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Cloud-Services gelten als zukunftsträchtiges Konzept zur Bereitstellung von IT-Leistungen und verdrängen zunehmend klassische IT-Outsourcing-Modelle. Allerdings weichen noch viele Unternehmen auf traditionelle Bereitstellungskonzepte (z. B. Betrieb eines eigenen Rechenzentrums, Klassisches Outsourcing) aus. Ein Grund hierfür ist das fehlende Vertrauen in die „Cloud“. Der Kunde kann in der Regel die möglichen Risiken und das Sicherheitsniveau des Anbieters nicht beurteilen, da er meist auch keine direkte Einsicht in die Abläufe und Strukturen des Dienstleisters hat (Winkelmann, 2010).
Die weitere Verbreitung von Cloud-Diensten hängt stark davon ab, ob die Leistungsabnehmer ausreichend Vertrauen in die IT-Dienstleister, die technische Infrastruktur und das gesamte organisatorisch-rechtliche Umfeld (z.B. auch den jeweiligen Rechtsschutz, Anspruchs- und Klagemöglichkeiten) haben. Eine Möglichkeit, diese Situation im Sinne einer Entscheidungshilfe zu verbessern ist es, ein neutrales „Zertifikat für ITSicherheit von Cloud-Services“ zu nutzen. Im Rahmen der weiteren Vertrauensbildung in die „Cloud“ ist der unabhängigen Zertifizierung von Cloud-Services eine erhebliche Bedeutung beizumessen.
Dieses White-Paper beschreibt typische Kategorien von Cloud-Services, thematisiert die hohe Bedeutung des Vertrauens in die Cloud und geht auf Anforderungen an eine „vertrauenswürdige Zertifizierung von Cloud-Dienstleistungen“ (Trusted Cloud-Services) ein.
Abschließend wird ein praxisreifes Lösungsangebot zur Zertifizierung von Cloud-Diensten vorgestellt, welches die zuvor beschriebenen Anforderungen erfüllen kann.
YAWL Symposium 2013. Proceedings of the First YAWL Symposium, Sankt Augustin, Germany, June 7, 2013
(2013)
Wirtschaftsinformatikstudium an Universitäten und Fachhochschulen – Konvergenz oder Differenzierung?
(2013)
Wirtschaft und Entwicklung: Die Bedeutung der Privatwirtschaft in der Entwicklungszusammenarbeit
(2013)
Web-based Editor for YAWL
(2013)
This paper presents a web-based editor that offers YAWL editing capabilities and comprehensive support for the XML format of YAWL. The open-source project Signavio Core Components is extended with a graphical user interface (GUI) for parts of the YAWL Language, and an import-/export component that converts between YAWL and the internal format of Signavio Core Components. This conversion, between the web-based editor and the offcial YAWL Editor, is lossless so both tools may be used together. Compared to the offcial YAWL Editor, the web-based editor is missing some features, but could still facilitate the usage of the YAWL system in use cases that are not supported by a desktop application.
Vom Signal zur Information
(2013)
"Die richtige Information zur richtigen Zeit am richtigen Ort", so lautet das Diktum der modernen Informationsgesellschaften. Methoden zur Beschaffung aktueller Informationen lernen die Studierenden des Fachbereichs Sozialversicherung gleich in mehreren Modulen während ihres Studiums in Hennef. Auf die Nutzung von BG-internen Informationssystemen wird dabei ebenso eingegangen wie auf die Inanspruchnahme sogenannter Informationsprovider wie beispielsweise dem Deutschen Institut für Medizinische Dokumentation und Information (DIMDI) oder den National Institutes of Health (NIH).
Die Jahresberichte der Hochschule Bonn-Rhein-Sieg haben jedes Mal ein anderes Schwerpunktthema. Für den Jahresbericht 2012 lautet das Thema "Verantwortlich handeln und Vorbild sein: Die Hochschule in der Gesellschaft".
Den Anfang bildet ein Gespräch zwischen dem Intendanten der Deutschen Welle, Erik Bettermann, und Hochschulpräsident Hartmut Ihne über Verantwortung in der Ausbildung und das Engagement in der Entwicklungszusammenarbeit. In den Kapiteln Studium & Lehre, Forschung, Campus, Region und Internationales findet sich ein vielfältiges Themenspektrum, wobei die Übergänge fließend sind, denn viele Themen ließen sich auch durchaus anderen Kapiteln zuordnen.
