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Advances in computer graphics enable us to create digital images of astonishing complexity and realism. However, processing resources are still a limiting factor. Hence, many costly but desirable aspects of realism are often not accounted for, including global illumination, accurate depth of field and motion blur, spectral effects, etc. especially in real‐time rendering. At the same time, there is a strong trend towards more pixels per display due to larger displays, higher pixel densities or larger fields of view. Further observable trends in current display technology include more bits per pixel (high dynamic range, wider color gamut/fidelity), increasing refresh rates (better motion depiction), and an increasing number of displayed views per pixel (stereo, multi‐view, all the way to holographic or lightfield displays). These developments cause significant unsolved technical challenges due to aspects such as limited compute power and bandwidth. Fortunately, the human visual system has certain limitations, which mean that providing the highest possible visual quality is not always necessary. In this report, we present the key research and models that exploit the limitations of perception to tackle visual quality and workload alike. Moreover, we present the open problems and promising future research targeting the question of how we can minimize the effort to compute and display only the necessary pixels while still offering a user full visual experience.
Mobilitäts- und Nachhaltigkeitsforscher sehen sich bei der Erforschung des Mobilitätsverhaltens von Personen mit einer bunten Palette an Erhebungsmethoden konfrontiert. Erweitert wird diese Vielfalt in der letzten Zeit durch die Möglichkeit, dieses Verhalten direkt über die Smartphones der Probanden zu erfassen. Um die Auswahl geeigneter Methoden zu erleichtern, liefert die vorliegende Literaturstudie einen detaillierten Überblick zu Fragestellungen, Daten und Erhebungsmethoden, die im Bereich der Mobilitätsforschung zur Erfassung von Alltagsmobilität eingesetzt werden.
This paper introduces our robotic system named UGAV (Unmanned Ground-Air Vehicle) consisting of two semi-autonomous robot platforms, an Unmanned Ground Vehicle (UGV) and an Unmanned Aerial Vehicles (UAV). The paper focuses on three topics of the inspection with the combined UGV and UAV: (A) teleoperated control by means of cell or smart phones with a new concept of automatic configuration of the smart phone based on a RKI-XML description of the vehicles control capabilities, (B) the camera and vision system with the focus to real time feature extraction e.g. for the tracking of the UAV and (C) the architecture and hardware of the UAV.
Multiple myeloma is the second most common hematological malignancy. Despite all the progress made in treating multiple myeloma, it still remains an incurable disease. Patients are left with a median survival of 4-5 years. The combined treatment of multiple myeloma with histone deacetylase inhibitors and cytokine-induced killer cells provides a promising targeted treatment option for patients. This study investigated the impact of a combined treatment compared to treatment with histone deacetylase inhibitors. The experiments revealed that a treatment with histone deacetylase (HDAC) inhibitors could reduce cell viability to 59% for KMS 18 cell line and 46% for the U-266 cell line. The combined treatment led to a decrease of cell viability to 33% for KMS 18 and 27% for the U-266 cell line, thus showing a significantly better efficacy than the single treatment.
This study contributes to the growing body of research concerning management consultancies by linking two previously disparate fields of study: (1) the examination of the effectiveness of consulting interventions and (2) the examination of the social processes that aim to create and legitimize the insights, knowledge and capabilities of management consultancies. We propose that consulting firms accumulate social authority in the course of pre-intervention discourse processes that is reflected in their reputation and celebrity. With respect to intervention, this social authority affects change recipients’ commitment to and compliance with the requirements of change implementation. We test the proposed relationships by conducting a measured variable path analysis of 117 change initiatives in German companies that were set up and implemented with the assistance of external consultancies. Our findings indicate that a consulting firm’s levels of both celebrity and reputation affect the change recipients’ commitment to proposed change strategies and thus, indirectly affect their behavioral compliance with the explicit requirements of change implementation.
