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Mensch-Roboter-Kollaboration
(2016)
Eine enge Zusammenarbeit von Mensch und Roboter, die sogenannte Mensch-Roboter-Kollaboration (MRK), könnte eine bisher beispielslose Produktivität entstehen lassen. Bis zur allgemeinen Nutzung der Technologie sind noch zahlreiche Probleme zu lösen, insbesondere die des Arbeits- und Gesundheitsschutzes. Am Institut für Sicherheitsforschung der Hochschule Bonn-Rhein-Sieg wurde in den vergangenen Jahren eine Reihe von Projekten zur Entwicklung von optischen Sensorsystemen für Schutzeinrichtungen durchgeführt. Im Projekt SPAI (Sichere Personendetektion im Arbeitsbereich von Industrierobotern durch ein aktives NIR-Kamerasystem) wurde ein spezielles Kamerasystem für den nahinfraroten (NIR) Spektralbereich entwickelt.
Nicht im Elfenbeinturm
(2016)
Domestic Robotics
(2016)
Dieser Artikel stützt sich auf das vom 13.10.2015 bis 12.01.2016 gemeinsam durchgeführten Praxisprojekt von ORBIT und der Hochschule Bonn-Rhein-Sieg. Thema des Projekts waren die Methodenevaluation und Automatisierung von Auswertungsprozessen. Speziell ging es um die Überprüfung der von ORBIT entwickelten Methodik zur Anforderungsanalyse und Standortbestimmung – dem ORBIT-Navigator.
Neues Lizenzmanagement
(2016)
This report summarises and integrates two different tracks of research for the purpose of envisioning and preparing a joint research project proposal. Soft- and hardware systems have become increasingly complex and act "concurrently", both with respect to memory access (i.e. information flow) and computational resources (i.e. "services"). The software development metaphor of cloud-storage, cloud-computing and service-oriented design has been anticipated by artificial intelligence (AI) research at least 30 years ago (parallel and distributed computation already dates back to the 1950’s and 1970s). What is known as a "service" today is what in AI is known as the capability of an agent; and the problem of information flow and consistency has been a headstone of information processing ever since. Based on a real-world robotics application we demonstrate how an increasingly abstract description of collaborating or competing agents correspond to a set of concurrent processes.
Mit den Themen Digitalisierung, Big Data, Industrie 4.0 und Cloud-Computing erfährt auch Geschäftsprozessmanagement immer mehr Aufmerksamkeit. Doch was sind die Treiber und Einflussfaktoren für erfolgreiches Business Process Management? Der BPM-Compass 2016 zeigt, dass Menschen auch während der digitalen Transformation entscheidend für erfolgreich umgesetzte Geschäftsprozesse sind.
Job-related migration has been fostered across Europe balancing unemployment in one country with demands for employees in others. However, the numbers of early school leavers and university dropouts significantly increased in the hosting countries. We propose a higher measure of cultural sensitivity in education in order to prevent frustration. The Learning Culture Survey investigates learners’ expectations towards and perceptions of education on international level with the aim to make culture in the context of education better understandable. After a brief introduction, we subsume the steps taken during the past seven years and found results. Subsequently, we introduce a method for the determination of conflict potential, which bases on the understanding of culture as the level to which people within a society accept deviations from the usual. We close with demonstrating the usefulness of the data and insights from our Learning Culture Survey in the context of practical scenarios.
In this paper, we introduce the international program erp4students as general example on how to successfully prepare university students for the world of works without having to give up the basic principle in higher education, i.e., to exclusively provide sustainable education. We start with introducing the basic concept and design of the program and provide information regarding the demographic development over the past decade and implemented quality assurance mechanisms. Subsequently, the scope and design of and hitherto achieved insights from the Learning Culture Survey are outlined. On the basis of found results, we finally discuss how erp4students can deal with possible culture-specific issues that latest might emerge when the program gets available for learners in the Asian context.
