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DNA Sequencing
(2011)
Orešković and Porsdam Mann draw a distinction between ‘fast’ and ‘slow’ science. Whereas the latter involves rigorous and laborious adherence to the scientific method, the former represents the reality that much scientific work faces time pressures which at times force shortcuts. The distinction can be seen to operate in contemporary research into the coronavirus pandemic: whereas the development of vaccines and treatments usually requires years of meticulous laboratory work and several more years of clinical testing, the many millions suffering from the disease need a treatment now. However, by taking too many safeguards off the treatment discovery and testing pipelines, or by refusing to act in accordance with scientific advice, governments risk sacrificing the public’s trust not only in the government’s scientific bona fides but in the scientific process itself. This is a heavy price to pay, argue Orešković and Porsdam Mann, and point to evidence indicating that the success of Germany and Japan in combating COVID-19 can be traced to public trust in science and government, as well as scientifically-informed and respectful national leadership.
The development of mobile robotic systems is a demanding task regarding its complexity, required resources and skills in multiple fields such as software development, artificial intelligence, mechanical design, electrical engineering, signal processing, sensor technology or control theory. This holds true particularly for soccer playing robots, where additional aspects like high dynamics, cooperation and high physical stress have to be dealt with. In robot competitions such as RoboCup, additional skills in the domains of team, project and knowledge management are of importance.
Isolation of DNA and RNA
(2021)
Isolation of DNA and RNA
(2011)
The Decision Tree Procedure
(2024)
From September 2016 to February 2017, I did an internship at the University of Cape Coast, Ghana (UCC) as part of my studies in Business Administration at Hochschule Bonn-Rhein-Sieg, University of Applied Sciences, Germany (H-BRS). At H-BRS, an internship of five or six months (or, alternatively, one exchange semester) is an obligatory part of the curriculum so students get hands-on experience even before they enter the job market. My internship was also part of the intercontinental partnership between UCC and H-BRS, which has resulted in many different projects.
Germany
(2012)
Insights from an Exergame-Based Training System for People with Dementia and Their Caregivers
(2020)
Mass Spectrometry: Pyrolysis
(2019)
Mesenchymal Stem Cells
(2020)
The European General Data Protection Regulation requires the implementation of Technical and Organizational Measures (TOMs) to reduce the risk of illegitimate processing of personal data. For these measures to be effective, they must be applied correctly by employees who process personal data under the authority of their organization. However, even data processing employees often have limited knowledge of data protection policies and regulations, which increases the likelihood of misconduct and privacy breaches. To lower the likelihood of unintentional privacy breaches, TOMs must be developed with employees’ needs, capabilities, and usability requirements in mind. To reduce implementation costs and help organizations and IT engineers with the implementation, privacy patterns have proven to be effective for this purpose. In this chapter, we introduce the privacy pattern Data Cart, which specifically helps to develop TOMs for data processing employees. Based on a user-centered design approach with employees from two public organizations in Germany, we present a concept that illustrates how Privacy by Design can be effectively implemented. Organizations, IT engineers, and researchers will gain insight on how to improve the usability of privacy-compliant tools for managing personal data.
Embryonic stem cells (ES) have the potential of long-term viability, selfrenewal and pluripotency which makes them interesting candidates for tissue engineering and gene therapy applications. On the other hand ethical and political issues arise while using theses cells and severe problems such as their tumorgenicity have not been solved yet. In the last couple of month a new source of cells with stem cell character was developed, the induced pluripotent stem cells (iPS). These cells are derived from differentiated adult cells via transduction of three transcription factors and show features similar to embryonic stem cells. Unfortunately, this includes the tumorgenicity which is even higher in those cells since the transcription factor transduction needed until now, is performed with retrovial vectors, which have a tumor potential on their own. Thus, adult stem cells are investigated extensively as alternative source of self-renewing cells. Human mesenchymal stem cells (HMSCs), which have in addition the advantage of potential autologous transplantation, can be found in various differentiated tissues since they are needed for maintenance and repair. They can be differentiated in chondrogenic, osteogenic, adipogenic and myogenic lineages which makes them an excellent tool for future tissue replacement strategies.
Managing the Work-Nonwork Interface: Personal Social Media Use as a Tool to Craft Boundaries?
