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Cysticfibrosis (CF) arises from mutations in the CF transmembrane conductance regulator (CFTR) gene, resulting in progressiveand life-limiting respiratory disease. R751L is a rare CFTR mutation that is poorly characterized. Our aims were to describe theclinical and molecular phenotypes associated with R751L. Relevant clinical data were collected from three heterozygote individu-als harboring R751L (2 patients with G551D/R751L and 1 with F508del/R751L). Assessment of R751L-CFTR function was made inprimary human bronchial epithelial cultures (HBEs) andXenopusoocytes. Molecular properties of R751L-CFTR were investigatedin the presence of known CFTR modulators. Although sweat chloride was elevated in all three patients, the clinical phenotypeassociated with R751L was mild. Chloride secretion in F508del/R751L HBEs was reduced compared with non-CF HBEs and asso-ciated with a reduction in sodium absorption by the epithelial sodium channel (ENaC). However, R751L-CFTR function inXenopusoocytes, together with folding and cell surface transport of R751L-CFTR, was not different from wild-type CFTR. Overall,R751L-CFTR was associated with reduced sodium chloride absorption but had functional properties similar to wild-type CFTR.This is thefirst report of R751L-CFTR that combines clinical phenotype with characterization of functional and biological proper-ties of the mutant channel. Our work will build upon existing knowledge of mutations within this region of CFTR and, importantly,inform approaches for clinical management. Elevated sweat chloride and reduced chloride secretion in HBEs may be due to al-ternative non-CFTR factors, which require further investigation.
Females are influenced more than males by visual cues during many spatial orientation tasks; but females rely more heavily on gravitational cues during visual-vestibular conflict. Are there gender biases in the relative contributions of vision, gravity and the internal representation of the body to the perception of upright? And might any such biases be affected by low gravity? 16 participants (8 female) viewed a highly polarized visual scene tilted ±112° while lying supine on the European Space Agency's short-arm human centrifuge. The centrifuge was rotated to simulate 24 logarithmically spaced g-levels along the long axis of the body (0.04-0.5g at ear-level). The perception of upright was measured using the Oriented Character Recognition Test (OCHART). OCHART uses the ambiguous symbol "p" shown in different orientations. Participants decided whether it was a "p" or a "d" from which the perceptual upright (PU) can be calculated for each visual/gravity combination. The relative contribution of vision, gravity and the internal representation of the body were then calculated. Experiments were repeated while upright. The relative contribution of vision on the PU was less in females compared to males (t=-18.48, p≤0.01). Females placed more emphasis on the gravity cue instead (f:28.4%, m:24.9%) while body weightings were constant (f:63.0%, m:63.2%). When upright (1g) in this and other studies (e.g., Barnett-Cowan et al. 2010, EJN, 31,1899) females placed more emphasis on vision in this task than males. The reduction in weight allocated by females to vision when in simulated low-gravity conditions compared to when upright under normal gravity may be related to similar female behaviour in response to other instances of visual-vestibular conflict. Why this is the case and at which point the perceptual change happens requires further research.
Might the gravity levels found on other planets and on the moon be sufficient to provide an adequate perception of upright for astronauts? Can the amount of gravity required be predicted from the physiological threshold for linear acceleration? The perception of upright is determined not only by gravity but also visual information when available and assumptions about the orientation of the body. Here, we used a human centrifuge to simulate gravity levels from zero to earth gravity along the long-axis of the body and measured observers' perception of upright using the Oriented Character Recognition Test (OCHART) with and without visual cues arranged to indicate a direction of gravity that differed from the body's long axis. This procedure allowed us to assess the relative contribution of the added gravity in determining the perceptual upright. Control experiments off the centrifuge allowed us to measure the relative contributions of normal gravity, vision, and body orientation for each participant. We found that the influence of 1 g in determining the perceptual upright did not depend on whether the acceleration was created by lying on the centrifuge or by normal gravity. The 50% threshold for centrifuge-simulated gravity's ability to influence the perceptual upright was at around 0.15 g, close to the level of moon gravity but much higher than the threshold for detecting linear acceleration along the long axis of the body. This observation may partially explain the instability of moonwalkers but is good news for future missions to Mars.
