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A firm link between endoplasmic reticulum (ER) stress and tumors has been wildly reported. Endoplasmic reticulum oxidoreductase 1 alpha (ERO1α), an ER-resident thiol oxidoreductase, is confirmed to be highly upregulated in various cancer types and associated with a significantly worse prognosis. Of importance, under ER stress, the functional interplay of ERO1α/PDI axis plays a pivotal role to orchestrate proper protein folding and other key processes. Multiple lines of evidence propose ERO1α as an attractive potential target for cancer treatment. However, the unavailability of specific inhibitor for ERO1α, its molecular inter-relatedness with closely related paralog ERO1β and the tightly regulated processes with other members of flavoenzyme family of enzymes, raises several concerns about its clinical translation. Herein, we have provided a detailed description of ERO1α in human cancers and its vulnerability towards the aforementioned concerns. Besides, we have discussed a few key considerations that may improve our understanding about ERO1α in tumors.
Dieses Einführungspapier ist als Orientierungshilfe zum Thema Künstliche Intelligenz (KI) (engl. Artifical Intelligence, AI) im DaF/DaZ-Kontext gedacht. Ausgehend von häufig gestellten Fragen enthält es grundsätzliche Informationen zu technischen und historischen Hintergründen, didaktisch-methodische Reflexionsanregungen sowie praktische Ideen zum Einsatz von KI im DaF/DaZ-Kontext.
Accurate global horizontal irradiance (GHI) forecasting is critical for integrating solar energy into the power grid and operating solar power plants. The Weather Research and Forecasting model with its solar radiation extension (WRF-Solar) has been used to forecast solar irradiance in different regions around the world. However, the application of the WRF-Solar model to the prediction of GHI in West Africa, particularly Ghana, has not yet been investigated. The aim of this study is to evaluate the performance of the WRF-Solar model for predicting GHI in Ghana, focusing on three automatic weather stations (Akwatia, Kumasi and Kologo) for the year 2021. We used two one-way nested domains (D1 = 15 km and D2 = 3 km) to investigate the ability of the fully coupled WRF-Solar model to forecast GHI up to 72-hour ahead under different atmospheric conditions. The initial and lateral boundary conditions were taken from the ECMWF high-resolution operational forecasts. Our findings reveal that the WRF-Solar model performs better under clear skies than cloudy skies. Under clear skies, Kologo performed best in predicting 72-hour GHI, with a first day nRMSE of 9.62 %. However, forecasting GHI under cloudy skies at all three sites had significant uncertainties. Additionally, WRF-Solar model is able to reproduce the observed GHI diurnal cycle under high AOD conditions in most of the selected days. This study enhances the understanding of the WRF-Solar model’s capabilities and limitations for GHI forecasting in West Africa, particularly in Ghana. The findings provide valuable information for stakeholders involved in solar energy generation and grid integration towards optimized management in the region.
In vision tasks, a larger effective receptive field (ERF) is associated with better performance. While attention natively supports global context, convolution requires multiple stacked layers and a hierarchical structure for large context. In this work, we extend Hyena, a convolution-based attention replacement, from causal sequences to the non-causal two-dimensional image space. We scale the Hyena convolution kernels beyond the feature map size up to 191$\times$191 to maximize the ERF while maintaining sub-quadratic complexity in the number of pixels. We integrate our two-dimensional Hyena, HyenaPixel, and bidirectional Hyena into the MetaFormer framework. For image categorization, HyenaPixel and bidirectional Hyena achieve a competitive ImageNet-1k top-1 accuracy of 83.0% and 83.5%, respectively, while outperforming other large-kernel networks. Combining HyenaPixel with attention further increases accuracy to 83.6%. We attribute the success of attention to the lack of spatial bias in later stages and support this finding with bidirectional Hyena.
Green infrastructure has been widely recognized for the benefits to human health and biodiversity conservation. However, knowledge of the qualities and requirements of such spaces and structures for the effective delivery of the range of ecosystem services expected is still limited, as well as the identification of trade-offs between services. In this study, we apply the One Health approach in the context of green spaces to investigate how urban park characteristics affect human mental health and wildlife support outcomes and identify synergies and trade-offs between these dimensions. Here we show that perceived restorativeness of park users varies significantly across sites and is mainly affected by safety and naturalness perceptions. In turn, these perceptions are driven by objective indicators of quality, such as maintenance of facilities and vegetation structure, and subjective estimations of biodiversity levels. The presence of water bodies benefited both mental health and wildlife. However, high tree canopy coverage provided greater restoration potential whereas a certain level of habitat heterogeneity was important to support a wider range of bird species requirements. To reconcile human and wildlife needs in green spaces, cities should strategically implement a heterogeneous green infrastructure network that considers trade-offs and maximizes synergies between these dimensions.
Pipeline transport is an efficient method for transporting fluids in energy supply and other technical applications. While natural gas is the classical example, the transport of hydrogen is becoming more and more important; both are transmitted under high pressure in a gaseous state. Also relevant is the transport of carbon dioxide, captured in the places of formation, transferred under high pressure in a liquid or supercritical state and pumped into underground reservoirs for storage. The transport of other fluids is also required in technical applications. Meanwhile, the transport equations for different fluids are essentially the same, and the simulation can be performed using the same methods. In this paper, the effect of control elements such as compressors, regulators and flaptraps on the stability of fluid transport simulations is studied. It is shown that modeling of these elements can lead to instabilities, both in stationary and dynamic simulations. Special regularization methods were developed to overcome these problems. Their functionality also for dynamic simulations is demonstrated for a number of numerical experiments.