(2021)
A Method of Lines Flux-Difference Splitting Finite Volume Approach for 1D and 2D River Flow Problems
(2001)
A soluble form of the complement receptor CD21 (sCD21) is shed from the lymphocyte surface. The sCD21 is able to bind all known ligands such as CD23, sCD23, Epstein-Barr virus and C3d in immune complexes. Here, we show the serum levels of sCD21 in sera the of antiphospholipid syndrome (APS) patients. Antiphospholipid syndrome is an autoimmune disorder in which autoantibodies cause heart attack, stroke and miscarriage. Antiphospholipid syndrome may appear as primary or in association with systemic lupus erythromatosus (SLE) and other autoimmune diseases. Here, we ask whether APS patients have different sCD21 titers compared to healthy persons and whether sCD21 levels correlate with the presence of anti-β2-GPI autoantibodies. We show that autoimmune APS patients have significantly reduced amounts of sCD21 in their sera, irrespective of the presence of anti-β2-GPI autoantibodies. In our APS patients cohort additional SLE, vasculities, DVT (deep vein thrombosis), fetal loss or thrombosis did not correlate to the reduced level of sCD21.
Actors
(2021)
Social protection is for many international organizations a state’s affair.1 While the state definitely plays an important role, the state is by far not the only actor and there is no predefined institutional arrangement of how social protection should be implemented. An exclusive focus on the state would therefore be short-sighted when assessing and comparing the performance of social protection systems. It is hence important to understand the mix of actors involved, the type of contribution they can make to social protection and their modes of cooperation. This contribution will therefore first sketch out the role and interplay of the main actors in social protection and then challenge some of the common assumptions made around how roles are best allocated in the social protection system concerning the providers of informal social protection, the private sector, civil society organizations (CSO) as well as international actors.
Social transfers
(2021)
Social transfers are on the rise in the Global South but they have also been in the centre of discussion in the Global North as an attractive instrument to buffer new risks and uncertainties in a changing world. They have experienced a dramatic change since the beginning of the new century, starting off as a revolutionary programmatic intervention in countries such as Mexico and Brazil or as a fledgling pilot programme in countries such as Zambia, Kenya and Malawi. They have now become a standard intervention across the globe, a truly global social policy as Hickey and Seekings (2019, 249) coined it. This global trend has been facilitated by donors’ strive to move away from ever recurring humanitarian actions, by increased pressure on donors to show aid effectiveness with the money finally reaching the most vulnerable as well as by international concerted actions such as the United Nations initiative of a global social protection floor.
While there is a standard set of instruments that can be used in social protection systems, this needs to be adapted and combined in different ways in order to serve different groups in society best. The needs of a young person who is just starting life and should not be trapped from birth in unfavourable socio-economic conditions are different from the social protection requirements of a retired person who has finished the active part of life and requires income and care security for an indefinite time period.
Designing a social protection system is of course not only a technical exercise but a very political affair. A systems approach to social protection is shaped by the political elites and the respective coalitions of change, the political institutions as well as the political system of a country. This explains why also seemingly similar countries in terms of their risk profile, poverty situation and economic situation can adopt very different social protection systems or make very different progress with respect to social protection expansion. Not only are the established welfare states of the Global North but also the nascent social protection systems in the Global South a testimony of this variety.
Heuristic Methods
(2024)
A Bicycle Simulator Based on a Motion Platform in a Virtual Reality Environment - FIVIS Project
(2007)
Any political phenomenon can only be properly understood in its broader con-text. Questions of international cooperation are thus necessarily framed by his-torical processes and relations of power. We therefore start our first discussion with an examination of the global ‘status quo’ and embed the topic of this pub-lication, ODA graduation, into the shifting world order, analysing current roles and settings in international relations and identifying changes in positions, sta-tus and categories. What are the overarching issues determining world politics and who are the old and the new actors driving them? What is the impact of these global shifts on international cooperation, especially development coop-eration? Of what relevance are roles, status and categories and what is the im-pact of changes in positions and relations? What challenges face multilateralism and what ways exist to maintain and renew strategic partnerships and shared values?
The UN Declaration on the Right to Development (UNDRTD) adopted in 1986 and the 2030 Agenda for Sustainable Development adopted in 2015 share a universal concept of development that refers both to individual and collective dimensions of prosperity and thus includes the rights of future generations.2 They thus offer a definition of the relationship between development and human rights that is very relevant for the 21st century. The core norm of the UNDRTD has been defined later as “the right of peoples and individuals to the constant improvement of their wellbeing and to a national and global enabling environment conducive to just, equitable, participatory and human-centred development respectful of all human rights”3.