BACKGROUND: Humans demonstrate many physiological changes in microgravity for which long-duration head down bed rest (HDBR) is a reliable analog. However, information on how HDBR affects sensory processing is lacking.
OBJECTIVE: We previously showed [25] that microgravity alters the weighting applied to visual cues in determining the perceptual upright (PU), an effect that lasts long after return. Does long-duration HDBR have comparable effects?
METHODS: We assessed static spatial orientation using the luminous line test (subjective visual vertical, SVV) and the oriented character recognition test (PU) before, during and after 21 days of 6° HDBR in 10 participants. Methods were essentially identical as previously used in orbit [25].
RESULTS: Overall, HDBR had no effect on the reliance on visual relative to body cues in determining the PU. However, when considering the three critical time points (pre-bed rest, end of bed rest, and 14 days post-bed rest) there was a significant decrease in reliance on visual relative to body cues, as found in microgravity. The ratio had an average time constant of 7.28 days and returned to pre-bed-rest levels within 14 days. The SVV was unaffected.
CONCLUSIONS: We conclude that bed rest can be a useful analog for the study of the perception of static self-orientation during long-term exposure to microgravity. More detailed work on the precise time course of our effects is needed in both bed rest and microgravity conditions.
Population ageing and growing prevalence of disability have resulted in a growing need for personal care and assistance. The insufficient supply of personal care workers and the rising costs of long-term care have turned this phenomenon into a greater social concern. This has resulted in a growing interest in assistive technology in general, and assistive robots in particular, as a means of substituting or supplementing the care provided by humans, and as a means of increasing the independence and overall quality of life of persons with special needs. Although many assistive robots have been developed in research labs world-wide, very few are commercially available. One of the reasons for this, is the cost. One way of optimising cost is to develop solutions that address specific needs of users. As a precursor to this, it is important to identify gaps between what the users need and what the technology (assistive robots) currently provides. This information is obtained through technology mapping.
The current literature lacks a mapping between user needs and assistive robots, at the level of individual systems. The user needs are not expressed in uniform terminology across studies, which makes comparison of results difficult. In this research work, we have illustrated the technology mapping of assistive robots using the International Classification of Functioning, Disability and Health (ICF). ICF provides standard terminology for expressing user needs in detail. Expressing the assistive functions of robots also in ICF terminology facilitates communication between different stakeholders (rehabilitation professionals, robotics researchers, etc.).
We also investigated existing taxonomies for assistive robots. It was observed that there is no widely accepted taxonomy for classifying assistive robots. However, there exists an international standard, ISO 9999, which classifies commercially available assistive products. The applicability of the latest revision of ISO 9999 standard for classifying mobility assistance robots has been studied. A partial classification of assistive robots based on ISO 9999 is suggested. The taxonomy and technology mapping are illustrated with the help of four robots that have the potential to provide mobility assistance. These are the SmartCane, the SmartWalker, MAid and Care-O-bot (R) 3. SmartCane, SmartWalker and MAid provide assistance by supporting physical movement. Care-O-bot (R) 3 provides assistance by reducing the need to move.
Emotional communication is a key element of habilitation care of persons with dementia. It is, therefore, highly preferable for assistive robots that are used to supplement human care provided to persons with dementia, to possess the ability to recognize and respond to emotions expressed by those who are being cared-for. Facial expressions are one of the key modalities through which emotions are conveyed. This work focuses on computer vision-based recognition of facial expressions of emotions conveyed by the elderly.
Although there has been much work on automatic facial expression recognition, the algorithms have been experimentally validated primarily on young faces. The facial expressions on older faces has been totally excluded. This is due to the fact that the facial expression databases that were available and that have been used in facial expression recognition research so far do not contain images of facial expressions of people above the age of 65 years. To overcome this problem, we adopt a recently published database, namely, the FACES database, which was developed to address exactly the same problem in the area of human behavioural research. The FACES database contains 2052 images of six different facial expressions, with almost identical and systematic representation of the young, middle-aged and older age-groups.
