impact of flood and droughts on health provided a good example of intersectoral collaborations achieved by sectoral integration; however, the human health component was only involved in the response stage in the case of Ghana, while for India, there were broader schemes of intersectoral collaborations for prevention, adaptation, and response concerning climate change and disaster.
Diversity of Insects in Nature protected Areas (DINA): an interdisciplinary German research project
(2021)
Insect declines and biodiversity loss have attracted much attention in recent years, but lack of comprehensive data, conflicting interests among stakeholders and insufficient policy guidance hinder progress in preserving biodiversity. The project DINA (Diversity of Insects in Nature protected Areas) investigates insect communities in 21 nature reserves in Germany. All selected conservation sites border arable land, with agricultural practices assumed to influence insect populations. We taught citizen scientists how to manage Malaise traps for insect collection, and subsequently used a DNA metabarcoding approach for species identification. Vegetation surveys, plant metabarcoding as well as geospatial and ecotoxicological analyses will help to unravel contributing factors for the deterioration of insect communities. As a pioneering research project in this field, DINA includes a transdisciplinary dialogue involving relevant stakeholders such as local authorities, policymakers, and farmers, which aims at a shared understanding of conservation goals and action pathways. Stakeholder engagement combined with scientific results will support the development of sound policy recommendations to improve legal frameworks, landscape planning, land use, and conservation strategies. With this transdisciplinary approach, we aim to provide the background knowledge to implement policy strategies that will halt further decline of insects in German protected areas.
Design of a Medium Voltage Generator with DC-Cascade for High Power Wind Energy Conversion Systems
(2021)
This paper shows a new concept to generate medium voltage (MV) in wind power application to avoid an additional transformer. Therefore, the generator must be redesigned with additional constraints and a new topology for the power rectifier system by using multiple low voltage (LV) power rectifiers connected in series and parallel to increase the DC output voltage. The combination of parallel and series connection of rectifiers is further introduced as DC-cascade. With the resulting DC-cascade, medium output voltage is achieved with low voltage rectifiers and without a bulky transformer. This approach to form a DC-cascade reduces the effort required to achieve medium DC voltage with a simple rectifier system. In this context, a suitable DC-cascade control was presented and verified with a laboratory test setup. A gearless synchronous generator, which is highly segmented so that each segment can be connected to its own power rectifier, is investigated. Due to the mixed AC and DC voltage given by the DC-cascade structure, it becomes more demanding to the design of the generator insulation, which influences the copper fill factor and the design of the cooling system. A design strategy for the overall generator design is carried out considering the new boundary conditions.
The promotion of sustainable packaging is part of the European Green Deal and plays a key role in the EU’s social and political strategy. One option is the use of renewable resources and biomass waste as raw materials for polymer production. Lignocellulose biomass from annual and perennial industrial crops and agricultural residues are a major source of polysaccharides, proteins, and lignin, and can also be used to obtain plant-based extracts and essential oils. Therefore, these biomasses are considered as potential substitute for fossil-based resources. Here, the status quo of bio-based polymers is discussed and evaluated in terms of properties related to packaging applications such as gas and water vapor permeability as well as mechanical properties. So far, their practical use is still restricted due to lower performance in fundamental packaging functions that directly influence food quality and safety, the length of shelf life and thus the amount of food waste. Besides bio-based polymers, this review focuses on plant extracts as active packaging agents. Incorporating extracts of herbs, flowers, trees, and their fruits is inevitable to achieve desired material properties that are capable to prolong the food shelf life. Finally, the adoption potential of packaging based on polymers from renewable resources is discussed from a bioeconomy perspective.
Threats to passwords are still very relevant due to attacks like phishing or credential stuffing. One way to solve this problem is to remove passwords completely. User studies on passwordless FIDO2 authentication using security tokens demonstrated the potential to replace passwords. However, widespread acceptance of FIDO2 depends, among other things, on how user accounts can be recovered when the security token becomes permanently unavailable. For this reason, we provide a heuristic evaluation of 12 account recovery mechanisms regarding their properties for FIDO2 passwordless authentication. Our results show that the currently used methods have many drawbacks. Some even rely on passwords, taking passwordless authentication ad absurdum. Still, our evaluation identifies promising account recovery solutions and provides recommendations for further studies.
Risk-based authentication (RBA) is an adaptive security measure to strengthen password-based authentication against account takeover attacks. Our study on 65 participants shows that users find RBA more usable than two-factor authentication equivalents and more secure than password-only authentication. We identify pitfalls and provide guidelines for putting RBA into practice.
The article contributes to understanding the political economy of implementation of social protection programmes at local level. Current debates are dominated by technocratic arguments, emphasizing the lack of financial resources, technology or skills as major barriers for effective implementation. Describing how chiefs, assistant-chiefs and community elders are routinely at the centre stage of core implementation processes, including targeting, enrolment, delivery, monitoring, awareness and information, data collection or grievance and redress, this study on Kenya argues for the need to look more closely into the local political economy as an important mediating arena for implementing social policies. Implementation is heavily contingent upon the local social, political and institutional context that influences and shapes its outcomes. These processes are ambivalent involving multiple forms of interactions between ‘formal’ and ‘informal’ institutional structures, which may support initial policy objectives or induce policy outcomes substantially diverging from intended policy objectives.