Sonderseiten sind in der neuen Ausgabe der "Pause" gewidmet: Forschungssemestern und Sabbatjahr, die Pause im wissenschaftlichen Fokus oder die ganz normale Kaffeepause. Pausen müssen sein.
Using an Embroidery Machine to Achieve a Deeper Understanding of Electromechanical Applications
(2013)
Unternehmen sind in verstärktem Ausmaß Veränderungen der Umwelt ausgesetzt. Mit zunehmender Globalisierung und der wachsenden Komplexität der Wertschöpfungsnetze steigt die Anzahl der Veränderungen, ihre Geschwindigkeit und Stärke und zwingt die Unternehmen schneller und öfter zu zeitnahen (Re-)Aktionen. Die Planung erlaubt es mögliche Entwicklungen gedanklich vorwegzunehmen und frühzeitig rationale richtungweisende Entscheidungen zu treffen, Potenziale zu erschließen, zu sichern und zu nutzen sowie Risiken zu erkennen, zu analysieren und zu minimieren. Die Kontrolle der Entscheidungen erlaubt eine Ursachenanalyse der Abweichungen zwischen Planung und Realität. Kontrolle bildet damit die Basis für Lernprozesse in Unternehmen.
Updating a shared data structure in a parallel program is usually done with some sort of high-level synchronization operation to ensure correctness and consistency. However, underlying synchronization instructions in a processor architecture are costly and rather limited in their scalability on larger multi-core/multi-processors systems. In this paper, we examine work queue operations where such costly atomic update operations are replaced with non-atomic modifiers (simple read+write). In this approach, we trade the exact amount of work with atomic operations against doing more and redundant work but without atomic operations and without violating the correctness of the algorithm. We show results for the application of this idea to the concrete scenario of parallel Breadth First Search (BFS) algorithms for undirected graphs on two large NUMA shared memory system with up to 64 cores.
In this paper we present the steps towards a well-designed concept of a 5VR6 system for school experiments in scientific domains like physics, biology and chemistry. The steps include the analysis of system requirements in general, the analysis of school experiments and the analysis of input and output devices demands. Based on the results of these steps we show a taxonomy of school experiments and provide a comparison between several currently available devices which can be used for building such a system. We also compare the advantages and shortcomings of 5VR6 and 5AR6 systems in general to show why, in our opinion, 5VR6 systems are better suited for school-use.
The aim of our research is preserving the learners’ initial motivation in educational settings by avoiding unnecessary conflicts that could decrease the learners’ joy of learning. In order to get a better understanding of particularly cul-ture-related factors that could jeopardize the learners’ motivation in international e-Learning scenarios, we devel-oped and exemplarily implemented the standardized questionnaire ‘Learning Culture’ in the Higher Education contexts of Germany and South Korea. Regarding motivation, we analysed how the students evaluated their own motivational predispositions towards outer influences, their purpose of learning and affections towards particular knowledge, and their strategies to deal with educational tasks that appear unmanageable or too difficult for them.
The reciprocal translocation t(12;21)(p13;q22), the most common structural genomic alteration in B-cell precursor acute lymphoblastic leukaemia in children, results in a chimeric transcription factor TEL-AML1 (ETV6-RUNX1). We identified directly and indirectly regulated target genes utilizing an inducible TEL-AML1 system derived from the murine pro B-cell line BA/F3 and a monoclonal antibody directed against TEL-AML1. By integration of promoter binding identified with chromatin immunoprecipitation (ChIP)-on-chip, gene expression and protein output through microarray technology and stable labelling of amino acids in cell culture, we identified 217 directly and 118 indirectly regulated targets of the TEL-AML1 fusion protein. Directly, but not indirectly, regulated promoters were enriched in AML1-binding sites. The majority of promoter regions were specific for the fusion protein and not bound by native AML1 or TEL. Comparison with gene expression profiles from TEL-AML1-positive patients identified 56 concordantly misregulated genes with negative effects on proliferation and cellular transport mechanisms and positive effects on cellular migration, and stress responses including immunological responses. In summary, this work for the first time gives a comprehensive insight into how TEL-AML1 expression may directly and indirectly contribute to alter cells to become prone for leukemic transformation.
