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Die Norm EN ISO 13849-1 stellt explizite Anforderungen an sicherheitsgerichtete SPS-Software. Wie lassen sich diese im Maschinenbau praxisgerecht umsetzen? Mit dieser Frage hat sich ein von der DGUV gefördertes und an der Hochschule Bonn-Rhein-Sieg durchgeführtes Projekt beschäftigt. Der Beitrag skizziert die Vorgehensweise zur möglichen Umsetzung der normativen Anforderungen. Diese Vorgehensweise ist unabhängig von der verwendeten Sicherheits-SPS und daher allgemein anwendbar. Es wird auf insgesamt 10 dokumentierte Beispiele und einen ausführlichen Forschungsbericht verwiesen, die downloadbar sind.
Agricultural activities within city boundaries have a long history in both developed and developing countries. In this paper, a broad approach to Urban AgriCulture (UAC) is used, one that includes the production of crops in urban and peri-urban areas and ranges in developed countries from allotment gardens over community gardens to semi-entrepreneurial self-harvest farms and fully commercialized agriculture. With an empirical case study on UAC Initiatives in the Bonn/Rhein-Sieg region this work fills a gap since the lack of comprehensive and comparative studies on urban agriculture (UA) currently makes it difficult for researchers to identify the benefits of UA activities.
Mit den Themen Digitalisierung, Big Data, Industrie 4.0 und Cloud-Computing erfährt auch Geschäftsprozessmanagement immer mehr Aufmerksamkeit. Doch was sind die Treiber und Einflussfaktoren für erfolgreiches Business Process Management? Der BPM-Compass 2016 zeigt, dass Menschen auch während der digitalen Transformation entscheidend für erfolgreich umgesetzte Geschäftsprozesse sind.
The development of advanced robotic systems is challenging as expertise from multiple domains needs to be integrated conceptually and technically. Model-driven engineering promises an efficient and flexible approach for developing robotics applications that copes with this challenge. Domain-specific modeling allows to describe robotics concerns with concepts and notations closer to the respective problem domain. This raises the level of abstraction and results in models that are easier to understand and validate. Furthermore, model-driven engineering allows to increase the level of automation, e.g. through code generation, and to bridge the gap between modeling and implementation. The anticipated results are improved efficiency and quality of the robotics systems engineering process. Within this contribution, we survey the available literature on domain-specific modeling and languages that target core robotics concerns. In total 137 publications were identified that comply with a set of defined criteria, which we consider essential for contributions in this field. With the presented survey, we provide an overview on the state-of-the-art of domain-specific modeling approaches in robotics. The surveyed publications are investigated from the perspective of users and developers of model-based approaches in robotics along a set of quantitative and qualitative research questions. The presented quantitative analysis clearly indicates the rising popularity of applying domain-specific modeling approaches to robotics in the academic community. Beyond this statistical analysis, we map the selected publications to a defined set of robotics subdomains and typical development phases in robotic systems engineering as reference for potential users. Furthermore, we analyze these contributions from a language engineering viewpoint and discuss aspects such as the methods and tools used for their implementation as well as their documentation status, platform integration, typical use cases and the evaluation strategies used for validation of the proposed approaches. Finally, we conclude with recommendations for discussion in the model-driven engineering and robotics community based on the insights gained in this survey.
Steigende psychische Arbeitsanforderungen werden im betrieblichen Alltag zunehmend als Normalität empfunden. Trotz erhöhtem Leistungsdruck werden Arbeitspausen oftmals unregelmäßig bis gar nicht wahrgenommen, obwohl mit einer Pause eine gesteigerte Erholung und eine erhöhte Produktivität einhergehen. Der vorliegende Artikel zeigt auf, wie Arbeitspausen und deren systematische Implementierung zu einem "gesunden Unternehmen" beitragen können.
Knowledge-Based Instrumentation and Control for Competitive Industry-Inspired Robotic Domains
(2016)
We are happy to present you the special issue on Best Practice in Robot Software Development of the Journal on Software Engineering for Robotics! The spark for this special issue came during the eighth workshop on Software Development and Integration in Robotics (SDIR) at the 2013 IEEE International Conference on Robotics and Automation. The workshop focused on Robot Software Architectures, and the fruitful discussions made it clear that the design, development, and deployment of robot software is always an interplay between competing aspects. These are often couched in antagonistic pairs, such as dependability versus performance, and prominently include quality attributes as well as functional, nonfunctional, and application requirements.
