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Introduction: Antimicrobial resistance (AMR) has emerged as one of the leading threats to public health. AMR possesses a multidimensional challenge that has social, economic, and environmental dimensions that encompass the food production system, influencing human and animal health. The One Health approach highlights the inextricable linkage and interdependence between the health of people, animals, agriculture, and the environment. Antibiotic use in any of these One Health areas can potentially impact the health of other areas. There is a dearth of evidence on AMR from the natural environment, such as the plant-based agriculture sector. Antibiotics, antibiotic-resistant bacteria (ARB), and related AMR genes (ARGs) are assumed to present in the natural environment and disseminate resistance to fresh produce/vegetables and thus to human health upon consumption. Therefore, this study aims to investigate the role of vegetables in the spread of AMR through an agroecosystem exploration from a One Health perspective in Ahmedabad, India.
Protocol: The present study will be executed in Ahmedabad, located in Gujarat state in the Western part of India, by adopting a mixed-method approach. First, a systematic review will be conducted to document the prevalence of ARB and ARGs on fresh produce in South Asia. Second, agriculture farmland surveys will be used to collect the general farming practices and the data on common vegetables consumed raw by the households in Ahmedabad. Third, vegetable and soil samples will be collected from the selected agriculture farms and analyzed for the presence or absence of ARB and ARGs using standard microbiological and molecular methods.
Discussion: The analysis will help to understand the spread of ARB/ARGs through the agroecosystem. This is anticipated to provide an insight into the current state of ARB/ARGs contamination of fresh produce/vegetables and will assist in identifying the relevant strategies for effectively controlling and preventing the spread of AMR.
RELA haploinsufficiency is a recently described autoinflammatory condition presenting with intermittent fevers and mucocutaneous ulcerations. The RELA gene encodes the p65 protein, one of five NF-κB family transcription factors. As RELA is an essential regulator of mucosal homeostasis, haploinsufficiency leads to decreased NF-κB signaling which promotes TNF-driven mucosal apoptosis with impaired epithelial recovery. Thus far, only eight cases have been reported in the literature. Here, we report four families with three novel and one previously described pathogenic variant in RELA. These four families included 23 affected individuals for which genetic testing was available in 16. Almost half of these patients had been previously diagnosed with more common rheumatologic entities (such as Behcet's Disease; BD) prior to the discovery of their pathogenic RELA variants. The most common clinical features were orogenital ulcers, rash, joint inflammation, and fever. The least common were conjunctivitis and recurrent infections. Clinical variability was remarkable even among familial cases, and incomplete penetrance was observed. Patients in our series were treated with a variety of medications, and benefit was observed with glucocorticoids, colchicine, and TNF inhibitors. Altogether, our work adds to the current literature and doubles the number of reported cases with RELA-Associated Inflammatory Disease (RAID). It reaffirms the central importance of the NF-κB pathway in immunity and inflammation, as well as the important regulatory role of RELA in mucosal homeostasis. RELA associated inflammatory disease should be considered in all patients with BD, particularly those with early onset and/or with a strong family history.
The paper investigates the nature of Kenya's entrepreneurship education ecosystem (EEE) through a comparative analysis of three entrepreneurship education programs and an examination of how the institutions foster a favourable entrepreneurial environment. This study looks at the entrepreneurship education ecosystem through the lens of universities, NGO's and private institutes in Kenya.
A systemic analysis of EEE is provided by utilizing the Actiotope Model as a conceptual framework. The exploratory research adopts a pragmatic mixed-method methodological approach best suited to understand the research problem.
The results reveal that entrepreneurship education at higher education institutions was primarily theoretical and relied on traditional forms of entrepreneurship education. Recurring rigid patterns show minimal personalization of content and learning styles within the University, with more personalization reported in the Mully Model of education and the more specialized entrepreneurship program of the Identity Projects.
The adaptation of the Actiotope Model provided a new and unique approach to analyzing entrepreneurship ecosystems. The person-centred approach of the model provides valuable insights to learners and to entrepreneurship education institutions and researchers.
Enhanced collaboration between the different entrepreneurial education stakeholders could be a more effective short to medium-term solution to addressing the gaps in entrepreneurial education at tertiary institutions.
In the long term, the study recommends adopting practical-based and goal-oriented entrepreneurship teaching models.