The BRICS component model: a model-based development paradigm for complex robotics software systems
(2013)
One idea behind Open Educational Resources (OERs) is opening up the access to learning resources for stakeholders who were not the originally targeted users. Even though making educational resources available for the public already is a remarkable achievement, their usefulness often is limited to a very particular context because of unclear or missing appropriateness regarding other contexts. In this paper, contextual appropriateness is investigated as a special quality criterion for OERs. We will introduce barriers against the use of OERs and demands from the educational community that need to be addressed in order to overcome such barriers. We will show that the hitherto implemented quality standards for Technology Enhanced Learning do not yet fully support such particular demands and discuss which additional steps are required for the context of OERs. We conclude with an outlook and recommendations that can open up the full potential of OERs.
Tamoxifen therapy of invasive breast cancer has been associated with increased levels of endothelin-1 (ET-1) so that an endothelin-1 receptor (ETR) blockade has been suggested as a new therapeutic approach. This study analyzed the relationship between Tamoxifen and ET-1 signalling in invasive breast cancer. Using paraffinized tissue from 50 randomly chosen cases of invasive and in-situ ductal carcinoma from our archive, the expression of ETRs was analyzed by immune histology. ETRs were regularly detectable in normal breast tissue, but rarely in adjacent tumor areas (3/50 cases). By immunoprecipitation, a complex was found consisting of ET-1, estrogen receptors and Tamoxifen. Consequently, transcription of several target genes of ET-1 and estrogen receptors was detectable (interleukin-6, wnt-11 and a vimentin spliceform). In particular, the combination of Tamoxifen, ET-1, and estrogen receptors induced further increasing levels of these target genes. Some of these genes have been found upregulated in metastatically spreading breast cancer cells. We conclude: i) ETRs do not play a role in invasive or in-situ ductal breast cancer; ii) estrogen receptors and Tamoxifen build a complex with ET-1; and iii) upregulated transcription of target genes by ET-1–estrogen receptor–Tamoxifen complex may negatively influence breast cancer prognosis. These results indicate a role for ET-1 in Tamoxifen treated breast cancer patients leading to a potentially worsening prognosis.
The Report starts with an interview between Eric Bettermann, Director of the German radio station Deutsche Welle, and University President Hartmut Ihne, which deals with responsibility in education and our University’s activities in the area of development cooperation. The chapters “Studies & Research”, “Research”, “Campus” , “The Region and International Issues” cover a wide spectrum of topics that are not rigidly defined because many topics might just as readily be assigned to other chapters.
In the latest edition, some special pages have been dedicated to the topic of “Taking a break”, i.e. to research semesters and sabbaticals, to breaks as a scientific focal point or to absolutely normal coffee breaks. Breaks are an essential part of our lives.
Molecular modeling is an important subdomain in the field of computational modeling, regarding both scientific and industrial applications. This is because computer simulations on a molecular level are a virtuous instrument to study the impact of microscopic on macroscopic phenomena. Accurate molecular models are indispensable for such simulations in order to predict physical target observables, like density, pressure, diffusion coefficients or energetic properties, quantitatively over a wide range of temperatures. Thereby, molecular interactions are described mathematically by force fields. The mathematical description includes parameters for both intramolecular and intermolecular interactions. While intramolecular force field parameters can be determined by quantum mechanics, the parameterization of the intermolecular part is often tedious. Recently, an empirical procedure, based on the minimization of a loss function between simulated and experimental physical properties, was published by the authors. Thereby, efficient gradient-based numerical optimization algorithms were used. However, empirical force field optimization is inhibited by the two following central issues appearing in molecular simulations: firstly, they are extremely time-consuming, even on modern and high-performance computer clusters, and secondly, simulation data is affected by statistical noise. The latter provokes the fact that an accurate computation of gradients or Hessians is nearly impossible close to a local or global minimum, mainly because the loss function is flat. Therefore, the question arises of whether to apply a derivative-free method approximating the loss function by an appropriate model function. In this paper, a new Sparse Grid-based Optimization Workflow (SpaGrOW) is presented, which accomplishes this task robustly and, at the same time, keeps the number of time-consuming simulations relatively small. This is achieved by an efficient sampling procedure for the approximation based on sparse grids, which is described in full detail: in order to counteract the fact that sparse grids are fully occupied on their boundaries, a mathematical transformation is applied to generate homogeneous Dirichlet boundary conditions. As the main drawback of sparse grids methods is the assumption that the function to be modeled exhibits certain smoothness properties, it has to be approximated by smooth functions first. Radial basis functions turned out to be very suitable to solve this task. The smoothing procedure and the subsequent interpolation on sparse grids are performed within sufficiently large compact trust regions of the parameter space. It is shown and explained how the combination of the three ingredients leads to a new efficient derivative-free algorithm, which has the additional advantage that it is capable of reducing the overall number of simulations by a factor of about two in comparison to gradient-based optimization methods. At the same time, the robustness with respect to statistical noise is maintained. This assertion is proven by both theoretical considerations and practical evaluations for molecular simulations on chemical example substances.
