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Das Kernanliegen des Datenschutzes ist es, natürliche Personen vor nachteiligen Effekten der Speicherung und Verarbeitung der sie betreffenden Daten zu schützen. Aber viele Personen scheinen gar nicht geschützt werden zu wollen. Im Gegenteil, viele Endanwender willigen “freiwillig“ – bewusst oder unbewusst – in eine umfassende Verarbeitung ihrer personenbezogenen Daten ein. Warum tun Menschen dies? Es werden verschiedene Ursachen diskutiert (beispielsweise in [79]), hierzu gehören Uninformiertheit, mangelnde Sensibilität, das Gefühl der Hilflosigkeit, mangelnde Zahlungsbereitschaft und mangelnde Alternativen. Auch wenn dies in Einzelfällen zutrifft, so gibt es oft sehr wohl datenschutzfreundliche Alternativen. Beispielsweise existiert zu WhatsApp (als Instant Messaging App) die Alternative Threema. Threema gilt als EU-DS-GVO-konform und funktional durchaus mit WhatsApp vergleichbar [62]. Allerdings ist inzwischen die aktuelle Netzwerkgröße ein entscheidendes Auswahlkriterium: Im Januar 2018 hatte Threema 4,5 Millionen Nutzer [172], WhatsApp dagegen 1,5 Milliarden [171]. Dies ist ein Indiz dafür, dass WhatsApp sich quasi zum De-facto-Standard entwickelt hat und es für die einzelne Person nur schwer möglich ist, viele andere “zum Wechsel auf ein anderes Produkt zu bewegen. [. . . ] Bei Diensten mit Nutzerzahlen im Milliardenbereich kann von ’Freiwilligkeit’ nur noch bedingt gesprochen werden.“ [9]
Information reliability and automatic computation are two important aspects that are continuously pushing the Web to be more semantic. Information uploaded to the Web should be reusable and extractable automatically to other applications, platforms, etc. Several tools exist to explicitly markup Web content. The Web services may also have a positive role on the automatic processing of Web contents, especially when they act as flexible and agile agents. However, Web services themselves should be developed with semantics in mind. They should include and provide structured information to facilitate their use, reuse, composition, query, etc. In this chapter, the authors focus on evaluating state-of-the-art semantic aspects and approaches in Web services. Ultimately, this contributes to the goal of Web knowledge management, execution, and transfer.
Software testing in web services environment faces different challenges in comparison with testing in traditional software environments. Regression testing activities are triggered based on software changes or evolutions. In web services, evolution is not a choice for service clients. They have always to use the current updated version of the software. In addition test execution or invocation is expensive in web services and hence providing algorithms to optimize test case generation and execution is vital. In this environment, we proposed several approach for test cases' selection in web services' regression testing. Testing in this new environment should evolve to be included part of the service contract. Service providers should provide data or usage sessions that can help service clients reduce testing expenses through optimizing the selected and executed test cases.
The gasotransmitter hydrogen sulphide decreases Na⁺ transport across pulmonary epithelial cells
(2012)
BACKGROUND AND PURPOSE The transepithelial absorption of Na(+) in the lungs is crucial for the maintenance of the volume and composition of epithelial lining fluid. The regulation of Na(+) transport is essential, because hypo- or hyperabsorption of Na(+) is associated with lung diseases such as pulmonary oedema or cystic fibrosis. This study investigated the effects of the gaseous signalling molecule hydrogen sulphide (H(2) S) on Na(+) absorption across pulmonary epithelial cells. EXPERIMENTAL APPROACH Ion transport processes were electrophysiologically assessed in Ussing chambers on H441 cells grown on permeable supports at air/liquid interface and on native tracheal preparations of pigs and mice. The effects of H(2)S were further investigated on Na(+) channels expressed in Xenopus oocytes and Na(+) /K(+)-ATPase activity in vitro. Membrane abundance of Na(+) /K(+)-ATPase was determined by surface biotinylation and Western blot. Cellular ATP concentrations were measured colorimetrically, and cytosolic Ca(2+) concentrations were measured with Fura-2. KEY RESULTS H(2)S rapidly and reversibly inhibited Na(+) transport in all the models employed. H(2)S had no effect on Na(+) channels, whereas it decreased Na(+) /K(+)-ATPase currents. H(2)S did not affect the membrane abundance of Na(+) /K(+)-ATPase, its metabolic or calcium-dependent regulation, or its direct activity. However, H(2)S inhibited basolateral calcium-dependent K(+) channels, which consequently decreased Na(+) absorption by H441 monolayers. CONCLUSIONS AND IMPLICATIONS H(2) S impairs pulmonary transepithelial Na(+) absorption, mainly by inhibiting basolateral Ca(2+)-dependent K(+) channels. These data suggest that the H(2)S signalling system might represent a novel pharmacological target for modifying pulmonary transepithelial Na(+) transport.
The vectorial transport of Na+ across epithelia is crucial for the maintenance of Na+ and water homeostasis in organs such as the kidneys, lung, or intestine. Dysregulated Na+ transport processes are associated with various human diseases such as hypertension, the salt-wasting syndrome pseudohypoaldosteronism type 1, pulmonary edema, cystic fibrosis, or intestinal disorders, which indicate that a precise regulation of epithelial Na+ transport is essential. Novel regulatory signaling molecules are gasotransmitters. There are currently three known gasotransmitters: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). These molecules are endogenously produced in mammalian cells by specific enzymes and have been shown to regulate various physiological processes. There is a growing body of evidence which indicates that gasotransmitters may also regulate Na+ transport across epithelia. This review will summarize the available data concerning NO, CO, and H2S dependent regulation of epithelial Na+ transport processes and will discuss whether or not these mediators can be considered as true physiological regulators of epithelial Na+ transport biology.