Social businesses have a great positive impact on communities and are a sustainable way to do business today and in the future. This impact can be amplified through the means of digitalization. In the past, traditional for-profit business models have been used to understand the structures of business operations. However, the underlying business model of digital social businesses has not yet been explored. This study presents a building block analysis of business models and a subsequent typology. Digital and social business models are identified via a literature review. The building block analysis encompasses an assessment of the individual business activities contained in the business models. The typology is developed from existing literature utilizing a matrix for the evaluation of digital social businesses. Additionally, five semi-structured expert interviews are conducted to inform, extend, or content the findings of this study. To this end, an inductive coding procedure is applied to the transcribed interviews for the detection of themes within the text. This study contributes to social business model research by providing a first insight into the unique building blocks of digital social business models. It also creates a typology tool based on two parameters, which enables the comparison of digital social businesses.
Mobile technologies have evolved into the means of gaining access to information for learning. Its application in higher education is still a novel concept, particularly in underdeveloped countries. This study is aimed at exploring the views of doctoral students regarding their learning experiences with mobile technologies. Student focus group interviews of 24 doctoral students from 3 different academic institutions were interviewed. The participants’ responses were recorded, transcribed, and analyzed to make conclusions. According to the findings of this study, mobile devices play an important part in the learning experiences of doctoral students. The participating students engaged in collaborative learning using mobile technologies. Given the benefits of adopting mobile technologies for learning activities, academic institutions should focus on teaching faculty members to use this to involve students in their learning process. The implications of this study call for the continued advancement of mobile technologies to facilitate effective learning experience for the multitude of mobile learners in developing countries. Another implication is that academic institutions with collaboration with libraries should see the need to develop user friendly mobile app that is linked to the library management system. Such an application would allow the students to optimally use their smartphones and tablets to search the library’s resources from their mobile devices. Training should be offered to the teaching faculty members to come to terms with the benefits of mobile technologies for learning activities.
Tourism in Rwanda is challenging. Since the country is small and hilly, it is difficult to tap the potential. As the country is blessed with diverse nature, the Rwandan government decided to combine ecotourism with high-end tourism, to exploit the full potential. This study aims to assess the extent to which these two types of tourism fit together, as well as if sustainability is a decisive argument in this upscale segment. In this context, ecotourism is characterized by its 3 core criteria: education, nature and sustainability. To evaluate the main question: to what extent can ecotourism projects help to promote the perception of Rwanda as a high-end tourist destination on the German market? As well as if sustainability is a decisive argument, interviews with stakeholder from the Rwandan tourism industry as well as German tour operators were conducted, to gain an understanding of both sites and then evaluate them according to the 3 ecotourism core criteria and the demands of high-end tourists. The results showed that there is a difference in the perception of the needs of high-end tourists. While the 3 core criteria seem to be too relevant while they are in booking decision with the tour operator. The high-end lodges in Rwanda state an interest in these three criteria. It is evident from the results that there is a limited active demand for sustainable tourist products, while nature and education are more relevant, but not yet fully exploited. However, all interviewees indicated that ecotourism, and in particular sustainability, is experiencing an increase in demand and will continue to grow in importance in the future. Accordingly, the results suggest the driving markets approach is relevant to further drive demand in that segment.
As a developing economy, Rwanda has been exploring transitioning to being a technologically driven and sustainable economy. Moreover, research on economic growth have focused on the need to improve human capacity potential within increasing demands of climate change activists but there remains a theoretic and practical lacuna in including renewable energy resources in economic growth and expansion of electricity access. Therefore, it is necessary to study the impact of competent skill acquisition and graduate employment market on the interaction mix between economic growth and the expansion of energy access in Rwanda, particularly finding out the problems advancing the non-inclusiveness of engineering graduates, which result to high rate of unemployment and diversions, especially for the graduates specializing in energy fields. As a result, the following open questions were raised with variations 1; how did employees penetrate energy-sector labour market opportunity in Rwanda? 2; what influenced employee’s decision in pursuing a career in Rwanda’s labour market, 3; what were the specific employee competent skills that enabled smooth transition in energy-sector employment after graduation and the ones required to maintain their current positions? 4; what specific competent skills are required for inclusivity of today's engineering graduates in energy sector employment market? The study is qualitative and it uses the exploratory research design. It is based on the growth pole theory employing snowball/chain purposeful sampling technique, whereby key informants in Rwanda energy sector were located. Data was specifically collected from these primary sources through semi-structured interviews and documentary method. Interview data and text from documents were inductively analysed. The study generally recommended institution or program for connecting learning institutions, industry and employment market in the distributed and renewable energy resources to promote competent skills acquisition, competition and improve graduates’ inclusiveness in the expansion of electricity access, thereby leading to economic growth in Rwanda.
