Refine
Departments, institutes and facilities
- Institut für funktionale Gen-Analytik (IFGA) (584) (remove)
Document Type
- Article (493)
- Conference Object (56)
- Part of a Book (29)
- Contribution to a Periodical (2)
- Doctoral Thesis (2)
- Preprint (1)
- Working Paper (1)
Year of publication
Keywords
- ENaC (13)
- apoptosis (9)
- cytokine-induced killer cells (9)
- immunotherapy (7)
- DNA methylation (5)
- Organic aciduria (5)
- CD21 (4)
- Inborn error of metabolism (4)
- 5-Methylcytosine (3)
- Amiloride (3)
- Arthritis (3)
- Bcl-2 (3)
- DNA damage (3)
- DNA typing (3)
- K/BxN (3)
- Ketolysis (3)
- Ketone body (3)
- Metabolic acidosis (3)
- Na+/K+-ATPase (3)
- autophagy (3)
- cancer (3)
- cell death (3)
- cytokine-induced killer (CIK) cells (3)
- delta-subunit (3)
- evolution (3)
- extremophiles (3)
- shedding (3)
- unfolded protein response (3)
- 3-hydroxyisobutyrate dehydrogenase (2)
- 3-hydroxyisobutyric aciduria (2)
- Aminoacylase (2)
- B cell activation (2)
- CIK cells (2)
- Canavan disease (2)
- Capillary electrophoresis – laser-induced fluorescence (2)
- Chronic lymphocytic leukemia (2)
- Complement receptor (2)
- Complement receptor 2/CD21 (2)
- Content Module (2)
- DNA (2)
- DNA adducts (2)
- Enzyme activity (2)
- Epithelial Na+ channel (2)
- Epithelial sodium channel (2)
- Fatty acid metabolism (2)
- Fuzzy logic (2)
- GLYCTK (2)
- Glycine conjugation (2)
- H2S (2)
- HIBADH (2)
- HIBADH deficiency (2)
- Hyperammonemia (2)
- IRE1 (2)
- Isovaleric acidemia (2)
- Ketoacidosis (2)
- Ketogenesis (2)
- Ketone body utilization (2)
- Mars (2)
- Mass spectrometry (2)
- Mast cells (2)
- Membrane Transport (2)
- Metabolic decompensation (2)
- Metabolicdecompensation (2)
- Movement disorder (2)
- NF-κB (2)
- Original Story (2)
- Oxidative stress (2)
- PERK (2)
- Programmed cell death (2)
- Rheumatoid arthritis (2)
- SLC (2)
- Shedding (2)
- Short tandem repeat (STR) (2)
- Valproic acid (2)
- Whole genome amplification (2)
- acetylcholine (2)
- cystic fibrosis (2)
- d-Glycerate kinase deficiency (2)
- d-Glyceric aciduria (2)
- edutainment (2)
- endocytosis (2)
- endoplasmic reticulum stress (2)
- epithelial sodium channel (ENaC) (2)
- extraterrestrial analogue (2)
- extremophile (2)
- force generation (2)
- fungi (2)
- fuzzy logic (2)
- gasotransmitter (2)
- hydrogen sulfide (2)
- hypermedia (2)
- ketogenesis (2)
- ketolysis (2)
- life detection (2)
- lymphoma (2)
- melanin (2)
- mucociliary clearance (2)
- myosin (2)
- organic aciduria (2)
- sodium channel (2)
- sodium self-inhibition (2)
- sodium transport (2)
- transgenic mice (2)
- water-to-land transition (2)
- 16S rRNA gene sequencing (1)
- 2B4 (1)
- 3-hydroxy-n-butyric acid (1)
- 3-hydroxyisobutyrate dehydrogenase deficiency (1)
- 3-hydroxyisobutyric acid dehydrogenase deficiency (1)
- 3D shape (1)
- 5-HT (1)
- 5-Oxoprolinase (1)
- 5-oxoprolinuria (1)
- ACAT1 (1)
- ACacylcarnitines (1)
- ADA2 (1)
- ADP release (1)
- AMAtypical myopathy (1)
- AMT (1)
- APC superfamily (1)
- AR (1)
- ASIC (1)
- ASPA (1)
- ATB0,+ (1)
- ATF4 (1)
- ATF6 (1)
- ATPase cycle (1)
- Acute lymphoblastic leukemia (1)
- Acylpeptide hydrolase (1)
- Adaptation (1)
- Affinity proteomics (1)
- Airway surface liquid (1)
- Algorithms (1)
- Alkane (1)
- Allicin (1)
- Amino Acid Sequence (1)
- Aminoacylase 1 (1)
- Amylose stationary phases (1)
- Anionic surfactant (1)
- Ankle Joint (1)
- Ankle thickness (1)
- Antarctic Polar Plateau (1)
- Antarctic ice sheet (1)
- Antibodies* (1)
- Antibody Induced Arthritis (1)
- Antibody analysis (1)
- Antigen analysis (1)
- Antiphospholipid syndrome (APS) (1)
- Apheresis therapy (1)
- Articular Cartilage (1)
- Aspartoacylase (1)
- Assay development (1)
- Augmented reality (1)
- Autism (1)
- Autoantibody (1)
- Automated multiple development (1)
- Autophagy induction (1)
- B cells (1)
- B lymphocyte (1)
- B-cell lymphoma (1)
- BAD (1)
- BLAST (1)
- Bacillus (1)
- Background music (1)
- Bacteria, Anaerobic (1)
- Bactericidal effect (1)
- Basis set (1)
- BcL-2 family (1)
- Bcl-2 proteins (1)
- Behcet’s Disease (1)
- Benzyl alkyl ammonium chloride (1)
- Beta-ketothiolase (1)
- Beta-ketothiolase deficiency (1)