ENaC channels
(2023)
More than 25 years ago, it was a big surprise for physiologists that nitric oxide (NO) was identified as the endothelium derived relaxing factor which is responsible for endothelium-induced smooth muscle relaxation (Ignarro et al., 1987). Until then, small gaseous molecules were simply regarded as byproducts of cellular metabolism which were unlikely to be of any physiological relevance. The discovery that NO was synthesized by specific enzymes (NO-synthases), upon stimulation by specific, physiologically relevant stimuli (e.g., acetylcholine stimulation of endothelial cells), as well as the fact that it acted on specific cellular targets (e.g., soluble guanylate cyclase), set the course for numerous studies which investigated the physiological roles of gaseous signaling molecules—in other words, gasotransmitters (Wang, 2002).
The development of pulmonary edema can be considered as a combination of alveolar flooding via increased fluid filtration, impaired alveolar-capillary barrier integrity, and disturbed resolution due to decreased alveolar fluid clearance. An important mechanism regulating alveolar fluid clearance is sodium transport across the alveolar epithelium. Transepithelial sodium transport is largely dependent on the activity of sodium channels in alveolar epithelial cells. This paper describes how sodium channels contribute to alveolar fluid clearance under physiological conditions and how deregulation of sodium channel activity might contribute to the pathogenesis of lung diseases associated with pulmonary edema. Furthermore, sodium channels as putative molecular targets for the treatment of pulmonary edema are discussed.
Carbon Monoxide Rapidly Impairs Alveolar Fluid Clearance by Inhibiting Epithelial Sodium Channels
(2009)
Carbon monoxide (CO) is currently being evaluated as a therapeutic modality in the treatment of patients with acute lung injury and acute respiratory distress syndrome. No study has assessed the effects of CO on transepithelial ion transport and alveolar fluid reabsorption, two key aspects of alveolocapillary barrier function that are perturbed in acute lung injury/acute respiratory distress syndrome. Both CO gas (250 ppm) and CO donated by the CO donor, CO-releasing molecule (CORM)-3 (100 mu M in epithelial lining fluid), applied to healthy, isolated, ventilated, and perfused rabbit lungs, significantly blocked Na-22(+) clearance from the alveolar compartment, and blocked alveolar fluid reabsorption after fluid challenge. Apical application of two CO donors, CORM-3 or CORM-A1 (100 mu M), irreversibly inhibited amiloride-sensitive short-circuit currents in H441 human bronchiolar epithelial cells and primary rat alveolar type II cells by up to 40%. Using a nystatin permabilization approach, the CO effect was localized to amiloride-sensitive channels on the apical surface. This effect was abolished by hemoglobin, a scavenger of CO, and was not observed when inactive forms of CO donors were employed. The effects of CO were not blocked by 8-bromoguanosine-3',5'-cyclic guanosine monophosphate, soluble guanylate cyclase inhibitors (methylene blue and 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one), or inhibitors of trafficking events (phalloidin oleate, MG-132, and brefeldin A), but the amiloride affinity of H441 cells was reduced after CO exposure. These data indicate that CO rapidly inhibits sodium absorption across the airway epithelium by cyclic guanosine monophosphate-and trafficking-independent mechanisms, which may rely on critical histidine residues in amiloride-sensitive channels or associated regulatory proteins on the apical surface of lung epithelial cells.
The epithelial sodium channel (ENaC) is a heterotrimeric ion channel that plays a key role in sodium and water homeostasis in tetrapod vertebrates. In the aldosterone-sensitive distal nephron, hormonally controlled ENaC expression matches dietary sodium intake to its excretion. Furthermore, ENaC mediates sodium absorption across the epithelia of the colon, sweat ducts, reproductive tract, and lung. ENaC is a constitutively active ion channel and its expression, membrane abundance, and open probability (PO) are controlled by multiple intracellular and extracellular mediators and mechanisms [9]. Aberrant ENaC regulation is associated with severe human diseases, including hypertension, cystic fibrosis, pulmonary edema, pseudohypoaldosteronism type 1, and nephrotic syndrome [9].
Nitric oxide (NO) is an important regulator of Na+ reabsorption by pulmonary epithelial cells and therefore of alveolar fluid clearance. The mechanisms by which NO affects epithelial ion transport are poorly understood and vary from model to model. In this study, the effects of NO on sodium reabsorption by H441 cell monolayers were studied in an Ussing chamber. Two NO donors, (Z)-1-[N-(3-aminopropyl)-N-(n-propyl) amino]diazen-1-ium-1,2-diolate and diethylammonium(Z)-1-(N, N-diethylamino) diazen-1-ium-1,2-diolate, rapidly, reversibly, and dose-dependently reduced amiloride-sensitive, short-circuit currents across H441 cell monolayers. This effect was neutralized by the NO scavenger hemoglobin and was not observed with inactive NO donors. The effects of NO were not blocked by 8-bromoguanosine-3',5'-cyclic monophosphate or by soluble guanylate cyclase inhibitors (methylene blue and 1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one) and were therefore independent of soluble guanylate cyclase signaling. NO targeted apical, highly selective, amiloride-sensitive Na+ channels in basolaterally permeabilized H441 cell monolayers. NO had no effect on the activity of the human epithelial sodium channel heterologously expressed in Xenopus oocytes. NO decreased Na+/K+-ATPase activity in apically permeabilized H441 cell monolayers. The inhibition of Na+/K+-ATPase activity by NO was reversed by mercury and was mimicked by N-ethylmaleimide, which are agents that reverse and mimic, respectively, the reaction of NO with thiol groups. Consistent with these data, S-NO groups were detected on the Na+/K+-ATPase a subunit in response to NO-donor application, using a biotin-switch approach coupled to a Western blot. These data demonstrate that, in the H441 cell model, NO impairs Na+ reabsorption by interfering with the activity of highly selective Na+ channels and the Na+/K+-ATPase.
Introduction: After cellulose, lignin represents the most abundant biopolymer on earth that accounts for up to 18-35 % by weight of lignocellulose biomass. Today, it is a by-product of the paper and pulping industry. Although lignin is available in huge amounts, mainly in form of so called black liquor produced via Kraft-pulping, processes for the valorization of lignin are still limited [1]. Due to its hyperbranched polyphenol-like structure, lignin gained increasing interest as biobased building block for polymer synthesis [2]. The present work is focused on extraction and purification of lignin from industrial black liquor and synthesis of lignin-based polyurethanes.