Providing universal access to social protection and health systems for all members of society, including the poor and vulnerable, is increasingly considered crucial to international development debates. This is the first book to explore from an interdisciplinary and global perspective the reforms of social protection systems introduced in recent years by many governments of low and middle-income countries.
Fast täglich werden neue Angriffe auf IT-Systeme bekannt, bei denen sensible Daten entwendet werden. Das vorliegende Buch vermittelt die wesentlichen Grundlagen und Technologien, die zur Absicherung von Computernetzwerken benötigt werden. Stets legen die Autoren dabei Wert auf eine verständliche Darstellung, die – soweit möglich – auf abstrakte Modelle und formalen Notationen verzichtet. Zu jedem Kapitel werden Aufgaben zur Kontrolle von Wissensstand und Verständnis angeboten.
Für die Durchführung größerer Projekte innerhalb des DLR ist es häufig notwendig, dass sich Wissenschaftler fachübergreifend in Themengebiete einarbeiten müssen. Im Rahmen dieser Einarbeitung führen Wissenschaftler Recherchen in fremden Fachbereichen durch. Das DLR hat zu diesem Zweck das Wissensportal KnowledgeFinder entwickelt. Dieses Framework setzt klassische Suchverfahren zum Auffinden von Informationen in beliebigen Datenbeständen ein. Wenn Wissenschaftler in fremden Fachbereichen recherchieren, dann fällt es ihnen aufgrund des oberflächlichen Einblicks oftmals schwer, zielgerichtet nach Informationen zu suchen. Die im KnowledgeFinder eingesetzten klassischen Suchverfahren, die auf textueller und struktureller Ähnlichkeit basieren, können bei diesen unspezifischen Suchanfragen nur bedingt beim Auffinden von relevanten Informationen helfen. Aufgrund von Mehrdeutigkeiten und unterschiedlichen Kontexten stoße solche Verfahren oftmals an ihre Grenzen. Semantische Technologien haben zum Ziel diesen Mangel zu beheben. Hier wird neben der textuellen und strukturellen Ähnlichkeit zusätzlich die Dimension der Bedeutung betrachtet. In dieser Masterthesis wurde untersucht, ob die Suchergebnisqualität des KnowledgeFinder durch den Einsatz semantischer Technologien verbessert werden kann. Innerhalb einer Machbarkeitsstudie wurde dazu das KnowledgeFinder Framework um semantische Suchverfahren erweitert. Diese Verfahren sollen die fachübergreifende Recherche von DLR-Wissenschaftlern erleichtern, indem sie ihnen helfen, passende Suchergebnisse in den entsprechenden Fachbereichen zu finden.
Traffic simulations are generally used to forecast traffic behavior or to simulate non-player characters in computer games and virual environments. These systems are usually modeled in such a way that traffic rules are strictly followed. However, rule violations are a common part of real-life traffic and thus should be integrated into such models.
