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In order to help journalists investigate inside large audiovisual archives, as maintained by news broadcast agencies, the multimedia data must be indexed by text-based search engies. By automatically creating a transcript through automatic speech recognition (ASR), the spoken word becomes accessible to text search, and queries for keywords are made possible. But stil, important contextual information like the identity of the speaker is not captured. Especially when gathering original footage in the political domain, the identity of the speaker can be the most important query constraint, although this name may not be prominent in the words spoken. It is thus desireable to have this information provided explicitely to the search engine. To provide this information, the archive must be an alyzed by automatic Speaker Identification (SID). While this research topic has seen substantial gains in accuracy and robustness over last years, it has not yet established itself as a helpful, large-scale tool outside the research community. This thesis sets out to establish a workflow to provide automatic speaker identification. Its application is to help journalists searching on speeches given in the German parliament (Bundestag). This is a contribution to the News-Stream 3.0 project, a BMBF funded research project that addresses accessibility of various data sources for journalists.
We present a new interface for interactive comparisons of more than two alternative documents in the context of a generative design system that uses generative data-flow networks defined via directed acyclic graphs. To better show differences between such networks, we emphasize added, deleted, (un)changed nodes and edges. We emphasize differences in the output as well as parameters using highlighting and enable post-hoc merging of the state of a parameter across a selected set of alternatives. To minimize visual clutter, we introduce new difference visualizations for selected nodes and alternatives using additive and subtractive encodings, which improve readability and keep visual clutter low. We analyzed similarities in networks from a set of alternative designs produced by architecture students and found that the number of similarities outweighs the differences, which motivates use of subtractive encoding. We ran a user study to evaluate the two main proposed difference visualization encodings and found that they are equally effective.
Das autonome Fahren wird die Mobilität revolutionieren. Um die Auswirkung der Vollautomation auf dieEigenschaften der Verkehrsmittel und die Präferenzen der Nutzer besser zu verstehen, haben wir dieNutzenwerte neuen Verkehrsmodi im Vergleich zu den bestehenden Verkehrsmodi analysiert und imRahmen einer Online-Umfrage von potentiellen Nutzern in Form eines vollständigen Paarvergleichsbewerten lassen. Die Studie zeigt, dass der Privat-PKW, unabhängig davon ob traditionell odervollautomatisiert, zwar nach wie vor das präferierte Verkehrsmittel ist, im direkten Vergleich das Carsharingjedoch viel stärker von der Vollautomation profitiert. Darüber hinaus gibt es Hinweise darauf, dass dasvollautomatisierte Carsharing verstärkt in Konkurrenz zum ÖPNV tritt.
In diesem Artikel wird darüber berichtet, ob die Glaubwürdigkeit von Avataren als mögliches Modulationskriterium für die virtuelle Expositionstherapie von Agoraphobie in Frage kommt. Dafür werden mehrere Glaubwürdigkeitsstufen für Avatare, die hypothetisch einen Einfluss auf die virtuelle Expositionstherapie von Agoraphobie haben könnten sowie ein potentielles Expositionsszenario entwickelt. Die Arbeit kann innerhalb einer Studie einen signifikanten Einfluss der Glaubwürdigkeitsstufen auf Präsenz, Kopräsenz und Realismus aufzeigen.
Recent approaches in scaffold engineering for bone defects feature hybrid hydrogels made of a polymeric network (retains water and provides light and porous structures) and inorganic ceramics (add mechanical strength and improve cell-adhesion). Innovative scaffold materials should also induce bone tissue formation and incorporation of stem cells (osteogenic differentiation) and/or growth factors (inducing/supporting differentiation). Recently, purinergic P2X and P2Y receptors have been found to significantly influence the osteogenic differentiation process of human mesenchymal stem cells (hMSC). (1) Aim of this work is to develop polysaccharide (PS) composites to be used as scaffolds containing complementary receptor ligands to enable guided stem cell differentiation towards bone formation.
Elektronik für Entscheider
(2017)
Dieses Buch gibt Nichtingenieuren, die sich beruflich mit Elektronik beschäftigen, die Möglichkeit, sich ein Stück auf dieses Fachgebiet zu begeben, um Aufgaben, Sprache und Vorgehensweise von Ingenieuren zu verstehen. Ziel ist es dabei nicht, nach dem Lesen dieses Buches eine elektronische Schaltung entwickeln zu können. Im Vordergrund steht vielmehr ein generelles Verständnis für die Zusammenhänge und Grundbegriffe der Elektronik.