Lignocellulose feedstock (LCF) provides a sustainable source of components to produce bioenergy, biofuel, and novel biomaterials. Besides hard and soft wood, so-called low-input plants such as Miscanthus are interesting crops to be investigated as potential feedstock for the second generation biorefinery. The status quo regarding the availability and composition of different plants, including grasses and fast-growing trees (i.e., Miscanthus, Paulownia), is reviewed here. The second focus of this review is the potential of multivariate data processing to be used for biomass analysis and quality control. Experimental data obtained by spectroscopic methods, such as nuclear magnetic resonance (NMR) and Fourier-transform infrared spectroscopy (FTIR), can be processed using computational techniques to characterize the 3D structure and energetic properties of the feedstock building blocks, including complex linkages. Here, we provide a brief summary of recently reported experimental data for structural analysis of LCF biomasses, and give our perspectives on the role of chemometrics in understanding and elucidating on LCF composition and lignin 3D structure.
Renewable resources gain increasing interest as source for environmentally benign biomaterials, such as drug encapsulation/release compounds, and scaffolds for tissue engineering in regenerative medicine. Being the second largest naturally abundant polymer, the interest in lignin valorization for biomedical utilization is rapidly growing. Depending on resource and isolation procedure, lignin shows specific antioxidant and antimicrobial activity. Today, efforts in research and industry are directed toward lignin utilization as renewable macromolecular building block for the preparation of polymeric drug encapsulation and scaffold materials. Within the last five years, remarkable progress has been made in isolation, functionalization and modification of lignin and lignin-derived compounds. However, literature so far mainly focuses lignin-derived fuels, lubricants and resins. The purpose of this review is to summarize the current state of the art and to highlight the most important results in the field of lignin-based materials for potential use in biomedicine (reported in 2014–2018). Special focus is drawn on lignin-derived nanomaterials for drug encapsulation and release as well as lignin hybrid materials used as scaffolds for guided bone regeneration in stem cell-based therapies.
Antioxidant activity is an essential aspect of oxygen-sensitive merchandise and goods, such as food and corresponding packaging, cosmetics, and biomedicine. Technical lignin has not yet been applied as a natural antioxidant, mainly due to the complex heterogeneous structure and polydispersity of lignin. This report presents antioxidant capacity studies completed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The influence of purification on lignin structure and activity was investigated. The purification procedure showed that double-fold selective extraction is the most efficient (confirmed by ultraviolet-visible (UV/Vis), Fourier transform infrared (FTIR), heteronuclear single quantum coherence (HSQC) and 31P nuclear magnetic resonance spectroscopy, size exclusion chromatography, and X-ray diffraction), resulting in fractions of very narrow polydispersity (3.2⁻1.6), up to four distinct absorption bands in UV/Vis spectroscopy. Due to differential scanning calorimetry measurements, the glass transition temperature increased from 123 to 185 °C for the purest fraction. Antioxidant capacity is discussed regarding the biomass source, pulping process, and degree of purification. Lignin obtained from industrial black liquor are compared with beech wood samples: antioxidant activity (DPPH inhibition) of kraft lignin fractions were 62⁻68%, whereas beech and spruce/pine-mixed lignin showed values of 42% and 64%, respectively. Total phenol content (TPC) of the isolated kraft lignin fractions varied between 26 and 35%, whereas beech and spruce/pine lignin were 33% and 34%, respectively. Storage decreased the TPC values but increased the DPPH inhibition.
Antioxidant activity is an essential feature required for oxygen-sensitive merchandise and goods, such as food and corresponding packaging as well as materials used in cosmetics and biomedicine. For example, vanillin, one of the most prominent antioxidants, is fabricated from lignin, the second most abundant natural polymer in the world. Antioxidant potential is primarily related to the termination of oxidation propagation reactions through hydrogen transfer. The application of technical lignin as a natural antioxidant has not yet been implemented in the industrial sector, mainly due to the complex heterogeneous structure and polydispersity of lignin. Thus, current research focuses on various isolation and purification strategies to improve the compatibility of lignin material with substrates and enhancing its stabilizing effect.
The antiradical and antimicrobial activity of lignin and lignin-based films are both of great interest for applications such as food packaging additives. The polyphenolic structure of lignin in addition to the presence of O-containing functional groups is potentially responsible for these activities. This study used DPPH assays to discuss the antiradical activity of HPMC/lignin and HPMC/lignin/chitosan films. The scavenging activity (SA) of both binary (HPMC/lignin) and ternary (HPMC/lignin/chitosan) systems was affected by the percentage of the added lignin: the 5% addition showed the highest activity and the 30% addition had the lowest. Both scavenging activity and antimicrobial activity are dependent on the biomass source showing the following trend: organosolv of softwood > kraft of softwood > organosolv of grass. Testing the antimicrobial activities of lignins and lignin-containing films showed high antimicrobial activities against Gram-positive and Gram-negative bacteria at 35 °C and at low temperatures (0-7 °C). Purification of kraft lignin has a negative effect on the antimicrobial activity while storage has positive effect. The lignin release in the produced films affected the activity positively and the chitosan addition enhances the activity even more for both Gram-positive and Gram-negative bacteria. Testing the films against spoilage bacteria that grow at low temperatures revealed the activity of the 30% addition on HPMC/L1 film against both B. thermosphacta and P. fluorescens while L5 was active only against B. thermosphacta. In HPMC/lignin/chitosan films, the 5% addition exhibited activity against both B. thermosphacta and P. fluorescens.