- Bicycle Simulator (1)
- Biomarkers stability (1)
- Biophysics (1)
- Biosignatures (1)
- Biotin (1)
- Block copolymer (1)
- Breast (1)
- CD146 (1)
- CD30+ cells (1)
- CD40 (1)
- CD40, CTLA-4 (1)
- CDH1 (1)
- CE-LIF (1)
- CFTR (1)
- CFTR inhibitors (1)
- CFTR mutations (1)
- CHRNA (1)
- CIBERSORT (1)
- CIK-Zellen (1)
- CLL (1)
- CO (1)
- CR2 (1)
- CREBBP (1)
- Calcium signaling (1)
- Calcium storage (1)
- Cancer (1)
- Capillary electrophoresis (1)
- Carbapenem (1)
- Carboxy-terminal fragments (1)
- Carcinogenic (1)
- Cartilage Destruction (1)
- Caspase (1)
- Cationic surfactant (1)
- Cell activation (1)
- Cellulose stationary phases (1)
- Ceramides (1)
- Cervical cancer screening (1)
- Cervicovaginal microbiome (1)
- Chaetocin (1)
- Chalcogenide glass sensor (1)
- Chiral stationary phases (1)
- Chloroquine (1)
- Cholesterol (1)
- Chromatogramm (1)
- Cislunar (1)
- Cognition (1)
- Collision induced dissociation (1)
- Color/Spot-Test (1)
- Colposcopy (1)
- Complement (1)
- Complement receptor 2 (1)
- Complement receptor 2 /CD21 (1)
- Comprehensive two-dimensional liquid chromatography (1)
- Computer Graphics (1)
- Confocal microscopy (1)
- Container Structure (1)
- Cross-sensitivity (1)
- Cytochrome c (1)
- Cytokine (1)
- Cytokine-induced killer (CIK) cells (1)
- DADA2 (1)
- DBSdried blot spots (1)
- DEG/ENaC family (1)
- DIDMOAD (1)
- DNA double- strand breaks (1)
- DNA extraction protocols (1)
- DNA profile (1)
- Daptomycin (1)
- Database Management Systems (1)
- Databases, Factual (1)
- Deficiency of ADA2 (1)
- Degraded DNA (1)
- Dehydrogenase (1)
- Delta-ENaC (1)
- Diaminphenylderivat (1)
- Digital Storytelling (1)
- Diselenide bridge (1)
- Docking (1)
- Dried serum spots (1)
- Drift tube (1)
- Drug resistance (1)
- Dystonia (1)
- E-cadherin (1)
- EEG (1)
- EPHB2 (1)
- ER stress (1)
- ER-mitochondria crosstalk (1)
- ERAD (1)
- ERO1α (1)
- ESKAPEE pathogens (1)
- Ectodomain shedding (1)
- Electronic tongue (1)
- Elephantiasis (1)
- Enantioselective gas chromatography (1)
- Endoplasmatic reticulum (1)
- Endoplasmic reticulum (1)
- Endosomes (1)
- Endothelial cells (1)
- Enhancer (1)
- Enzyme activity assays (1)
- Epigenomics (1)
- Epilepsy (1)
- Epithelial-mesenchymal transition (1)
- Epitope mapping: Epitope extraction (1)
- Eriodictyol (1)
- Esterquat (1)
- Evans blue (1)
- Ewing´s Sarcoma Family of Tumors (1)
- ExoMars (1)
- Exome sequencing (1)
- FGR (1)
- FOXA1 (1)
- FOXP3 (1)
- Fabry disease (1)
- Familial glioma (1)
- Fatty acids (1)
- Fatty alcohol alkoxylate (1)
- Fatty alcohol alkoxylates (1)
- Fe-ion radiation (1)
- Fibroblast-like synoviocytes (FLS) (1)
- Food allergy (1)
- Forensic genetics (1)
- Forensic genomics (1)
- Forkhead (1)
- Fructose (1)
- GC × GC (1)
- GC×GC (1)
- GC–MSgas chromatography–mass spectrometry (1)
- GSK-3b (1)
- Galactic Cosmic Rays (GCRs) (1)
- Garlic (1)
- Gas chromatography (1)
- Gelatin Zymography (1)
- Genomics/methods (1)
- Genregulation (1)
- Gesamt-Exom-Sequenzierung (1)
- Glutathione (1)
- Glutathione synthetase (1)
- Glycerate (1)
- Glyceric aciduria (1)
- Glycine N-Acyltransferase (GLYAT) (1)
- Glycine N-acyltransferase (1)
- Glycogen storage disease type (1)
- Glycopeptides (1)
- Golgi (1)
- HCI (1)
- HDAC inhibitor (1)
- HIF1α (1)
- HILIC (1)
- HMGCL (1)
- HPLC Optimierung (1)
- HPTLC (1)
- HPV diagnostic (1)
- HSD10 (1)
- HSP90 (1)
- Head-Mounted Displays (1)
- Health care policy (1)
- High hyperdiploidy (1)
- High performance liquid chromatography (1)
- Histamine (1)
- Histamine receptors (1)
- Humans (1)
- Hydrophobic interaction (1)
- Hydrophobicity (1)
- Hydroxychloroquine (1)
- Hypoglycemia (1)
- IR microspectroscopy (1)
- Ikaros (1)
- Illegal Wildlife Trade (1)
- Immersive Virtual Environments (1)
- Immersive Visualization Environment (1)
- Immune escape (1)
- Immunoadsorption (1)
- Immunology* (1)
- In silico epitope prediction (1)
- In silico modelling (1)
- Inborn errors of metabolism (1)
- Inherited metabolic disorders (1)
- Inhibitor (1)
- Intellectual disability (1)
- Interactive computer graphics (1)
- Intracellular Ca2+ (1)
- Involution (1)
- Ion mobility (1)
- Ion mobility spectrometer (1)
- Ionizing radiation (1)