Die Detektion von Explosivstoffen stellt ein zentrales Feld der zivilen Sicherheitsforschung dar. Eine besondere Herausforderung liegt hierbei in dem Nachweis verpackter Substanzen, wie es bei Unkonventionellen Spreng- und Brandvorrichtung (USBV) häufig der Fall ist. Derzeit eingesetzte Verfahren arbeiten meist mit bildgebenden Techniken, durch die sich ein Anfangsverdacht ergibt. Der tatsächliche chemische Inhalt der USBV lässt sich jedoch nicht exakt ermitteln. Eine genaue Beurteilung der Gefährdung durch solche Substanzen ist allerdings von großer Bedeutung, insbesondere wenn die Entschärfung des Objekts in bewohntem Gebiet stattfinden muss. In der vorliegenden Arbeit wird ein Verfahren vorgestellt, das sich als Verifikationsverfahren bei bestehendem Anfangsverdacht gezielt einsetzen lässt. Hierzu wird mittels Laserbohrtechnik zunächst die äußere Hülle des zu untersuchenden Gegenstandes durchdrungen. Anschließend finden eine lasergestützte Probenahme des Inhalts sowie die Detektion unter Verwendung geeigneter Analysemöglichkeiten statt. Der Bohr- und Probenahmefortschritt wird über verschiedene spektroskopische und sensorische Verfahren begleitend überwacht. Zukünftig soll das System abstandsfähig auf Entschärfungsrobotern eingesetzt werden.
Controlling und Leadership: Überlegungen im Kontext der Unternehmensnachfolge in Familienunternehmen
(2017)
Advances in computer graphics enable us to create digital images of astonishing complexity and realism. However, processing resources are still a limiting factor. Hence, many costly but desirable aspects of realism are often not accounted for, including global illumination, accurate depth of field and motion blur, spectral effects, etc. especially in real‐time rendering. At the same time, there is a strong trend towards more pixels per display due to larger displays, higher pixel densities or larger fields of view. Further observable trends in current display technology include more bits per pixel (high dynamic range, wider color gamut/fidelity), increasing refresh rates (better motion depiction), and an increasing number of displayed views per pixel (stereo, multi‐view, all the way to holographic or lightfield displays). These developments cause significant unsolved technical challenges due to aspects such as limited compute power and bandwidth. Fortunately, the human visual system has certain limitations, which mean that providing the highest possible visual quality is not always necessary. In this report, we present the key research and models that exploit the limitations of perception to tackle visual quality and workload alike. Moreover, we present the open problems and promising future research targeting the question of how we can minimize the effort to compute and display only the necessary pixels while still offering a user full visual experience.
Marketing und Innovation
(2017)
Innovation und Marketing zählen zu den zentralen Herausforderungen für Unternehmen, durch die sie Differenzierung und Vorsprung im Wettbewerb erzielen können. Innovation ohne Marketing und Marketing ohne Innovation können nicht erfolgreich sein, weshalb beide Unternehmerfunktionen im Zusammenspiel zu betrachten sind. Das vorliegende Lehrbuch verfolgt deshalb ein zusammenschauendes Konzept, zu dem es das theoretische und praktische Grundlagenwissen vermittelt. Zunächst wird die Bedeutung von Innovation und Marketing als Erfolgsfaktor analysiert. Anschließend wird ein marketingfokussierter Innovationsprozess diskutiert, bei dem auf jeder Stufe die Frage nach der Marktakzeptanz gestellt wird und der ausgeweitet ist auf die Marktausbreitung von Innovationen (Diffusion) sowie die Problematik der Innovationsakzeptanz.
Do remittances and social assistance transfers have different impacts on household’s expenditure patterns? While two separate strands of literature have looked at how social assistance or remittances have been spent, few studies have compared them directly. Using data from a household survey conducted in Moldova in 2011, this paper assesses the impact both types of transfers have on household expenditure patterns. Contrary to the common assumption that money is fungible, we find that social assistance and remittances have different impacts on expenditure patterns (having controlled for potential endogeneity). In other words, where the income comes from can determine how it is spent. As such, different sources of income may have different poverty impacts. In our sample, the two types of transfers are received by different, but slightly overlapping population groups. The fact that the two transfers are spent in different ways means that, to some extent, social assistance and remittances are complements rather than substitutes.
