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Novel Automated Three-Dimensional Genome Scanning Based on the Nuclear Architecture of Telomeres
(2011)
While industrialized countries are becoming service economies, all countries are becoming global. As competition becomes more global, understanding and accommodating the needs of international customers with different cultural backgrounds has become increasingly important. This study highlights cross-cultural perceptions of service problems in the tourist industry.
Nowadays, we input text not only on stationary devices, but also on handheld devices while walking, driving, or commuting. Text entry on the move, which we term as nomadic text entry, is generally slower. This is partially due to the need for users to move their visual focus from the device to their surroundings for navigational purposes and back. To investigate if better feedback about users' surroundings on the device can improve performance, we present a number of new and existing feedback systems: textual, visual, textual & visual, and textual & visual via translucent keyboard. Experimental comparisons between the conventional and these techniques established that increased ambient awareness for mobile users enhances nomadic text entry performance. Results showed that the textual and the textual & visual via translucent keyboard conditions increased text entry speed by 14% and 11%, respectively, and reduced the error rate by 13% compared to the regular technique. The two methods also significantly reduced the number of collisions with obstacles.
Aufgrund der zunehmenden Behandlung von sozialen Netzwerken in den Medien war es das Ziel der Arbeit das Geschäftsmodell von sozialen Netzwerken näher zu analysieren. Die Arbeit zeigt, dass soziale Online-Netzwerke zu den Diensten im Internet gehören, die zwar schon länger existieren, ihren eigentlichen Durchbruch aber erst in den letzten Jahren erlebten. Zu Beginn als reine Kommunikationsplattform genutzt, werden sie heute zur allgemeinen Freizeitgestaltung verwendet und integrieren sich zunehmend in das alltägliche Leben. Die Arbeit beschäftigt sich mit den ökonomischen Besonderheiten von sozialen Online-Netzwerken. Analysiert werden Netzwerkeffekte, Angebots- und Nachfrageverhalten, kritische Masse-Phänomene, Tippy markets, Netzwerkgesetze, Lock-In-Effekte und Wechselkosten. Es wird untersucht, ob und inwieweit sich hinter den sozialen Online-Netzwerken auch klar erkennbare Geschäftsmodelle verbergen. Aufbauend auf einer kritischen Auseinandersetzung mit der Vielfalt existierender Geschäftsmodelle erfolgt die Entwicklung eines eigenen tragfähigen Ansatzes. Auf dieser Basis wird eine Analyse existierender Online-Netzwerke und eine Beurteilung ihres Innovationsgrades vorgenommen.
Erstellung des Online-Tutorials "Einführung in Fachdatenbanken und Fachportale der Niederlandistik"
(2011)
Green IT (Green IS, Green ICT) is a concept of saving energy consumption to reduce IT costs. A current survey shows that only few companies in German speaking countries consider this aspect in their daily business. This is important facing the current situation of attempts of cost saving during the current economic crisis worldwide. This paper introduces into Green IT and presents an IT management and controlling concept. Then the main results of a currently presented survey are used to modify the concept. Finally an agenda for future research is given
Measuring the Understandability of Business Process Models - Are We Asking the Right Questions?
(2011)
Governance and Sustainability in Information Systems. Managing the Transfer and Diffusion of IT
(2011)
Despite perfect functioning of its internal components, a robot can be unsuccessful in performing its tasks because of unforeseen situations. These situations occur when the behavior of the objects in the robot’s environment deviates from its expected values. For robots, such deviations are exhibited in the form of unknown external faults which prohibit them from performing their tasks successfully. In this work we propose to use naive physics knowledge to reason about such faults in the robotics domain. We propose an approach that uses naive physics concepts to find information about the situations which result in a detected unknown fault. The naive physics knowledge is represented by the physical properties of objects which are formalized in a logical framework. The proposed approach applies a qualitative version of physical laws to these properties for reasoning about the detected fault. By interpreting the reasoning results the robot finds the information about the situations which can cause the fault. We apply the proposed approach to the scenarios in which a robot performs manipulation tasks of picking and placing objects. Results of this application show that naive physics holds great promise for reasoning about unknown ex- ternal faults in robotics.
Schwarz-Grün
(2011)
JNK1, but Not JNK2, Is Required in Two Mechanistically Distinct Models of Inflammatory Arthritis
(2011)
Streptococcus agalactiae is the leading cause of bacterial sepsis and meningitis in neonates and is also the causative agent of several serious infections in immunocompromised adults. S. agalactiae encounters multiple niches during an infection, suggesting that regulatory mechanisms control the expression of specific virulence factors in this bacterium. The present study describes the functional characterization of a gene from S. agalactiae, designated rga, which encodes a protein with significant similarity to members of the RofA-like protein (RALP) family of transcriptional regulators. After deletion of the rga gene in the genome of S. agalactiae, the mutant strain exhibited significantly reduced expression of the genes srr-1 and pilA, which encode a serine-rich repeat surface glycoprotein and a pilus protein, respectively, and moderately increased expression of the fbsA gene, which encodes a fibrinogen-binding protein. Electrophoretic mobility shift assays demonstrated specific DNA binding of purified Rga to the promoter regions of pilA and fbsA, suggesting that Rga directly controls pilA and fbsA. Adherence assays revealed significantly reduced binding of the Δrga mutant to epithelial HEp-2 cells and to immobilized human keratin 4, respectively. In contrast, the adherence of the Δrga mutant to A549 cells and its binding to human fibrinogen was significantly increased. Immunoblot and immunoelectron microscopy revealed that the quantity of pilus structures was significantly reduced in the Δrga mutant compared with the parental strain. The wild-type phenotype could be restored by plasmid-mediated expression of rga, demonstrating that the mutant phenotypes resulted from a loss of Rga function.