In recent years, eXtended Reality (XR) technology like Augmented Reality and Virtual Reality became both technically feasible as well as affordable which lead to a drastic demand of professionally designed and developed applications. However, this demand combined with a rapid pace of innovation revealed a lack of design tool support for professional interaction designers as well as a knowledge gap regarding their approaches and needs. To address this gap, this thesis engages with the work of professional XR interaction designers in a qualitative research into XR interaction design approach. Therefore, this thesis applies two complementary lenses stemming from scientific design and social practice theory discourses to observe, describe, analyze, and understand professional XR interaction designers' challenges and approaches with a focus on application prototyping.
This paper seeks to explore the framework within which the International Labour Office should promote a principled, practical approach to social security policy in the new millennium. Integration has to be built around a joint coherent policy vision and building such a policy vision requires debate. This paper is a product of a joint effort of members of the ILO Social Security Department and social security specialists working in the ILO field offices.
Grundordnung der Fachhochschule Bonn-Rhein-Sieg (GrundO) vom 20. April 2006 (3. Änderungssatzung)
(2006)
Projekte des maschinellen Lernens (ML), insbesondere im Bereich der Zeitreihenanalyse, gewinnen heute zunehmend an Bedeutung. Die Bereitstellung solcher Projekte in einer Produktionsumgebung mit dem gleichen Automatisierungsgrad wie bei klassischen Softwareprojekten ist ein komplexes Unterfangen. Die Umsetzung in Produktionsumgebungen erfordert neben klassischen DevOps auch Machine Learning Operation (MLOps) Technologien und Werkzeuge. Ziel dieser Studie ist es, einen umfassenden Überblick über verfügbare MLOps Tools zu bieten und einen spezifischen Techstack für Zeitreihen ML Projekte zu entwickeln. Es werden aktuelle Trends und Werkzeuge im Bereich MLOps durch eine multivokale Literaturrecherche (MLR) untersucht und analysiert. Die Studie identifiziert passende MLOps Werkzeuge und Methoden für die Zeitreihenanalyse und präsentiert eine spezifische Implementierung einer MLOps Pipeline für die Aktienkursprognose des S&P 500. MLOps und DevOps Tools nehmen eine essenzielle Rolle bei der effektiven Konstruktion und Verwaltung von ML Pipelines ein. Bei der Auswahl geeigneter Werkzeuge ist stets eine spezifische Anpassung an die jeweiligen Projektanforderungen erforderlich. Die Bereitstellung einer detaillierten Darstellung der aktuellen MLOps Tool Landschaft erweist sich hierbei als wertvolle Ressource, die es Entwicklern ermöglicht, die Effizienz und Effektivität ihrer ML Projekte zu optimieren.
Angesichts der raschen Entwicklungen und der Besonderheiten von Softwaresystemen, welche Künstliche Intelligenz (KI) nutzen, ist ein angepasstes Requirements Engineering (RE) erforderlich. Die spezifischen Anforderungen von KI-Projekten müssen dabei erkannt und angegangen werden. Hierfür wird eine systematische Überprufung bestehender Herausforderungen des RE in KI-Projekten durchgeführt. Darauf aufbauend werden neue RE-Ansätze und Empfehlungen präsentiert, die auf die Datensicht von KI-Projekten abzielen. Mithilfe der Analyse bestehender Lösungsansatze, Methoden, Frameworks und Tools soll aufgezeigt werden, inwiefern die Herausforderungen im RE bewältigt werden können. Noch bestehende Lücken im Forschungsstand werden identifiziert und aufgezeigt.
Farming communities confronted with climate change adopt formal and informal adaptation strategies to mitigate the effects of climate change. While the environmental and social effects of climate change are well documented, there is still a dearth of literature on girl-child marriage (formal marriage or informal union between a child under the age of 18 and an adult or another child) as a response to the effects of climate change. In this research, we ask if girl-child marriage is promoted as a social protection mechanism first, rather than as simply a response to climate-induced poverty. We use qualitative semi-structured interviews and focus group discussions to explore this question in a rural farming community in Northern Ghana. Our findings reveal that climate change shocks result in poverty and compel farmers to marry off their young daughters. The unmarried girl-child is perceived as an ‘extra mouth to feed’, a liability whose marriage becomes a strategy for protecting the family, the family’s reputation, and the girl child. The emphasis in girl-child marriage is not on the girl-child as an individual but on the family as a group. Hence, what is good for the family is assumed to be in the best interest of the girl-child. We place our analysis at the intersection of climate change, social protection, and the incidence of girl-child marriages. We argue that understanding this link is crucial and can contribute significantly to our knowledge of girl-child marriage as well as our ability to address this in Sub-Saharan Africa.
Verwaltungs- und Benutzungsordnung der Hochschul- und Kreisbibliothek Bonn-Rhein-Sieg vom 18.07.2005
(2005)
2. Änderung der Geschäftsordnung für den Senat der Fachhochschule Bonn-Rein-Sieg vom 07. April 2005
(2005)