- Isoleucine (1)
- Isoleucine degradation (1)
- Joint Destruction (1)
- Juvenile arthritis (JA) (1)
- K/BxN mouse model (1)
- K/B×N model (1)
- Ketoasidoz (1)
- Ketogenic diet (1)
- Ketone body synthesis (1)
- Kozak-sequence (1)
- Krebsforschung (1)
- Kriminaltechnik (1)
- LCxLC-MS (1)
- LEF1 (1)
- LET (1)
- LFA-1 (1)
- Laser-induced fluorescence (1)
- Leg (1)
- LeuT (1)
- Leucine (1)
- Leucine degradation (1)
- Ligand -Receptor Interactions* (1)
- Linezolid (1)
- Lipophilicity (1)
- Lipophilicity potential (1)
- Locomotion (1)
- Lymphedema (1)
- Lysosome (1)
- Lysosomes (1)
- MADDMultiple acyl-CoA dehydrogenase deficiency (1)
- MALDI QIT TOF MS (1)
- MCF-10A (1)
- MCT (1)
- MICA/B (1)
- MMP-9 (1)
- MOCS1 (1)
- MP2.5 (1)
- MPV17 monoclonal antibody (1)
- MRPP (1)
- MS/MS peptide sequencing (1)
- MYB (1)
- Macrophage (1)
- Macrophage migration inhibitory factor (1)
- Macrophages (1)
- Magnetic resonance imaging (MRI) (1)
- Mammary (1)
- Marbled crayfish (1)
- Mars environment (1)
- Mars exploration (1)
- Matrix metalloproteases (1)
- Mechanosensitive (1)
- Media in education (1)
- Memory (1)
- Metabolic stroke (-like event) (1)
- Methylation (1)
- Methylmalonic acidemia (1)
- Methylmalonic aciduria (1)
- Methylmalonyl-CoAmutase (1)
- Methyltransferase (1)
- Micromanipulation (1)
- Mitochondria (1)
- Mitochondria associated ER membranes (1)
- Mitochondrial DNA depletion syndrome (1)
- Mitochondrial apoptogens (1)
- Mitochondrial outer membrane permeabilization (MOMP) (1)
- Mitochondrial tRNA (1)
- Moco deficiency (1)
- Molecular Sequence Data (1)
- Molecular dynamics (1)
- Molecular modelling (1)
- Molecular rotation (1)
- Molecular surface (1)
- Molybdenum cofactor (1)
- Monocarboxylate transporter 1 (1)
- Motion tracking (1)
- Multi-component heavy metal solution (1)
- N-acetylaspartic acid (1)
- N-acylated amino acids (1)
- N-isovalerylglycine (1)
- NGS (1)
- NKG2D (1)
- NO (1)
- NSS family (1)
- Na+ absorption (1)
- Na+/K+ ATPase (1)
- Narration Module (1)
- Native mass spectrometry (1)
- Neugeborenenscreening (1)
- Neurometabolic disease (1)
- Neuropilin (1)
- Next Generation Sequencing (NGS) (1)
- Next generation sequencing (1)
- Nitrogruppe (1)
- Nitrosamine (1)
- Non-covalent interaction MS* (1)
- Nonketotic hyperglycinemia (1)
- OA, organic acids (1)
- OXCT1 (1)
- Occupational safety (1)
- Off-target effects (1)
- Oligodendroglioma (1)
- Orai1 (1)
- Organic acids (1)
- Organic compounds and Functional groups (1)
- Organische Säuren (1)
- Orion (1)
- PCR inhibitors (1)
- PD-1/CTLA-4 (1)
- PDI (1)
- PK-B/Akt (1)
- PLASM (1)
- Pain Reduction (1)
- Partikeltechnologie (1)
- Partition coefficients (1)
- Patient serum (1)
- Peroxisomes (1)
- Pervanadate (1)
- Pharmacogenetics (1)
- Phase II reaction (1)
- Physical exercising game platform (1)
- Polymorphism (1)
- Pre-punched filter paper discs (1)
- Pregnancy (1)
- Probabilistic methods (1)
- Prognosis (1)
- Propionic acidemia (1)
- Propionic aciduria (1)
- Propionyl-CoA carboxylase (1)
- Proteasome (1)
- Proteasome maturation (1)
- Protein Conformation (1)
- Protein Folding (1)
- Protein complex analysis (1)
- Protein folding (1)
- Protein homeostasis (1)
- Protein-protein interaction (1)
- Proteins/chemistry (1)
- Proteome analysis (1)
- Pulmonary epithelium (1)
- Pyroglutamic aciduria (1)
- Quantum mechanical methods (1)
- Quasi equilibrium conditions (1)
- R751L (1)
- RAID (1)
- RAS (1)
- RELA (1)
- RELA haploinsufficiency (1)
- RELA-associated inflammatory disease (1)
- Raman and FTIR spectroscopies (1)
- Random copolymer (1)
- Redox potential (1)
- Relapse (1)
- Relative Energies (1)
- Restorative Virtual Environments (1)
- RhoA GTPases (1)
- S-sulfocysteine (1)
- SAHA (1)
- SARS-COV-2 virus (1)
- SARS-CoV-2 (1)
- SCNN1D (1)
- SERS (1)
- SGN-35 (1)
- SLC6 (1)
- SLC6A14 (1)
- SNPSTR (1)
- SOS-LC (1)
- STARLIFE project (1)
- Scalable Vector Graphic (1)
- Schmauchspur (1)
- Schusswaffe (1)
- Seizures (1)
- Selektives Screening (1)
- Selenocysteine (1)
- Sequence Homology, Amino Acid (1)
- Serine (1)
- Sexual assault (1)
- Shear force (1)
- Silmitasertib (1)
- Single sperm cells (1)
- Skin (1)
- Soluble CD21 (1)