In the last 5 years a close co-operation between the Bonn-Rhein-Sieg University of Applied Sciences and the Philips Research Laboratories in Aachen has been established. In this article I want to report on the co-operation of the Department of Electrical Engineering, Mechanical Engineering and Technical Journalism with Philips. Besides a number of diploma theses on the field of water treatment with new discharge lamps, power electronics and modelling of electromagnetic field configurations, there is running also an activity on a new generation of highly efficient light sources based on molecular discharges.
While Anglo-Saxon HEIs focus on a strong educational background and personal development of students, the German system, in particular Universities of Applied Sciences, emphasize employability through the transfer of job-related professional and soft skills. In this context, learning by practical application of skills has become an important instrument. Concepts for linking theory and application include research-based learning, practical internships or service learning – methods, which also maintain high standards of academic education.
Introduction
(2018)
This handbook describes the processes and success factors of marketoriented university services to the non-academic world, and the processes to integrate these services into teaching. It aims to highlight benchmark examples from Africa and Germany in order to outline motivational factors, influencing aspects, as well as drivers and barriers to applied university services in developing countries.
What is Design Theory?
(2021)
Social services
(2021)
People are usually exposed to multiple economic and social risks, including discrimination, abuse, violence and social exclusion. While material support has a positive impact on the reduction of social risks and aspects of exclusion (WHO 2019), some situations require concrete, personal and guiding support on an individual basis. This type of service is commonly referred to as social services (Trukeschitz 2006).
With the roll out of social protection programmes to national scale, questions about implementation and delivery move more and more into the centre of debate (e.g. UNDP 2020; UNDP and UNCDF 2014; Kramon 2019). This concerns in particular the local level, where key processes of implementation are taking place, but where at the same time institutional, operational and financial capacities are often the weakest. While social protection programmes are usually based on a clearly defined set of operational rules and regulations – usually set out in a programme manual – in practice these processes often tend to look quite different. Although many social protection programmes have explicitly excluded traditional authorities from playing an active role in programme delivery, there is ample evidence from across countries that in many local contexts, these ‘informal institutions’ continue to play an important role in the delivery of social protection programmes.
In the presented project, a new approach for the prevention of hand movements leading to hazards and for non-contact detection of fingers is intended to permit comprehensive and economical protection on circular saws. The basic principles may also be applied to other machines with manual loading and / or unloading. With an automatic blade guard an improved integration of the protection system can be achieved. In addition a new detection principle is explained. The distinction between skin and wood or other material is achieved by a dedicated spectral analysis in the near infrared region. Using LED and photodiodes it is possible to detect fingers and hands reliably. With a kind of light curtain the intrusion of hands or fingers into the dangerous zone near the blade guard can be prevented.
Domestic Robotics
(2016)
Domestic Robotics
(2008)
In Artificial Intelligence, numerous learning paradigms have been developed over the past decades. In most cases of embodied and situated agents, the learning goal for the artificial agent is to „map“ or classify the environment and the objects therein [1, 2], in order to improve navigation or the execution of some other domain-specific task. Dynamic environments and changing tasks still pose a major challenge for robotic learning in real-world domains. In order to intelligently adapt its task strategies, the agent needs cognitive abilities to more deeply understand its environment and the effects of its actions. In order to approach this challenge within an open-ended learning loop, the XPERO project (http://www.xpero.org) explores the paradigm of Learning by Experimentation to increase the robot's conceptual world knowledge autonomously. In this setting, tasks which are selected by an actionselection mechanism are interrupted by a learning loop in those cases where the robot identifies learning as necessary for solving a task or for explaining observations. It is important to note that our approach targets unsupervised learning, since there is no oracle available to the agent, nor does it have access to a reward function providing direct feedback on the quality of its learned model, as e.g. in reinforcement learning approaches. In the following sections we present our framework for integrating autonomous robotic experimentation into such a learning loop. In section 1 we explain the different modules for stimulation and design of experiments and their interaction. In section 2 we describe our implementation of these modules and how we applied them to a real world scenario to gather target-oriented data for learning conceptual knowledge. There we also indicate how the goaloriented data generation enables machine learning algorithms to revise the failed prediction model.
Poland
(2018)
Poland belongs to the first wave of pension reformers in Central and Eastern Europe. The Polish pension reform of the late 1990s can serve as a case study for the challenges faced when implementing a radical paradigmatic pension reform towards a privatized DC scheme. This report analyses the background of the original reform, discusses its political, social and economic impact and explains the reasons for later reform reversals. The report stresses that the two re-reform waves, which took place in 2011 and 2013, were mainly driven by fiscal considerations. Since the current system maintains the DC scheme applied to both public and private tiers, the recent reversal of privatization will not improve benefit levels.