Once aberrantly activated, the Wnt/βcatenin pathway may result in uncontrolled proliferation and eventually cancer. Efforts to counter and inhibit this pathway are mainly directed against βcatenin, as it serves a role on the cytoplasm and the nucleus. In addition, speciallygenerated lymphocytes are recruited for the purpose of treating liver cancer. Peripheral blood mononuclear lymphocytes are expanded by the timely addition of interferon γ, interleukin (IL)1β, IL2 and anticluster of differentiation 3 antibody. The resulting cells are called cytokineinduced killer (CIK) cells. The present study utilised these cells and combine them with drugs inhibiting the Wnt pathway in order to examine whether this resulted in an improvement in the killing ability of CIK cells against liver cancer cells. Drugs including ethacrynic acid (EA) and ciclopirox olamine (CPX) were determined to be suitable candidates, as determined by previous studies. Drugs were administered on their own and combined with CIK cells and then a cell viability assay was performed. These results suggest that EAtreated cells demonstrated apoptosis and were significantly affected compared with untreated cells. Unlike EA, CPX killed normal and cancerous cells even at low concentrations. Subsequent to combining EA with CIK cells, the potency of killing was increased and a greater number of cells died, which proves a synergistic action. In summary, EA may be used as an antihepatocellular carcinoma drug, while CPX possesses a high toxicity to cancerous as well as to normal cells. It was proposed that EA should be integrated into present therapeutic methods for cancer.
In today’s business, culture plays a vital role or to a high degree influences the attitude, perception and decision making process of an individual. Culture is an unavoidable state of rules and regulations that defines people’s daily life in a particular environment or society. There are plenty examples of business failures or stagnation or failure of joint ventures, on account of the management's inability to recognize cross-cultural challenges and tackle them appropriately.
BWL kompakt für Dummies
(2018)
"BWL kompakt für Dummies" bietet Ihnen eine verständliche Einführung in die Betriebswirtschaftslehre, egal ob Sie sie für die Aus- oder Weiterbildung brauchen oder sich einfach schlau machen wollen. Tobias Amely stellt Ihnen die wesentlichen Elemente und Grundbegriffe der Betriebswirtschaftslehre vor und zeigt die Bezüge zur Unternehmenspraxis auf: Materialwirtschaft, Leistungsbereitstellung und Produktion, Marketing, Investition und Finanzierung, Unternehmensorganisation und -führung, Rechnungswesen und Controlling.
BWL-Formeln für Dummies
(2012)
BWL-Formeln für Dummies
(2018)
Können Sie sich auch Formeln so schlecht merken? Das ist mit diesem handlichen Nachschlagewerk auch gar nicht mehr nötig! Der Autor des Bestsellers "BWL für Dummies" Tobias Amely hat für Sie die wichtigsten BWL-Formeln zusammengestellt. Zu jeder Formel finden Sie auch gleich ein anschauliches Beispiel, wie sie eingesetzt wird und eine Erklärung, wofür man sie eigentlich braucht. "BWL-Formeln für Dummies" ist also viel mehr als eine reine Auflistung von Formeln.
BWL kompakt für Dummies
(2016)
BWL-Klausuren für Dummies
(2019)
Investition und Finanzierung sind wichtige Themen in der Unternehmenspraxis und im Studium der Betriebswirtschaftslehre. Dieses Buch führt Sie anhand anschaulicher Beispiele in die Grundlagen des Themas ein und zeigt die Ziele finanzwirtschaftlichen Handelns auf. Tobias Amely und Christine Immenkötter zeigen Ihnen die Grundzüge der Finanzwirtschaft und stellen Ihnen die wichtigsten Instrumente sowohl der Außen- und Innenfinanzierung als auch des Finanzmanagements vor. Lernen Sie die statische und dynamische Investitionsrechnung kennen und erfahren Sie, was man über Investitionen in Wertpapiere wissen muss. So liefert Ihnen dieses Buch im bewährten ... für Dummies-Stil einen guten und leicht verständlichen Überblick über alle wichtigen Themen der Investition und Finanzierung. (Verlagsangaben)
BWL für Dummies
(2021)
BWL für Dummies
(2009)
BWL für Dummies
(2016)
"BWL für Dummies" führt kompetent, prägnant und umfassend in die Betriebswirtschaftslehre ein. Dabei werden die wesentlichen Elemente der Betriebswirtschaftslehre praxisorientiert vorgestellt und in ihrem Zusammenhang dargestellt. Folgende Themen werden behandelt: Materialwirtschaft, Leistungsbereitstellung und Produktion, Marketing, Investition und Finanzierung, Unternehmensorganisation und -führung, Rechnungswesen, Controlling.
BWL für Dummies
(2013)
Competitions for Benchmarking: Task and Functionality Scoring Complete Performance Assessment
(2015)
RELA haploinsufficiency is a recently described autoinflammatory condition presenting with intermittent fevers and mucocutaneous ulcerations. The RELA gene encodes the p65 protein, one of five NF-κB family transcription factors. As RELA is an essential regulator of mucosal homeostasis, haploinsufficiency leads to decreased NF-κB signaling which promotes TNF-driven mucosal apoptosis with impaired epithelial recovery. Thus far, only eight cases have been reported in the literature. Here, we report four families with three novel and one previously described pathogenic variant in RELA. These four families included 23 affected individuals for which genetic testing was available in 16. Almost half of these patients had been previously diagnosed with more common rheumatologic entities (such as Behcet's Disease; BD) prior to the discovery of their pathogenic RELA variants. The most common clinical features were orogenital ulcers, rash, joint inflammation, and fever. The least common were conjunctivitis and recurrent infections. Clinical variability was remarkable even among familial cases, and incomplete penetrance was observed. Patients in our series were treated with a variety of medications, and benefit was observed with glucocorticoids, colchicine, and TNF inhibitors. Altogether, our work adds to the current literature and doubles the number of reported cases with RELA-Associated Inflammatory Disease (RAID). It reaffirms the central importance of the NF-κB pathway in immunity and inflammation, as well as the important regulatory role of RELA in mucosal homeostasis. RELA associated inflammatory disease should be considered in all patients with BD, particularly those with early onset and/or with a strong family history.