Die Erfindung betrifft eine elektrische Insektenabwehrvorrichtung (1) zur Abwehr kriechender Insekten (2) umfassend eine Spannungserzeugungseinrichtung (4a, 4b) zur Erzeugung einer Abwehrspannung sowie umfassend zumindest zwei nebeneinander angeordnete und beabstandet zueinander verlaufende blanke elektrische Leiter (5a, 5b, 5c, 5d), die derart mit der Spannungserzeugungseinrichtung (4a, 4b) verbunden sind, dass die Abwehrspannung zwischen ihnen liegt. Die elektrischen Leiter sind als flache Leiterbahnen (5a, 5b, 5c, 5d) auf oder in der Oberfläche eines gemeinsamen Trägers (12, 13, 50, 60) ausgebildet, so dass ein Insekt (2) bei einem Berühren der Leiterbahnen (5a, 5b, 5c, 5d) einen elektrischen Schlag erhält.
A deployment of the Vehicle-2-Vehicle communication technology according to ETSI is in preparation in Europe. Currently, a policy for a necessary Public Key Infrastructure to enrol cryptographic keys and certificates for vehicles and infrastructure component is in discussion to enable an interoperable Vehicle-2-Vehicle communication. Vehicle-2-Vehicle communication means that vehicles periodically send Cooperative Awareness Messages. These messages contain the current geographic position, driving direction, speed, acceleration, and the current time of a vehicle. To protect privacy (location privacy, “speed privacy”) of vehicles and drivers ETSI provides a specific pseudonym concept. We show that the Vehicle-2-Vehicle communication can be misused by an attacker to plot a trace of sequent Cooperative Awareness Messages and to link this trace to a specific vehicle. Such a trace is non-disputable due to the cryptographic signing of the messages. So, the periodically sending of Cooperative Awareness Messages causes privacy problems even if the pseudonym concept is applied.
Current global challenges such as climate change, lack of resources, desertification, land degradation as well as loss of biodiversity can ultimately be due to human actions. Reasons are excessive production and consumption of goods and services, along with using and consuming natural resources, causing emissions and waste products. Demand in the form of consumption and supply in the form of production are closely intertwined.
Das Buch beschreibt den seit 2012 bereits eingeleiteten Agenda-2030-Konsultationsprozess, der insbesondere in Europa bis zum Jahr 2020 zu einer Umgestaltung von Wirtschaft und Gesellschaft führen wird. Erstmalig in der Geschichte kommt ab Mitte des Jahres 2016 ein globales Managementsystem zum Einsatz, das zur Fortschrittsüberwachung der 17 Sustainable Development Goals (SDGs) und den 169 globalen Unterzielen weltweit eingesetzt wird. Ein Screening der relevanten politischen Strategien und Beschlüsse verdeutlicht, dass Europa und Deutschland gut auf die Umsetzung der neuen Agenda vorbereitet sind und sich im Zuge der neuen Rechenschaftspflicht zur Umsetzung der SDGs verpflichtet haben. Traditionelle Footprint-Indikatoren, neue Ergänzungsindikatoren sowie standardisierte Richt- und Leitlinien kommen im vorstehenden Zusammenhang zukünftig zum Einsatz. Die zielorientierte globale Steuerung der SDGs fällt in das Aufgabenfeld der Koordinationsfunktion des Life-Cycle-Controllings, das beschrieben wird. Unternehmen tragen maßgeblich zur Umsetzung der SDGs bei und sind daher zunehmend verpflichtet, die negativen Auswirkungen ihres unternehmerischen Handelns transparent zu machen. Dies geschieht mithilfe von Product-Footprints und Footprints für Transportdienstleistungen, die bezüglich ihrer aktuellen und zukünftigen Praxisrelevanz ebenfalls vorgestellt werden. Zahlreiche Praxisbeispiele zeigen zudem, wie Unternehmen schon heute über den Einsatz von SDG- und CSR-Fortschrittsindikatoren ihrer globalen Sorgfaltspflicht in den Lieferantenketten nachkommen.
Traditionally automotive UI focusses on the ergonomic design of controls and the user experience in the car. Bringing networked sensors into the car, connected cars can provide additional information to car drivers and owners, for and beyond the driving task. While there already are technological solutions, such as mobile applications commercially available, research on users’ information demands in such applications is scarce. We conducted four focus groups to uncover what kind of information users might be interested in to see on a second dashboard. Our findings show that besides control screens of todays’ dashboards, people are also interested in connected car services providing context information for a current driving situation and allowing strategic planning of driving safety or supporting car management when not driving. Our use cases inform the design of content for secondary dashboards for and especially beyond the driving context with a user perspective.
