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„Auf uns hört ja keiner“
(2019)
Ethik im Medizintourismus
(2022)
Autonomous mobile robots need internal environment representations or models of their environment in order to act in a goal-directed manner, plan actions and navigate effectively. Especially in those situations where a robot can not be provided with a manually constructed model or in environments that change over time, the robot needs to possess the ability of autonomously constructing models and maintaining these models on its own. To construct a model of an environment multiple sensor readings have to be acquired and integrated into a single representation. Where the robot has to take these sensor readings is determined by an exploration strategy. The strategy allows the robot to sense all environmental structures and to construct a complete model of its workspace. Given a complete environment model, the task of inspection is to guide the robot to all modeled environmental structures in order to detect changes and to update the model if necessary. Informally stated, exploration and inspection provide the means for acquiring as much information as possible by the robot itself. Both exploration and inspection are highly integrated problems. In addition to the according strategies, they require for several abilities of a robotic system and comprise various problems from the field of mobile robotics including Simultaneous localization and Mapping (SLAM), motion planning and control as well as reliable collision avoidance. The goal of this thesis is to develop and implement a complete system and a set of algorithms for robotic exploration and inspection. That is, instead of focussing on specific strategies, robotic exploration and inspection are addressed as the integrated problems that they are. Given the set of algorithms a real mobile service robot has to be able to autonomously explore its workspace, construct a model of its workspace and use this model in subsequent tasks e.g. for navigating in the workspace or inspecting the workspace itself. The algorithms need to be reliable, robust against environment dynamics and internal failures and applicable online in real-time on a real mobile robot. The resulting system should allow a mobile service robot to navigate effectively and reliably in a domestic environment and avoid all kinds of collisions. In the context of mobile robotics, domestic environments combine the characteristics of being cluttered, dynamic and populated by humans and domestic animals. SLAM is going to be addressed in terms of incremental range image registration which provides efficient means to construct internal environment representations online while moving through the environment. Two registration algorithms are presented that can be applied on two-dimensional and three-dimensional data together with several extensions and an incremental registration procedure. The algorithms are used to construct two different types of environment representations, memory-efficient sparse points and probabilistic reflection maps. For effective navigation in the robot’s workspace, different path planning algorithms are going to be presented for the two types of environment representations. Furthermore, two motion controllers will be described that allow a mobile robot to follow planned paths and to approach a target position and orientation. Finally this thesis will present different exploration and inspection strategies that use the aforementioned algorithms to move the robot to previously unexplored or uninspected terrain and update the internal environment representations accordingly. These strategies are augmented with algorithms for detecting changes in the environment and for segmenting internal models into individual rooms. The resulting system performed very successfully in the 2008 and 2009 RoboCup@Home competitions.
Mobiles Laser-Schneidsystem zur Unterstützung der USBV-Entschärfung und Beweissicherung (mobiLaS)
(2022)
Als rohstoffarme und exportorientierte Wirtschaftsnation ist die Bundesrepublik in ho- hem Maß auf die Sicherung und Sicherheit der Logistikketten im grenzüberschreiten- den Verkehr angewiesen. Angesichts der komplexen Transportstrukturen bei grenz- überschreitenden Transporten kommt den eingesetzten Kontroll- und Prüfverfahren besondere Bedeutung zu: Einerseits müssen Kostenbelastungen, Unterbrechungen und Verzögerungen in der Transportkette minimiert, andererseits besonders illegale Einfuhren, Transporte und Substanzen unterbunden werden. Von besonderer Bedeu- tung für Verdachts- bzw. Stichprobenkontrollen ist der Einsatz speziell trainierter Spür- hunde. Als besonders leistungsfähige ‚lebende Sensoren‘ sind sie in der Lage, eine Vielzahl von Stoffen zu detektieren. Der Einsatz von Spürhunden unterliegt allerdings engen Grenzen: Hoher Trainingsaufwand, eng begrenzte Einsatzdauer, begrenzte Verfügbarkeit. Die Entwicklung neuer, optimierter Einsatzverfahren für Spürhunde z. B. mit höheren Durchsatzraten und überprüfbarer Verlässlichkeit durch Einbindung technischer Systeme ist daher ein wichtiger Beitrag für die Sicherung und Sicherheit der Logistikketten.