This paper presents the preliminary results of the Socialist Republic of Vietnam country case study conducted as part of the research project Sustainable Labour Migration implemented by the University of Applied Science Bonn-Rhein-Sieg. The project focuses on stakeholder perspectives on countries of origin benefits and the sustainability of different transnational skill partnership schemes. Existing and ongoing small-scale initiatives indicate that opportunities exist for all three types of labour mobility pathways, from recruiting youth for apprenticeships and subsequent skilled work to recruitment and recognition of skilled 'professionals' certificates for direct work contracts to initial vocational education and training programs in a dual-track approach. While the latter has the highest potential to be more beneficial than other approaches, pursuing and supporting the scaling up of all three pathways in parallel will have additional, mutually reinforcing and supporting effects. The potential for benefits over and above those already realised by existing skill partnerships appears high, especially considering the favourable framework conditions specific to the long-standing German-Vietnamese relationship. If the potential of well-managed skill partnerships was realised, such sustainable models of skilled labour migration could serve as a unique selling point in the international competition for skilled labour.
IT-Governance, Prüfung & Revision mal agil gedacht! Herausforderungen und Notwendigkeit eines Perspektivwechsels für IT-Governance, Prüfung & Revision viele Fallbeispiele zeigen die praktische Umsetzbarkeit auf Agilität und der Einsatz agiler Methoden sind heute nicht mehr nur auf IT-Projekte begrenzt, sondern prägen zunehmend ganze Organisationen. Dieses Buch zeigt auf, wie sich IT-Governance, Prüfung & Revision erfolgreich dem durch Agilität ausgelösten Wandel stellen können und wie sich der Umgang mit den Kernthemen Risiko & Unsicherheit verändert. Zum einen werden Ansätze für eine agile IT-Governance und eine agile Prüfung & Revision beschrieben, indem sie sich agile Werte und Vorgehensweisen zu eigen machen. Zum anderen werden IT-Governance, Prüfung & Revision befähigt, agile Projekte angemessen steuern und wirksam prüfen zu können.
The invention relates to compounds that include peptide and peptidomimetics that inhibit estrogen receptor dependent cell proliferation. The compounds of the invention are useful for treating cell proliferative disorders or physiological conditions characterized by undesirable or unwanted estrogen induced cell proliferation, including breast cancer.
SLC6A14 (ATB0,+) is unique among SLC proteins in its ability to transport 18 of the 20 proteinogenic (dipolar and cationic) amino acids and naturally occurring and synthetic analogues (including anti-viral prodrugs and nitric oxide synthase (NOS) inhibitors). SLC6A14 mediates amino acid uptake in multiple cell types where increased expression is associated with pathophysiological conditions including some cancers. Here, we investigated how a key position within the core LeuT-fold structure of SLC6A14 influences substrate specificity. Homology modelling and sequence analysis identified the transmembrane domain 3 residue V128 as equivalent to a position known to influence substrate specificity in distantly related SLC36 and SLC38 amino acid transporters. SLC6A14, with and without V128 mutations, was heterologously expressed and function determined by radiotracer solute uptake and electrophysiological measurement of transporter-associated current. Substituting the amino acid residue occupying the SLC6A14 128 position modified the binding pocket environment and selectively disrupted transport of cationic (but not dipolar) amino acids and related NOS inhibitors. By understanding the molecular basis of amino acid transporter substrate specificity we can improve knowledge of how this multi-functional transporter can be targeted and how the LeuT-fold facilitates such diversity in function among the SLC6 family and other SLC amino acid transporters.
This study presents the findings of a quantitative study on the use of Open Educational Resources (OER) and Open Educational Practices (OEP) in Higher Education and Adult Learning Institutions. The study is based on the results of an online survey targeted at four educational roles: educational policy makers; institutional policy makers/managers; educational professionals; and learners. The report encompasses five chapters and four annexes. Chapter I presents the survey and Chapter II discloses the main research questions and models. Chapter III characterises the universe of respondents. Chapter IV advances with a detailed survey analysis including an overview of key statistical data. Finally, Chapter V provides an exploratory in-depth analysis of some key issues: representations, attitudes and uses of OEP. The table of contents and the complete list of diagrams and tables can be found at the end of the report.
LiDAR-based Indoor Localization with Optimal Particle Filters using Surface Normal Constraints
(2023)
Die Darlegungsform von Nachhaltigkeitsleistungen sind üblicherweise gesondert ausgegebene Nachhaltigkeitsberichte auf die DAX-30-Unternehmen in ihren Geschäftsberichten hinweisen. Insbesondere die für kapitalmarktorientierte Unternehmen bedeutende Stakeholdergruppe der Analysten und Investoren fordert jedoch zunehmend eine integrative Darstellung aller Dimensionen der Triple-Bottom-Line auch im Lagebericht. Die gesetzlichen Offenlegungspflichten nach § 289 Abs. 3 bzw. § 315 Abs. 1 S. 4 HGB und DRS 15.32 erhöhen den Druck auf die DAX-30-Unternehmen zusätzlich. Diese Arbeit thematisiert im Kern das aktuelle Spannungsfeld zwischen Ökonomie, Ökologie und sozialem Engagement von Unternehmen. Auf Basis einer umfassenden theoretischen Analyse werden konkrete Kennzahlen zur Erfassung von Indikatoren der Nachhaltigkeit gebildet und deren Ausprägung bei den DAX 30 Unternehmen erarbeitet.
Over the years, entrepreneurship has proven to be one of the key roles towards development. The cycle of business start-ups and growth are linked to the socio-economic benefits of the global world at large. With a growing world population of over 7billion people, the existence of universities (both public &private) as well as enterprises has increased globally in the 21st century. The mission and purpose behind Universities, Entrepreneurship and Enterprises thrive on development in the areas of capacity building, skill acquisition, training and knowledge amongst others. Africa alone has a population of over 1.2billion people with about 650 recognized universities and over 140,000 registered businesses (enterprises) in Ghana alone. A case study in Ghana reveals three key drivers towards entrepreneurship and the role university education has played in various business establishments. The drivers are problem statements, resources and research findings. Some of these notions to business include the management of risk, research findings and customer relationship. These are major features that need critical attention and play a role in business and entrepreneurship in Africa. A major success in business and entrepreneurship is the utilization of the human resource population and the lifeline support given to households in terms of income, while a barrier being the limited access to credit support from the financial companies at the inception stages. In conclusion, this conference should develop a practical book guide on business start-ups and entrepreneurship knowledge to be used at the various universities in Africa to enhance development.