Marketing und Recht kompakt
(2016)
"Marketing und Recht - was soll das denn?" So oder ähnlich wird der eine oder andere auf den Titel des vorliegenden Buches spontan reagieren. Das verwundert nicht, ist die Buch-Landschaft doch vor allem dadurch geprägt, dass Marketing-Werke und Abhandlungen zu marketingrelevanten Rechtsthemen am Büchermarkt stets "getrennt marschieren". Wer Marketingkonzepte entwirft, Vorhaben im Rahmen der Marketingforschung durchführen will oder beabsichtigt, Entscheidungen im Rahmen des Marketings zu treffen, sollte unseres Erachtens möglichst frühzeitig die gängigen "juristischen Fallstricke" erkennen und in seinen Überlegungen berücksichtigen.
Effects of Workspace Awareness and Territoriality in Environments with Large, Shared Displays
(2016)
Synchronous cooperative work of multiple collaborators in large, high-resolution display systems comprises such psychological phenomena like workspace awareness and human territoriality. The phenomena and interplay between them can cause a significant impact on human-human and human-environment interaction. In a non-digital environment humans rely on their own physical abilities, utilities, and social protocols to control those phenomena (e.g. close eyes, or use earplugs to reduce workspace awareness; rotate oneself towards collaborators to increase workspace awareness). Digital environments, on the other hand, provide us with a possibility to ease, automate, and unify control processes, thus taking off that burden from users. Yet, we have to understand first, what effects workspace awareness and territoriality have within a collaborative environment. The aim of this doctoral thesis is to investigate effects of workspace awareness and territoriality on users and interaction processes in mixed-focus scenarios of various collaborative settings.
The aim of design science research (DSR) in information systems is the user-centred creation of IT-artifacts with regard to specific social environments. For culture research in the field, which is necessary for a proper localization of IT-artifacts, models and research approaches from social sciences usually are adopted. Descriptive dimension-based culture models most commonly are applied for this purpose, which assume culture being a national phenomenon and tend to reduce it to basic values. Such models are useful for investigations in behavioural culture research because it aims to isolate, describe and explain culture-specific attitudes and characteristics within a selected society. In contrast, with the necessity to deduce concrete decisions for artifact-design, research results from DSR need to go beyond this aim. As hypothesis, this contribution generally questions the applicability of such generic culture dimensions’ models for DSR and focuses on their theoretical foundation, which goes back to Hofstede’s conceptual Onion Model of Culture. The herein applied literature-based analysis confirms the hypothesis. Consequently, an alternative conceptual culture model is being introduced and discussed as theoretical foundation for culture research in DSR.
MOOCs in POM Education
(2016)
Basic demand from enterprises towards academic education: provide students not only methodological/theoretical knowledge, but also prepare them for the future tasks in the world of works! This contradicts academia’s focus on sustainably teaching basic principles. With the extra-curricular international online program erp4students, we successfully managed to bridge this "conflict-of-interest”.
Recent years have seen extensive adoption of domain generation algorithms (DGA) by modern botnets. The main goal is to generate a large number of domain names and then use a small subset for actual C&C communication. This makes DGAs very compelling for botmasters to harden the infrastructure of their botnets and make it resilient to blacklisting and attacks such as takedown efforts. While early DGAs were used as a backup communication mechanism, several new botnets use them as their primary communication method, making it extremely important to study DGAs in detail.
In this paper, we perform a comprehensive measurement study of the DGA landscape by analyzing 43 DGAbased malware families and variants. We also present a taxonomy for DGAs and use it to characterize and compare the properties of the studied families. By reimplementing the algorithms, we pre-compute all possible domains they generate, covering the majority of known and active DGAs. Then, we study the registration status of over 18 million DGA domains and show that corresponding malware families and related campaigns can be reliably identified by pre-computing future DGA domains. We also give insights into botmasters’ strategies regarding domain registration and identify several pitfalls in previous takedown efforts of DGA-based botnets. We will share the dataset for future research and will also provide a web service to check domains for potential DGA identity.
Helping Johnny to Analyze Malware: A Usability-Optimized Decompiler and Malware Analysis User Study
(2016)
Noch sind sich die Experten nicht einig, wie schnell Blockchain das Internet revolutionieren wird. Dass das Potenzial dafür riesig ist, ist sich Professor Jens Böcker sicher. Er unterhält eine Professur für Betriebswirtschaftslehre und Marketing an der Hochschule Bonn-Rhein-Sieg und forscht zu diesem Thema.