In this work, we evaluate and compare the performance of two of the existing imagebased approaches for facial expression recognition, over a broad spectrum of age ranging from 19 to 80 years. The evaluated systems use Gabor filters and uniform local binary patterns (LBP) for feature extraction, and AdaBoost.MH with multi-threshold stump learner for expression classification. We have experimentally validated the hypotheses that facial expression recognition systems trained only on young faces perform poorly on middle-aged and older faces, and that such systems confuse ageing-related facial features on neutral faces with other expressions of emotions. We also identified that, among the three age-groups, the middle-aged group provides the best generalization performance across the entire age spectrum. The performance of the systems was also compared to the performance of humans in recognizing facial expressions of emotions. Some similarities were observed, such as, difficulty in recognizing the expressions on older faces, and difficulty in recognizing the expression of sadness.
The findings of our work establish the need for developing approaches for facial expression recognition that are robust to the effects of ageing on the face. The scientific results of our work can be used as a basis to guide future research in this direction.
Als Basis für Simulationen innerhalb virtueller Umgebungen werden meist unterliegende Semantiken benötigt. Im Fall von Verkehrssimulationen werden in der Regel definierte Verkehrsnetzwerke genutzt. Die Erstellung dieser Netzwerke wird meist per Hand durchgeführt, wodurch sie fehleranfällig ist und viel Zeit erfordert. Dieses Projekt wurde im Rahmen des AVeSi Projektes durchgeführt, in dem an der Entwicklung einer realistischen Verkehrssimulation für virtuelle Umgebung geforscht wird. Der im Projekt angestrebte Simulationsansatz basiert auf der Nutzung von zwei Komplexitätsebenen – einer mikroskopischen und einer mesoskopischen. Um einen Übergang zwischen den Simulationsebenen zu realisieren ist eine Verknüpfung der Verkehrsnetzwerke notwendig, was ebenfalls mit einem hohen Zeitaufwand verbunden ist. In diesem Bericht werden Modelle für Verkehrsnetzwerke beider Ebenen vorgestellt. Anschließend wird ein Ansatz beschrieben, der eine automatische Generierung und Verknüpfung von Verkehrsnetzwerken beider Modelle ermöglicht. Als Grundlage für die Generierung der Netzwerke dienen Daten im OpenDRIVE®-Format. Zur Evaluierung wurden wirklichkeitsgetreue OpenStreetMap-Daten, durch Verwendung einer Drittanbietersoftware, in OpenDRIVE®-Datensätze überführt. Es konnte nachgewiesen werden, dass es durch den Ansatz möglich ist, innerhalb weniger Minuten, große Verkehrsnetzwerke zu erzeugen, auf denen unmittelbar Simulationen ausgeführt werden können. Die Qualität der zur Evaluierung generierten Netzwerke reicht jedoch für Umgebungen, in denen ein hoher Realitätsgrad gefordert wird, nicht aus, was einen zusätzlichen Bearbeitungsschritt notwendig macht. Die Qualitätsprobleme konnten darauf zurückgeführt werden, dass der Detailgrad, der den Evaluierungsdaten zu Grunde liegenden OpenStreetMap-Daten, nicht hoch genug und der Überführungsprozess nicht ausreichend transparent ist.