In a research project funded by the German Research Foundation, meteorologists, data publication experts, and computer scientists optimised the publication process of meteorological data and developed software that supports metadata review. The project group placed particular emphasis on scientific and technical quality assurance of primary data and metadata. At the end, the software automatically registers a Digital Object Identifier at DataCite. The software has been successfully integrated into the infrastructure of the World Data Center for Climate, but a key was to make the results applicable to data publication processes in other sciences as well.
At present, data publication is one of the most dynamic topics in e-Research. While the fundamental problems of electronic text publication have been solved in the past decade, standards for the external and internal organisation of data repositories are advanced in some research disciplines but underdeveloped in others. We discuss the differences between an electronic text publication and a data publication and the challenges that result from these differences for the data publication process. We place the data publication process in the context of the human knowledge spiral and discuss key factors for the successful acquisition of research data from the point of view of a data repository. For the relevant activities of the publication process, we list some of the measures and best practices of successful data repositories.
Within an elementary decision of March 28th, 2006 the German Federal Constitutional Court implemented the following: “According to the status quo of research it is certain, that gambling and bets can result in morbid addictive behaviour. ... However different gambling products exhibit different addictive potentials.” Up to now a specific identification of the addictive potential of a concrete gambling product was nearly impossible. This being said, the Wissenschaftliches Forum Glücksspiel (Gambling Scientific Forum) developed a globally applicable assessment tool to measure and evaluate the risk potential of gambling products.
AsTERiG is developed by the Gambling Scientific Forum in the years 2006-2010. At the completion of this final version as well as in the composition of this survey the following scientists were involved: Prof. Dr. Reiner Clement, Bonn-Rhein-Sieg University; Prof. Dr. Jörg Ennuschat, University of Konstanz; Prof. Jörg Häfeli, Lucerne University of Applied Sciences and Arts; Prof. Dr. Gerhard Meyer, University of Bremen; Chantal Mörsen, Charité Berlin; Prof. Dr. Dr. Franz W. Peren, Bonn-Rhein-Sieg University; Prof. Dr. Wiltrud Terlau, Bonn-Rhein-Sieg University.
We propose an artificial slime mould model (ASMM) inspired by the plasmodium of Physarum polucephalum (P. polucephalum). ASMM consists of plural slimes, and each slime shares energy via a tube with neighboring slimes. Outer slimes sense their environment and conform to it. Outer slimes periodically transmit information about their surrounding environment via a contraction wave to inner slimes. Thus, ASMM shows how slimes can sense a better environment even if that environment is not adjacent to the slimes. The slimes subsequently can move in the direction of an attractant.
Brentuximab vedotin (SGN-35) is an antibody–drug conjugate with a high selectivity against CD30+ cell lines and more than 300-fold less activity against antigen-negative cells. In the last years, the results of many in vitro and in vivo studies have led to the fast approval of this drug to treat lymphoma patients. Another innovative method to treat tumor cells including lymphoma cells is the use cytokine-induced killer (CIK) cells, which have also been approved and proven to be a safe treatment with only minor adverse events. In this study, a possible additive effect when combining SGN-35 with CIK cells was investigated. The combinational treatment showed that it reduces the viability of CD30+ cell lines significantly in vitro. Additionally, the amount of lymphoma cells was significantly reduced when exposed to CIK cells as well as when exposed to SGN-35. A significant negative effect of SGN-35 on the function of CIK cells could be excluded. These results lead to the assumption that SGN-35 and CIK cells in combination might achieve better results in an in vitro setting compared to the single use of SGN-35 and CIK cells. Further investigations in in vivo models must be conducted to obtain a better understanding of the exact mechanisms of both treatments when applied in combination.
