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Hox genes are an evolutionary highly conserved gene family. They determine the anterior-posterior body axis in bilateral organisms and influence the developmental fate of cells. Embryonic stem cells are usually devoid of any Hox gene expression, but these transcription factors are activated in varying spatial and temporal patterns defining the development of various body regions. In the adult body, Hox genes are among others responsible for driving the differentiation of tissue stem cells towards their respective lineages in order to repair and maintain the correct function of tissues and organs. Due to their involvement in the embryonic and adult body, they have been suggested to be useable for improving stem cell differentiations in vitro and in vivo. In many studies Hox genes have been found as driving factors in stem cell differentiation towards adipogenesis, in lineages involved in bone and joint formation, mainly chondrogenesis and osteogenesis, in cardiovascular lineages including endothelial and smooth muscle cell differentiations, and in neurogenesis. As life expectancy is rising, the demand for tissue reconstruction continues to increase. Stem cells have become an increasingly popular choice for creating therapies in regenerative medicine due to their self-renewal and differentiation potential. Especially mesenchymal stem cells are used more and more frequently due to their easy handling and accessibility, combined with a low tumorgenicity and little ethical concerns. This review therefore intends to summarize to date known correlations between natural Hox gene expression patterns in body tissues and during the differentiation of various stem cells towards their respective lineages with a major focus on mesenchymal stem cell differentiations. This overview shall help to understand the complex interactions of Hox genes and differentiation processes all over the body as well as in vitro for further improvement of stem cell treatments in future regenerative medicine approaches.
The steadily decreasing prices of display technologies and computer graphics hardware contribute to the increasing popularity of multiple-display environments, like large, high-resolution displays. It is therefore necessary that educational organizations give the new generation of computer scientists an opportunity to become familiar with this kind of technology. However, there is a lack of tools that allow for getting started easily. Existing frameworks and libraries that provide support for multi-display rendering are often complex in understanding, configuration and extension. This is critical especially in educational context where the time that students have for their projects is limited and quite short. These tools are also rather known and used in research communities only, thus providing less benefit for future non-scientists. In this work we present an extension for the Unity game engine. The extension allows – with a small overhead – for implementation of applications that are apt to run on both single-display and multi-display systems. It takes care of the most common issues in the context of distributed and multi-display rendering like frame, camera and animation synchronization, thus reducing and simplifying the first steps into the topic. In conjunction with Unity, which significantly simplifies the creation of different kinds of virtual environments, the extension affords students to build mock-up virtual reality applications for large, high-resolution displays, and to implement and evaluate new interaction techniques and metaphors and visualization concepts. Unity itself, in our experience, is very popular among computer graphics students and therefore familiar to most of them. It is also often employed in projects of both research institutions and commercial organizations; so learning it will provide students with qualification in high demand.
Die Vorteile, Nutzer aktiv, früh und langfristig in ntwicklungsprozesse zu integrieren, um Fehlentwicklungen zu vermeiden und Nutzerbedürfnisse zu adressieren, sind nicht nur in der akademischen Forschung bekannt. Prozesse und Strukturen in Unternehmen der IKT-Branche sind bereits häufig agil implementiert. Dennoch schaffen es kleine und mittlere Unternehmen (KMU) oftmals nicht, die Potentiale einer Nutzerintegration konsequent auszuschöpfen. In Fallstudien wurden drei unterschiedliche KMU analysiert, wie sie die Stimme des Nutzers im Entwicklungsprozess berücksichtigen. Unterschiedliche Strategien der Nutzerintegration, die sich in Rollen und Werkzeugen, in Anforderungen und Problemen an das Nutzersample, Methoden und Datenaufbereitung widerspiegeln, werden beleuchtet. Unser Beitrag soll helfen, Herausforderungen und Probleme von KMU auf der Suche nach angemessenen und passgenauen Wegen der Nutzerintegration zu verstehen und Lösungen zu gestalten.
Sustainable development needs sustainable production and sustainable consumption. During the last decades the encouragement of sustainable production has been the focus of research and policy makers under the implicit assumption that the observable increasing ‘green’ values of consumers would also entail a growing sustainable consumption. However, it has been found that the actual purchasing behaviour often deviates from ‘green’ attitudes. This phenomenon is called the attitude-behaviour gap. It is influenced by individual, social and situational factors. The main purchasing barriers for sustainable (organic) food are price, lack of immediate availability, sensory criteria, lack or overload of information as well as the low-involvement feature of food products in conjunction with well-established consumption routines, lack of transparency and trust towards labels and certifications.