The technological development of the digital computer and new options to collect, store and transfer mass data have changed the world in the last 40 years. Moreover, due to the ongoing progress of computer power, the establishment of the Internet as critical infrastructure and the options of ubiquitous sensor systems will have a dramatic impact on economies and societies in the future. We give a brief overview about the technological basics especially with regard to the exponential growth of big data and current turn towards sensor-based data collection. From this stance, we reconsider the various dimensions of personal data and and market mechanisms that have an impact of data usage and protection.
Multiple myeloma is the second most common hematological malignancy. Despite all the progress made in treating multiple myeloma, it still remains an incurable disease. Patients are left with a median survival of 4-5 years. The combined treatment of multiple myeloma with histone deacetylase inhibitors and cytokine-induced killer cells provides a promising targeted treatment option for patients. This study investigated the impact of a combined treatment compared to treatment with histone deacetylase inhibitors. The experiments revealed that a treatment with histone deacetylase (HDAC) inhibitors could reduce cell viability to 59% for KMS 18 cell line and 46% for the U-266 cell line. The combined treatment led to a decrease of cell viability to 33% for KMS 18 and 27% for the U-266 cell line, thus showing a significantly better efficacy than the single treatment.
Vor Gericht werden Einsätze geruchsdifferenzierender Hunde derzeit nur unter bestimmten Voraussetzungen als Indizien-Beweis zugelassen (dokumentierter, ausreichender Ausbildungsstand des Hundes, Bestätigung der Suche durch zweiten Hund). Oft sind Leistungsgrenzen der Hunde hinsichtlich Alter der Geruchsspur, Einfluss bestimmter Witterungsbedingungen (Temperatur, Feuchtigkeit, etc.) auf die Detektierbarkeit menschlicher Geruchsspuren unklar und umstritten. Auch ist bis heute nicht wissenschaftlich untersucht, welche Bestandteile und Einzelsubstanzen des humanen Geruchs für die Hunde tatsächlich wahrnehmbar und wichtig zur Personensuche und -identifikation sind. Daher widmet sich ein aktuelles Promotionsprojekt im Institut für Detektionstechnologien der Erforschung dieser Fragen.
The detection of human skin in images is a very desirable feature for applications such as biometric face recognition, which is becoming more frequently used for, e.g., automated border or access control. However, distinguishing real skin from other materials based on imagery captured in the visual spectrum alone and in spite of varying skin types and lighting conditions can be dicult and unreliable. Therefore, spoofing attacks with facial disguises or masks are still a serious problem for state of the art face recognition algorithms. This dissertation presents a novel approach for reliable skin detection based on spectral remission properties in the short-wave infrared (SWIR) spectrum and proposes a cross-modal method that enhances existing solutions for face verification to ensure the authenticity of a face even in the presence of partial disguises or masks. Furthermore, it presents a reference design and the necessary building blocks for an active multispectral camera system that implements this approach, as well as an in-depth evaluation. The system acquires four-band multispectral images within T = 50ms. Using a machine-learning-based classifier, it achieves unprecedented skin detection accuracy, even in the presence of skin-like materials used for spoofing attacks. Paired with a commercial face recognition software, the system successfully rejected all evaluated attempts to counterfeit a foreign face.
Simulating eye movements for virtual humans or avatars can improve social experiences in virtual reality (VR) games, especially when wearing head mounted displays. While other researchers have already demonstrated the importance of simulating meaningful eye movements, we compare three gaze models with different levels of fidelity regarding realism: (1) a base model with static fixation and saccadic movements, (2) a proposed simulation model that extends the saccadic model with gaze shifts based on a neural network, and (3) a user's real eye movements recorded by a proprietary eye tracker. Our between-groups design study with 42 subjects evaluates impact of eye movements on social VR user experience regarding perceived quality of communication and presence. The tasks include free conversation and two guessing games in a co-located setting. Results indicate that a high quality of communication in co-located VR can be achieved without using extended gaze behavior models besides saccadic simulation. Users might have to gain more experience with VR technology before being able to notice subtle details in gaze animation. In the future, remote VR collaboration involving different tasks requires further investigation.