Die Forschung zur kontrovers diskutierten Robotik in der Pflege und Begleitung von Personen mit Demenz steht noch am Anfang, wenngleich bereits erste Systeme auf dem Markt sind. Der Beitrag gibt entlang beispielhafter, fallbezogener Auszüge Einblicke in das laufende multidisziplinäre Projekt EmoRobot, das sich explorativ und interpretativ mit der Erkundung des Einsatzes von Robotik in der emotionsorientierten Pflege und Versorgung von Personen mit Demenz befasst. Fokussiert werden dabei die je eigenen Relevanzen der Personen mit Demenz.
Die allgemeine Konnotation von Technik mit Männlichkeit hat Auswirkungen auf die Berufswahlentscheidungen und das Technikverständnis von jungen Frauen. Nur gut 22 Prozent aller Studierenden in den Ingenieurswissenschaften waren 2014 in Deutschland weiblich (vgl. MonitorING)1. Seit Jahren wird versucht, diese Zahlen nach oben zu korrigieren, indem man Programme für Mädchen und junge Frauen anbietet, die erste Kontakte zu technischen Arbeitsfeldern her stellen. Auch für bereits berufstätige Ingenieurinnen gibt es zahlreiche Förderprogramme, um den Drop-out hochqualiizierter Frauen auf der Karriere leiter zu verhindern. Dennoch verändern sich die prozentualen Anteile von Frauen in ingenieurswissenschaftlichen Studiengängen und Berufen kaum. Aktuelle Studien belegen, dass vor allem kulturell bedingte Erwartungen und Einstellungen hierfür verantwortlich sind (vgl. Paulitz 2012).
„Big Data“, „Industrie 4.0“ und „Digitalisierung“ sind in aller Munde und das nicht nur als Heilsbringer. Der „Jobkiller Digitalisierung“ führt in vielen Branchen und auch im Controlling zu einem potenziellen Ersatz des Menschen. Glaubt man diesen düsteren Szenarien, so übernehmen Algorithmen zukünftig weitgehend die Steuerung der Geschäftsprozesse. Der Manager entscheidet allein auf Basis der Informationen, die in Echtzeit automatisch auf sein Handy übermittelt werden. Den Controller sucht man in diesen Prognosen vergeblich.
Geschäftsprozessmanagement
(2017)
SpMV Runtime Improvements with Program Optimization Techniques on Different Abstraction Levels
(2016)
The multiplication of a sparse matrix with a dense vector is a performance critical computational kernel in many applications, especially in natural and engineering sciences. To speed up this operation, many optimization techniques have been developed in the past, mainly focusing on the data layout for the sparse matrix. Strongly related to the data layout is the program code for the multiplication. But even for a fixed data layout with an accommodated kernel, there are several alternatives for program optimizations. This paper discusses a spectrum of program optimization techniques on different abstraction layers for six different sparse matrix data format and kernels. At the one end of the spectrum, compiler options can be used that hide from the programmer all optimizations done by the compiler internally. On the other end of the spectrum, a multiplication kernel can be programmed that use highly sophisticated intrinsics on an assembler level that ask for a programmer with a deep understanding of processor architectures. These special instructions can be used to efficiently utilize hardware features in processors like vector units that have the potential to speed up sparse matrix computations. The paper compares the programming effort and required knowledge level for certain program optimizations in relation to the gained runtime improvements.
With the rising interest in vehicular communication systems many proposals for secure vehicle-to-vehicle commu- nication were made in recent years. Also, several standard- ization activities concerning the security and privacy measures in these communication systems were initiated in Europe and in US. Here, we discuss some limitations for secure vehicle- to-infrastructure communication in the existing standards of the European Telecommunications Standards Institute. Next, a vulnerability analysis for roadside stations on one side and security and privacy requirements for roadside stations on the other side are given. Afterwards, a proposal for a multi-domain public key architecture for intelligent transport systems, which considers the necessities of road infrastructure authorities and vehicle manufacturers, is introduced. The domains of the public key infrastructure are cryptographically linked based on local trust lists. In addition, a crypto agility concept is suggested, which takes adaptation of key length and cryptographic algorithms during PKI operation into account.