- Soluble CD23 (1)
- Space radiation (1)
- Splicing (1)
- Star Trek (1)
- Store-operated calcium entry (1)
- Story Element (1)
- Stratum corneum lipids (1)
- Stress Management (1)
- Submerge and dry protocol (1)
- Submucosal plexus (1)
- Sulfite oxidase (1)
- Surfactants (1)
- Survey (1)
- Synovial fluid (1)
- Systemic lupus erythomatosus (SLE) (1)
- TNF inhibitors (1)
- TP53 (1)
- Tandem-Massenspektrometrie (1)
- Targeted mass spectrometry (1)
- Telemedicine (1)
- Telogen hair (1)
- Tetramerisation (1)
- Therapeutic antibodies* (1)
- Thiol antioxidants (1)
- Time–kill methodology (1)
- Transcriptional enhancer (1)
- Transgenic mice (1)
- Triangle mesh (1)
- UI design (1)
- UPR signaling (1)
- UV-vis spectroscopy (1)
- Urea cycle defect (1)
- Urinary organic acids (1)
- Urine organic acid analysis (1)
- Urothione (1)
- User-Centered Approach (1)
- User-Computer Interface (1)
- VR (1)
- Vascular permeability (1)
- Virtual Environment (1)
- Virtual Memory Palace (1)
- Virtual Reality (1)
- Virtual reality (1)
- Vitamin A acetate isomers (1)
- Vitamin B12/adenosylcobalamin (1)
- Western blot (1)
- Whole-genome sequencing (1)
- Wild Type Mouse (1)
- Wildlife Forensics (1)
- Wnt/β-catenin (1)
- Wolframin (1)
- X-STR (1)
- XBP1 (1)
- Xenopus (1)
- Xenopus laevis (1)
- Xenopus oocyte (1)
- Y-STR (1)
- Yeast (1)
- Yersinia toxins (1)
- ZAP-70 (1)
- Zytokin-induzierte Killerzellen (1)
- accelerated iron ions (1)
- acetoacetic acid (1)
- acetone (1)
- actin (1)
- acute (1)
- acute respiratory distress syndrome (1)
- adaptive filters (1)
- adoptive cell transfer (1)
- affective computing (1)
- air-blood barrier (1)
- airway (1)
- airway rehydration (1)
- airway smooth muscle (1)
- albuminuria (1)
- alkaline phosphatase (1)
- allopurinol (1)
- allosteric communication (1)
- allosteric regulation (1)
- altered mitochondrial homeostasis (1)
- alveolar epithelium (1)
- alveolar fluid (1)
- alveolar fluid transport (1)
- alveoli (1)
- amino acid transport (1)
- amino acid transporter (1)
- amplicon sequencing (1)
- anaplastic lymphoma kinase (1)
- anorganische Schmauchspur (1)
- anti-TNF (1)
- antibody–drug conjugate (1)
- arthritis (1)
- astrobiology (1)
- atopy (1)
- autoimmune disease (1)
- autoimmunity (1)
- autoinflammation (1)
- autoinflammatory (1)
- autoinflammatory diseases (1)
- automated electrophysiology (1)
- automatic segmentation (1)
- automation of sample processing (1)
- autophagy signaling pathways (1)
- bacteria (1)
- bdelloid rotifer (1)
- biochemical fingerprinting (1)
- biochemistry (1)
- biofilm removal (1)
- biofilm-related infections (1)
- bioinformatics (1)
- biomarker (1)
- black fungi (1)
- blebbistatin (1)
- bone marrow failure (1)
- brain computer interfaces (1)
- brain tumor (1)
- branched-chain amino acids (1)
- breast cancer (1)
- breathing (1)
- bronchus (1)
- brush cells (1)
- built environment (1)
- cPMP (1)
- cancer progression (1)
- cancer treatment (1)
- cannabidiol, immunotherapy (1)
- carbohydrate metabolism (1)
- carbon monoxide (1)
- carbon monoxide-releasing molecule (1)
- caspase (1)
- caspase-3 (1)
- caspases (1)
- caveolin-1 (1)
- cell division (1)
- cell stress (1)
- chaetocin (1)
- chemical pathology (1)
- chemical sensors (1)
- chemosensory cells (1)
- childhood (1)
- childhood cancer syndrome (1)
- cholinergic (1)
- chromatin remodeling (1)
- chymotrypsin (1)
- ciclopirox olamine (1)
- clear cell renal cell carcinoma (1)
- clinical study (1)
- clinical trials (1)
- colorimetry (1)
- common variable immunodeficiency (1)
- compensation (1)
- complete basis set limit (1)
- computer vision (1)
- conformations (1)
- constitutional mismatch repair syndrome (1)
- contraction (1)
- cosmic rays (1)
- cyanide (1)
- cysticfibrosis (1)
- cytoskeleton (1)
- data base search (1)
- deficiency of adenosine deaminase 2 (1)
- degraded DNA (1)
- desert cyanobacteria (1)
- diagnosis and management (1)
- differentiation (1)
- digital storytelling (1)
- disabled people (1)
- distributed authoring (1)
- drug detoxification (1)
- drugs (1)
- duty ratio (1)
- dynamin (1)
- electrochemical sensor (1)
- electrolyte transport (1)
- electrophysiology (1)