Digitale Gemeingüter
(2016)
Currently, there is a global problem of an increasing need of energy. There will be less fossil fuel, which will be more expensive in the future. The regenerative energies are becoming more and more important. The subject deals the problem of economical feasibility of geothermal energy systems. Its goal is to analyze necesary conditions and aspects of realizing geothermal energy systems in comparison to and competition with traditional energy sources. The geothermal energy recovery is economically advantageous if the investment costs, esp. the drilling costs, could be reduced significantly. It only seems possible to open up a big opportunity for realizing geothermal energy systems by using a rock melt drilling technology, to reduce the investment costs significantly.
The analysis of Δ9-tetrahydrocannabinol (THC) and its metabolites 11-hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH) from blood serum is a routine task in forensic toxicology laboratories. For examination of consumption habits, the concentration of the phase I metabolite THC-COOH is used. Recommendations for interpretation of analysis values in medical-psychological assessments (regranting of driver’s licenses, Germany) include threshold values for the free, unconjugated THC-COOH. Using a fully automated two-step liquid-liquid extraction, THC, 11-OH-THC, and free, unconjugated THC-COOH were extracted from blood serum, silylated with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA), and analyzed by GC/MS. The automation was carried out by an x-y-z sample robot equipped with modules for shaking, centrifugation, and solvent evaporation. This method was based on a previously developed manual sample preparation method. Validation guidelines of the Society of Toxicological and Forensic Chemistry (GTFCh) were fulfilled for both methods, at which the focus of this article is the automated one. Limits of detection and quantification for THC were 0.3 and 0.6 μg/L, for 11-OH-THC were 0.1 and 0.8 μg/L, and for THC-COOH were 0.3 and 1.1 μg/L, when extracting only 0.5 mL of blood serum. Therefore, the required limit of quantification for THC of 1 μg/L in driving under the influence of cannabis cases in Germany (and other countries) can be reached and the method can be employed in that context. Real and external control samples were analyzed, and a round robin test was passed successfully. To date, the method is employed in the Institute of Legal Medicine in Giessen, Germany, in daily routine. Automation helps in avoiding errors during sample preparation and reduces the workload of the laboratory personnel. Due to its flexibility, the analysis system can be employed for other liquid-liquid extractions as well. To the best of our knowledge, this is the first publication on a comprehensively automated classical liquid-liquid extraction workflow in the field of forensic toxicological analysis.
We examined the cytotoxic effects of chaetocin on clear cell renal cell carcinoma (ccRCC) cells and the possibility to combine the effects of chaetocin with the effects of cytokine-induced killer cells (CIK) assayed by MTT assay and FACS analysis. Chaetocin is a thiodioxopiperazine produced by fungi belonging to the chaetomiaceae family. In 2007, it was first reported that chaetocin shows potent and selective ex vivo anti-cancer activity by inducing reactive oxygen species. CIK cells are generated from CD3+/CD56- T lymphocytes with double negative CD4-/CD8- phenotype that are isolated from human blood. The addition of distinct interleukins and antibodies results in the generation of CIK cells that are able to specifically target and destroy renal carcinoma cells. The results of this research state that the anti-ccRCC activity of chaetocin is weak and does not show a high grade of selectivity on clear cell renal cell carcinoma cells. Although the CIK cells show a high grade of selective anti-ccRCC activity, this effect could not be improved by the addition of chaetocin. So chaetocin seems to be no suitable agent for specific targeting ccRCC cells or for the combination therapy with CIK cells in renal cancer.
Breadth-First Search is a graph traversal technique used in many applications as a building block, e.g., to systematically explore a search space or to determine single source shortest paths in unweighted graphs. For modern multicore processors and as application graphs get larger, well-performing parallel algorithms are favorable. In this paper, we systematically evaluate an important class of parallel algorithms for this problem and discuss programming optimization techniques for their implementation on parallel systems with shared memory. We concentrate our discussion on level-synchronous algorithms for larger multicore and multiprocessor systems. In our results, we show that for small core counts many of these algorithms show rather similar performance behavior. But, for large core counts and large graphs, there are considerable differences in performance and scalability influenced by several factors, including graph topology. This paper gives advice, which algorithm should be used under which circumstances.