Die Debatte um das menschliche Erkenntnisvermögen, also die Frage nach der Art und Weise, wie Menschen Wissen und Erkenntnis erlangen, ist nicht neu, sondern sie stellt sich seitdem philosophische Fragen gestellt werden – ohne dass allerdings über die Jahrhunderte hinweg eine definitive Antwort auf diese Frage gefunden werden konnte.
Ausgangspunkt unserer Überlegungen ist die Feststellung, dass die Legitimierung moderner Formen des Wissens mit dem Verlust von legitimierenden Metaerzählungen einhergeht. Diese Feststellung bezieht sich nicht nur ganz allgemein auf die klassischen Geistes- und Sozialwissenschaften, sondern auch konkret auf die angewandte Management- und Organisationsforschung. Traditionell werden diese untergeordneten Diskursarten durch den übergeordneten Diskurs der Aufklärung legitimiert und unterwerfen sich dem Diktat der Rationalität des Modernismus (Ant 2004).
„Ein Wort gibt das andere“ – zwischenmenschliche Kommunikation folgt bestimmten Regeln. Wer diese Mechanismen durchschaut, kann nicht nur eigene Gesprächsziele besser erreichen, sondern auch andere Menschen leichter verstehen und erfolgreicher mit ihnen interagieren.
Nicht von ungefähr zählt Kommunikationskompetenz zu den gefragtesten Soft Skills in Beruf und Alltag. Diese Einführung in die Theorie und Praxis der Kommunikation erläutert die Prinzipien effizienter Kommunikation nach wie vor ein Klassiker zur Veranschaulichung von gruppendynamischen Prozessen und Rollenverhalten. Das Lehrbuch erklärt das Phänomen der Kommunikation anhand verschiedener sozialpsychologischer Untersuchungen, Theorien, Beispiele und Sichtweisen, regt zu einer erweiterten Reflexion darüber an und liefert konkrete Hinweise und Übungen, welche die eigene Kommunikationspraxis effektiv verbessern.
(Verlagsangaben)
The human MPV17-related mitochondrial DNA depletion syndrome is an inherited autosomal recessive disease caused by mutations in the inner mitochondrial membrane protein MPV17. Although more than 30 MPV17 gene mutations were shown to be associated with mitochondrial DNA depletion syndrome, the function of MPV17 is still unknown. Mice deficient in Mpv17 show signs of premature aging. In the present study, we used electrophysiological measurements with recombinant MPV17 to reveal that this protein forms a non-selective channel with a pore diameter of 1.8 nm and located the channel's selectivity filter. The channel was weakly cation-selective and showed several subconductance states. Voltage-dependent gating of the channel was regulated by redox conditions and pH and was affected also in mutants mimicking a phosphorylated state. Likewise, the mitochondrial membrane potential (Δψm) and the cellular production of reactive oxygen species were higher in embryonic fibroblasts from Mpv17−/− mice. However, despite the elevated Δψm, the Mpv17-deficient mitochondria showed signs of accelerated fission. Together, these observations uncover the role of MPV17 as a Δψm-modulating channel that apparently contributes to mitochondrial homeostasis under different conditions.
The transport of carbon dioxide through pipelines is one of the important components of Carbon dioxide Capture and Storage (CCS) systems that are currently being developed. If high flow rates are desired a transportation in the liquid or supercritical phase is to be preferred. For technical reasons, the transport must stay in that phase, without transitioning to the gaseous state. In this paper, a numerical simulation of the stationary process of carbon dioxide transport with impurities and phase transitions is considered. We use the Homogeneous Equilibrium Model (HEM) and the GERG-2008 thermodynamic equation of state to describe the transport parameters. The algorithms used allow to solve scenarios of carbon dioxide transport in the liquid or supercritical phase, with the detection of approaching the phase transition region. Convergence of the solution algorithms is analyzed in connection with fast and abrupt changes of the equation of state and the enthalpy function in the region of phase transitions.
Pipeline transport is an efficient method for transporting fluids in energy supply and other technical applications. While natural gas is the classical example, the transport of hydrogen is becoming more and more important; both are transmitted under high pressure in a gaseous state. Also relevant is the transport of carbon dioxide, captured in the places of formation, transferred under high pressure in a liquid or supercritical state and pumped into underground reservoirs for storage. The transport of other fluids is also required in technical applications. Meanwhile, the transport equations for different fluids are essentially the same, and the simulation can be performed using the same methods. In this paper, the effect of control elements such as compressors, regulators and flaptraps on the stability of fluid transport simulations is studied. It is shown that modeling of these elements can lead to instabilities, both in stationary and dynamic simulations. Special regularization methods were developed to overcome these problems. Their functionality also for dynamic simulations is demonstrated for a number of numerical experiments.
This study sought to examine the relationship between the components of SMEs social capital and firm performance. Using the social capital theory and the resource-based view as the theoretical foundations and census, 1,532 SMEs were selected in the Accra Metropolis for the study. Empirical results from 717 SMEs, utilising the hierarchical linear regression model, revealed that owner/manger’s network relationships are beneficial to the firm depending on when the relationships are closed or opened. Moreover, the study found that social capital has a significant impact on the sales and market performance of small and medium-sized enterprises. The results also brought to the fore the fact that most social networks of SME entrepreneurs are family, friends and relatives, which most times can only be used for expressive purposes and not for instrumental gain. The practical implications of the results are also discussed.