Satzung der Fachschaft Wirtschaftswissenschaften der Hochschule Bonn-Rhein-Sieg vom 24.04.2013
(2013)
The device (10) has a handrail (18) provided with an optical contactless monitoring device formed as an active sensor system, where the monitoring device is arranged in a region of a guide (14) of the handrail at a front base (16) of an escalator (12) or a moving pavement. The monitoring device has two transmission paths (28, 30) with wavelength bands that are different from each other, where one of the paths includes the handrail. Ratio or difference between signals of the paths is used for recognizing foreign bodies e.g. hands of adults and children.
The Java Virtual Machine (JVM) executes the compiled bytecode version of a Java program and acts as a layer between the program and the operating system. The JVM provides additional features such as Process, Thread, and Memory Management to manage the execution of these programs. The Garbage Collection (GC) is part of the memory management and has an impact on the overall runtime performance because it is responsible for removing dead objects from the heap. Currently, the execution of a program needs to be halted during every GC run. The problem of this stop-the-world approach is that all threads in the JVM need to be suspended. It would be desirable to have a thread-local GC that only blocks the current thread and does not affect any other threads. In particular, this would improve the execution of multi-threaded Java programs. An object that is accessible by more than one thread is called escaped. It is not possible to thread-locally determine if escaped objects are still alive so that they cannot be handled in a thread-local GC. To gain significant performance improvements with a thread-local GC, it is therefore necessary to determine if it is possible to reliably predict if a given object will escape. Experimental results show that the escaping of objects can be predicted with high accuracy based on the line of code the object was allocated from. A thread-local GC was developed to minimize the number of stop-the-world GCs. The prototype implementation delivers a proof-of-concept that shows that this goal can be achieved in certain scenarios.
Issues in an issue tracking system contain different kinds of information like requirements, features, development tasks, bug reports, bug fixing tasks, refactoring tasks and so on. This information is generally accompanied by discussions or comments, which again are different kinds of information (e.g. social interaction, implementation ideas, stack traces or error messages). We propose to improve automatic categorization of this information and use the categorized data to support software engineering tasks. We want to obtain improvements in two different ways. Firstly, we want to obtain algorithmic improvements (e.g. natural language processing techniques) to retrieve and use categorized auxiliary data. Secondly we want to utilize multiple task-based categorizations to support different software engineering tasks.
Real-Time Simulation of Camera Errors and Their Effect on Some Basic Robotic Vision Algorithms
(2013)
Reactive oxygen species and the bacteriostatic and bactericidal effects of isoconazole nitrate
(2013)
Qualitätsverbesserung und Zeitersparnis bei der Stipendienvergabe durch automatisierten Workflow
(2013)
Für die Vergabe der Deutschlandstipendien hatte die Hochschule anfangs ein Verfahren festgelegt, das viel manuelle Arbeitsschritte umfasst: Die Studierenden hatten ihre Bewerbungsunterlagen schriftlich einzureichen. Dazu gehörten neben einem Motivationsschreiben, einem Ausdruck des aktuellen Notenspiegels alle weiteren Referenzen zur Einschätzung der Bewerbung gemäß den gesetzlichen Auswahlkriterien. Als Grundlage zur Bewertung der „sozialen Kriterien“ sollten die Bewerberinnen und Bewerber ein Gutachten eines Professors oder einer Professorin der Hochschule einholen.
BACKGROUND
Propionic acidemia is an inherited disorder caused by deficiency of propionyl-CoA carboxylase. Although it is one of the most frequent organic acidurias, information on the outcome of affected individuals is still limited.
STUDY DESIGN/METHODS
Clinical and outcome data of 55 patients with propionic acidemia from 16 European metabolic centers were evaluated retrospectively. 35 patients were diagnosed by selective metabolic screening while 20 patients were identified by newborn screening. Endocrine parameters and bone age were evaluated. In addition, IQ testing was performed and the patients' and their families' quality of life was assessed.
RESULTS
The vast majority of patients (>85%) presented with metabolic decompensation in the neonatal period. Asymptomatic individuals were the exception. About three quarters of the study population was mentally retarded, median IQ was 55. Apart from neurologic symptoms, complications comprised hematologic abnormalities, cardiac diseases, feeding problems and impaired growth. Most patients considered their quality of life high. However, according to the parents' point of view psychic problems were four times more common in propionic acidemia patients than in healthy controls.