Ohne Zweifel kein Wissen und keine Innovation, dies gilt für die Forschung im Allgemeinen und natürlich auch an unserer Hochschule. Gerade in der Wissenschaft ist der methodische Zweifel oft der Ausgangspunkt einer spezifischen Untersuchung. Er soll dabei behilflich sein, Klarheit zu erlangen. Frei nach dem Philosophen Rene Descartes: Was kann ich eigentlich mit Sicherheit wissen? Nur wer ab und an zweifelt, der schaut um die Ecke, stellt sich, andere und seine Umwelt in Frage, sucht nach neuen Wegen, Antworten und strebt nach Veränderung. Und auch dort, wo Wissenschaft vermittelt wird, also im Seminar, in einer Übung oder Vorlesung, muss Platz sein für eine selbstreflexive Grundhaltung. An der H-BRS ist Zweifeln also nicht nur erlaubt, sondern erwünscht.
Noncooperative Game Theory
(2016)
Doubting - Path to Science
(2016)
The analysis of Δ9-tetrahydrocannabinol (THC) and its metabolites 11-hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH) from blood serum is a routine task in forensic toxicology laboratories. For examination of consumption habits, the concentration of the phase I metabolite THC-COOH is used. Recommendations for interpretation of analysis values in medical-psychological assessments (regranting of driver’s licenses, Germany) include threshold values for the free, unconjugated THC-COOH. Using a fully automated two-step liquid-liquid extraction, THC, 11-OH-THC, and free, unconjugated THC-COOH were extracted from blood serum, silylated with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA), and analyzed by GC/MS. The automation was carried out by an x-y-z sample robot equipped with modules for shaking, centrifugation, and solvent evaporation. This method was based on a previously developed manual sample preparation method. Validation guidelines of the Society of Toxicological and Forensic Chemistry (GTFCh) were fulfilled for both methods, at which the focus of this article is the automated one. Limits of detection and quantification for THC were 0.3 and 0.6 μg/L, for 11-OH-THC were 0.1 and 0.8 μg/L, and for THC-COOH were 0.3 and 1.1 μg/L, when extracting only 0.5 mL of blood serum. Therefore, the required limit of quantification for THC of 1 μg/L in driving under the influence of cannabis cases in Germany (and other countries) can be reached and the method can be employed in that context. Real and external control samples were analyzed, and a round robin test was passed successfully. To date, the method is employed in the Institute of Legal Medicine in Giessen, Germany, in daily routine. Automation helps in avoiding errors during sample preparation and reduces the workload of the laboratory personnel. Due to its flexibility, the analysis system can be employed for other liquid-liquid extractions as well. To the best of our knowledge, this is the first publication on a comprehensively automated classical liquid-liquid extraction workflow in the field of forensic toxicological analysis.
The development of advanced robotic systems is challenging as expertise from multiple domains needs to be integrated conceptually and technically. Model-driven engineering promises an efficient and flexible approach for developing robotics applications that copes with this challenge. Domain-specific modeling allows to describe robotics concerns with concepts and notations closer to the respective problem domain. This raises the level of abstraction and results in models that are easier to understand and validate. Furthermore, model-driven engineering allows to increase the level of automation, e.g. through code generation, and to bridge the gap between modeling and implementation. The anticipated results are improved efficiency and quality of the robotics systems engineering process. Within this contribution, we survey the available literature on domain-specific modeling and languages that target core robotics concerns. In total 137 publications were identified that comply with a set of defined criteria, which we consider essential for contributions in this field. With the presented survey, we provide an overview on the state-of-the-art of domain-specific modeling approaches in robotics. The surveyed publications are investigated from the perspective of users and developers of model-based approaches in robotics along a set of quantitative and qualitative research questions. The presented quantitative analysis clearly indicates the rising popularity of applying domain-specific modeling approaches to robotics in the academic community. Beyond this statistical analysis, we map the selected publications to a defined set of robotics subdomains and typical development phases in robotic systems engineering as reference for potential users. Furthermore, we analyze these contributions from a language engineering viewpoint and discuss aspects such as the methods and tools used for their implementation as well as their documentation status, platform integration, typical use cases and the evaluation strategies used for validation of the proposed approaches. Finally, we conclude with recommendations for discussion in the model-driven engineering and robotics community based on the insights gained in this survey.