Rapid and sustained innovation in developed markets triggers the generation of innovative start-ups, some with disruptive innovations. However, when their offering faces a saturated market with satisfactory and widely available established traditional solutions, many innovative start-ups from these markets may fail. The literature on some start-ups that successfully brought their innovation to emerging markets shows how using leapfrogging traditional solutions to innovative solutions can offer survival and growth opportunities to these start-ups. However, a wide exploitation of leapfrogging processes in emerging markets for survival or business growth of innovative start-ups from developed markets is not yet theorized. To contribute to closing this gap, we propose a conceptual framework to assess the readiness of an emerging market to leapfrog to innovative solutions.
The design of the conceptual framework uses a scenario-planning like approach with two key factors, namely Context Readiness and Value Network Integration. To test and refine the proposed framework and show its relevance for coming to an informed expansion decision making, we used PAR (Participatory Action Research). For the illustration of the application of the proposed conceptual framework, the case of telehealth in Morocco is used.
While 14 % of the world's working-age population currently lives in sub-Saharan Africa (SSA), this figure will predictably be higher than the rest of the world combined by 2036. If this demographic group finds meaningful employment, Africa experiences an economic and social upswing. To tap this potential, the paper intends to answer the research question, "What are the prerequisites and how are they defined for the successful implementation of sustainable business model ideas in SSA?", by developing a top ten ranking consisting of previously identified sustainable business model ideas best suited for productive use. This achieves a novel approach to implementing future-oriented business models and contributes to current research on sustainable models. Since the geographical scope of SSA is pervasive, this paper focuses on Namibia, Rwanda, Senegal, and Uganda. An extensive literature review on these countries was conducted to gain a broader understanding of the situation in SSA. Additionally, research was carried out on the agricultural, energy, and information and communications technology (ICT) sectors to identify the most promising ideas. To contribute to current knowledge, experts were interviewed, and panel discussions were analyzed. Furthermore, the Business Model Canvas (BMC) was combined with the circular economy concept, which served as a framework for the business model ideas. Experts evaluated these ideas, which were subsequently ranked using fuzzy logic with artificial intelligence, based on the system for exploring country risks (CRISK-Explorer). The paper shows that skipping individual development processes opens up promising opportunities, such as the ICT-based business model e-crowd logistics or the renewable energy-based model e-Boda-Boda. Seven prerequisites for the successful implementation of these ideas were identified and defined: value delivery, promising customers, sufficient capital, presence of key resources, possibility to perform the key activities, sustainability, and profitability. The paper concludes by identifying limitations and suggesting avenues for future research.
Channels of distribution are important factors in the connection between goods and services produced for the final consumer and, therefore, determine the effectiveness with which they are delivered and ultimately availed to the final consumers. Globally, studies show that channels of distribution and sales play an essential role in building bonds between manufacturers, retailers, wholesalers and their consumers. The main purpose of this study is to examine the influence of distribution channels and networks on customer choice of fast-moving consumer goods (FCMG) in the Upper East Region of Ghana. The study adopted a quantitative approach and questionnaires were used to collect primary data from 110 customers of Unilever Ghana Limited in the Upper East Region of Ghana. The findings reveal that product-related factors, such as the price of products, perishability of products, size and weight of products, promote the effective distribution of Unilever goods and services, whilst consumer-related factors, such as the number of customers and increased consumer base, promote effective distribution channels. The study also established a positive influence of factors, such as incentives, receiving feedback and sales performance, on customer choice of fast-moving consumer goods (FMCG). Managers and producers in the FMCGs industry should implement reward and incentive programmes and policies to boost the sale and distribution of fast-moving consumer goods and services in the retail industry in Ghana.
Entrepreneurship is labelled as the panacea for graduate unemployment in Ghana. In the training process, students are mandatorily required to read a course in entrepreneurship, so as to be able to start their own businesses in the face of job adversities caused by the inadequacy of job opportunities created by government and lack of government drive to diversify the economy for more jobs to be created. This study, therefore aimed at investigating the critical precursors of entrepreneurial intentions among higher education students in Ghana. Using the analytical cross-sectional survey design, 250 respondents were recruited from public universities using probability sampling techniques (stratified-disproportionate and simple random) to participate in the survey. Respondents were required to respond to three constructs (entrepreneurial scaffolding, psychological capital, and entrepreneurial intentions). The data analyses were performed using multivariate regression. The study findings showed that entrepreneurial scaffolding and psychological capital were significant predictors of entrepreneurial intentions. The researchers concluded that students' convictions in succeeding or otherwise and planning to engage in entrepreneurial behaviours depended on proper entrepreneurial guidance and a positive mind-set. Therefore, it was recommended that higher education institutions in Ghana strengthened and included practical guides to entrepreneurial training. This will encourage higher education students to consider entrepreneurship, hence, reducing graduate unemployment in Ghana.
