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Projektmanagement im Mittelstand? Häufig Fehlanzeige, seufzen Beobachter. Mit modernen Methoden der Projektabwicklung, wie sie sich seit vielen Jahren etwa in Konzernen bewährt haben, wollen mittelständische Unternehmen wenig zu tun haben. Doch Vorsicht! Professor Uwe Braehmer warnt vor Pauschalurteilen. Einige Mittelständler beherrschen meisterhaft die Klaviatur des Projektmanagements. Andere erkennen derzeit neue Geschäftschancen durch Projektmanagement. Und wieder andere brauchen ein dem Mittelstand speziell angepasstes Projektmanagement. Professor Uwe Braehmer weiß: „Auf viele mittelständische Geschäftsführer wirkt Projektmanagement zu akademisch und zu groß dimensioniert.“ Bedarfsgerecht gestaltet könne es im Mittelstand eine wesentlich breitere Akzeptanz finden.
Routing Attacks are a serious threat to communication in tactical MANETs. TOGBAD is a centralised approach, using topology graphs to detect such attacks. In this paper, we present TOGBAD's newly added wormhole detection capability. It is an adaptation of a wormhole detection method developed by Hu et al. This method is based on nodes' positions. We adapted it to the specific properties of tactical environments. Furthermore, we present simulation results which show TOGBAD's performance regarding the detection of wormhole attacks.
While industrialized countries are becoming service economies, all countries are becoming global. As competition becomes more global, understanding and accommodating the needs of international customers with different cultural backgrounds has become increasingly important. This study highlights cross-cultural perceptions of service problems in the tourist industry.
Selective screening for inborn errors of metabolism--assessment of metabolites in body fluids
(2011)
Streptococcus agalactiae is the leading cause of bacterial sepsis and meningitis in neonates and is also the causative agent of several serious infections in immunocompromised adults. S. agalactiae encounters multiple niches during an infection, suggesting that regulatory mechanisms control the expression of specific virulence factors in this bacterium. The present study describes the functional characterization of a gene from S. agalactiae, designated rga, which encodes a protein with significant similarity to members of the RofA-like protein (RALP) family of transcriptional regulators. After deletion of the rga gene in the genome of S. agalactiae, the mutant strain exhibited significantly reduced expression of the genes srr-1 and pilA, which encode a serine-rich repeat surface glycoprotein and a pilus protein, respectively, and moderately increased expression of the fbsA gene, which encodes a fibrinogen-binding protein. Electrophoretic mobility shift assays demonstrated specific DNA binding of purified Rga to the promoter regions of pilA and fbsA, suggesting that Rga directly controls pilA and fbsA. Adherence assays revealed significantly reduced binding of the Δrga mutant to epithelial HEp-2 cells and to immobilized human keratin 4, respectively. In contrast, the adherence of the Δrga mutant to A549 cells and its binding to human fibrinogen was significantly increased. Immunoblot and immunoelectron microscopy revealed that the quantity of pilus structures was significantly reduced in the Δrga mutant compared with the parental strain. The wild-type phenotype could be restored by plasmid-mediated expression of rga, demonstrating that the mutant phenotypes resulted from a loss of Rga function.
In this paper, the performance evaluation of Frequency Modulated Chaotic On-Off Keying (FM-COOK) in AWGN, Rayleigh and Rician fading channels is given. The simulation results show that an improvement in BER can be gained by incorporating the FM modulation with COOK for SNR values less than 10dB in AWGN case and less than 6dB for Rayleigh and Rician fading channels.
Novel Automated Three-Dimensional Genome Scanning Based on the Nuclear Architecture of Telomeres
(2011)
NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site
(2011)
Nitric oxide (NO) is an important regulator of Na+ reabsorption by pulmonary epithelial cells and therefore of alveolar fluid clearance. The mechanisms by which NO affects epithelial ion transport are poorly understood and vary from model to model. In this study, the effects of NO on sodium reabsorption by H441 cell monolayers were studied in an Ussing chamber. Two NO donors, (Z)-1-[N-(3-aminopropyl)-N-(n-propyl) amino]diazen-1-ium-1,2-diolate and diethylammonium(Z)-1-(N, N-diethylamino) diazen-1-ium-1,2-diolate, rapidly, reversibly, and dose-dependently reduced amiloride-sensitive, short-circuit currents across H441 cell monolayers. This effect was neutralized by the NO scavenger hemoglobin and was not observed with inactive NO donors. The effects of NO were not blocked by 8-bromoguanosine-3',5'-cyclic monophosphate or by soluble guanylate cyclase inhibitors (methylene blue and 1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one) and were therefore independent of soluble guanylate cyclase signaling. NO targeted apical, highly selective, amiloride-sensitive Na+ channels in basolaterally permeabilized H441 cell monolayers. NO had no effect on the activity of the human epithelial sodium channel heterologously expressed in Xenopus oocytes. NO decreased Na+/K+-ATPase activity in apically permeabilized H441 cell monolayers. The inhibition of Na+/K+-ATPase activity by NO was reversed by mercury and was mimicked by N-ethylmaleimide, which are agents that reverse and mimic, respectively, the reaction of NO with thiol groups. Consistent with these data, S-NO groups were detected on the Na+/K+-ATPase a subunit in response to NO-donor application, using a biotin-switch approach coupled to a Western blot. These data demonstrate that, in the H441 cell model, NO impairs Na+ reabsorption by interfering with the activity of highly selective Na+ channels and the Na+/K+-ATPase.
Ein SLA (Service Level Agreement) legt alle Punkte einer vertraglichen Zusammenarbeit zwischen Unternehmen und Service Provider verbindlich fest. Ein SLA muss sorgfältig erstellt werden, um ein Vertrauensverhältnis zwischen beiden Seiten herzustellen. Dabei geht es um inhaltliche, organisatorische und technische Anforderungen sowie um eine exakte Festlegung auf verwendete Fachbegriffe und Leistungskriterien. Der vorliegende Beitrag beschreibt Punkt für Punkt den Inhalt eines SLA. Das sind u.a. die Benennung der Vetragspartner, die Leistungskriterien, die die Qualität des Dienstes sicherstellen sowie die Überwachung der Erbringung der vereinbarten Leistung und die Dauer des Vertrages.