Background: To protect renewable packaging materials against autoxidation and decomposition when substituting harmful synthetic stabilizers with bioactive and bio-based compounds, extracts from Aesculus hippocastanum L. seeds were evaluated. The study objectives were to determine the antioxidant efficacy of bioactive compounds in horse chestnut seeds with regard to different seed fractions, improve their extraction, and to evaluate waste reuse. Methods: Different extraction techniques for field samples were evaluated and compared with extracts of industrial waste samples based on total phenolic content and total antioxidant capacity (2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS)). The molecular weight distribution and absorbance in ultraviolet range (UV) of seed coat extracts were determined, and the possibility of extracts containing proanthocyanidins was examined. Results: Seed coat extracts show a remarkable antioxidant activity and a high UV absorbance. Passive extractions are efficient and much less laborious. Applying waste product seed coats leads to a reduced antioxidant activity, total phenolic content, and UV absorbance compared to the field sample counterparts. In contrast to peeled seed extracts, all seed coat extracts contain proanthocyanidins. Discussion: Seed coats are a potential source of bioactive compounds, particularly regarding sustainable production and waste reuse. With minimum effort, highly bioactive extracts with high potential as additives can be prepared.
Different analyses and feasibility studies have been conducted on the plant extracts of thyme (Thymus vulgaris), European horse chestnut (Aesculus hippocastanum), Nordmann fir (Abies nordmanniana), and snowdrop (Galanthus elwesii) to evaluate bio‐based alternatives to common petrol‐based stabilisers. For this purpose, in this study, plant extracts were incorporated into poly‐lactic acid films (PLA) at different concentrations. The films’ UV absorbance and migration into packed food was analysed via photometric assays (ABTS radical cation scavenging capacity assay, β‐carotene assay) and GC–MS analysis. Furthermore, the synergistic antioxidant effects of various combinations of extracts and isolated active compounds were determined. This way, antioxidant effects can be increased, allowing for a highly effective use of resources. All extracts were successfully incorporated into PLA films and showed notable photoabsorbing effects, while no migration risk was observed. Depending on extract combinations, high synergistic effects of up to 726% can be utilised to improve the effectiveness of bio‐based extracts. This applies particularly to tomato paste and Aesculus hippocastanum extracts, which overall show high synergistic and antioxidant effects in combination with each other and with isolated active compounds. The study shows that it is possible to create safe bio‐based antioxidant films which show even improved properties when using highlighted target combinations.
Background: Coniferous woods (Abies nordmanniana (Stev.) Spach, Abies procera Rehd, Picea abies (L.) H.Karst, and Picea pungens Engelm.) could contain useful secondary metabolites to produce sustainable packaging materials, e.g., by substitution of harmful petrol-based additives in plastic packaging. This study aims to characterise the antioxidant and light-absorbing properties and ingredients of different coniferous wood extracts with regard to different plant fragments and drying conditions. Furthermore, the valorisation of used Christmas trees is evaluated. Methods: Different drying and extraction techniques were applied with the extracts being characterised by determining the total phenolic content (TPC), total antioxidant capacity (TAC), and absorbance in the ultraviolet range (UV). Gas chromatography coupled with mass spectrometry (GC-MS) and an acid–butanol assay (ABA) were used to characterise the extract constituents. Results: All the extracts show a considerably high UV absorbance while interspecies differences did occur. All the fresh and some of the dried biomass extracts reached utilisable TAC and TPC values. A simplified extraction setup for industrial application is evaluated; comparable TAC results could be reached with modifications. Conclusion: Coniferous woods are a promising renewable resource for preparation of sustainable antioxidants and photostabilisers. This particularly applies to Christmas trees used for up to 12 days. After extraction, the biomass can be fully valorised by incorporation in paper packaging.
Bei Thymian (Thymus vulgaris) handelt es sich um eine sehr varietätenreiche Art, die aufgrund ihres Gehaltes an therapeutisch wirksamen Inhaltsstoffen als Arzneipflanze monographiert ist. Insbesondere das ätherische Öl mit dem Hauptbestandteil Thymol (ca. 50%) hat eine hohe antioxidative Wirkung. Ziel ist es, dieses Potential als nachhaltig produzierte Additive zu nutzen. Hierfür eignen sich antioxidativ bzw. antimikrobiell wirksame sowie UV-absorbierende Substanzen, die das Produkt bei Zusatz vor oxidativem Stress, mikrobiellem Abbau und Qualitätsverlust schützen.