Ziel der vorliegenden Forschungsarbeit ist es, den Einfluss von Persönlichkeit auf nachhaltige Maßnahmen anhand des Streamingkonsums zu eruieren. Der allgemein steigende Streamingkonsum und die damit einhergehenden Umweltschäden einerseits und ein wachsendes gesellschaftliches Umweltbewusstsein andererseits stellen einen Widerspruch dar. An einer Online-Umfrage zu diesen und weiterführenden Aspekten nahmen 204 Probanden teil. Während sich die Eigenschaften Verträglichkeit und Offenheit in hoher Ausprägung positiv auf die Umwelteinstellung, das Umweltverhalten und die Umweltbesorgnis auswirkten, wurden die umweltfreundlichen Maßnahmen in einer Clusteranalyse hingegen stärker von der Gruppe bevorzugt, deren Verträglichkeit und Offenheit verhältnismäßig schwach ausgeprägt waren. Ein geringes Wissen über die streamingbedingten Umweltfolgen lag grundsätzlich vor und dient als möglicher Erklärungsansatz des genannten Widerspruchs. Die Probanden forderten, ein Bewusstsein für diese Thematik zu schaffen. Um Streamingkonsum umweltfreundlicher zu gestalten empfiehlt es sich, alle am Prozess beteiligten Akteure einzubeziehen. Die befragten Konsumenten bevorzugten dabei vor allem die Verwendung von Ökostrom und lehnten eine Umstellung der Bezahlstruktur vorwiegend ab.
Nowadays, we input text not only on stationary devices, but also on handheld devices while walking, driving, or commuting. Text entry on the move, which we term as nomadic text entry, is generally slower. This is partially due to the need for users to move their visual focus from the device to their surroundings for navigational purposes and back. To investigate if better feedback about users' surroundings on the device can improve performance, we present a number of new and existing feedback systems: textual, visual, textual & visual, and textual & visual via translucent keyboard. Experimental comparisons between the conventional and these techniques established that increased ambient awareness for mobile users enhances nomadic text entry performance. Results showed that the textual and the textual & visual via translucent keyboard conditions increased text entry speed by 14% and 11%, respectively, and reduced the error rate by 13% compared to the regular technique. The two methods also significantly reduced the number of collisions with obstacles.
In den letzten Jahren haben sich elektronische Zahlungssysteme als populäre Alternative zur klassischen Bargeldzahlung etabliert. Diese Zahlungssysteme bestehen in der Regel aus zwei elementaren Komponenten: einem Terminal und einer Kasse. Damit ist der Käufer eines Produktes in der Lage, seine Schuld gegenüber dem Verkäufer bargeldlos und elektronisch zu begleichen. Die dabei am Häufigsten anfallenden Geschäftsprozesse, das Buchen und das Stornieren von Zahlungsbelegen, werden hierbei als Transaktionen bezeichnet, da diese entweder vollständig gelingen oder im Fehlerfall ohne Auswirkungen bleiben müssen. In diesem Buch wird daher die Implementierung eines zuverlässigen Zahlungssystems mit einem TeleCash-Terminal dargestellt. Dabei werden in den geforderten Geschäftsprozessen die wichtigen Transaktionseigenschaften sichergestellt. Es werden dazu zunächst die Grundlagen von Transaktionen erarbeitet und ein geeignetes Transaktionskonzept entwickelt. Anschließend wird die konkrete Realisierung des Systems mit Hilfe der Java Transaction Services durchgeführt. Abschließend wird das entstandene System hinsichtlich seiner Transaktionseigenschaften untersucht.
Recent work in image captioning and scene-segmentation has shown significant results in the context of scene-understanding. However, most of these developments have not been extrapolated to research areas such as robotics. In this work we review the current state-ofthe- art models, datasets and metrics in image captioning and scenesegmentation. We introduce an anomaly detection dataset for the purpose of robotic applications, and we present a deep learning architecture that describes and classifies anomalous situations. We report a METEOR score of 16.2 and a classification accuracy of 97 %.
Current robot platforms are being employed to collaborate with humans in a wide range of domestic and industrial tasks. These environments require autonomous systems that are able to classify and communicate anomalous situations such as fires, injured persons, car accidents; or generally, any potentially dangerous situation for humans. In this paper we introduce an anomaly detection dataset for the purpose of robot applications as well as the design and implementation of a deep learning architecture that classifies and describes dangerous situations using only a single image as input. We report a classification accuracy of 97 % and METEOR score of 16.2. We will make the dataset publicly available after this paper is accepted.
In this paper we introduce the Perception for Autonomous Systems (PAZ) software library. PAZ is a hierarchical perception library that allow users to manipulate multiple levels of abstraction in accordance to their requirements or skill level. More specifically, PAZ is divided into three hierarchical levels which we refer to as pipelines, processors, and backends. These abstractions allows users to compose functions in a hierarchical modular scheme that can be applied for preprocessing, data-augmentation, prediction and postprocessing of inputs and outputs of machine learning (ML) models. PAZ uses these abstractions to build reusable training and prediction pipelines for multiple robot perception tasks such as: 2D keypoint estimation, 2D object detection, 3D keypoint discovery, 6D pose estimation, emotion classification, face recognition, instance segmentation, and attention mechanisms.
Emotion and gender recognition from facial features are important properties of human empathy. Robots should also have these capabilities. For this purpose we have designed special convolutional modules that allow a model to recognize emotions and gender with a considerable lower number of parameters, enabling real-time evaluation on a constrained platform. We report accuracies of 96% in the IMDB gender dataset and 66% in the FER-2013 emotion dataset, while requiring a computation time of less than 0.008 seconds on a Core i7 CPU. All our code, demos and pre-trained architectures have been released under an open-source license in our repository at https://github.com/oarriaga/face classification.
In this paper we propose an implement a general convolutional neural network (CNN) building framework for designing real-time CNNs. We validate our models by creating a real-time vision system which accomplishes the tasks of face detection, gender classification and emotion classification simultaneously in one blended step using our proposed CNN architecture. After presenting the details of the training procedure setup we proceed to evaluate on standard benchmark sets. We report accuracies of 96% in the IMDB gender dataset and 66% in the FER-2013 emotion dataset. Along with this we also introduced the very recent real-time enabled guided back-propagation visualization technique. Guided back-propagation uncovers the dynamics of the weight changes and evaluates the learned features. We argue that the careful implementation of modern CNN architectures, the use of the current regularization methods and the visualization of previously hidden features are necessary in order to reduce the gap between slow performances and real-time architectures. Our system has been validated by its deployment on a Care-O-bot 3 robot used during RoboCup@Home competitions. All our code, demos and pre-trained architectures have been released under an open-source license in our public repository.