Updating a shared data structure in a parallel program is usually done with some sort of high-level synchronization operation to ensure correctness and consistency. The realization of such high-level synchronization operations is done with appropriate low-level atomic synchronization instructions that the target processor architecture provides. These instructions are costly and often limited in their scalability on larger multi-core / multi-processor systems. In this paper, a technique is discussed that replaces atomic updates of a shared data structure with ordinary and cheaper read/write operations. The necessary conditions are specified that must be fulfilled to ensure overall correctness of the program despite missing synchronization. The advantage of this technique is the reduction of access costs as well as more scalability due to elided atomic operations. But on the other side, possibly more work has to be done caused by missing synchronization. Therefore, additional work is traded against costly atomic operations. A practical application is shown with level-synchronous parallel Breadth-First Search on an undirected graph where two vertex frontiers are accessed in parallel. This application scenario is also used for an evaluation of the technique. Tests were done on four different large parallel systems with up to 64-way parallelism. It will be shown that for the graph application examined the amount of additional work caused by missing synchronization is neglectible and the performance is almost always better than the approach with atomic operations.
In Zeiten der Krise kommt den Controllern eine wachsende Bedeutung im Unternehmen zu. Controller gehören auch in wirtschaftlich turbulenten Situationen zu den gesuchten Fachleuten. Die Autoren behandeln die Frage: Welche Anforderungen in fachlicher sowie persönlicher Sicht werden an den Controller gestellt und wie stark verändern sich seine Aufgaben.
Salts and proteins comprise two of the basic molecular components of biological materials. Kosmotropic/chaotropic co-solvation and matching ion water affinities explain basic ionic effects on protein aggregation observed in simple solutions. However, it is unclear how these theories apply to proteins in complex biological environments and what the underlying ionic binding patterns are. Using the positive ion Ca2+ and the negatively charged membrane protein SNAP25, we studied ion effects on protein oligomerization in solution, in native membranes and in molecular dynamics (MD) simulations. We find that concentration-dependent ion-induced protein oligomerization is a fundamental chemico-physical principle applying not only to soluble but also to membrane-anchored proteins in their native environment. Oligomerization is driven by the interaction of Ca2+ ions with the carboxylate groups of aspartate and glutamate. From low up to middle concentrations, salt bridges between Ca2+ ions and two or more protein residues lead to increasingly larger oligomers, while at high concentrations oligomers disperse due to overcharging effects. The insights provide a conceptual framework at the interface of physics, chemistry and biology to explain binding of ions to charged protein surfaces on an atomistic scale, as occurring during protein solubilisation, aggregation and oligomerization both in simple solutions and membrane systems.
Duale Studiengänge liegen einerseits stark im Trend, andererseits funktioniert die Abstimmung zwischen Hochschulstudium und Praxisphasen oftmals nicht. Obwohl eine Lernortkooperation zwischen »Praxis« und »Hochschule« das Engagement beider Seiten erfordert, wird in einem Projekt der Hochschule Bonn-Rhein-Sieg, der Deutschen Gesetzlichen Unfallversicherung (DGUV) und des BIBB zunächst erprobt, wie das Verständnis der Praxisbetreuer/-innen für Studierende und Studium verbessert werden kann. Hierzu werden im Beitrag Konzeption und Zielsetzung eines zweitägigen Seminars bei der Akademie der DGUV vorgestellt und erste Erfahrungen geschildert.
Háttér és célkitűzések: A játékszenvedély vizsgálatával foglalkozó tudományos cikkek sora dinamikusan bővült az elmúlt években. Kutatások folynak a témában például Nagy-Britanniában, (1) Finnországban(2) és Svédországban(3) is. Ugyanakkor ezen kutatások empirikus eredményei még nem publikáltak, így az értékelésük is csak később lehetséges.(4)
Das Land Baden-Württemberg beauftragte im Auftrag aller in der Ministerpräsidentenkonferenz der Bundesrepublik Deutschland zusammengeschlossenen Länder die Goldmedia GmbH Strategy Consulting, Berlin, am 24.2.2014 mit der Erstellung einer wirtschaftswissenschaftlichen Studie, die mit dem Titel "International vergleichende Analyse des Glücksspielwesens" am 30.9.2014 dem Auftraggeber vorgelegt wurde. Zur nationalen Evaluierung des Ersten GlüÄndStV soll dessen Zielerreichung auch durch die hier betrachtete ökonomische Analyse erfasst und bewertet werden.
