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In contrast to projection-based systems, large, high resolution multi-display systems offer a high pixel density on a large visualization area. This enables users to step up to the displays and see a small but highly detailed area. If the users move back a few steps they don't perceive details at pixel level but will instead get an overview of the whole visualization. Rendering techniques for design evaluation and review or for visualizing large volume data (e.g. Big Data applications) often use computationally expensive ray-based methods. Due to the number of pixels and the amount of data, these methods often do not achieve interactive frame rates.
A view direction based (VDB) rendering technique renders the user's central field of view in high quality whereas the surrounding is rendered with a level-of-detail approach depending on the distance to the user's central field of view. This approach mimics the physiology of the human eye and conserves the advantage of highly detailed information when standing close to the multi-display system as well as the general overview of the whole scene. In this paper we propose a prototype implementation and evaluation of a focus-based rendering technique based on a hybrid ray tracing/sparse voxel octree rendering approach.
Rendering techniques for design evaluation and review or for visualizing large volume data often use computationally expensive ray-based methods. Due to the number of pixels and the amount of data, these methods often do not achieve interactive frame rates. A view direction based rendering technique renders the users central field of view in high quality whereas the surrounding is rendered with a level of detail approach depending on the distance to the users central field of view thus giving the opportunity to increase rendering efficiency. We propose a prototype implementation and evaluation of a focus-based rendering technique based on a hybrid ray tracing/sparse voxel octree rendering approach.
Over the past two decades social protection has gained importance at the international and the national level of many low and middle income countries. Despite reforms in this sector being a global phenomenon, they differ from country to country. Traditional efforts to explain these dif- ferences focus on domestic factors. Yet it remains unclear how international influences and interdependencies contrib- ute to policy change. The study ‘International Policy Learn- ing and Policy Change’ aims at providing an answer to this question, by focusing on ‘soft governance’ via horizontal processes, meaning processes between equal actors. The studie was carried out in two parts. While in Part I the cur- rent state of the art in relevant research fields was assessed, in Part II the findings from Part I were used to conduct a survey which analyses the role of policy networks.
Low power dissipation is a current topic in digital design, and therefore, it should be covered in a state-of-the-art electrical engineering curriculum. This paper describes how low-power design can be addressed within a digital design course. Doing so would be beneficial for both topics because low-power design is not detached from the systems perspective, and the digital design course would be enriched by references to current challenges and applications. Thus, the presented course should serve as an example of how a course can be developed to also teach students about sustainable engineering.
Improving the study entry supports students in a decisive phase of their university education. Implementing improvements is a change process and can only be successful if the relevant stakeholders are addressed and convinced. In the described Teaching Quality Pact project evaluation data is used as a mean to discuss in the university the situation of the study programs. As these discussions were based on empirical data rather than on opinion, it was possible to achieve an open discussion about measures that are implemented. The open discussion is maintained during the project when results of the measures taken are analyzed.
The Project SupraMetall: Towards Commercial Fabrication of High-Temperature Superconducting Tapes
(2014)
Structure-activity relationships of thiostrepton derivatives: implications for rational drug design
(2014)
During space missions astronauts suffer from cardiovascular deconditioning, when they are exposed to microgravity conditions. Until now, no specific drugs are available for effective countermeasures, since the underlying mechanism is not completely understood. Endothelial cells (ECs) and smooth muscle cells (SMCs) play crucial roles in a variety of cardiovascular functions, many of which are regulated via P2 receptors. However, their function in ECs and SMCs under microgravity condition is still unknown. In this study, ECs and SMCs were isolated from bovine aorta and differentiated from human mesenchymal stem cells (hMSCs), respectively. Subsequently, the cells were verified based on specific markers. An altered P2 receptor expression pattern was detected during the commitment of hMSC towards ECs and SMCs. The administration of natural and artificial P2 receptor agonists and antagonists directly affected the differentiation process. By using EC growth medium as conditioned medium, a vessel cell model was created to culture SMCs and vice versa. Within this study, we were able to show for the first time that the expression of some P2 receptors were altered in ECs and SMCs grown for 24h under simulated microgravity conditions. On the other hand, in some P2 receptor expressions such as P2X7 conditioned medium compensated this change.
In conclusion, our data show that P2 receptors play an important functional role in hMSC differentiation towards ECs and SMCs. Since some P2 receptor artificial ligands are already used as drugs for patients with cardiovascular diseases, it is reasonable to assume that in the future they might be promising candidates for treating cardiovascular deconditioning.
Exposure to microgravity conditions causes cardiovascular deconditioning in astronauts during spaceflight. Until now, no specific drugs are available for countermeasure, since the underlying mechanism is largely unknown. Endothelial cells (ECs) and smooth muscle cells (SMCs) play key roles in various vascular functions, many of which are regulated by purinergic 2 (P2) receptors. However, their function in ECs and SMCs under microgravity conditions is still unclear. In this study, primary ECs and SMCs were isolated from bovine aorta and verified with specific markers. We show for the first time that the P2 receptor expression pattern is altered in ECs and SMCs after 24 h exposure to simulated microgravity using a clinostat. However, conditioned medium compensates this change in specific P2 receptors, for example, P2X7. Notably, P2 receptors such as P2X7 might be the important players during the paracrine interaction. Additionally, ECs and SMCs secreted different cytokines under simulated microgravity, leading into a pathogenic proliferation and migration. In conclusion, our data indicate P2 receptors might be important players responding to gravity changes in ECs and SMCs. Since some artificial P2 receptor ligands are applied as drugs, it is reasonable to assume that they might be promising candidates against cardiovascular deconditioning in the future.
The title of the annual report 2013 "Shaping change: The University Addresses Society‘s Probing Challenges" reveals the great importance placed on social, economic and technological changes at the university.
This key aspect thus runs through the contents of the 90-page annual report like a common thread, without losing track of the enormous variety of research and teaching at Bonn-Rhein-Sieg University. Whether the exploration of gaps in robot safety during a European Intensive Programme, a report about the Philipines crisis region from a graduate who has worked as an organizer for Care International, or the chapter "What does change look like?" – The annual report provides the full spectrum of opportunities, activities and findings of university members.
The Fifth International Workshop on Domain-Specific Languages and Models for Robotic Systems (DSLRob'14) was held in conjunction with the 2014 International Conference on Simulation, Modeling, and Programming for Autonomous Robots (SIMPAR 2014), October 2014 in Bergamo, Italy. The main topics of the workshop were Domain-Specific Languages (DSLs) and Model-driven Software Development (MDSD) for robotics. A domain-specific language is a programming language dedicated to a particular problem domain that offers specific notations and abstractions that increase programmer productivity within that domain. Model-driven software development offers a high-level way for domain users to specify the functionality of their system at the right level of abstraction. DSLs and models have historically been used for programming complex systems. However recently they have garnered interest as a separate field of study. Robotic systems blend hardware and software in a holistic way that intrinsically raises many crosscutting concerns (concurrency, uncertainty, time constraints, ...), for which reason, traditional general-purpose languages often lead to a poor fit between the language features and the implementation requirements. DSLs and models offer a powerful, systematic way to overcome this problem, enabling the programmer to quickly and precisely implement novel software solutions to complex problems within the robotics domain.