In der Regel werden für die Hundeausbildung lose Explosivstoffe im Grammbereich eingesetzt. Deren Umgang unterliegt jedoch aufgrund des Gefährdungspotenzials und aus rechtlichen Gründen sehr strikten Regeln. Diese können nur mit Schwierigkeiten mit den Erfordernissen der Hundeausbildung in Einklang gebracht werden. Der Umgang mit hoch-brisanten Zündstoffen und Selbstlaboraten (z.B. TATP und HMTD) stellt aufgrund der nochmals erhöhten Gefährlichkeit und zusätzlicher gesetzlicher Regelungen eine spezielle Herausforderung dar. Das Poster beschreibt die EMPK® (Echtstoff-Mikromengen-Prüfkörper), die eine sichere Alternative als Trainingshilfsmittel für Sprengstoffspürhunde darstellen.
A reference model is always developed in order to support a specific purpose. The development environment is setting the broader context. Limitations are not only set by size and experience of the modeler team or by budget and time constraints. The intended usage scenario also defines the fundamental contour of a reference model. During the practical work with reference models, a range of key issues has come up to increase the suitability of reference models for daily use. As the result of many projects, the authors have summarized the key issues and formulated critical success factors for reference modeling projects.
The increasing ubiquity of Artificial Intelligence (AI) poses significant political consequences. The rapid proliferation of AI over the past decade has prompted legislators and regulators to attempt to contain AI’s technological consequences. For Germany, relevant design requirements have been expressed by the European Commission’s High-Level Expert Group on Artificial Intelligence (HLEG AI), and, at the national level, by the German government’s Data Ethics Commission (DEK) as well as the German Bundestag’s Commission of Inquiry on Artificial Intelligence (EKKI).
Wie KI Innere Führung lernt
(2022)
Dass sich künstliche Intelligenz (KI) weltweit ausgebreitet hat, ist eine Binsenwahrheit. Die rasche und unaufhaltsame Proliferation von KI der letzten zehn Jahre spricht für sich, und längst ziehen auch Gesetzgeber und Regulierungsbehörden nach, um KI und ihre Technikfolgen einzuhegen. Für Deutschland relevante Gestaltungsanforderungen haben die High-Level Expert Group on Artificial Intelligence der Europäischen Kommission (HLEG AI) und auf nationaler Ebene die Datenethikkommission der Bundesregierung (DEK) und die Enquetekommission Künstliche Intelligenz des Deutschen Bundestags (EKKI) geäußert.
Dieses Einführungspapier ist als Orientierungshilfe zum Thema Künstliche Intelligenz (KI) (engl. Artifical Intelligence, AI) im DaF/DaZ-Kontext gedacht. Ausgehend von häufig gestellten Fragen enthält es grundsätzliche Informationen zu technischen und historischen Hintergründen, didaktisch-methodische Reflexionsanregungen sowie praktische Ideen zum Einsatz von KI im DaF/DaZ-Kontext.
Survival of patients with pediatric acute lymphoblastic leukemia (ALL) after allogeneic hematopoietic stem cell transplantation (allo-SCT) is mainly compromised by leukemia relapse, carrying dismal prognosis. As novel individualized therapeutic approaches are urgently needed, we performed whole-exome sequencing of leukemic blasts of 10 children with post–allo-SCT relapses with the aim of thoroughly characterizing the mutational landscape and identifying druggable mutations. We found that post–allo-SCT ALL relapses display highly diverse and mostly patient-individual genetic lesions. Moreover, mutational cluster analysis showed substantial clonal dynamics during leukemia progression from initial diagnosis to relapse after allo-SCT. Only very few alterations stayed constant over time. This dynamic clonality was exemplified by the detection of thiopurine resistance-mediating mutations in the nucleotidase NT5C2 in 3 patients’ first relapses, which disappeared in the post–allo-SCT relapses on relief of selective pressure of maintenance chemotherapy. Moreover, we identified TP53 mutations in 4 of 10 patients after allo-SCT, reflecting acquired chemoresistance associated with selective pressure of prior antineoplastic treatment. Finally, in 9 of 10 children’s post–allo-SCT relapse, we found alterations in genes for which targeted therapies with novel agents are readily available. We could show efficient targeting of leukemic blasts by APR-246 in 2 patients carrying TP53 mutations. Our findings shed light on the genetic basis of post–allo-SCT relapse and may pave the way for unraveling novel therapeutic strategies in this challenging situation.