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Gender disproportions have been part and parcel of most African cultures since time immemorial. Demographically, women are over a half population in most of the African countries but their participation in sectors of socio-economic and political spheres have remained inadequately represented. The enduring and biased beliefs on gender roles that view women much less important as compared to men are what forms the basis of concern to the welfare of women and most importantly the women entrepreneurs. This study reveals the long-standing cultural practices that have contributed to gender inequality and goes further to demystify areas in which women have continually experienced inequality and thus affecting their entrepreneurial spirit. Through the desk research methodology, it can be deduced that the following are key areas that pause a threat to women socio-economic and political development and hence the inequality being experienced even today in the twenty first century: harmful marriage, female genital mutilation, wife inheritance and HIV scourge, access to land including land rights and right to property, over-emphasizing patriarchal system of family, and gender violence. These factors compounded together, have resulted for unfortunate experiences that have been witnessed in the education sector, political participation, participation in policy making, gender division of labour and inaccess to credit facility. These experiences have severely thwarted entrepreneurial growth of women. The study therefore recommends that there is imperative need for a paradigm shift in these areas to ensure women are not only liberated and empowered but also their full participation in the entrepreneurship activities are highly strengthened and promoted.
Hox genes are an evolutionary highly conserved gene family. They determine the anterior-posterior body axis in bilateral organisms and influence the developmental fate of cells. Embryonic stem cells are usually devoid of any Hox gene expression, but these transcription factors are activated in varying spatial and temporal patterns defining the development of various body regions. In the adult body, Hox genes are among others responsible for driving the differentiation of tissue stem cells towards their respective lineages in order to repair and maintain the correct function of tissues and organs. Due to their involvement in the embryonic and adult body, they have been suggested to be useable for improving stem cell differentiations in vitro and in vivo. In many studies Hox genes have been found as driving factors in stem cell differentiation towards adipogenesis, in lineages involved in bone and joint formation, mainly chondrogenesis and osteogenesis, in cardiovascular lineages including endothelial and smooth muscle cell differentiations, and in neurogenesis. As life expectancy is rising, the demand for tissue reconstruction continues to increase. Stem cells have become an increasingly popular choice for creating therapies in regenerative medicine due to their self-renewal and differentiation potential. Especially mesenchymal stem cells are used more and more frequently due to their easy handling and accessibility, combined with a low tumorgenicity and little ethical concerns. This review therefore intends to summarize to date known correlations between natural Hox gene expression patterns in body tissues and during the differentiation of various stem cells towards their respective lineages with a major focus on mesenchymal stem cell differentiations. This overview shall help to understand the complex interactions of Hox genes and differentiation processes all over the body as well as in vitro for further improvement of stem cell treatments in future regenerative medicine approaches.