The latest advances in the field of smart card technologies allow modern cards to be more than just simple security tokens. Recent developments facilitate the use of interactive components like buttons, displays or even touch-sensors within the card's body thus conquering whole new areas of application. With interactive functionalities the usability aspect becomes the most important one for designing secure and popularly accepted products. Unfortunately, the usability can only be tested fully with completely integrated hence expensive smart card prototypes. This restricts severely application specific research, case studies of new smart card user interfaces and the optimization of design aspects, as well as hardware requirements by making usability and acceptance tests in smart card development very costly and time-consuming. Rapid development and simulation of smart card interfaces and applications can help to avoid this restriction. This paper presents a rapid development process for new smart card interfaces and applications based on common smartphone technology using a tool called SCUID^Sim. We will demonstrate the variety of usability aspects that can be analyzed with such a simulator by discussing some selected example projects.
Rehabilitation wirkt
(2014)
Die medizinische Rehabilitation bildet im bundesdeutschen Gesundheitssystem eine wichtige Säule. Sie wird weltweit immer wieder als vorbildlich angesehen und ist im internationalen Vergleich mit Mitteln, Infrastruktur, Know-how und Behandlungsqualität hervorragend ausgestattet. Dies ist gut so, aber ist es gut genug?
Insolvenzanfechtung von Beitragszahlungen an Sozialversicherungsträger – aktuelle Rechtsprechung
(2010)
Die Klausur: VWL
(2016)
IT-Controlling
(2016)
Die Klausur: VWL
(2016)
Die Prognose über den Studienerfolg von Studierenden in MINT-Fächern wird häufig an ihre Prüfungsleistungen in mathematischen und naturwissenschaftlichen Veranstaltungen geknüpft. Die Relevanz von sprachlichen Kompetenzen, insbesondere der Textrezeption und -produktion, für Studium und Berufstätigkeit, gerade auch in ingenieurwissenschaftlichen Betätigungsfeldern, wird sowohl von den Studierenden als auch von Dozent*innen nicht erkannt oder zurückgestellt.
Die Glücksforschung befasst sich primär mit einzelnen Konstrukten wie Arbeitszufriedenheit oder subjektivem Wohlbefinden. Allerdings fehlt ein zusammenhängendes Konzept, um die Erkenntnisse in der Praxis umzusetzen. Daher wird ein Bedürfnismodell vorgestellt, das sich nach ersten empirischen Untersuchungen als geeigneter Indikator für Wohlbefinden erweist. Außerdem lassen sich daraus konkrete Handlungsempfehlungen ableiten.
Non-Destructive Sensor-Based Prediction of Maturity and Optimum Harvest Date of Sweet Cherry Fruit
(2017)
(1) Background: The aim of the study was to use innovative sensor technology for non-destructive determination and prediction of optimum harvest date (OHD), using sweet cherry as a model fruit, based on different ripening parameters. (2) Methods: Two cherry varieties in two growing systems viz. field and polytunnel in two years were employed. The fruit quality parameters such as fruit weight and size proved unsuitable to detect OHD alone due to their dependence on crop load, climatic conditions, cultural practices, and season. Coloration during cherry ripening was characterized by a complete decline of green chlorophyll and saturation of the red anthocyanins, and was measured with a portable sensor viz. spectrometer 3-4 weeks before expected harvest until 2 weeks after harvest. (3) Results: Expressed as green NDVI (normalized differential vegetation index) and red NAI (normalized anthocyanin index) values, NAI increased from -0.5 (unripe) to +0.7 to +0.8 in mature fruit and remained at this saturation level with overripe fruits, irrespective of variety, treatment, and year. A model was developed to predict the OHD, which coincided with when NDVI reached and exceeded zero and the first derivative of NAI asymptotically approached zero. (4) Conclusion: The use of this sensor technology appears suitable for several cherry varieties and growing systems to predict the optimum harvest date.
The design of future materials for biotechnological applications via deposition of molecules on surfaces will require not only exquisite control of the deposition procedure, but of equal importance will be our ability to predict the shapes and stability of individual molecules on various surfaces. Furthermore, one will need to be able to predict the structure patterns generated during the self-organization of whole layers of (bio)molecules on the surface. In this review, we present an overview over the current state of the art regarding the prediction and clarification of structures of biomolecules on surfaces using theoretical and computational methods.