Hierzu werden zunächst sechs Varianten auf verschiedene Parameter analysiert, um die potenteste Variante auszuwählen. Auf diese Variante wird sich die weitere Forschung konzentrieren.
Daher wird das ätherische Öl durch azeotrope Destillation extrahiert und mittels GCMS analysiert. In Extrakten werden zudem das AP und Absorptionsverhalten bestimmt. Auch die chemische Zusammensetzung des Extrakts sowie die flüchtigen Stoffe des Thymians werden untersucht. Generell gibt es wenig qualitative, teilweise jedoch quantitative Unterschiede: Eine Variante weist u.a. einen deutlich höheren Thymolgehalt im Öl (ca. 65 %) und ein hohes hydrophiles AP auf. Somit ist eine vielversprechende Variante für die weitere Entwicklung und Optimierung bioaktiver Additive gefunden.
Unsachgemäß entsorgte Zigarettenkippen stellen aufgrund der in ihnen enthaltenen Giftstoffe ein relevantes, ökologisches Problem dar. Diese Forschungsarbeit untersucht den Einsatz von Nudging zur Bekämpfung der Problematik. In einer quantiativen Online-Befragung wurden zunächst die Gründe für das umweltschädliche Verhalten untersucht (N = 96). Hierbei konnte die Gegenwartstendenz von Personen als statistisch signifikanter Hauptgrund ermittelt werden. Viele Personen gaben an, die langfristigen ökologischen Kosten einer unsachgemäßen Entsorgung aufgrund des kurzfristigen persönlichen Nutzens zu ignorieren. Dieser entsteht durch die Gemütlichkeit des „Wegschnipsens“ einer Zigarettenkippe. Im Anschluss wurde ein auf die Gegenwartstendenz von Personen fokussierter Nudge entwickelt und in einem Feldexperiment auf seine Wirksamkeit überprüft, indem die Relation von unsachgemäß zu sachgemäß entsorgten Zigarettenkippen vor und nach dem Einsatz des Nudges dokumentiert wurde. Ohne Einsatz des Nudges (N = 92) wurden am Erhebungsort 64.1 Prozent und mit Einsatz des Nudges (N = 142) lediglich 38.0 Prozent der Zigarettenkippen unsachgemäß entsorgt. In dem Feldexperiment konnte der Nudge effektiv zur Förderung von nachhaltigem Verhalten eingesetzt werden.
The ability of detecting people has become a crucial subtask, especially in robotic systems which aim an application in public or domestic environments. Robots already provide their services e.g. in real home improvement markets and guide people to a desired product. In such a scenario many robot internal tasks would benefit from the knowledge of knowing the number and positions of people in the vicinity. The navigation for example could treat them as dynamical moving objects and also predict their next motion directions in order to compute a much safer path. Or the robot could specifically approach customers and offer its services. This requires to detect a person or even a group of people in a reasonable range in front of the robot. Challenges of such a real-world task are e.g. changing lightning conditions, a dynamic environment and different people shapes. In this thesis a 3D people detection approach based on point cloud data provided by the Microsoft Kinect is implemented and integrated on mobile service robot. A Top-Down/Bottom-Up segmentation is applied to increase the systems flexibility and provided the capability to the detect people even if they are partially occluded. A feature set is proposed to detect people in various pose configurations and motions using a machine learning technique. The system can detect people up to a distance of 5 meters. The experimental evaluation compared different machine learning techniques and showed that standing people can be detected with a rate of 87.29% and sitting people with 74.94% using a Random Forest classifier. Certain objects caused several false detections. To elimante those a verification is proposed which further evaluates the persons shape in the 2D space. The detection component has been implemented as s sequential (frame rate of 10 Hz) and a parallel application (frame rate of 16 Hz). Finally, the component has been embedded into complete people search task which explorates the environment, find all people and approach each detected person.