Populating virtual worlds with intelligent agents can drastically improve a user's sense of presence. Applying these worlds to virtual training, simulations, or (serious) games, often requires multiple agents to be simulated in real time. The process of generating believable agent behavior starts with providing a plausible perception and attention process that is both efficient and controllable. We describe a conceptual framework for synthetic perception that specifically considers the mentioned requirements: plausibility, real-time performance, and controllability. A sample implementation will focus on sensing, attention, and memory to demonstrate the framework's capabilities in a real-time game engine scenario. A combination of dynamic geometric sensing and false coloring with static saliency information is provided to exemplify the collection of environmental stimuli. The subsequent attention process handles both bottom-up processing and task-oriented, top-down factors. Behavioral results can be influenced by controlling memory and attention The example case is demonstrated and discussed alongside future extensions.
Integration of Multi-modal Cues in Synthetic Attention Processes to Drive Virtual Agent Behavior
(2017)
This study aims to highlight the significance of social protection as an autonomous strategy for migration policies and research. It focuses particularly on the German strategies for combating the causes of flight and migration. By managing migration flows, stabilizing societies and encouraging economic development, social protection can play an important role in reducing migration flows. At the same time, social protection can act as a stabilizer in the countries of origin and accelerate economic growth as well as supporting individual decisions to return to the countries of origin.
Blended Learning Set up of the Master Programme "Analysis and Design of Social Protection Systems"
(2017)
The master's programme "Analysis and Design of Social Protection Systems" is a newly designed programme. The international Master’s programme is aimed at students who wish to deal with social security systems and who are also interested in intercultural exchange. The on-campus and online phases provide students with the opportunity to develop an international network, while facilitating the combination of studies and professional engagement.
Biomass in general, wood and grasses in particular represent attractive renewable sources for the fabrication of so-called building block chemicals (1). Thus, environmentally benign antimicrobial nanoparticles based on a silver-infused lignin core were recently reported underlying the high potential for valorization of lignin (2). The contribution presents specific correlations regarding the structural differences of lignins depending on both: source (wood vs. grass) and isolation procedure (Kraft vs. Organosolv). Special focus will be drawn on detailed structure deviations caused by Miscanthus genotypes (M. gigantheus, M. robustus, M. sisnensis).
An Experimental Field-Study on Active and Passive Work Breaks in a Stressful Work Environment
(2017)
Work breaks are known to have positive effects on employees’ health, performance, and safety. However, prior research has focused mainly on their timing, duration, and frequency but less on break activities. Moreover, most studies examined work breaks in rather repetitive and physical demanding work. Thus, we conducted an experimental field study with a sample of employees’ working in a stressful and cognitive demanding working environment and examined how different types of work breaks (boxing, deep relaxation, and usual breaks) affect participants’ mood, cognitive performance, and neuro-physiological state.
Das vorgestellte Buch ist kein Lehrbuch im eigentlichen Sinne. Aus Vorlesungsskripten entstanden, verfolgt es das Ziel, den Studenten der Wirtschaftswissenschaften an Fachhochschulen und Universitäten eine systematische, auf das Wesentliche konzentrierte Lernhilfe mit Übungen zur Vorbereitung auf Prüfungen im Fach „externes Rechnungswesen“ anzubieten. Hierzu wird zunächst auf die Rechnungslegung im handelsrechtlichen Jahresabschluss eingegangen. Dabei wurden die Änderungen durch das Bilanzrichtlinie-Umsetzungsgesetz (BilRUG) berücksichtigt. Die Vorgehensweise folgt dabei mit Ansatz, Ausweis und Bewertung der einzelnen Posten der Systematik der Aufstellung des Jahresabschlusses.
Media development cooperation has aimed for decades at enhancing free and independent media in developing countries as well as economies in transition. Within this field of activity, the concept of media viability has gained more and more attention in recent years. This is mainly due to a proposal of UNESCO`s intergovernmental Bureau of the International Programme for the Development of Communication (IPDC). The UNESCO, in partnership with DW Akademie, has drafted a list of indicators that delineate the influencing factors of media viability for media organizations in any given country (UNESCO 2015).
As a consequence of the novelty of the media viability concept, the state of scientific research is restricted. It is frequently focused on isolated case studies without providing a scientific basis for comparison. Empirical studies and comparative analyses are limited to certain media sectors such as the print market, as well as for journalism startups and spin-offs in developed economies.