Nach einer wirtschaftswissenschaftlichen Bestandaufnahme ist festzustellen, dass diese Studie jedoch wissenschaftlich unzulänglich ist und aufgrund ihrer vielfältigen definitorischen und methodischen Defizite keinen tragfähigen Beitrag für die Evaluierung des Ersten GlüÄndStV bildet. Das gilt vor allem, weil ein Großteil des zu evaluierenden Glücksspielmarkts in Deutschland von der Studie gar nicht abgebildet wird.
Polyether and polyether/ester based TPU (thermoplastic polyurethanes) were investigated with wide-angle XRD (X-ray diffraction) and SAXS (small angle X-ray scattering). Furthermore, SAXS measurements were performed in the temperature range of 30 °C to 130 °C. Polyether based polymers exhibit only one broad diffraction signal in a region of 2 θ 15° to 25°. In case of polyurethanes with ether/ester modification, the broad diffraction signal arises with small sharp diffraction signals. SAXS measurements of polymers reveal the size and shape of the crystalline zones of the polymer. Between 30 °C and 130 °C the size of the crystalline zone changes significantly. The size decreases in most of investigated TPU. In the case of Desmopan 9365D an increase of the particle size was observed.
Recessive mutations in the MPV17 gene cause mitochondrial DNA depletion syndrome, a fatal infantile genetic liver disease in humans. Loss of function in mice leads to glomerulosclerosis and sensineural deafness accompanied with mitochondrial DNA depletion. Mutations in the yeast homolog Sym1, and in the zebra fish homolog tra cause interesting, but not obviously related phenotypes, although the human gene can complement the yeast Sym1 mutation. The MPV17 protein is a hydrophobic membrane protein of 176 amino acids and unknown function. Initially localised in murine peroxisomes, it was later reported to be a mitochondrial inner membrane protein in humans and in yeast. To resolve this contradiction we tested two new mouse monoclonal antibodies directed against the human MPV17 protein in Western blots and immunohistochemistry on human U2OS cells. One of these monoclonal antibodies showed specific reactivity to a protein of 20 kD absent in MPV17 negative mouse cells. Immunofluorescence studies revealed colocalisation with peroxisomal, endosomal and lysosomal markers, but not with mitochondria. This data reveal a novel connection between a possible peroxisomal/endosomal/lysosomal function and mitochondrial DNA depletion.
Der Beitrag stellt auf Basis einer Literaturanalyse den aktuellen Forschungsstand zu Controlling Shared Service Centern dar. Darauf aufbauend wird dieser um die praktischen Erfahrungen bei der Deutschen Telekom ergänzt. Insbesondere der Prozess des Risikomanagements wird hierzu auf seine Eignung für Shared Services auf Grundlage der etwa dreijährigen Erfahrungen des Unternehmens geprüft.
People are getting older because of the demographic changes and the rate of disabled people is also going up. This article shows the challenge for BPMTool developer due to these circumstances. It illustrates how these changes impact the usage of BPM-Tools based on an Evaluation of an exemplary BPMTool (Cooper & Patterson, 2007) in terms of IT-Usability and IT-Accessibility. This evaluation was conducted in a research laboratory at the university.
We investigated graphene structures grafted with fullerenes. The size of the graphene sheets ranges from 6400 to 640,000 atoms. The fullerenes (C60 and C240) are placed on top of the graphene sheets, using different impact velocities we could distinguish three types of impact. Furthermore, we investigated the changes of the vibrational properties. The modified graphene planes show additional features in the vibronic density of states.