Die vorliegende Arbeit befasst sich mit der Entwicklung eines Schaltungskonzepts und Labormusters einer externen Beleuchtung für den Einsatz in der Forschung an Time-of-Flight (ToF) Kameras mit Amplitude-Modulated Continuous Wave (AMCW)-Verfahren. Die externe Beleuchtung stellt einen leistungsstarken Repeater der internen Beleuchtung einer ToF Kamera dar und ist in der Lage die von ToF Kameras genutzten hochfrequenten Rechtecksignale zu emittieren.
Da von ToF Kameras in der Regel kein elektrisches Steuersignal (Triggersignal) für den Einsatz einer externen Beleuchtung zur Verfügung gestellt wird, wird dieses aus dem optischen Signal der ToF Kamera gewonnen. Dafür wird ein Konzept für einen optischen Detektor (Trigger) vorgestellt. Dieser setzt sich aus einer Photodiode, einem Transimpedanzverstärker und einer anschließenden Signalaufbereitung zusammen. Außerdem wird gezeigt, wie eine schnelle externe Beleuchtung mit hoher Strahlungsleistung mithilfe eines Metal-Oxid-Semiconductor Field-Effekt-Transistor (MOSFET) und vier Vertical-Cavitiy Surface-Emitting Laser (VCSEL) umgesetzt werden kann. Dafür werden mit der Serien- und Parallelschaltung von MOSFET und VCSEL zwei Schaltungskonzepte vorgestellt. Als Lichtquellen kommen VCSEL mit einer für ToF Kameras typischen Wellenlänge von 940 nm im Nahinfraroten (NIR) zum Einsatz.
Es konnte gezeigt werden, dass mit dem optischen Trigger Signale von bis zu 100 MHz in elektrische Ausgangssignale gewandelt werden können. Außerdem wurden rechteckige Triggersignale mit Anstiegszeiten von 650 ps und Abfallzeiten von 440 ps erzielt. Mit der externen Beleuchtung konnten Signale mit bis zu 100 MHz emittiert werden. Es wurden im Zusammenspiel mit dem optischen Trigger optische Signale mit Anstiegszeiten von 1,5 ns und Abfallzeiten von 960 ps erreicht. Dabei konnten Strahlungsleistungen von knapp 7 W erzielt werden. Das gesamte System aus optischem Trigger und externer Beleuchtung weist eine Latenz von 16 ns auf. Als Ergebnis dieser Arbeit konnte ein System aufgebaut werden, das aufgrund der erzielten Ergebnisse höchstwahrscheinlich als externe Beleuchtung zu Forschungszwecken mit verschiedenen ToF Kameras eingesetzt werden kann. Außerdem besteht die Möglichkeit den optischen Trigger und die Beleuchtung separat zu nutzen.
Blickpunkt
(2024)
We analyze short-term effects of free hospitalization insurance for the poorest quintile of the population in the province of Khyber Pakhtunkhwa, Pakistan. First, we exploit that eligibility is based on an exogenous poverty score threshold and apply a regression discontinuity design. Second, we exploit imperfect rollout and compare insured and uninsured households using propensity score matching. With both methods we fail to detect significant effects on the incidence of hospitalization. Whereas the program did not meaningfully increase the quantity of health care consumed, insured households more often choose private hospitals, indicating a shift towards higher perceived quality of care.