Wo Laborexperimente zu aufwendig, zu teuer, zu langsam oder zu gefährlich oder Stoffeigenschaften gar nicht erst experimentell zugänglich sind, können Computersimulationen von Atomen und Molekülen diese ersetzen oder ergänzen. Sie ermöglichen dadurch Reduktion von Kosten, Entwicklungszeit und Materialeinsatz. Die für diese Simulationen benötigten Molekülmodelle beinhalten zahlreiche Parameter, die der Simulant einstellen oder auswählen muss. Eine passende Parametrierung ist nur bei entsprechenden Kenntnissen über die Auswirkungen der Parameter auf die zu berechnenden Größen und Eigenschaften möglich. Eine Gruppe von Standardparametern in molekularen Simulationen sind die Partialladungen der einzelnen Atome innerhalb eines Moleküls. Die räumliche Ladungsverteilung innerhalb des Moleküls wird durch Punktladungen auf den Atomzentren angenähert. Für diese Annäherung existieren diverse Ansätze für verschiedene Molekülklassen und Anwendungen. In diesem Teilprojekt des Promotionsvorhabens wurde systematisch der Einfluss der Wahl des Partialladungssatzes auf potentielle Energien und ausgewählte makroskopische Eigenschaften aus Molekulardynamik-Simulationen evaluiert. Es konnte gezeigt werden, dass insbesondere bei stark polaren Molekülen die Auswahl des geeigneten Partialladungssatzes entscheidenden Einfluss auf die Simulationsergebnisse hat und daher nicht naiv, sondern nur ganz gezielt getroffen werden darf.
This work presents the analysis of data recorded by an eye tracking device in the course of evaluating a foveated rendering approach for head-mounted displays (HMDs). Foveated rendering methods adapt the image synthesis process to the user’s gaze and exploiting the human visual system’s limitations to increase rendering performance. Especially, foveated rendering has great potential when certain requirements have to be fulfilled, like low-latency rendering to cope with high display refresh rates. This is crucial for virtual reality (VR), as a high level of immersion, which can only be achieved with high rendering performance and also helps to reduce nausea, is an important factor in this field. We put things in context by first providing basic information about our rendering system, followed by a description of the user study and the collected data. This data stems from fixation tasks that subjects had to perform while being shown fly-through sequences of virtual scenes on an HMD. These fixation tasks consisted of a combination of various scenes and fixation modes. Besides static fixation targets, moving tar- gets on randomized paths as well as a free focus mode were tested. Using this data, we estimate the precision of the utilized eye tracker and analyze the participants’ accuracy in focusing the displayed fixation targets. Here, we also take a look at eccentricity-dependent quality ratings. Comparing this information with the users’ quality ratings given for the displayed sequences then reveals an interesting connection between fixation modes, fixation accuracy and quality ratings.
Die gesättigten Konsumgütermärkte zwingen Handel und Hersteller der Fleischbranche immer wieder zur Suche nach neuen ausreichend großen Nischen, um Wachstum zu generieren. Nach Bio, Regionalität und Veggie könnte Halal die nächste sein. Eine persönliche Befragung von 900 Muslimen vorwiegend türkischer Abstammung beleuchtet die Hintergründe.
Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases
(2017)
ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. As few ETV6-RUNX1 carriers develop precursor B cell acute lymphocytic leukemia (pB-ALL), the underlying genetic basis for development of full-blown leukemia remains to be identified, but the appearance of leukemia cases in time-space clusters keeps infection as a potential causal factor. Here we present in vivo genetic evidence mechanistically connecting preleukemic ETV6-RUNX1 expression in hematopoetic stem cells/peripheral cells (HSC/PC) and postnatal infections for human-like pB-ALL. In our model, ETV6-RUNX1 conferred a low risk of developing pB-ALL after exposure to common pathogens, corroborating the low incidence observed in humans. Murine preleukemic ETV6-RUNX1 pro/preB cells showed high Rag1/2 expression, known for human ETV6-RUNX1 pB-ALL. Murine and human ETV6-RUNX1 pB-ALL revealed recurrent genomic alterations, with a relevant proportion affecting genes of the lysine demethylase (KDM) family. KDM5C loss-of-function resulted in increased levels of H3K4me3, which co-precipitated with RAG2 in a human cell line model, laying the molecular basis for recombination activity. We conclude that alterations of KDM family members represent a disease-driving mechanism and an explanation for RAG off-target cleavage observed in humans. Our results explain the genetic basis for clonal evolution of an ETV6-RUNX1 preleukemic clone to pB-ALL after infection exposure and offer the possibility of novel therapeutic approaches.