Atomic oxygen in the mesosphere and lower thermosphere measured by terahertz heterodyne spectroscopy
(2021)
Atomic oxygen is a main component of the mesosphere and lower thermosphere (MLT). The photochemistry and the energy balance of the MLT are governed by atomic oxygen. In addition, it is a tracer for dynamical motions in the MLT. It is difficult to measure with remote sensing techniques. Concentrations can be inferred indirectly from the oxygen air glow or from observations of OH, which is involved in photochemical processes related to atomic oxygen. Such measurements have been performed with several satellite instruments such as SCIAMACHY, SABER, WINDII and OSIRIS. However, the methods are indirect and rely on photochemical models and assumptions such as quenching rates, radiative lifetimes, and reaction coefficients. The results are not always in agreement, particularly when obtained with different instruments.
Photovoltaic (PV) power data are a valuable but as yet under-utilised resource that could be used to characterise global irradiance with unprecedented spatio-temporal resolution. The resulting knowledge of atmospheric conditions can then be fed back into weather models and will ultimately serve to improve forecasts of PV power itself. This provides a data-driven alternative to statistical methods that use post-processing to overcome inconsistencies between ground-based irradiance measurements and the corresponding predictions of regional weather models (see for instance Frank et al., 2018). This work reports first results from an algorithm developed to infer global horizontal irradiance as well as atmospheric optical properties such as aerosol or cloud optical depth from PV power measurements.
The genetic basis of brain tumor development is poorly understood. Here, leukocyte DNA of 21 patients from 15 families with ≥ 2 glioma cases each was analyzed by whole-genome or targeted sequencing. As a result, we identified two families with rare germline variants, p.(A592T) or p.(A817V), in the E-cadherin gene CDH1 that co-segregate with the tumor phenotype, consisting primarily of oligodendrogliomas, WHO grade II/III, IDH-mutant, 1p/19q-codeleted (ODs). Rare CDH1 variants, previously shown to predispose to gastric and breast cancer, were significantly overrepresented in these glioma families (13.3%) versus controls (1.7%). In 68 individuals from 28 gastric cancer families with pathogenic CDH1 germline variants, brain tumors, including a pituitary adenoma, were observed in three cases (4.4%), a significantly higher prevalence than in the general population (0.2%). Furthermore, rare CDH1 variants were identified in tumor DNA of 6/99 (6%) ODs. CDH1 expression was detected in undifferentiated and differentiating oligodendroglial cells isolated from rat brain. Functional studies using CRISPR/Cas9-mediated knock-in or stably transfected cell models demonstrated that the identified CDH1 germline variants affect cell membrane expression, cell migration and aggregation. E-cadherin ectodomain containing variant p.(A592T) had an increased intramolecular flexibility in a molecular dynamics simulation model. E-cadherin harboring intracellular variant p.(A817V) showed reduced β-catenin binding resulting in increased cytosolic and nuclear β-catenin levels reverted by treatment with the MAPK interacting serine/threonine kinase 1 inhibitor CGP 57380. Our data provide evidence for a role of deactivating CDH1 variants in the risk and tumorigenesis of neuroepithelial and epithelial brain tumors, particularly ODs, possibly via WNT/β-catenin signaling.
Die vorliegende Studie untersucht als Erste simultan die Auswirkungen des dreidimensionalen Konstrukts der prozeduralen, distributiven und kommunikativen Lohntransparenz auf Arbeitnehmer, auch unter Berücksichtigung von persönlichen Einstellungen und dem tatsächlichen Gehalt anhand einer deutschen Stichprobe (N = 159). Hierfür wurden Angestellte in einer querschnittlichen Online-Fragebogenstudie zu der wahrgenommenen Lohntransparenz in ihrer Organisation sowie zu weiteren arbeitnehmer- und organisationsrelevanten Variablen befragt. Mittels regressionsanalytischer Untersuchungen konnten hypothesenkonform positive Zusammenhänge der Lohntransparenz mit der Lohnzufriedenheit, der Wahrnehmung prozeduraler und distributiver Gerechtigkeit sowie mit dem Empfinden organisationalen Vertrauens nachgewiesen werden. Von wesentlicher Bedeutung für die Zusammenhänge war allerdings lediglich die prozedurale Lohntransparenz als eine der drei Dimensionen. Weiterhin ergaben Moderatoranalysen, dass ein geringes Bedürfnis nach informationeller Privatheit sowie ein geringes Bruttoentgelt die positiven Zusammenhänge der Lohntransparenz mit den Kriteriumsvariablen partiell verstärken. Abschließend werden Implikationen der Befunde für die Forschung und Praxis vor dem Hintergrund der Einschränkungen, denen diese Studie unterliegt, erläutert.