Beta-ketothiolase deficiency, also known as mitochondrial acetoacetyl-CoA thiolase (T2) deficiency, is an autosomal recessive disease caused by mutations in the acetylCoA acetyltransferase 1 (ACAT1) gene. A German T2deficient patient that developed a severe ketoacidotic episode at the age of 11 months, was revealed to be a compound heterozygote of a previously reported null mutation, c.472A>G (p.N158D) and a novel mutation, c.949G>A (p.D317N), in ACAT1. The c.949G>A mutation was suspected to cause aberrant splicing as it is located within an exonic splicing enhancer sequence (c. 947CTGACGC) that is a potential binding site for serine/argininerich splicing factor 1. A mutation in this sequence, c.951C>T, results in exon 10 skipping. A minigene construct was synthesized that included exon 9truncated intron 9exon 10truncated intron 10exon 11, and the splicing of this minigene revealed that the c.949G>A mutant construct caused exon 10 skipping in a proportion of the transcripts. Furthermore, additional substitution of G for C at the first nucleotide of exon 10 (c.941G>C) abolished the effect of the c.949G>A mutation. Transient expression analysis of the c.949G>A mutant cDNA revealed no residual T2 activity in the mutated D317N enzyme. Therefore, c.949G>A (D317N) is a pathogenic missense mutation, and diminishes the effect of an exonic splicing enhancer and causes exon 10 skipping. The present study demonstrates that a missense mutation, or even a synonymous substitution, may disrupt enzyme function by interference with splicing.
Oft wird die Gewinnung von Gastärzten aus dem Ausland als Möglichkeit zur kurz- und mittelfristigen Deckung des Ärztebedarfs in Kliniken in Erwägung gezogen. Die hohen Anforderungen von Landesprüfungsämtern, Arbeitsagenturen, Ausländerbehörden und Botschaften erweisen sich sowohl für Ärzte als auch Kliniken als schwer überwindbare Hürden. Insbesondere Sprachschwierigkeiten sowie mangelhafte fachliche und kulturelle Kenntnisse der internationalen Ärzte sind ohne professionelle Unterstützung kaum zu kompensieren.
Background: Type 2 diabetes mellitus is associated with increased cardiovascular risk. One laboratory marker for cardiovascular risk assessment is high-sensitivity C-reactive protein (hsCRP).
Methods: This cross-sectional study attempted to analyze the association of hsCRP levels with insulin resistance, β-cell dysfunction and macrovascular disease in 4270 non-insulin-treated patients with type 2 diabetes [2146 male, 2124 female; mean age ±SD, 63.9±11.1years; body mass index (BMI) 30.1±5.5kg/m2; disease duration 5.4±5.6years; hemoglobin A1c (HbA1c) 6.8±1.3%]. It consisted of a single morning visit with collection of a fasting blood sample. Observational parameters included several clinical scores and laboratory biomarkers.
Results: Stratification into cardiovascular risk groups according to hsCRP levels revealed that 934 patients had low risk (hsCRP <1mg/L), 1369 patients had intermediate risk (hsCRP 1–3mg/L), 1352 patients had high risk (hsCRP >3–10mg/L), and 610 patients had unspecific hsCRP elevation (>10mg/L). Increased hsCRP levels were associated with other indicators of diabetes-related cardiovascular risk (homeostatic model assessment, intact proinsulin, insulin, BMI, β-cell dysfunction, all p<0.001), but showed no correlation with disease duration or glucose control. The majority of the patients were treated with diet (34.1%; hsCRP levels 2.85±2.39mg/L) or metformin monotherapy (21.1%; 2.95±2.50mg/L hsCRP). The highest hsCRP levels were observed in patients treated with sulfonylurea (17.0%; 3.00±2.43mg/L).
Conclusions: Our results indicate that hsCRP may be used as a cardiovascular risk marker in patients with type 2 diabetes mellitus and should be evaluated in further prospective studies.
