Refine
H-BRS Bibliography
- yes (82) (remove)
Departments, institutes and facilities
- Fachbereich Angewandte Naturwissenschaften (25)
- Fachbereich Wirtschaftswissenschaften (23)
- Fachbereich Informatik (17)
- Institut für Technik, Ressourcenschonung und Energieeffizienz (TREE) (12)
- Fachbereich Ingenieurwissenschaften und Kommunikation (10)
- Institut für funktionale Gen-Analytik (IFGA) (9)
- Fachbereich Sozialpolitik und Soziale Sicherung (7)
- Institut für Sicherheitsforschung (ISF) (4)
- Institut für Verbraucherinformatik (IVI) (4)
- Institut für Cyber Security & Privacy (ICSP) (3)
Document Type
- Article (82) (remove)
Year of publication
- 2016 (82) (remove)
Keywords
- Dielectric analysis (2)
- 31P NMR (1)
- 5-Oxoprolinase (1)
- 5-oxoprolinuria (1)
- Access regulation (1)
- Advanced Driver Assistance Systems (1)
- Africa (1)
- Age estimation (1)
- Alltagsmobilität (1)
- Aminoacylase 1 (1)
Salts and proteins comprise two of the basic molecular components of biological materials. Kosmotropic/chaotropic co-solvation and matching ion water affinities explain basic ionic effects on protein aggregation observed in simple solutions. However, it is unclear how these theories apply to proteins in complex biological environments and what the underlying ionic binding patterns are. Using the positive ion Ca2+ and the negatively charged membrane protein SNAP25, we studied ion effects on protein oligomerization in solution, in native membranes and in molecular dynamics (MD) simulations. We find that concentration-dependent ion-induced protein oligomerization is a fundamental chemico-physical principle applying not only to soluble but also to membrane-anchored proteins in their native environment. Oligomerization is driven by the interaction of Ca2+ ions with the carboxylate groups of aspartate and glutamate. From low up to middle concentrations, salt bridges between Ca2+ ions and two or more protein residues lead to increasingly larger oligomers, while at high concentrations oligomers disperse due to overcharging effects. The insights provide a conceptual framework at the interface of physics, chemistry and biology to explain binding of ions to charged protein surfaces on an atomistic scale, as occurring during protein solubilisation, aggregation and oligomerization both in simple solutions and membrane systems.
SpMV Runtime Improvements with Program Optimization Techniques on Different Abstraction Levels
(2016)
The multiplication of a sparse matrix with a dense vector is a performance critical computational kernel in many applications, especially in natural and engineering sciences. To speed up this operation, many optimization techniques have been developed in the past, mainly focusing on the data layout for the sparse matrix. Strongly related to the data layout is the program code for the multiplication. But even for a fixed data layout with an accommodated kernel, there are several alternatives for program optimizations. This paper discusses a spectrum of program optimization techniques on different abstraction layers for six different sparse matrix data format and kernels. At the one end of the spectrum, compiler options can be used that hide from the programmer all optimizations done by the compiler internally. On the other end of the spectrum, a multiplication kernel can be programmed that use highly sophisticated intrinsics on an assembler level that ask for a programmer with a deep understanding of processor architectures. These special instructions can be used to efficiently utilize hardware features in processors like vector units that have the potential to speed up sparse matrix computations. The paper compares the programming effort and required knowledge level for certain program optimizations in relation to the gained runtime improvements.
Digitale Gemeingüter
(2016)
Die Klausur: VWL
(2016)
Zweiseitige Märkte
(2016)
Die Klausur: VWL
(2016)
Brentuximab vedotin (SGN-35) is an antibody–drug conjugate with a high selectivity against CD30+ cell lines and more than 300-fold less activity against antigen-negative cells. In the last years, the results of many in vitro and in vivo studies have led to the fast approval of this drug to treat lymphoma patients. Another innovative method to treat tumor cells including lymphoma cells is the use cytokine-induced killer (CIK) cells, which have also been approved and proven to be a safe treatment with only minor adverse events. In this study, a possible additive effect when combining SGN-35 with CIK cells was investigated. The combinational treatment showed that it reduces the viability of CD30+ cell lines significantly in vitro. Additionally, the amount of lymphoma cells was significantly reduced when exposed to CIK cells as well as when exposed to SGN-35. A significant negative effect of SGN-35 on the function of CIK cells could be excluded. These results lead to the assumption that SGN-35 and CIK cells in combination might achieve better results in an in vitro setting compared to the single use of SGN-35 and CIK cells. Further investigations in in vivo models must be conducted to obtain a better understanding of the exact mechanisms of both treatments when applied in combination.
IT-Controlling
(2016)
Steigende psychische Arbeitsanforderungen werden im betrieblichen Alltag zunehmend als Normalität empfunden. Trotz erhöhtem Leistungsdruck werden Arbeitspausen oftmals unregelmäßig bis gar nicht wahrgenommen, obwohl mit einer Pause eine gesteigerte Erholung und eine erhöhte Produktivität einhergehen. Der vorliegende Artikel zeigt auf, wie Arbeitspausen und deren systematische Implementierung zu einem "gesunden Unternehmen" beitragen können.
The mechanical properties of plastic components, especially if they are made of semi-crystalline polymers, are considerably influenced by the process conditions. The degree of crystallization influences thermal and mechanical properties. Even more important is the orientation of molecules due to stretching of the polymer melt. Anisotropic material properties are the result of such orientations. Up to now all these effects are not considered within the simulation models of blow molded parts.
Agricultural activities within city boundaries have a long history in both developed and developing countries. In this paper, a broad approach to Urban AgriCulture (UAC) is used, one that includes the production of crops in urban and peri-urban areas and ranges in developed countries from allotment gardens over community gardens to semi-entrepreneurial self-harvest farms and fully commercialized agriculture. With an empirical case study on UAC Initiatives in the Bonn/Rhein-Sieg region this work fills a gap since the lack of comprehensive and comparative studies on urban agriculture (UA) currently makes it difficult for researchers to identify the benefits of UA activities.