Die vergangene Forschung zeigte, dass Werte und Persönlichkeitseigenschaften von (potentiellen) Arbeitnehmern die wahrgenommene Attraktivität bestimmter Arbeitgebermerkmale wie der Corporate Social Responsibility (CSR) beeinflussen. Weitere Forschung wird hingegen benötigt, um die in diesem Zusammenhang relevanten Persönlichkeitsmerkmale zu identifizieren. Diese Studie zielt darauf ab, die Werte und Persönlichkeitseigenschaften zu ermitteln, welche die unterschiedliche Attraktivität von CSR und weiteren Arbeitgebermerkmalen, die sich nicht auf die CSR beziehen, erklären können. Dazu bewerteten (potentielle) Arbeitnehmer (N = 145) auf zwei eigenentwickelten Skalen sowohl CSR-basierte Faktoren der Arbeitgeberattraktivität (z.B. Wassersparen) als auch Nicht-CSR-basierte Faktoren der Arbeitgeberattraktivität (z.B. erwünschte Unternehmenslage) hinsichtlich ihrer Wichtigkeit. Für die CSR-basierte Arbeitgeberattraktivität konnten unter Kontrolle der Big-Five hypothesenkonform die Wertedimension Selbst-Überwindung, die Persönlichkeitsdimension Communion und die prosoziale Persönlichkeit als Prädiktoren identifiziert werden. Die Wertedimensionen Selbst-Erhöhung und Selbst-Überwindung sowie die Persönlichkeitsdimensionen Agency und Communion leisten – ebenfalls über die Big-Five hinaus – einen bedeutenden Beitrag zur Vorhersage der Nicht-CSR-basierten Arbeitgeberattraktivität.
Due to the policy goals for sustainable energy production, renewable energy plants such as photovoltaics are increasingly in use. The energy production from solar radiation depends strongly on atmospheric conditions. As the weather mostly changes, electrical power generation fluctuates, making technical planning and control of power grids to a complex problem.
Der Einsatz von Agentensystemen ist vielfältig, dennoch sind aktuelle Realisierungen lediglich in der Lage primär regelkonformes oder aber „geskriptetes“ Verhalten auch unter Einsatz von randomisierten Verfahren abzubilden. Für eine realistische Repräsentation sind jedoch auch Abweichungen von den Regeln notwendig, die nicht zufällig sondern kontextbedingt auftreten. Im Rahmen dieses Forschungsprojektes wurde ein realitätsnaher Straßenverkehrssimulator realisiert, der mittels eines detailliert definierten Systems für kognitive Agenten auch diese irregulären Verhaltensweisen generiert und somit ein realistisches Verkehrsverhalten für die Verwendung in VR-Anwendungen simuliert. Durch das Erweitern der Agenten mit psychologischen Persönlichkeitsprofilen, basierend auf dem „Fünf-Faktoren-Modell“, zeigen die Agenten individualisierte und gleichzeitig konsistente Verhaltensmuster. Ein dynamisches Emotionsmodell sorgt zusätzlich für eine situationsbedingte Adaption des Verhaltens, z.B. bei langen Wartezeiten. Da die detaillierte Simulation kognitiver Prozesse, der Persönlichkeitseinflüsse und der emotionalen Zustände erhebliche Rechenleistungen verlangt, wurde ein mehrschichtiger Simulationsansatz entwickelt, der es erlaubt den Detailgrad der Berechnung und Darstellung jedes Agenten während der Simulation stufenweise zu verändern, so dass alle im System befindlichen Agenten konsistent simuliert werden können. Im Rahmen diverser Evaluierungsiterationen in einer bestehenden VR-Anwendung – dem FIVIS-Fahrradfahrsimulator des Antragstellers - konnte eindrucksvoll nachgewiesen werden, dass die realisierten Konzepte die ursprünglich formulierten Forschungsfragestellung überzeugend und effizient lösen.
Maintaining orientation in an environment with non-Earth gravity (1 g) is critical for an astronaut's operational performance. Such environments present a number of complexities for balance and motion. For example, when an astronaut tilts due to ascending or descending an inclined plane on the moon, the gravity vector will be tilted correctly, but the magnitude will be different from on earth. If this results in a mis-perceived tilt, then that may lead to postural and perceptual errors, such as mis-perceiving the orientation of oneself or the ground plane and corresponding errors in task judgment.