Exploring Gridmap-based Interfaces for the Remote Control of UAVs under Bandwidth Limitations
(2017)
Enterprises demand universities not to limit education to theoretical knowledge, but instead, to prepare students for future challenges in the job. While demanding a focus on current technologies and practices appears reasonable, it contradicts academia’s general focus on sustainable knowledge. This “conflict-ofinterest” can be bridged through extra-curricular professional training. MOOCs are hyped as solution because they allow to simultaneously addressing masses of students. However, with the increasing number of learners, anonymity in education increases and first-level support decreases. Within the extracurricular online program erp4students we found that individual support is considered most relevant to successfully complete professional training.
The Sparse Matrix Vector Multiplication is an important operation on sparse matrices. This operation is the most time consuming operation in iterative solvers and therefore an efficient execution of that operation is of great importance for many applications. Numerous different storage formats that store sparse matrices efficiently have already been established. Often, these storage formats utilize the sparsity pattern of a matrix in an appropiate manner. For one class of sparse matrices the nonzero values occur in small dense blocks and appropriate block storage formats are well suited for such patterns. But on the other side, these formats perform often poor on general matrices without an explicit / regular block structure. In this paper, the newly developed sparse matrix format DynB is introduced. The aim is to efficiently use several optimization approaches and vectorization with current processors, even for matrices without an explicit block structure of nonzero elements. The DynB matrix format uses 2D rectangular blocks of variable size, allowing fill-ins per block of explicit zero values up to a user controllable threshold. We give a simple and fast heuristic to detect such 2D blocks in a sparse matrix. The performance of the Sparse Matrix Vector Multiplication for a selection of different block formats and matrices with different sparsity structures is compared. Results show that the benefit of blocking formats depend – as to be expected – on the structure of the matrix and that variable sized block formats like DynB can have advantages over fixed size formats and deliver good performance results even for general sparse matrices.
Unternehmensberatung
(2017)
Kulturmanagement
(2017)
En el siguiente trabajo se presentan las diferentes alternativas tecnológicas que brindarán soporte para las comunicaciones en el Proyecto Campo Conectado, priorizando el bajo consumo y mantenimiento. Esta plataforma de transmisión proveerá la conectividad necesaria para la recolección y envío de los datos requeridos por los productores agropecuarios, con el fin de mejorar la gestión de los procesos productivos y comerciales. Se comenta además los orígenes del proyecto y los actores involucrados en el mismo, destacándose el trabajo interinstitucional e interdisciplinar que se lleva a cabo.
The combination of Software-Defined Networking (SDN) and Wireless Mesh Network (WMN) is challenging due to the different natures of both concepts. SDN describes networks with homogeneous, static and centralized controlled topologies. In contrast, a WMN is characterized by a dynamic and distributed network control, and adds new challenges with respect to time-critical operation. However, SDN and WMN are both associated with decreasing the operational costs for communication networks which is especially beneficial for internet provisioning in rural areas. This work surveys the current status for Software-Defined Wireless Mesh Networking. Besides a general overview in the domain of wireless SDN, this work focuses especially on different identified aspects: representing and controlling wireless interfaces, control-plane connection and topology discovery, modulation and coding, routing and load-balancing and client handling. A complete overview of surveyed solutions, open issues and new research directions is provided with regard to each aspect.
WiFi-based Long Distance (WiLD) networks have emerged as a promising alternative approach for Internet in rural areas. The main hardware components of these networks are commercial off-the-shelf WiFi radios and directional antennas. During our experiences with real-world WiLD networks, we encountered that interference among long-distance links is a major issue even with high gain directional antennas. In this work, we are providing an in-depth analysis of these interference effects by conducting simulations in ns-3. To closely match the real-world interference effects, we implemented a module to load radiation pattern of commonly used antennas. We analyze two different interference scenarios typically present as a part of larger networks. The results show that side-lobes of directional antennas significantly influence the throughput of long-distance WiFi links depending on the orientation. This work emphasizes that the usage of simple directional antenna models needs to be considered carefully.
In order to achieve the highest possible performance, the ray traversal and intersection routines at the core of every high-performance ray tracer are usually hand-coded, heavily optimized, and implemented separately for each hardware platform—even though they share most of their algorithmic core. The results are implementations that heavily mix algorithmic aspects with hardware and implementation details, making the code non-portable and difficult to change and maintain.
