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Structure-activity relationships of thiostrepton derivatives: implications for rational drug design
(2014)
During space missions astronauts suffer from cardiovascular deconditioning, when they are exposed to microgravity conditions. Until now, no specific drugs are available for effective countermeasures, since the underlying mechanism is not completely understood. Endothelial cells (ECs) and smooth muscle cells (SMCs) play crucial roles in a variety of cardiovascular functions, many of which are regulated via P2 receptors. However, their function in ECs and SMCs under microgravity condition is still unknown. In this study, ECs and SMCs were isolated from bovine aorta and differentiated from human mesenchymal stem cells (hMSCs), respectively. Subsequently, the cells were verified based on specific markers. An altered P2 receptor expression pattern was detected during the commitment of hMSC towards ECs and SMCs. The administration of natural and artificial P2 receptor agonists and antagonists directly affected the differentiation process. By using EC growth medium as conditioned medium, a vessel cell model was created to culture SMCs and vice versa. Within this study, we were able to show for the first time that the expression of some P2 receptors were altered in ECs and SMCs grown for 24h under simulated microgravity conditions. On the other hand, in some P2 receptor expressions such as P2X7 conditioned medium compensated this change.
In conclusion, our data show that P2 receptors play an important functional role in hMSC differentiation towards ECs and SMCs. Since some P2 receptor artificial ligands are already used as drugs for patients with cardiovascular diseases, it is reasonable to assume that in the future they might be promising candidates for treating cardiovascular deconditioning.
Exposure to microgravity conditions causes cardiovascular deconditioning in astronauts during spaceflight. Until now, no specific drugs are available for countermeasure, since the underlying mechanism is largely unknown. Endothelial cells (ECs) and smooth muscle cells (SMCs) play key roles in various vascular functions, many of which are regulated by purinergic 2 (P2) receptors. However, their function in ECs and SMCs under microgravity conditions is still unclear. In this study, primary ECs and SMCs were isolated from bovine aorta and verified with specific markers. We show for the first time that the P2 receptor expression pattern is altered in ECs and SMCs after 24 h exposure to simulated microgravity using a clinostat. However, conditioned medium compensates this change in specific P2 receptors, for example, P2X7. Notably, P2 receptors such as P2X7 might be the important players during the paracrine interaction. Additionally, ECs and SMCs secreted different cytokines under simulated microgravity, leading into a pathogenic proliferation and migration. In conclusion, our data indicate P2 receptors might be important players responding to gravity changes in ECs and SMCs. Since some artificial P2 receptor ligands are applied as drugs, it is reasonable to assume that they might be promising candidates against cardiovascular deconditioning in the future.
Werkstattgeflüster
(2014)
Seit der Saison 2014 veröffentlichen wir alle 4 Monate unseren Newsletter "Werkstattgeflüster", der unseren Unterstützern, Förderern und Freunden gleichermaßen einen Einblick in unser Projekt geben soll. Über die Saison verteilt möchten wir so verstärkt über die Events und unsere Zusammenarbeit mit unseren Sponsoren berichten und unseren Mitgliedern die Chance geben, Ihre Arbeit im Team vorzustellen.
Schon der Titel des Jahresberichts 2013 "Den Wandel gestalten: Hochschule stellt sich drängenden Fragen der Gesellschaft" offenbart, welche Bedeutung gesellschaftlichen, wirtschaftlichen und technologischen Veränderungen an der Hochschule beigemessen wird.
Dieses Schwerpunkthema zieht sich folglich wie ein roter Faden durch die Inhalte des 90 Seiten starken Jahresberichts, ohne dabei die enorme Vielfalt von Forschung und Lehre an der Hochschule Bonn-Rhein-Sieg aus den Augen zu verlieren. Ob nun die Ergründung von Lücken in der Robotersicherheit während eines europäischen Intensivprogramms, ein Bericht aus dem Krisengebiet Philippinen von einer Absolventin, die als Organisatorin für Care International tätig ist, oder das Kapitel "Was bedeutet Wandel?" - der Jahresbericht bildet das ganze Spektrum der Möglichkeiten, Aktivitäten und Erkenntnisse der Hochschulangehörigen ab.