- electroretinography (1)
- electrostatic potential (1)
- emotion computing (1)
- endoplasmic reticulum (ER) stress (1)
- enzyme activity (1)
- epilepsy (1)
- epithelial sodium channel (1)
- epithelial sodium channels (1)
- epithelial transport (1)
- epitope mapping (1)
- erbliche Krebssyndrome (1)
- ethacrynic acid (1)
- exon fusion (1)
- extra column band broadening (1)
- extraction-linked bias (1)
- familial Mediterranean fever (1)
- fatty acid metabolism (1)
- fish gill (1)
- flow cytometry (1)
- forensic (1)
- forensic genetics (1)
- four-ply (1)
- fuel (1)
- fungal and bacterial amplicon sequencing (1)
- furin (1)
- gas exchange (1)
- gene expression (1)
- genes (1)
- genetic testing (1)
- genetics (1)
- genetische Testung (1)
- genome sequencing (1)
- genomic data (1)
- genotype-phenotype correlations (1)
- glycerol (1)
- glycerophosphocholine (1)
- glycosylation (1)
- growth hormone (1)
- guidelines (1)
- habitability (1)
- healthcare-associated infections (HAI) (1)
- heat shock proteins (1)
- heat shock response (1)
- heavy ion particle (HZE) radations (1)
- heavy metal (1)
- hematopoietic stem cell transplantation (1)
- hepatocellular carcinoma (1)
- heterozygous ALPL mutation (1)
- high-performance liquid chromatography (1)
- high-throughput DNA sequencing (1)
- high-throughput sequencing (1)
- histamine receptor (1)
- histamine receptor antagonist (1)
- histidine decarboxylase (1)
- histone deacetylase inhibitors (1)
- hospital environment (1)
- hospital-acquired infections (1)
- human microbiome (1)
- hydrocarbon (1)
- hypermedia applications (1)
- hypertension (1)
- hypogammaglobulinemia (1)
- hypophosphatasia (1)
- hypoxia (1)
- immune checkpoint inhibition programmed cell death-1 (1)
- immunhistochemistry (1)
- immunodeficiency (1)
- immunology (1)
- infection prevention (1)
- inflammasome (1)
- inherited metabolic disease (1)
- inhibitor (1)
- inorganic pyrophosphate (1)
- insertion (1)
- interactive computer graphics (1)
- interferon γ (1)
- interleukin-1beta (1)
- intrinsic pathway (1)
- ion-selective electrodes (1)
- isoleucine (1)
- isoleucine metabolism (1)
- ketogenesis defects (1)
- ketogenez defektleri (1)
- ketoliz defektleri (1)
- ketolysis defects (1)
- keton bodies (1)
- ketone body synthesis (1)
- klarzelliges Nierenzellkarzinom (1)
- leucine (1)
- leucine degradation (1)
- leukemia (1)
- life on Mars (1)
- life-detection (1)
- linguistic variable (1)
- linguistic variables (1)
- lipid (1)
- lipid biosynthesis (1)
- liquid chromatography (1)
- local lipophilicity (1)
- long interspersed nuclear element-1 (1)
- loss-of-function variants (1)
- lung (1)
- lung cancer (1)
- lung liquid clearance (1)
- lymphocytic (1)
- lysophosphatidylcholine (1)
- mTOR (1)
- macrophages. (1)
- major histocompatibility complex class I polypeptide-related sequence A (MICA) (1)
- mammary gland (1)
- massive parallel sequencing (1)
- member D (NKG2D) (1)
- membrane trafficking (1)
- metabolic acidosis (1)
- metabolic effects (1)
- metabolic integration (1)
- metabolically active cells (1)
- methylmalonic acidaemia (1)
- methylmalonic acidemia (1)
- microbial community structure (1)
- microbial ecology (1)
- microbiome (1)
- microbiome analyses (1)
- microcephaly (1)
- microdialysis (1)
- micromanipulation (1)
- mitochondrial biogenesis (1)
- mitosis (1)
- mixed reality (1)
- mixed-mode chromatography (1)
- molecular docking (1)
- molecular dynamics simulations (1)
- molecular evolution (1)
- molecular motor (1)
- molecular surfaces (1)
- momentary frequency (1)
- monoclonal antibody (1)
- mouse model (1)
- mp2 (1)
- mucosal ulcers (1)
- multiple myeloma (1)
- multiple myeloma (MM) (1)
- muscarine (1)
- mutation (1)
- myogenesis (1)
- natural killer group 2 (1)
- next generation sequencing (1)
- nicotine and phosphocholine (1)
- nitric oxide (1)
- non-apoptotic roles (1)
- non-small cell lung cancer (1)
- nonlinear storytelling (1)
- nosocomial infections (1)
- nucleic acids (1)
- nutrient germinants (1)
- octane (1)
- optimized geometries (1)
- organic acid analysis (1)
- organische Schmauchspur (1)
- outer space (1)
- outside-out (1)
- pH (1)
- paediatric clinical genetics & dysmorphology (1)