In this paper, we present a new approach that offers the ability to define in a functional language a set of conceptual, high-level language abstractions that are optimized away by a special compiler in order to maximize performance. Using this abstraction mechanism we separate a generic ray traversal and intersection algorithm from its low-level aspects that are specific to the target hardware. We demonstrate that our code is not only significantly more flexible, simpler to write, and more concise but also that the compiled results perform as well as state-of-the-art implementations on any of the tested CPU and GPU platforms.
In order to achieve the highest possible performance, the ray traversal and intersection routines at the core of every high-performance ray tracer are usually hand-coded, heavily optimized, and implemented separately for each hardware platform—even though they share most of their algorithmic core. The results are implementations that heavily mix algorithmic aspects with hardware and implementation details, making the code non-portable and difficult to change and maintain.
In this paper, we present a new approach that offers the ability to define in a functional language a set of conceptual, high-level language abstractions that are optimized away by a special compiler in order to maximize performance. Using this abstraction mechanism we separate a generic ray traversal and intersection algorithm from its low-level aspects that are specific to the target hardware. We demonstrate that our code is not only significantly more flexible, simpler to write, and more concise but also that the compiled results perform as well as state-of-the-art implementations on any of the tested CPU and GPU platforms.
These times are very troubled ones. Not only do wars and political unrest seem to prevail in different regions of the world, but, corruption and fraud have reached an incredible dimension, too. It seems that societies have, to a large extent, lost values in which they had formerly believed in. These issues may be the background why at the moment Corporate Social Responsibility (CSR) as a voluntary commitment is discussed in public that intensively. However, one gets the impression that this rather often seems to be superficial. Therefore, it is time to do some in-depth research to identify whether there is real substance behind these discussions or not. Latin America is a big continent with a greater number of countries which are running through difficult times as to corruption and fraud. Consequently, the author studied the policy of the central employers association Consejo Empresarial de America Latina (CEAL) with respect to the role of CSR. On the basis of statements, news and results of studies being regularly published, conclusions were drawn to which extent social and environmental aspects, along the line of ISO 26000, are playing a relevant role.
In order to avoid a too narrow view of the issue, a holistic approach concerning the generalsituation of Latin America has been selected using parameters such as economic growth, increase of population, poverty, inequality, and the global responsibility for environment. Furthermore, apart from the central organization CEAL, regional and national institutions with a specific mission for spreading and implementing CSR and two communal projects were analyzed as well. The conclusion of the paper is that there are some CSR "lighthouses" but an urgent need exists to spread the idea of CSR more intensively across the continent. Corresponding recommendations about how to increase the relevance of CSR in Latin America are given at the end of the paper.
Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis
(2017)
Background and Objectives: In advanced β-cell dysfunction, proinsulin is increasingly replacing insulin as major component of the secretion product. It has been speculated that proinsulin has at least the same adipogenic potency than insulin, leading to an increased tendency of lipid tissue formation in patients with late stage β-cell dysfunction. Methods and Results: Mesenchymal stem cells obtained from liposuction material were grown in differentiation media containing insulin (0.01 μmol), proinsulin (0.01 μmol) or insulin+proinsulin (each 0.005 μmol). Cell culture supernatants were taken from these experiments and an untreated control at weeks 1, 2, and 3, and were stored at -80°C until analysis. Cell differentiation was microscopically supervised and adiponectin concentrations were measured as marker for differentiation into mature lipid cells. This experiment was repeated three times. No growth of lipid cells and no change in adiponectin values was observed in the negative control group (after 7/14/12 days: 3.2±0.5/3.3±0.1/4.4±0.5 ng/ml/12 h). A continuous differentiation into mature adipocytes (also confirmed by Red-Oil-staining) and a corresponding increase in adiponectin values was observed in the experiments with insulin (3.6±1.9/5.1±1.4/13.3±1.5 ng/ml/12 h; p<0.05 week 1 vs. week 3) and proinsulin (3.3±1.2/3.5±0.3/12.2±1.2 ng/ml/12 h; p<0.05). Comparable effects were seen with the insulin/proinsulin combination. Conclusions: Proinsulin has the same adipogenic potential than insulin in vitro. Proinsulin has only 10∼20% of the glucose-lowering effect of insulin. It can be speculated that the adipogenic potential of proinsulin may be a large contributor to the increased body weight problems in patients with type 2 diabetes and advanced β-cell dysfunction.
Wissenschaft trifft Praxis
(2017)