High-sensitivity C-reactive protein as cardiovascular risk marker in patients with diabetes mellitus
(2006)
Eine Suite für den Patienten
(2006)
Improvement of Cardiovascular Risk Markers by Pioglitazone Is Independent From Glycemic Control
(2005)
Heilung mit Genuss
(2005)
Defect evolution in thermal barrier coating systems under multi-axial thermomechanical loading
(2005)
Companies often have difficulties determining which criteria to base their investment decisions in different countries on. When considering direct foreign investment several risk indices are available. The PCI (Peren-Clement-Index) in its original form was developed in 1998. Its further refinement improves the PCI in three major ways: First, it offers a dynamic adjustment of criteria and consideration of recent changes in the international environment. Second, it provides business specificities of a company or its industrial sector to be considered in addition to macroeconomic aspects by a two-dimensional presentation, which ensures a customized assessment. Third, the PCI allows for consolidating investment decisions by combining a resource-orientated with a market-oriented view. The PCI allows, unlike other indices, a customized and company-specific strategic planning process. Ultimately companies must take up both perspectives in the context of an international investment decision. The use of risk indices in corporate planning for assessing global investments decision creates a fundamentally new of risk assessment.
In this paper, a set of micro-benchmarks is proposed to determine basic performance parameters of single-node mainstream hardware architectures for High Performance Computing. Performance parameters of recent processors, including those of accelerators, are determined. The investigated systems are Intel server processor architectures and the two accelerator lines Intel Xeon Phi and Nvidia graphic processors. Additionally, the performance impact of thread mapping on multiprocessors and Intel Xeon Phi is shown. The results show similarities for some parameters between all architectures, but significant differences for others.
Softwarenutzung im Umbruch: Von der Software-Lizenz zum Cloudbasierten Business Process Outsourcing
(2017)
The mechanical properties of plastic components, especially if they are made of semi-crystalline polymers, are considerably influenced by the process conditions. The degree of crystallization influences thermal and mechanical properties. Even more important is the orientation of molecules due to stretching of the polymer melt. Anisotropic material properties are the result of such orientations. Up to now all these effects are not considered within the simulation models of blow molded parts.
We present a new multi-pixel high resolution (R ≳ 107) spectrometer for the Stratospheric Observatory for Far-Infrared Astronomy (SOFIA). The receiver uses 2 × 7-pixel subarrays in orthogonal polarization, each in an hexagonal array around a central pixel. We present the first results for this new instrument after commissioning campaigns in May and December 2015 and after science observations performed in May 2016. The receiver is designed to ultimately cover the full 1.8−2.5 THz frequency range but in its first implementation, the observing range was limited to observations of the [CII] line at 1.9 THz in 2015 and extended to 1.83−2.07 THz in 2016. The instrument sensitivities are state-of-the-art and the first scientific observations performed shortly after the commissioning confirm that the time efficiency for large scale imaging is improved by more than an order of magnitude as compared to single pixel receivers. An example of large scale mapping around the Horsehead Nebula is presented here illustrating this improvement. The array has been added to SOFIA’s instrument suite already for ongoing observing cycle 4.
Large bone defects require fabricated bone constructs that consist of three main components: an artificial extracellular matrix scaffold, stem cells with the potential to differentiate into osteoblasts, and bioactive substances, such as osteoinductive growth factors to direct the growth and differentiation of cells toward osteogenic lineage within the scaffold.
Falls and their consequences are arguably most important events for transition from independent living to institutional care for older adults. Information and communication technology (ICT)-based support of fall prevention and fall risk assessment under the control of the user has a tremendous potential to, over time, prevent falls and reduce associated harm and costs. Our research uses participative design and a persuasive health approach to allow for seamless integration of an ICT-based fall prevention system into older adults’ everyday life. Based on a 6-month field study with 12 participants, we present qualitative results regarding the system use and provide insights into attitudes and practices of older adults concerning fall prevention and ICT-supported self-management of health. Our study demonstrates how it can lead to positive aspects of embodiment and health literacy through continuous monitoring of personal results, improved technical confidence, and quality of life. Implications are provided for designing similar systems.