Co-design is concerned with the joint design of hardware and software making up an embedded computer system [Wol94]. A top down design flow for an embedded system begins with a system specification. If it is executable, it may be used for simulation, system verification or to identify algorithmical bottlenecks. In contrast to other chapters of this book, the specification is not developed in this case study, rather it is given from the beginning. Furthermore we are not concerned with partitioning or synthesis of dedicated HW. Instead we focus on the problem how to find an off-the-shelf micro-controller which implements the desired functionality and meets all specification constraints. If feasible, this is usually much cheaper then using dedicated hardware. This chapter will answer the question of feasibility for a real life problem from automobile industry.
With regard to performance well established SW-only design methodologies proceed by making the initial specification run first, then by enhancing its functionality and finally by optimizing it. When designing Embedded Systems (EbS) this approach is not viable since decisive design decisions like e.g. the estimation of required processing power or the identification of those parts of the specification which need to be delegated to dedicated HW depend on the fastness and fairness of the initial specification. We here propose a sequence of optimization steps embedded into the design flow, which enables a structured way to accelerate a given working EbS specification at different layers. This sequence of accelerations comprises algorithm selection, algorithm transformation, data transformation, implementation optimization and finally HW acceleration. It is analyzed how all acceleration steps are influenced by the specific attributes of the underlying EbS. The overall acceleration procedure is explained and quantified at hand of a real-life industrial example.
Linear Optimization
(2024)
The Peren Theorem
(2024)
Based on the WEF Travel & Tourism Report data, this study deploys k-means cluster analysis to build a global typology of national destination governance. Previous studies have focused on case studies, while this chapter focuses on classification of different destination types, by deploying indicators a set of following relevant indicators: wastewater treatment, fixed broadband internet subscriptions, ground transport efficiency, quality of roads, quality of railroad infrastructure, reliability of police services, ease of finding skilled employees. The results present a four-cluster solution of national destination governance types, as well as their major characteristics. The chapter than provides and discusses important implication for theory and practice of destination governance.
The labor market is dynamic and frequently calls for new skills, knowledge, and abilities. The changing needs of industry place a higher demand on institutions of higher learning to monitor trends in labor needs, identify skill gaps, and to use industry insights for developing programs and curricula that mold human resources to create value for employers and society at large. While several institutions of higher learning are responsive to industry needs through curricula reviews and the development of new programs, little attention is given to pedagogical issues that affect the delivery of knowledge and the development of skills intended by various education programs. Consequently, teachers are entrusted with the freedom to decide the teaching methods that are appropriate under each circumstance. Despite the changing face of the labor market, not much energy has been channeled towards adjusting teaching methods for effective delivery of skills required by students. The failure to adjust teaching methods for training graduates has led to what is commonly known as ‘halfbaked graduates’. In other words, graduates who lack the skills and abilities necessary for placement in the industry. However, the success of an institution of higher learning is illustrated by its ability to train people who perfectly match the needs of the industry.
Culture is the constellation of shared believes, mores, values, and traditions that define the behavior of people and it is unique to each community at local and national levels. Culture determines the languages spoken by the people, their attitude towards others, and their behavior. While the family is the immediate point through which culture is learned by children, socialization at institutions such as religious organizations, places of worship, schools, and the society’s dispute resolution system reinforce culture. Unlike the Internet, traditional media in the forms of local and national print and audio-visual content tend to reinforce cultural beliefs, values, and practices of specific communities. The uniqueness of culture creates market penetration challenges to entrepreneurs in international markets. Therefore, intercultural communication is a necessary skill for reducing cultural liability and increasing the success of entrepreneurial ventures.
Improving the Performance of Parallel SpMV Operations on NUMA Systems with Adaptive Load Balancing
(2018)
For a parallel Sparse Matrix Vector Multiply (SpMV) on a multiprocessor, rather simple and efficient work distributions often produce good results. In cases where this is not true, adaptive load balancing can improve the balance and performance. This paper introduces a low overhead framework for adaptive load balancing of parallel SpMV operations. It uses statistical filters to gather relevant runtime performance data and detects an imbalance situation. Three different algorithms were compared that adaptively balance the load with high quality and low overhead. Results show that for sparse matrices, where the adaptive load balancing was enabled, an average speedup of 1.15 (regarding the total execution time) could be achieved with our best algorithm over 4 different matrix formats and two different NUMA systems.
Sequencing Problems
(2024)
Dynamic Programming
(2024)