CONCLUSION
Our data show that the outcome of propionic acidemia is still unfavourable, in spite of improved clinical management. Many patients develop long-term complications affecting different organ systems. Impairment of neurocognitive development is of special concern. Nevertheless, self-assessment of quality of life of the patients and their parents yielded rather positive results.
Produktionswirtschaft
(2013)
PhD Project Management
(2013)
We derive rates of convergence for limit theorems that reveal the intricate structure of the phase transitions in a mean-field version of the Blume-Emery-Griffith model. The theorems consist of scaling limits for the total spin. The model depends on the inverse temperature β and the interaction strength K. The rates of convergence results are obtained as (β,K) converges along appropriate sequences (βn,Kn) to points belonging to various subsets of the phase diagram which include a curve of second-order points and a tricritical point. We apply Stein's method for normal and non-normal approximation avoiding the use of transforms and supplying bounds, such as those of Berry-Esseen quality, on approximation error. We observe an additional phase transition phenomenon in the sense that depending on how fast Kn and βn are converging to points in various subsets of the phase diagram, different rates of convergences to one and the same limiting distribution occur.
Ornithine transcarbamylase (OTC) deficiency is the most common urea cycle defect. The clinical presentation in female manifesting carriers varies both in onset and severity. We report on a female with insulin dependent diabetes mellitus and recurrent episodes of hyperammonemia. Since OTC activity measured in a liver biopsy sample was within normal limits, OTC deficiency was initially excluded from the differential diagnoses of hyperammonemia. Due to moderately elevated homocitrulline excretion, hyperornithinemia-hyperammonemia-homocitrullinuria-syndrome was suggested, but further assays in fibroblasts showed normal ornithine utilization. Later, when mutation analysis of the OTC gene became available, a known pathogenic missense mutation (c.533C>T) in exon 5 leading to an exchange of threonine-178 by methionine (p.Thr178Met) was detected. Skewed X-inactivation was demonstrated in leukocyte DNA. In the further clinical course the girl developed marked obesity. By initiating physical activities twice a week, therapeutic control of both diabetes and OTC deficiency improved, but obesity persisted. In conclusion, our case confirms that normal hepatic OTC enzyme activity measured in a single liver biopsy sample does not exclude a clinical relevant mosaic of OTC deficiency because of skewed X-inactivation. Mutation analysis of the OTC gene in whole blood may be a simple way to establish the diagnosis of OTC deficiency. The joint occurrence of OTC deficiency and diabetes in a patient has not been reported before.
Mathematische Vorkurse werden zur Vorbereitung auf das Studium allen Studienanfängerinnen und Studienanfängern der Ingenieurmathematik dringend empfohlen, aber leider fällt es immer schwerer, die Lücke zwischen den Erwartungen an die Vorkenntnisse der Studierenden und dem tatsächlichen Rüstwerkzeug der Studienanfänger/innen zu schließen. In diesem Artikel wird die Projektidee vorgestellt, im Rahmen einer Zusammenarbeit mit dem internationalen ROLE-Projekt einen mathematischen Vorkurs durch zusätzliche Elemente aus dem Bereich der Open Educational Resources sinnvoll zu ergänzen, um eine Binnendifferenzierung zu ermöglichen und den Studierenden zu erleichtern, sich in den Lehrstoff individuell einzuarbeiten.
Open Discovery Space
(2013)
Die vorliegende Geldwäsche-Studie soll im deutschen Glücksspielmarkt soll die Diskussion über die Geldwäschemöglichkeiten im Bereich Online Poker versachlichen und grundsätzliche Präventionsmaßnahmen herleiten. Auf dieser Grundlage wird die TÜV TRUST IT GmbH Unternehmensgruppe TÜV AUSTRIA als Auftraggeber der Studie mess- und bewertbare Prüfkriterien entwickeln und diese in ein Prüf- und Zertifizierverfahren überleiten. Damit werden dem Markt dann erstmals sachlich nachvollziehbare, wissenschaftlich fundiert, standardisierte Kriterien zur Verfügung stehen, um das Thema sachlich zu behandeln und Teilnehmer am Markt in die Lage zu versetzen, klare Regeln zu definieren und einzuhalten.