Low-frequency vibrational excitations in zeolite ZSM-5 and its partially crystalline derivatives
(2004)
Molecular dynamics investigation of vibrational properties of zeolite ZSM-5-based amorphous material
(2003)
Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that are over-expressed in joints of rheumatoid arthritis (RA) patients. However, the contribution of specific MMPs for the development of arthritic joints is unknown. This study is aimed at studying the role of matrix metalloproteinase-9 (MMP-9) in mice, using the K/BxN serum-transfer model of RA. Arthritis was induced in Balb/c mice by injecting K/BxN serum. Development of arthritis was followed in these mice by measuring ankle thickness and clinical index score. MMP-9 expression in the joints of mice killed at various time points during the disease progression was determined by gelatin zymography using ankle lysates. We found that MMP-9 expression increased with the severity of arthritis. Importantly MMP-9 deficient mice injected with K/BxN serum showed a milder form of arthritis in comparison to the control C57BL/6 mice injected with K/BxN serum. We therefore conclude that MMP-9 promotes arthritis in mice.
The steadily decreasing prices of display technologies and computer graphics hardware contribute to the increasing popularity of multiple-display environments, like large, high-resolution displays. It is therefore necessary that educational organizations give the new generation of computer scientists an opportunity to become familiar with this kind of technology. However, there is a lack of tools that allow for getting started easily. Existing frameworks and libraries that provide support for multi-display rendering are often complex in understanding, configuration and extension. This is critical especially in educational context where the time that students have for their projects is limited and quite short. These tools are also rather known and used in research communities only, thus providing less benefit for future non-scientists. In this work we present an extension for the Unity game engine. The extension allows – with a small overhead – for implementation of applications that are apt to run on both single-display and multi-display systems. It takes care of the most common issues in the context of distributed and multi-display rendering like frame, camera and animation synchronization, thus reducing and simplifying the first steps into the topic. In conjunction with Unity, which significantly simplifies the creation of different kinds of virtual environments, the extension affords students to build mock-up virtual reality applications for large, high-resolution displays, and to implement and evaluate new interaction techniques and metaphors and visualization concepts. Unity itself, in our experience, is very popular among computer graphics students and therefore familiar to most of them. It is also often employed in projects of both research institutions and commercial organizations; so learning it will provide students with qualification in high demand.
§ 28e Abs. 1 Satz 2 SGB IV – Lehrstück für den Gesetzgeber oder: Wie eine Norm sich selbst erledigt!
(2015)
Allgemeines Steuerrecht
(2015)
Zweiseitige Märkte
(2016)
Big Data und aktuelle Trends
(2015)
The analytical pyrolysis technique hyphenated to gas chromatography–mass spectrometry (GC–MS) has extended the range of possible tools for the characterization of synthetic polymers and copolymers. Pyrolysis involves thermal fragmentation of the analytical sample at temperatures of 500–1400 °C. In the presence of an inert gas, reproducible decomposition products characteristic for the original polymer or copolymer sample are formed. The pyrolysis products are chromatographically separated using a fused-silica capillary column and are subsequently identified by interpretation of the obtained mass spectra or by using mass spectra libraries. The analytical technique eliminates the need for pretreatment by performing analyses directly on the solid or liquid polymer sample. In this article, application examples of analytical pyrolysis hyphenated to GC–MS for the identification of different polymeric materials in the plastic and automotive industry, dentistry, and occupational safety are demonstrated. For the first time, results of identification of commercial light-curing dental filling material and a car wrapping foil by pyrolysis–GC–MS are presented.
The criteria for assessing the quality of rubber materials are the polymer or copolymer composition and the additives. These additives include plasticizers, extender oils, carbon black, inorganic fillers, antioxidants, heat and light stabilizers, processing aids, cross-linking agents, accelerators, retarders, adhesives, pigments, smoke and flame retardants, and others. Determination of additives in polymers or copolymers generally requires the extraction of these substances from the matrix as a first step, which can be challenging, and the subsequent analysis of the extracted additives by gas chromatography (GC), GC–mass spectrometry (MS), high performance liquid chromatography (HPLC), HPLC–MS, capillary electrophoresis, thin-layer chromatography, and other analytical techniques. In the present work, nitrile rubber materials were studied using direct analytical flash pyrolysis hyphenated to GC and electrospray ionization MS in both scan and selected ion monitoring modes to demonstrate that this technique is a good tool to identify the organic additives in nitrile rubber.