The phenomenon of the deviation between purchase attitudes and actual buying behaviour of responsible consumers is called the attitude-behaviour gap. It is influenced by individual, social and situational factors. The main purchasing barriers for sustainable (organic) food are price, lack of immediate availability, sensory criteria, lack or overload of information as well as the low-involvement feature of food products in conjunction with well-established consumption routines, lack of transparency and trust towards labels and certifications. The last three barriers are mainly of a psychological nature. Especially the low-involvement feature of food products due to daily purchase routines and relatively low prices tends to result in fast, automatic and subconscious decisions based on a so-called human mental system 1, derived from Daniel Kahneman’s (Nobel-Prize laureate in Behavioural Economics) model in behavioural psychology. In contrast, the human mental system 2 is especially important for the transformations of individual behaviour towards a more sustainable consumption. Decisions based on the human mental system 2 are slow, logical, rational, conscious and arduous. This so-called dual action model also influences the reliability of responses in consumer surveys. It seems that the consumer behaviour is the most unstable and unpredictable part of the entire supply chain and requires special attention. Concrete measures to influence consumer behaviour towards sustainable consumption are highly complex. Reviews of interdisciplinary research literature on behavioural psychology, behavioural economics and consumer behaviour and an empirical analysis of selected countries worldwide with a view to sustainable food are presented. The example of Denmark serves as a ‘best practice’ case study to illustrate how sustainable food consumption can be encouraged. It demonstrates that common efforts and a shared responsibility of consumers, business, interdisciplinary researchers, mass media and policy are needed. It takes pioneers of change who succeed in assembling a ‘critical mass’ willing to increase its ‘sustainable’ behaviour. Considering the strong psychological barriers of consumers and the continuing low market share of organic food, proactive policy measures would be conducive to foster the personal responsibility of the consumers and offer incentives towards a sustainable production. Also, further self-obligations of companies (Corporate Social Responsibility – CSR) as well as more transparency and simplification of reliable labels and certifications are needed to encourage the process towards a sustainable development.
Advanced driver assistance systems (ADAS) are technology systems and devices designed as an aid to the driver of a vehicle. One of the critical components of any ADAS is the traffic sign recognition module. For this module to achieve real-time performance, some preprocessing of input images must be done, which consists of a traffic sign detection (TSD) algorithm to reduce the possible hypothesis space. Performance of TSD algorithm is critical.
One of the best algorithms used for TSD is the Radial Symmetry Detector (RSD), which can detect both Circular [7] and Polygonal traffic signs [5]. This algorithm runs in real-time on high end personal computers, but computational performance of must be improved in order to be able to run in real-time in embedded computer platforms.
To improve the computational performance of the RSD, we propose a multiscale approach and the removal of a gaussian smoothing filter used in this algorithm. We evaluate the performance on both computation times, detection and false positive rates on a synthetic image dataset and on the german traffic sign detection benchmark [29].
We observed significant speedups compared to the original algorithm. Our Improved Radial Symmetry Detector is up to 5.8 times faster than the original on detecting Circles, up to 3.8 times faster on Triangle detection, 2.9 times faster on Square detection and 2.4 times faster on Octagon detection. All of this measurements were observed with better detection and false positive rates than the original RSD.
When evaluated on the GTSDB, we observed smaller speedups, in the range of 1.6 to 2.3 times faster for Circle and Regular Polygon detection, but for Circle detection we observed a decreased detection rate than the original algorithm, while for Regular Polygon detection we always observed better detection rates. False positive rates were high, in the range of 80% to 90%.
We conclude that our Improved Radial Symmetry Detector is a significant improvement of the Radial Symmetry Detector, both for Circle and Regular polygon detection. We expect that our improved algorithm will lead the way to obtain real-time traffic sign detection and recognition in embedded computer platforms.
Extraction of text information from visual sources is an important component of many modern applications, for example, extracting the text from traffic signs on a road scene in an autonomous vehicle. For natural images or road scenes this is a unsolved problem. In this thesis the use of histogram of stroke widths (HSW) for character and noncharacter region classification is presented. Stroke widths are extracted using two methods. One is based on the Stroke Width Transform and another based on run lengths. The HSW is combined with two simple region features– aspect and occupancy ratios– and then a linear SVM is used as classifier. One advantage of our method over the state of the art is that it is script-independent and can also be used to verify detected text regions with the purpose of reducing false positives. Our experiments on generated datasets of Latin, CJK, Hiragana and Katakana characters show that the HSW is able to correctly classify at least 90% of the character regions, a similar figure is obtained for non-character regions. This performance is also obtained when training the HSW with one script and testing with a different one, and even when characters are rotated. On the English and Kannada portions of the Chars74K dataset we obtained over 95% correctly classified character regions. The use of raycasting for text line grouping is also proposed. By combining it with our HSW-based character classifier, a text detector based on Maximally Stable Extremal Regions (MSER) was implemented. The text detector was evaluated on our own dataset of road scenes from the German Autobahn, where 65% precision, 72% recall with a f-score of 69% was obtained. Using the HSW as a text verifier increases precision while slightly reducing recall. Our HSW feature allows the building of a script-independent and low parameter count classifier for character and non-character regions.
