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Bone regeneration and replacement is a major focus in regenerative medicine since degenerative diseases and tumor surgery as well as accidents or dangerous recreational behavior is leading to an increasing need for bone reconstruction strategies. Especially for critical size bone defects, tissue engineering with mesenchymal stem cells is extensively studied because these cells are functioning as precursors for osteoblast in vivo. Nevertheless to reproduce the complex interaction of various factors in vitro is not an easy approach and further investigations have to be done. The status quo is summarized. A variety of growth and transcription factors are known to be involved in osteogenesis with bone morphogenetic proteins (BMPs) and the transcription factor Runx2 being the most extensively studied ones. But also PPAR γ and Osterix are generally regarded as the master regulators of osteoblast differentiation. Recently the large family of purinergic receptors has proven to be essential molecules in osteogenesis as well. In addition, scaffolding is needed to create a three-dimensional tissue. Recent developments in scaffold design are summarized, including natural and synthetic materials with or without the use of bioactive molecules constructed to mimic the natural environment. The status quo of scaffold fabrication methods such as 3D nanoprinting and their influence on cell-scaffold interactions is discussed. In this review we summarize the most interesting results and our related work focusing on two joined approaches: 1) the complex interaction of the most promising factors improving or accelerating osteogenic differentiation and ii) the development of scaffold materials with osteoconductive and osteoinductive properties.
Nicht im Elfenbeinturm
(2016)
Internet-Ökonomie
(2016)
Dieses Buch zeigt wie Unternehmen wie Apple, Amazon, Facebook und Google zu den wertvollsten Unternehmen der Welt werden konnten. Ihr Erfolg basiert auf dem Ergreifen von Chancen, die die digitale Welt und das Internet bieten. Traditionelle Geschäftsmodelle werden dadurch verändert und über Jahrzehnte gewachsene Marktstrukturen teilweise in Frage gestellt. Die dritte Auflage dieses Lehrbuchs ist in Form eines modularen Ansatzes grundlegend neu gestaltet.
Recessive mutations in the MPV17 gene cause mitochondrial DNA depletion syndrome, a fatal infantile genetic liver disease in humans. Loss of function in mice leads to glomerulosclerosis and sensineural deafness accompanied with mitochondrial DNA depletion. Mutations in the yeast homolog Sym1, and in the zebra fish homolog tra cause interesting, but not obviously related phenotypes, although the human gene can complement the yeast Sym1 mutation. The MPV17 protein is a hydrophobic membrane protein of 176 amino acids and unknown function. Initially localised in murine peroxisomes, it was later reported to be a mitochondrial inner membrane protein in humans and in yeast. To resolve this contradiction we tested two new mouse monoclonal antibodies directed against the human MPV17 protein in Western blots and immunohistochemistry on human U2OS cells. One of these monoclonal antibodies showed specific reactivity to a protein of 20 kD absent in MPV17 negative mouse cells. Immunofluorescence studies revealed colocalisation with peroxisomal, endosomal and lysosomal markers, but not with mitochondria. This data reveal a novel connection between a possible peroxisomal/endosomal/lysosomal function and mitochondrial DNA depletion.
Der Beitrag stellt auf Basis einer Literaturanalyse den aktuellen Forschungsstand zu Controlling Shared Service Centern dar. Darauf aufbauend wird dieser um die praktischen Erfahrungen bei der Deutschen Telekom ergänzt. Insbesondere der Prozess des Risikomanagements wird hierzu auf seine Eignung für Shared Services auf Grundlage der etwa dreijährigen Erfahrungen des Unternehmens geprüft.