The objective of this research project is to develop a user-friendly and cost-effective interactive input device that allows intuitive and efficient manipulation of 3D objects (6 DoF) in virtual reality (VR) visualization environments with flat projections walls. During this project, it was planned to develop an extended version of a laser pointer with multiple laser beams arranged in specific patterns. Using stationary cameras observing projections of these patterns from behind the screens, it is planned to develop an algorithm for reconstruction of the emitter’s absolute position and orientation in space. Laser pointer concept is an intuitive way of interaction that would provide user with a familiar, mobile and efficient navigation though a 3D environment. In order to navigate in a 3D world, it is required to know the absolute position (x, y and z position) and orientation (roll, pitch and yaw angles) of the device, a total of 6 degrees of freedom (DoF). Ordinary laser-based pointers when captured on a flat surface with a video camera system and then processed, will only provide x and y coordinates effectively reducing available input to 2 DoF only. In order to overcome this problem, an additional set of multiple (invisible) laser pointers should be used in the pointing device. These laser pointers should be arranged in a way that the projection of their rays will form one fixed dot pattern when intersected with the flat surface of projection screens. Images of such a pattern will be captured via a real-time camera-based system and then processed using mathematical re-projection algorithms. This would allow the reconstruction of the full absolute 3D pose (6 DoF) of the input device. Additionally, multi-user or collaborative work should be supported by the system, would allow several users to interact with a virtual environment at the same time. Possibilities to port processing algorithms into embedded processors or FPGAs will be investigated during this project as well.
Ziel des hier beschriebenen Forschungsprojekts war die Entwicklung eines prototypischen Fahrradfahrsimulators für den Einsatz in der Verkehrserziehung und im Verkehrssicherheitstraining. Der entwickelte Prototyp soll möglichst universell für verschiedene Altersklassen und Applikationen einsetzbar sowie mobil sein.
Viele Bereiche des Wirtschaftslebens werden heute durch die Digitalisierung beeinflusst. Sowohl auf Grundlage neuer technischer Möglichkeiten und der damit einhergehenden Vernetzung, als auch mit einem Wandel im Konsumverhalten hat sich die Sharing Economy entwickelt. Auf dem Gebiet der urbanen Mobilität ergibt sich für Anbieter und Nachfrager eine Vielzahl neuer Möglichkeiten im Rahmen der Sharing Economy. Die Arbeit setzt sich sowohl mit den aktuellen Mobilitätstrends, als auch mit dem Wandel im Konsumverhalten auseinander. Im Fokus steht hierbei das Ridesourcing, also die entgeltlichen Personenbeförderung von privaten Fahrern mit eigenem Fahrzeug, bei der der Fahrgast das Fahrziel bestimmt und die Vorteile die ein Markteintritt dieser Anbieter mit sich bringt.
Space exposure experiments from the last 15 years have unexpectedly shown that several terrestrial organisms, including some multi-cellular species, are able to survive in open space without protection. The robustness of bdelloid rotifers suggests that these tiny creatures can possibly be added to the still restricted list of animals that can deal with the exposure to harsh condition of space. Bdelloids are one of the smallest animals on Earth. Living all over the world, mostly in semi-terrestrial environments, they appear to be extremely stress tolerant. Their desiccation tolerance at any stage of their life cycle is known to confer tolerance to a variety of stresses including high doses of radiation and freezing. In addition, they constitute a major scandal in evolutionary biology due to the putative absence of sexual reproduction for at least 60 million years. Adineta vaga, with its unique characteristics and a draft genome available, was selected by ESA (European Space Agency) as a model system to study extreme resistance of organisms exposed to space environment. In this manuscript, we documented the resistance of desiccated A. vaga individuals exposed to increasing doses of X-ray, protons and Fe ions. Consequences of exposure to different sources of radiation were investigated in regard to the cellular type including somatic (survival assay) and germinal cells (fertility assay). Then, the capacity of A. vaga individuals to repair DNA DSB induced by different source of radiation was investigated. Bdelloid rotifers represent a promising model in order to investigate damage induced by high or low LET radiation. The possibility of exposure both on hydrated or desiccated specimens may help to decipher contribution of direct and indirect radiation damage on biological processes. Results achieved through this study consolidate our knowledge about the radioresistance of A. vaga and improve our capacity to compare extreme resistance against radiation among living organisms including metazoan.