The Fifth International Conference on Advances in Vehicular Systems, Technologies and Applications (VEHICULAR 2016), held between November 13-17, 2016 - Barcelona, Spain, continued the inaugural event considering the state-of-the-art technologies for information dissemination in vehicle-to-vehicle and vehicle-to-infrastructure and focusing on advances in vehicular systems, technologies and applications.
With the rising interest in vehicular communication systems many proposals for secure vehicle-to-vehicle commu- nication were made in recent years. Also, several standard- ization activities concerning the security and privacy measures in these communication systems were initiated in Europe and in US. Here, we discuss some limitations for secure vehicle- to-infrastructure communication in the existing standards of the European Telecommunications Standards Institute. Next, a vulnerability analysis for roadside stations on one side and security and privacy requirements for roadside stations on the other side are given. Afterwards, a proposal for a multi-domain public key architecture for intelligent transport systems, which considers the necessities of road infrastructure authorities and vehicle manufacturers, is introduced. The domains of the public key infrastructure are cryptographically linked based on local trust lists. In addition, a crypto agility concept is suggested, which takes adaptation of key length and cryptographic algorithms during PKI operation into account.
Steigende psychische Arbeitsanforderungen werden im betrieblichen Alltag zunehmend als Normalität empfunden. Trotz erhöhtem Leistungsdruck werden Arbeitspausen oftmals unregelmäßig bis gar nicht wahrgenommen, obwohl mit einer Pause eine gesteigerte Erholung und eine erhöhte Produktivität einhergehen. Der vorliegende Artikel zeigt auf, wie Arbeitspausen und deren systematische Implementierung zu einem "gesunden Unternehmen" beitragen können.
IT-Controlling
(2016)
Nachhaltige und zukunftsfähige Mobilität in Städten kann langfristig nur durch die aktive Partizipation ihrer Bürger und Institutionen erreicht werden. Betriebliches Mobilitätsmanagement (BMM) kann dabei einen positiven Beitrag im Hinblick auf Umwelt, Gesundheit und Kosten leisten. Die vorliegende Arbeit beschäftigt sich mit der Wahrnehmung gesundheitlicher und finanzieller Wertschöpfungsaspekte des BMM. Im Rahmen des Forschungsprojekts Betriebe lösen Verkehrsprobleme werden Mobilitätsverhalten und Maßnahmen der Betrieblichen Gesundheitsförderung (BFG) in Bonner Betrieben untersucht. Folgenden Aspekten wird besondere Beachtung geschenkt: Bedeutung Betrieblicher Gesundheitsförderung in Bonner Betrieben, Mobilitätsverhalten von Arbeitnehmern auf dem Weg zur Dienststelle, Wahrnehmung eines unmittelbaren Zusammenhangs zwischen körperlicher Aktivität und Gesundheit bzw. krankheitsbedingter Kosten und Umsatzeinbußen durch Bewegungsmangel. Die Analyse resultiert auf der Basis einer schriftlichen Befragung von 178 Unternehmen, einer Online-Umfrage von 1.341 Mitarbeitern aus 14 Unternehmen sowie auf persönlichen Interviews mit 22 Betriebsleitern bzw. Mobilitäts- und Gesundheitsbeauftragten. Die Ergebnisse der Studie machen sowohl Handlungsbedarf als auch Optimierungspotentiale im Bereich BMM auf Betriebsseite deutlich. Kostensimulationen zeigen darüber hinaus auf, dass durch die Implementierung von BGF-Maßnahmen, explizit der Förderung von Bewegung, auf betriebs- und volkswirtschaftlicher Seite beachtliche Kosten im Gesundheitsbereich eingespart sowie höhere Gewinne im Unternehmen erzielt werden können.
The design of future materials for biotechnological applications via deposition of molecules on surfaces will require not only exquisite control of the deposition procedure, but of equal importance will be our ability to predict the shapes and stability of individual molecules on various surfaces. Furthermore, one will need to be able to predict the structure patterns generated during the self-organization of whole layers of (bio)molecules on the surface. In this review, we present an overview over the current state of the art regarding the prediction and clarification of structures of biomolecules on surfaces using theoretical and computational methods.