Vielfalt ist unser Angebot
(2014)
Der Fachbereich Sozialversicherung der Hochschule Bonn-Rhein-Sieg blickt auf zehn erfolgreiche Jahre zurück. Seit Gründung des Fachbereichs im Jahr 2003 arbeiten Wissenschaftlerinnen und Wissenschaftler verschiedener Disziplinen auf dem Campus Hennef eng vernetzt im Untersuchungsfeld der Sozialversicherung.
The title of the annual report 2013 "Shaping change: The University Addresses Society‘s Probing Challenges" reveals the great importance placed on social, economic and technological changes at the university.
This key aspect thus runs through the contents of the 90-page annual report like a common thread, without losing track of the enormous variety of research and teaching at Bonn-Rhein-Sieg University. Whether the exploration of gaps in robot safety during a European Intensive Programme, a report about the Philipines crisis region from a graduate who has worked as an organizer for Care International, or the chapter "What does change look like?" – The annual report provides the full spectrum of opportunities, activities and findings of university members.
Förderpreise 2014
(2014)
The Fifth International Workshop on Domain-Specific Languages and Models for Robotic Systems (DSLRob'14) was held in conjunction with the 2014 International Conference on Simulation, Modeling, and Programming for Autonomous Robots (SIMPAR 2014), October 2014 in Bergamo, Italy. The main topics of the workshop were Domain-Specific Languages (DSLs) and Model-driven Software Development (MDSD) for robotics. A domain-specific language is a programming language dedicated to a particular problem domain that offers specific notations and abstractions that increase programmer productivity within that domain. Model-driven software development offers a high-level way for domain users to specify the functionality of their system at the right level of abstraction. DSLs and models have historically been used for programming complex systems. However recently they have garnered interest as a separate field of study. Robotic systems blend hardware and software in a holistic way that intrinsically raises many crosscutting concerns (concurrency, uncertainty, time constraints, ...), for which reason, traditional general-purpose languages often lead to a poor fit between the language features and the implementation requirements. DSLs and models offer a powerful, systematic way to overcome this problem, enabling the programmer to quickly and precisely implement novel software solutions to complex problems within the robotics domain.
Dies ist der Tagungsband zum elften aus einer Reihe erfolgreicher Workshops zum Thema Virtuelle und Erweiterte Realität, die von der Fachgruppe VR/AR der Gesellschaft für Informatik e.V. ins Leben gerufen wurde. Als etablierte Plattform für den Informations- und Ideenaustausch der deutschsprachigen VR/AR-Szene bietet der Workshop den idealen Rahmen, aktuelle Ergebnisse und Vorhaben aus Forschung und Entwicklung im Kreise eines fachkundigen Publikums zur Diskussion zu stellen. Insbesondere wollen wir auch jungen Nachwuchswissenschaftlern die Möglichkeit geben, ihre Arbeiten zu präsentieren.
Psychische Belastungen stehen in ihren negativen Ausprägungen als psychische Fehlbeanspruchungen im Zentrum der Diskussion im Arbeitsschutz. Ihr kontinuierlicher Anstieg sowie die Verbindung mit verschiedenen psychischen und körperlichen Erkrankungen werden durch zahlreiche internationale Studien belegt. Die Herausgeber möchten mit dem Praxishandbuch eine Hilfe für diejenigen bieten, die mit der Aufgabe des Erkennens und der Prävention psychischer Fehlbelastungen konfrontiert sind. Die Anregungen sind für alle Akteure im Bereich der Verhütung arbeitsbedingter Gesundheitgefahren geeignet: Betriebsärzte, Sozialmediziner, Psychologen, Sicherheitsfachkräfte, Führungskräfte, Betriebsräte und sonstige Ansprechpartner, Personalverantwortliche und Sozialpädagogen.