Farming communities confronted with climate change adopt formal and informal adaptation strategies to mitigate the effects of climate change. While the environmental and social effects of climate change are well documented, there is still a dearth of literature on girl-child marriage (formal marriage or informal union between a child under the age of 18 and an adult or another child) as a response to the effects of climate change. In this research, we ask if girl-child marriage is promoted as a social protection mechanism first, rather than as simply a response to climate-induced poverty. We use qualitative semi-structured interviews and focus group discussions to explore this question in a rural farming community in Northern Ghana. Our findings reveal that climate change shocks result in poverty and compel farmers to marry off their young daughters. The unmarried girl-child is perceived as an ‘extra mouth to feed’, a liability whose marriage becomes a strategy for protecting the family, the family’s reputation, and the girl child. The emphasis in girl-child marriage is not on the girl-child as an individual but on the family as a group. Hence, what is good for the family is assumed to be in the best interest of the girl-child. We place our analysis at the intersection of climate change, social protection, and the incidence of girl-child marriages. We argue that understanding this link is crucial and can contribute significantly to our knowledge of girl-child marriage as well as our ability to address this in Sub-Saharan Africa.
Dienstleister
(2022)
Internationale Patienten
(2022)
Interkulturelles Management
(2022)
Marketingmaßnahmen
(2022)
Die Komplexität der Entscheidungen im Fuhrparkmanagement hat in der jüngeren Vergangenheit deutlich zugenommen. Damit steigen die Anforderungen an den Fuhrparkcontroller, den Fuhrparkleiter mit entscheidungsrelevanten Informationen im Sinne eines internen Dienstleisters zu unterstützen. Das Dynamic Carbon Accounting bietet die Möglichkeit, strategische, strukturelle und kulturelle Anforderungen an das Fuhrparkcontrolling durch die Kombination von Prozesskostenrechnung, Target Costing, Life Cycle Costing und den Ideen des Carbon Accountings instrumentell zu berücksichtigen. Je nach Bedeutung der Nachhaltigkeit für den Unternehmenserfolg können die damit verbundenen Auszahlungen noch differenzierter aufgenommen werden. So ist es denkbar, externe Auszahlungen der Emissionen von NO(ind x), Nichtmethan-Kohlenwasserstoffen, Partikeln, Lärm und Unfällen in die Rechnung zu integrieren. Damit wird je Fahrzeug der Beitrag zur Erreichung von Emissionszielen transparent gemacht und ist durch eine zielgerichtete Integration in den Controllingprozess des Unternehmens plan- und steuerbar. Da von einer zukünftig zunehmenden Komplexität des wirtschaftlichen Handelns auszugehen ist, wird sich der praktische Bedarf an dynamischen, marktorientierten Instrumenten im Controlling generell und speziell im Fuhrparkcontrolling weiter erhöhen.
Ghanaian tertiary graduates' perception of entrepreneurship education on employment opportunities
(2017)
This study focuses on whether entrepreneurship education increases entrepreneurial interest in students to set up new businesses. Entrepreneurship is a core course taken in the third year by all students of Ho Technical University. Out of the 1329 population of level 300 students of the 2016/2017 academic year, data were collected by convenience sampling from 325 (217 males and 108 females) with mean age of 24.75 years from 14 departments of four faculties. The students responded to 43-survey items derived from reviewed literature on a 5-Point Likert-Scale. It is concluded that more than 84% of the respondents agreed that entrepreneurship education informed students about entrepreneurship through the acquisition of practical skills, knowledge about acquisition of personal orientation, knowledge about business management principles and the availability of entrepreneurial support agencies. This shows that the students are highly confident of setting up their own businesses through the knowledge acquired. The study therefore has important implications for policy makers, management of tertiary institutions, students and educational evaluators on how to ensure that tertiary graduates set up entrepreneurship ventures in order to partially solve the unemployment problem in Ghana.
In der vorliegenden Arbeit werden Verfahren vorgestellt, die geeignet sind, Modelle des menschlichen kardiovaskulären Systems an individuelle Kreislaufreaktionen anzupassen. Allgemeine Kreislaufmodelle des menschlichen kardiovaskulären Systems sind in der Regel nichtlineare Differentialgleichungssysteme, für die es keine effizienten Optimierungsverfahren gibt. Durch die Einschränkung auf relevante Aspekte (bzgl. der Individualisierungsaufgabe) wird ein solches Modell auf Modelle einfacherer Struktur projiziert, die eine Approximation durch Funktionsapproximatoren erlauben, für welche wiederum effiziente Optimierungsalgorithmen existieren. In Abhängigkeit von der Struktur der Individualisierungsaufgabe kommt zusätzlich ein modifiziertes BFGS-Verfahren zum Einsatz, das Approximationen solcher Modellaspekte verwendet um die Konvergenz der Modellindividualisierung zu verbessern.
Theoretische Informatik
(2002)
Eine anschauliche Einführung in die klassischen Themenbereiche der Theoretischen Informatik für Studierende der Informatik im Haupt- und Nebenfach. Die Autoren wählen einen Ansatz, der durch zahlreiche ausgearbeitete Beispiele auch LeserInnen mit nur elementaren Mathematikkenntnissen den Zugang zu Berechenbarkeit, Komplexitätstheorie und formalen Sprachen ermöglicht. Die mathematischen Konzepte werden sowohl formal eingeführt als auch informell erläutert und durch grafische Darstellungen veranschaulicht. Das Buch umfasst den Lehrstoff einführender Vorlesungen in die Theoretische Informatik und bietet zahlreiche Übungsaufgaben zu jedem Kapitel an. (Verlagsangaben)