Virtual reality environments are increasingly being used to encourage individuals to exercise more regularly, including as part of treatment in those with mental health or neurological disorders. The success of virtual environments likely depends on whether a sense of presence can be established, where participants become fully immersed in the virtual environment. Exposure to virtual environments is associated with physiological responses, including cortical activation changes. Whether the addition of a real exercise within a virtual environment alters sense of presence perception, or the accompanying physiological changes, is not known. In a randomized and controlled study design, trials of moderate-intensity exercise (i.e. self-paced cycling) and no-exercise (i.e. automatic propulsion) were performed within three levels of virtual environment exposure. Each trial was 5-min in duration and was followed by post-trial assessments of heart rate, perceived sense of presence, EEG, and mental state. Changes in psychological strain and physical state were generally mirrored by neural activation patterns. Furthermore these change indicated that exercise augments the demands of virtual environment exposures and this likely contributed to an enhanced sense of presence.
Polyether and polyether/ester based TPU (thermoplastic polyurethanes) were investigated with wide-angle XRD (X-ray diffraction) and SAXS (small angle X-ray scattering). Furthermore, SAXS measurements were performed in the temperature range of 30 °C to 130 °C. Polyether based polymers exhibit only one broad diffraction signal in a region of 2 θ 15° to 25°. In case of polyurethanes with ether/ester modification, the broad diffraction signal arises with small sharp diffraction signals. SAXS measurements of polymers reveal the size and shape of the crystalline zones of the polymer. Between 30 °C and 130 °C the size of the crystalline zone changes significantly. The size decreases in most of investigated TPU. In the case of Desmopan 9365D an increase of the particle size was observed.
Förderpreise 2015
(2015)
Praxisorientierte, wissenschaftliche Lehre und Forschung in enger Zusammenarbeit mit Unternehmen, Organisationen und gesellschaftlichen Gruppierungen ist das zentrale Leitbild des Fachbereichs Wirtschaftswissenschaften an der Hochschule Bonn-Rhein-Sieg.
Alles dreht sich um's Denken im gerade erschienenen Jahresbericht 2014.
Im Interview erörtern Hochschulpräsident Hartmut Ihne und 3Sat-Moderator Gert Scobel den Denkbegriff - "Dürfen wir unsere Autonomie aus freien Stücken an Algorithmen abgeben?".
James Chamberlain, Leiter des Sprachenzentrums der H-BRS, geht der Frage auf den Grund, in wieweit sich das Denken in unterschiedlichen Sprachen unterscheidet.
Professor Paul Plöger vom Fachbereich Informatik erklärt, warum Roboter große Probleme damit haben, komplexe Zusammenhänge in offenen Umgebungen zu verstehen.
Der knapp 90 Seiten starke Jahresbericht verknüpft sein großes Thema mit der enormen Vielfalt von Leben, Forschung und Lehre an der H-BRS und wirft nicht nur einen Blick in die Zukunft der Hochschule.
Lehren an Hochschulen
(2015)
Die Servicestelle Lehrbeauftragtenpool ist ein vom Bundesministerium für Bildung und Forschung (BMBF) gefördertes Verbundprojekt der Hochschulen Bonn-Rhein-Sieg, Düsseldorf, Niederrhein und Rhein-Waal. Unser Ziel ist es, die Qualität der Lehre zu verbessern, indem wir Menschen mit Berufserfahrung an die Hochschulen und in die Lehre bringen.
The central theme of the 2014 Annual Report is human thinking.
In an interview, University President Hartmut Ihne and 3Sat moderator Gert Scobel discuss the concept of thought: "Should we be allowed to give up our autonomy voluntarily?"
Our university’s Language Centre Director James Chamberlain examines to what extent thinking varies in different languages.
Professor Paul Plöger from the Department of Computer Science explains why robots have tremendous problems understanding complex relationships in open environments.
Rather than focusing solely on our university’s future, the Annual Report links the fascinating theme to the enormous variety of life, research and tuition offered by H-BRS.
Annual Report 2013 - 2014
(2015)