Refine
H-BRS Bibliography
- yes (627) (remove)
Departments, institutes and facilities
- Fachbereich Angewandte Naturwissenschaften (627) (remove)
Document Type
- Article (490)
- Part of a Book (56)
- Conference Object (42)
- Doctoral Thesis (18)
- Preprint (9)
- Book (monograph, edited volume) (6)
- Research Data (4)
- Contribution to a Periodical (1)
- Book review (1)
Year of publication
Language
- English (627) (remove)
Keywords
- GC/MS (13)
- Lignin (9)
- cytokine-induced killer cells (8)
- immunotherapy (7)
- lignin (7)
- stem cells (7)
- Chemometrics (6)
- drug release (6)
- Chromatography (5)
- Explosives (5)
Molecular dynamics investigation of vibrational properties of zeolite ZSM-5-based amorphous material
(2003)
Fasting Intact Proinsulin Is a Highly Specific Predictor of Insulin Resistance in Type 2 Diabetes
(2004)
OBJECTIVE—In later stages of type 2 diabetes, proinsulin and proinsulin-like molecules are secreted in increasing amounts with insulin. A recently introduced chemiluminescence assay is able to detect the uncleaved “intact” proinsulin and differentiate it from proinsulin-like molecules. This investigation explored the predictive value of intact proinsulin as an insulin resistance marker.
Headspace-SPME-GC-MS identification of volatile organic compounds released from expanded polystyrene
(2004)
Low-frequency vibrational excitations in zeolite ZSM-5 and its partially crystalline derivatives
(2004)
Although p27 plays a central role in cell cycle regulation, its role in breast cancer prognosis is controversial. Furthermore, the p27 gene CDKN1B carries a polymorphism with unknown functional relevance. This study was designed to evaluate p27 expression and p27 genotyping with respect to early breast cancer prognosis. 279 patients with infiltrating metastasis-free breast cancer were included in this study. p27 expression was determined in tumor tissue specimens from 261 patients by immunohistochemistry. From 108 patients, the CDKN1B genotype was examined by PCR and subsequent direct sequencing. 55.2% of the tumors were considered p27 positive. p27 expression did not correlate with any of the established parameters except for nodal involvement but significantly correlated to prolonged disease-free survival. In 35% of the tumors analyzed, the CDKN1B gene showed a polymorphism at codon 109 (V109G). The V109G polymorphism correlated with greater nodal involvement. In the node-negative subgroup, V109G correlated significantly with a shortened disease-free survival. In conclusion, the determination of the CDKN1B genotype might be a powerful tool for the prognosis of patients with early breast cancer.