Der Weltklimavertrag versucht, sowohl auf das Umsteuern bei klimaschädlichem Wirtschaften in den Industrieländern (und einigen Schwellenländern) als auch auf das Vermeiden von klimaschädlicher Ausgestaltung des Wirtschaftens in den Schwellen- und Entwicklungsländern eine Antwort zu geben. Doch noch ist diese Antwort zu abstrakt.
Cognitive robotics aims at understanding biological processes, though it has also the potential to improve future robotics systems. Here we show how a biologically inspired model of motor control with neural fields can be augmented with additional components such that it is able to solve a basic robotics task, that of obstacle avoidance. While obstacle avoidance is a well researched area, the focus here is on the extensibility of a biologically inspired framework. This work demonstrates how easily the biological inspired system can be used to adapt to new tasks. This flexibility is thought to be a major hallmark of biological agents.
A deployment of the Vehicle-to-Vehicle communication technology according to ETSI is in preparation in Europe. Currently, a Public Key Infrastructure policy for Intelligent Transport Systems in Europe is in discussion to enable V2V communication. This policy set aside two classes of keys and certificates for ITS vehicle stations: long term authentication keys and pseudonymous keys and certificates. We show that from our point of view the periodic sent Cooperative Awareness Messages with extensive data have technical limitations and together with the pseudonym concept cause privacy problems.
Supported by their large size and high resolution, display walls suit well for different collaboration types. However, in order to foster instead of impede collaboration processes, interaction techniques need to be carefully designed, taking into regard the possibilities and limitations of the display size, and their effects on human perception and performance. In this paper we investigate the impact of visual distractors (which, for instance, might be caused by other collaborators' input) in peripheral vision on short-term memory and attention. The distractors occur frequently when multiple users collaborate in large wall display systems and may draw attention away from the main task, as such potentially affecting performance and cognitive load. Yet, the effect of these distractors is hardly understood. Gaining a better understanding thus may provide valuable input for designing more effective user interfaces. In this article, we report on two interrelated studies that investigated the effect of distractors. Depending on when the distractor is inserted in the task performance sequence, as well as the location of the distractor, user performance can be disturbed: we will show that distractors may not affect short term memory, but do have an effect on attention. We will closely look into the effects, and identify future directions to design more effective interfaces.
Für die prototypische Erstellung von Virtual Reality (VR) Szenen auf Grundlage realer Umgebungen bieten sich Daten aus aktuellen Panorama-Kameras an. Diese Daten eignen sich jedoch nicht unmittelbar für die Integration in eine Game Engine. Wir stellen daher ein projektionsbasiertes Verfahren vor, mit dem Bilder und Videos im Fischaugenformat, wie sie z.B. die 360 Kamera Ricoh Theta erstellt, ohne Konvertierung in Echtzeit mit Hilfe der Unity Game Engine visualisiert werden können. Es wird weiterhin gezeigt, dass ein Panoramabild mit diesem Verfahren leicht manuell um grobe Tiefeninformation erweitert werden kann, sodass bei einer Darstellung in VR ein grober räumlicher Eindruck der Szene für einfach prototypische Umsetzungen ermöglicht wird.
We propose an artificial slime mould model (ASMM) inspired by the plasmodium of Physarum polucephalum (P. polucephalum). ASMM consists of plural slimes, and each slime shares energy via a tube with neighboring slimes. Outer slimes sense their environment and conform to it. Outer slimes periodically transmit information about their surrounding environment via a contraction wave to inner slimes. Thus, ASMM shows how slimes can sense a better environment even if that environment is not adjacent to the slimes. The slimes subsequently can move in the direction of an attractant.
The work at hand outlines a recording setup for capturing hand and finger movements of musicians. The focus is on a series of baseline experiments on the detectability of coloured markers under different lighting conditions. With the goal of capturing and recording hand and finger movements of musicians in mind, requirements for such a system and existing approaches are analysed and compared. The results of the experiments and the analysis of related work show that the envisioned setup is suited for the expected scenario.