- paediatric endocrinology (1)
- paediatric intensive & critical care (1)
- panspermia (1)
- patch clamp (1)
- patch-clamp (1)
- pathogen control (1)
- pathophysiology (1)
- peptide sequencing (1)
- pharmacokinetics (1)
- phenylketonuria (1)
- phosphoethanolamine (1)
- photometry (1)
- physiology (1)
- pigments (1)
- planetary protection (1)
- porphyria (1)
- power stroke (1)
- primary airway epithelial cells (1)
- probiotic cleaning (1)
- probiotic-based cleaning formulations (1)
- proliferation (1)
- propan-2-ol (1)
- propionic acidaemia (1)
- propionic acidemia (1)
- protease (1)
- protein microarray (1)
- protein secretion (1)
- proteomics (1)
- proximal tubule (1)
- pseudogene (1)
- pure red cell aplasia (1)
- pyridoxal phosphate (1)
- pyrin inflammasome (1)
- qPCR (1)
- quantum mechanics (1)
- radiation (1)
- radioresistance (1)
- real-time PCR (1)
- recurrent ketoacidotic episodes (1)
- renal cancer (1)
- renal cell carcinoma (1)
- renal tubular cells (1)
- resistance (1)
- retinal degeneration (1)
- rheumatoid arthritis (1)
- rodent (1)
- rodents (1)
- sCD21 (1)
- sFRP-4 (1)
- salt (1)
- screening (1)
- see-through display (1)
- selectivity tuning (1)
- sensitize (1)
- sequencing (1)
- serine-threonine kinase (1)
- serum and glucocorticoid-induced kinase 1 (1)
- sexual assault (1)
- short tandem repeat (1)
- short tandem repeat (STR) (1)
- single-cell RNA-seq (1)
- sirtuins (1)
- skin cancer (1)
- small molecule (1)
- sodium absorption (1)
- sodium/potassium-exchanging ATPase (1)
- solute carrier (1)
- space radiation environment (1)
- sperm cell (1)
- spore resistance (1)
- sporegermination (1)
- stationary phase (1)
- story authoring (1)
- structural biology (1)
- superficially porous particles (1)
- surface sanitization (1)
- surface shape (1)
- surface topography (1)
- surface topology (1)
- surrogate endpoint (1)
- survival (1)
- symbiosis (1)
- system optimization (1)
- tRNA processing (1)
- taste (1)
- temporomandibular joint (1)
- tetrapod (1)
- therapy (1)
- thermophoresis (1)
- three-ply (1)
- tiglyglycine (1)
- time series processing (1)
- transient kinetics (1)
- transient receptor potential vanilloid Type 2 (1)
- transporter (1)
- triiodothyronine (1)
- tumor microenvironment (1)
- tumor-infiltrating immune cells (1)
- two-electrode voltage clamp (1)
- ubiquitination (1)
- unfolded protein response (UPR) (1)
- urethra (1)
- urethral brush cells (1)
- valine catabolic pathway (1)
- valine degradation (1)
- van Deemter curve (1)
- vasculitis (1)
- voltage-independent Na+ channel (1)
- water dimer (1)
- whole genome amplification (WGA) (1)
- whole-exome sequencing (1)
- µCT (1)
- β-catenin (1)
- β-cells (1)
- γ-glutamyl cycle (1)
Two distinct sequence elements mediate retroviral gene expression in embryonal carcinoma cells
(1987)
Methoden zur computerunterstützten Untersuchung selektiver Oberflächeneigenschaften von Proteinen
(1993)
Fast generation of molecular surfaces from 3D data fields with an enhanced "marching cube" algorithm
(1993)
The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species
(1994)
We propose a new alignment procedure that is capable of aligning protein sequences and structures in a unified manner. Recursive dynamic programming (RDP) is a hierarchical method which, on each level of the hierarchy, identifies locally optimal solutions and assembles them into partial alignments of sequences and/or structures. In contrast to classical dynamic programming, RDP can also handle alignment problems that use objective functions not obeying the principle of prefix optimality, e.g.\ scoring schemes derived from energy potentials of mean force. For such alignment problems, RDP aims at computing solutions that are near-optimal with respect to the involved cost function and biologically meaningful at the same time. Towards this goal, RDP maintains a dynamic balance between different factors governing alignment fitness such as evolutionary relationships and structural preferences. As in the RDP method gaps are not scored explicitly, the problematic assignment of gap cost parameters is circumvented. In order to evaluate the RDP approach we analyse whether known and accepted multiple alignments based on structural information can be reproduced with the RDP method. For this purpose, we consider the family of ferredoxins as our prime example. Our experiments show that, if properly tuned, the RDP method can outperform methods based on classical sequence alignment algorithms as well as methods that take purely structural information into account.