Das Optimalziel für ein Logistiklager ist eine hohe Auslastung des Transportsystems. Es stellt sich somit die Frage nach der Auswahl der Aufträge, die gleichzeitig innerhalb des Lagers abgearbeitet werden, ohne Staus, Blockaden oder Überlastungen entstehen zu lassen. Dieser Auswahlprozess wird auch als Path-Packing bezeichnet. Diese Masterthesis untersucht das Path-Packing auf graphentheoretischer Ebene und stellt verschiedene Greedy-Heuristiken, eine Optimallösung auf Basis der Linearen Programmierung sowie einen kombinierten Ansatz gegenüber. Die Ansätze werden anhand von Messzeiten und Auslastungen unterschiedlich randomisiert erstellter Testdaten ausgewertet.
Wireless sensor networks are widely used in a variety of fields including industrial environments. In case of a clustered network the location of cluster head affects the reliability of the network operation. Finding of the optimum location of the cluster head, therefore, is critical for the design of a network. This paper discusses the optimisation approach, based on the brute force algorithm, in the context of topology optimisation of a cluster structure centralised wireless sensor network. Two examples are given to verify the approach that demonstrate the implementation of the brute force algorithm to find an optimum location of the cluster head.
Nachhaltiges Innovationsmanagement in KMU: Eine empirische Untersuchung zu Living Labs as a Service
(2016)
Die neue europäische Umweltstrategie der Integrierten Produktpolitik fordert von produzierenden kleinen und mittleren Unternehmen (KMU) eine eigenverantwortliche und produktbezogene Nachhaltigkeitsstrategie. Obgleich die Gestaltung von IKT-Services in nachhaltigkeitsrelevanten Bereichen ein großes Marktpotential verspricht, birgt das Innovationsmanagement für KMU einige Risiken. Um diese Herausforderungen zu adressieren motiviert diese Arbeit Living Labs, als Innovationsinfrastruktur, um den spezifischen Bedarfen von KMU für ein nachhaltiges Innovationsmanagement gerecht zu werden. Auf der Basis von 15 semi-strukturierten Interviews mit 7 KMU, die IKT-Lösungen in den Bereichen Wohnen und Mobilität entwickeln, wurden Herausforderungen sowie etablierte Strategien für ein nachhaltiges Innovationsmanagement erhoben sowie Potenziale und mögliche Risiken von Living Labs exploriert. Die Studie zeigt KMU spezifische Bedarfe auf, die eine Anpassung des Living Lab Ansatzes als Service-Dienstleistungen erforderlich machen.
Kleinere, günstigere und effizientere Sensoren und Aktoren sowie Funkprotokolle haben dazu geführt, dass Smart Home Produkte in zunehmend auch für den privaten Massenmarkt erschwinglich werden. Damit stehen Hersteller und Anbieter vor der Herausforderung, komplexe cyber-physische Systeme für Jedermann handhabbar zu gestalten. Es fehlen allerdings empirische Erkenntnisse über die Rolle von Smart Home im Alltag. Wir präsentieren Ergebnisse aus einer Living Lab Studie, in der 14 Haushalte mit einer am Markt erhältlichen Smart Home Nachrüstlösung ausgestattet und über neun Monate empirisch begleitet wurden. Anhand der Analyse von Interviews, Beobachtungen und Co-Design Workshops in den Phasen der Produktauswahl, Installation, Konfiguration und längerfristigen Nutzung zeigen wir Herausforderungen und Potentiale von Smart Home Systemen auf. Unsere Erkenntnisse deuten darauf hin, dass das Smart Home immer noch von technischen Details dominiert wird. Zugleich fehlen Nutzern angemessene Steuerungs- und Kontrollmöglichkeiten, um weiterhin die Entscheidungshoheit im eigenen Zuhause zu behalten.
SDN and WMN evolved to be sophisticated technologies used in a variety of applications. However, a combined approach called wmSDN has not been widely addressed in the research community. Our idea in this field consists of WiFi-based point-to-point links managed by the OpenFlow protocol. We investigate two different issues regarding this idea. First, which WiFi operational mode is suitable in an OpenFlow managed broadcast domain? Second, does the performance decrease compared with other routing or switching principles? Therefore, we set up a real-world testbed and a suitable simulation environment. Unlike previous work, we show that it is possible to use WiFi links without conducting MAC address rewriting at each hop by utilizing the 4-address-mode.
Das Cutting sticks-Problem ist ein NP-vollständiges Problem mit Anwendungspotenzialen im Bereich der Logistik. Es werden grundlegende Definitionen für die Behandlung sowie bisherige Ansätze zur Lösung des Problems aufgearbeitet und durch einige neue Aussagen ergänzt. Insbesondere stehen Ideen für eine algorithmische Lösung des Problems bzw. von Varianten des Problems im Fokus.