ATM virtual studio services
(1996)
The term "virtual studio" refers to real-time 3D graphics systems used to render a virtual set in sync with live camera motion. As the camera pans and zooms, the virtual set is redrawn from the correct perspective. Using blue room techniques, actors in front of the real camera are then “placed in” the virtual set. Current virtual studio systems are centralized – the blue room, cameras, renderers etc. are located at a single site. However distributed configurations offer significant economies such as the sharing of expensive rendering equipment among many sites. This paper describes early expe- riences of the DVP1 project in the realization of a distributed virtual studio. In particular we de- scribe the first video production using a distributed virtual studio over ATM and make observations concerning network QOS requirements.
This paper presents an overview on and reports on early experiences of the European ACTS project AC089 called „Distributed Video Production (DVP)“ which started in late 1995. Central to DVP are distributed pilot applications for professional digital video production over ATM broadband networks (LAN and WAN). Distributed video production refers to situations where the cameras, recorders, switches, mixers and other equipment used in video production (or post-production) are located at several sites linked by high bandwidth network connections. The DVP project investigates requirements of broadcasters for several forms of distributed video production and runs a series of trials of distributed virtual studios, distributed rehearsals and remote video editing and retrieval. Together with North American partners a transatlantic broadband ATM link will be tested for distributed virtual reality simulations. This paper reports about two initial tests with a German public broadcaster and the German Telekom. DVP project partners are GMD and about 20 broadcasters, computer and video equipment manufacturers, and video production companies. More information can be obtained from http://viswiz.gmd.de/DVP
Distributed Video Production
(1996)
Video production is inherently distributed: Broadcasters are physically distributed over several sites and studios, they increasingly outsource video production and post-production to specialized studios or upcoming virtual studios. Thus there is an increasing demand for the enabling technology for distributed video production.
Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis
(1996)
Benches and CAVEs
(1997)
Der virtuelle Wetterfrosch
(1997)
Expression of the apoptosis-inhibitory protein Bcl-2 has frequently been detected in human cancer including mammary carcinoma. The functional significance of its expression has been well established in experimental tumors of the lymphoid system, however, remains to be elucidated for epithelial tumors. In order to assess the role of Bcl-2 in mammary tumorigenesis we have generated WAP-bcl-2 transgenic mice. The strong overexpression of Bcl-2 in lactating mammary glands was preserved during early postlactational involution and apoptosis of alveolar epithelial cells was prevented without influencing the dedifferentiation of the milk-producing epithelium. Although Bcl-2 overexpression was not sufficient to induce spontaneous tumors it, however, led to an accelerated development of MMTV myc transgene-induced mammary tumors. In the mammary glands of MMTV myc transgenic mice, a high proportion of apoptotic cells was detected which was significantly reduced in the mammary glands of WAP-bcl-2/ MMTV myc double transgenic mice. Taken together, these results suggest that Bcl-2 contributes to mammary tumorigenesis by inhibiting apoptosis.