Mobilitäts- und Nachhaltigkeitsforscher sehen sich bei der Erforschung des Mobilitätsverhaltens von Personen mit einer bunten Palette an Erhebungsmethoden konfrontiert. Erweitert wird diese Vielfalt in der letzten Zeit durch die Möglichkeit, dieses Verhalten direkt über die Smartphones der Probanden zu erfassen. Um die Auswahl geeigneter Methoden zu erleichtern, liefert die vorliegende Literaturstudie einen detaillierten Überblick zu Fragestellungen, Daten und Erhebungsmethoden, die im Bereich der Mobilitätsforschung zur Erfassung von Alltagsmobilität eingesetzt werden.
We demonstrated previously that phosphocholine and phosphocholine-modified macromolecules efficiently inhibit ATP-dependent release of interleukin-1β from human and murine monocytes by a mechanism involving nicotinic acetylcholine receptors (nAChR). Interleukin-1β is a potent pro-inflammatory cytokine of innate immunity that plays pivotal roles in host defence. Control of interleukin-1β release is vital as excessively high systemic levels cause life threatening inflammatory diseases. In spite of its structural similarity to acetylcholine, there are no other reports on interactions of phosphocholine with nAChR. In this study, we demonstrate that phosphocholine inhibits ion-channel function of ATP receptor P2X7 in monocytic cells via nAChR containing α9 and α10 subunits. In stark contrast to choline, phosphocholine does not evoke ion current responses in Xenopus laevis oocytes, which heterologously express functional homomeric nAChR composed of α9 subunits or heteromeric receptors containing α9 and α10 subunits. Preincubation of these oocytes with phosphocholine, however, attenuated choline-induced ion current changes, suggesting that phosphocholine may act as a silent agonist. We conclude that phophocholine activates immuno-modulatory nAChR expressed by monocytes but does not stimulate canonical ionotropic receptor functions.
Hydrogen sulfide (H2S) is a well-known environmental chemical threat with an unpleasant smell of rotten eggs. Aside from the established toxic effects of high-dose H2S, research over the past decade revealed that cells endogenously produce small amounts of H2S with physiological functions. H2S has therefore been classified as a gasotransmitter. A major challenge for cells and tissues is the maintenance of low physiological concentrations of H2S in order to prevent potential toxicity. Epithelia of the respiratory and gastrointestinal tract are especially faced with this problem, since these barriers are predominantly exposed to exogenous H2S from environmental sources or sulfur-metabolising microbiota. In this paper, we review the cellular mechanisms by which epithelial cells maintain physiological, endogenous H2S concentrations. Furthermore, we suggest a concept by which epithelia use their electrolyte and liquid transport machinery as defence mechanisms in order to eliminate exogenous sources for potentially harmful H2S concentrations.
Hydrogen sulfide contributes to hypoxic inhibition of airway transepithelial sodium absorption
(2016)
BWL für Dummies
(2016)
"BWL für Dummies" führt kompetent, prägnant und umfassend in die Betriebswirtschaftslehre ein. Dabei werden die wesentlichen Elemente der Betriebswirtschaftslehre praxisorientiert vorgestellt und in ihrem Zusammenhang dargestellt. Folgende Themen werden behandelt: Materialwirtschaft, Leistungsbereitstellung und Produktion, Marketing, Investition und Finanzierung, Unternehmensorganisation und -führung, Rechnungswesen, Controlling.
An exploratory study: Analysis of Serbian tourism market and identification of major market segments
(2016)
The Participation Act, introduced in the Netherlands in 2015, puts into practice the idea that every individual has to make a contribution in a participatory society. The Act includes aspects of income support, compulsory activities in return for benefits, and labour market reintegration. Drawing on 45 interviews, we provide insights into interactions between the individual financial and social situation, an individual’s position in society, and reintegration activities. The narratives show the fundamental need for individual freedom and societal meaning, recognition, and appreciation, as well as the complex circumstances in which social assistance recipients make decisions. Conflicts between those needs and the Act lead to the question of how personal and societal objectives can be reconciled.