Benches and Caves
(1998)
MOTIVATION: The genome projects produce a wealth of protein sequences. Theoretical methods to predict possible structures and functions are needed for screening purposes, large-scale comparisons and in-depth analysis to identify worthwhile targets for further experimental research. Sequence-structure alignment is a basic tool for the identification of model folds for protein sequences and the construction of crude structural models. Empirical contact potentials (potentials of mean force) are used to optimize and evaluate such alignments. RESULTS: We propose new scoring schemes based on a contact definition derived from Voronoi decompositions of the three-dimensional coordinates of protein structures. We demonstrate that Voronoi potentials are superior to pure distance-based contact potentials with respect to recognition rate and significance for native folds. Moreover, the scoring scheme has the potential to provide a reasonable balance of detail and ion such that it is also useful for the recognition of distantly related (both homologous and non-homologous) proteins. This is demonstrated here on a set of structural alignments showing much better correspondence of native and model scores for the Voronoi potentials as compared to conventional distance-based potentials.
Benches and Caves
(1998)
Imagine a person navigating on the trackball of a mouse - it would need full body control. In this article we describe the Virtual Balance, an input device for a responsive virtual environment. This device is driven by weight shift on a small platform and does neither require special training nor wearing uncomfortable equipment. The Virtual Balance aims at intuitive navigation through complex 3D space. It can be used to skate or fly like on a magic carpet through a virtual world. With shifts of body posture the navigator controls speed and direction of his/her movement in the model world, which is calculated from the changing pressure on three weight cells under the platform. Different fields of application are presented, showing scenarios already realized as well as a variety of possibilities for future use.
Bcl-2 is an anti-apoptotic and anti-proliferative protein over-expressed in several different human cancers including breast. Gain of Bcl-2 function in mammary epithelial cells was superimposed on the WAP-TAg transgenic mouse model of breast cancer progression to determine its effect on epithelial cell survival and proliferation at three key stages in oncogenesis: the initial proliferative process, hyperplasia, and cancer. During the initial proliferative process, Bcl-2 strongly inhibited both apoptosis and mitotic activity. However as tumorigenesis progressed to hyperplasia and adenocarcinoma, the inhibitory effects on mitotic activity were lost. In contrast, anti-apoptotic activity persisted in both hyperplasias and adenocarcinomas. These results demonstrate that the inhibitory effect of Bcl-2 on epithelial cell proliferation and apoptosis can separate during cancer progression. In this model, retention of anti-apoptotic activity with loss of anti-proliferative action resulted in earlier tumor presentation.
Bcl-2 is an anti-apoptotic and anti-proliferative protein over-expressed in several different human cancers including breast. Gain of Bcl-2 function in mammary epithelial cells was superimposed on the WAP-TAg transgenic mouse model of breast cancer progression to determine its effect on epithelial cell survival and proliferation at three key stages in oncogenesis: the initial proliferative process, hyperplasia, and cancer. During the initial proliferative process, Bcl-2 strongly inhibited both apoptosis and mitotic activity. However as tumorigenesis progressed to hyperplasia and adenocarcinoma, the inhibitory effects on mitotic activity were lost. In contrast, anti-apoptotic activity persisted in both hyperplasias and adenocarcinomas. These results demonstrate that the inhibitory effect of Bcl-2 on epithelial cell proliferation and apoptosis can separate during cancer progression. In this model, retention of anti-apoptotic activity with loss of anti-proliferative action resulted in earlier tumor presentation.
//
Bcl-2 is an anti-apoptotic and anti-proliferative protein over-expressed in several different human cancers including breast. Gain of Bcl-2 function in mammary epithelial cells was superimposed on the WAP-TAg transgenic mouse model of breast cancer progression to determine its effect on epithelial cell survival and proliferation at three key stages in oncogenesis: the initial proliferative process, hyperplasia, and cancer. During the initial proliferative process, Bcl-2 strongly inhibited both apoptosis and mitotic activity. However as tumorigenesis progressed to hyperplasia and adenocarcinoma, the inhibitory effects on mitotic activity were lost. In contrast, anti-apoptotic activity persisted in both hyperplasias and adenocarcinomas. These results demonstrate that the inhibitory effect of Bcl-2 on epithelial cell proliferation and apoptosis can separate during cancer progression. In this model, retention of anti-apoptotic activity with loss of anti-proliferative action resulted in earlier tumor presentation.
Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo
(1999)
The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50% during the first stage and increased cell survival 70% during the second stage. Complete loss of Bax reduced apoptosis by 20% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo.
Bcl-2 is known to have dual antiproliferative and antiapoptotic roles. Overexpression of Bcl-2 in the mammary gland using a whey acidic protein (WAP) promoter-driven Bcl-2 transgene inhibits apoptosis in the mammary gland during pregnancy, lactation, and involution, and also counteracts apoptosis induced by overexpression of a mutant p53 transgene (WAP-p53 172 R-L). WAP-Bcl-2 mice and nontransgenic controls were treated with the carcinogen dimethylbenz(a)anthracene (DMBA). Surprisingly, the nontransgenic mice developed mammary tumors with decreased latency. Tumors arising in WAP-Bcl-2 mice displayed substantially reduced levels of proliferation relative to those seen in nontransgenic mice (P < 0.015), perhaps resulting in the observed increase in tumor latency following carcinogen treatment. This WAP-Bcl-2 mouse tumor model reflects the situation seen in some human breast cancers overexpressing Bcl-2, where expression of Bcl-2 has been shown to correlate with a lower proliferative index in tumors.
Virtuelle Umgebungen
(2000)