The dawn of the 21st Century has witnessed a tremendous increase in trade pacts among nations, resulting in renewed hopes for sustainable enterprise development in emerging economies worldwide. Ghana and other sub- Saharan African (SSA) countries have signed onto several North-South and South-South free trade agreements with the hope of strengthening their presence in the international trade arena, and to promote economic growth in SSA. For over two decades, however, very little has changed, and many have dashed their high hopes as enterprises continue to struggle in SSA. Not even the African Continental Free Trade Agreement (AfCFTA) could renew the hopes of sceptics. Several studies opined that enterprises in SSA could improve their domestic and international competitiveness by establishing mutually beneficial partnerships with their counterparts from the Global North and South. This study delved into the issues that affect North-South and South-South business collaborations and recommends key success factors that could help promote mutually beneficial cross-border business partnerships. The research includes both literature and empirical information on the key success factors of business partnerships between African enterprises as well as between African enterprises and firms from the Global North. We approached the study qualitatively using a phenomenological research design. Research participants included important stakeholders in Africa and Europe's international trade and sustainable enterprise development ecosystem. The study identified several challenges with the current business collaborations and recommended new ways of making such partnerships more beneficial.
The differentiation of the higher education sector in Ethiopia has created a new sector of Higher Education Institutions: Universities of Applied Sciences (UAS). Its focus is on educating academically trained experts for regional industries. Close cooperation between industries and UAS is set as a key requirement. However, Ethiopian industries in many regions are not developed enough that those could be considered as active partners for UASs and able to accommodate interns or to provide expert teachers to UAS classes. European UAS structures serve as benchmarks for the Ethiopian Ministry of Education (MoE). Therefore, UAS curricula of study programmes in building-construction, electro-engineering and economic/business/tourism from different European countries build a common ground for Ethiopian UASs. But, due to the lack of industries in the regions, Ethiopian UAS are not able to mirror the European counterparts, where study programmes at bachelor level comprise 70 credits out or 210 credits as practical works, internships and bachelor thesis. - The question is, how can Ethiopian UASs in the absence of companies offer practice-oriented education in their study programmes? This paper refers to the ongoing research, on how to integrate UAS (academic and non-academic) departments at UAS campuses to create internship placements for students in the absence of internship placements in the private sector. Kotebe University of Education (KUE) - as one of the newly founded UAS in Ethiopia - has agreed to act as subject of this try-out.
Based on the WEF Travel & Tourism Report data, this study deploys k-means cluster analysis to build a global typology of national destination governance. Previous studies have focused on case studies, while this chapter focuses on classification of different destination types, by deploying indicators a set of following relevant indicators: wastewater treatment, fixed broadband internet subscriptions, ground transport efficiency, quality of roads, quality of railroad infrastructure, reliability of police services, ease of finding skilled employees. The results present a four-cluster solution of national destination governance types, as well as their major characteristics. The chapter than provides and discusses important implication for theory and practice of destination governance.
The access to electricity and water in rural areas in Côte d’Ivoire as well as in large parts of Africa is limited. According to Ivorian government sources, the national coverage rate of drinkable water and electricity was about 80% in 2020, whereas there are differences between rural and urban regions. The coverages are lower in rural areas that are situated far from the governmental infrastructures. The poor supply of electricity also hinders education, since petroleum lamps are often the only source of light for learning after sunset. Besides, increasing demand for electricity is predicted in Côte d’Ivoire due to economic growth. The economic power is also affected by the poor supply of electricity, so only a limited production of goods is possible. A further big concern in Côte d’Ivoire is the employability of graduate students, as the educational system has a strong theoretic character, not yet taking enough into account practice orientation. Scientific public universities in Côte d'Ivoire often offer only subjects such as mathematics, physics, or chemistry but hardly any engineering.
In recent years, the ability of intelligent systems to be understood by developers and users has received growing attention. This holds in particular for social robots, which are supposed to act autonomously in the vicinity of human users and are known to raise peculiar, often unrealistic attributions and expectations. However, explainable models that, on the one hand, allow a robot to generate lively and autonomous behavior and, on the other, enable it to provide human-compatible explanations for this behavior are missing. In order to develop such a self-explaining autonomous social robot, we have equipped a robot with own needs that autonomously trigger intentions and proactive behavior, and form the basis for understandable self-explanations. Previous research has shown that undesirable robot behavior is rated more positively after receiving an explanation. We thus aim to equip a social robot with the capability to automatically generate verbal explanations of its own behavior, by tracing its internal decision-making routes. The goal is to generate social robot behavior in a way that is generally interpretable, and therefore explainable on a socio-behavioral level increasing users' understanding of the robot's behavior. In this article, we present a social robot interaction architecture, designed to autonomously generate social behavior and self-explanations. We set out requirements for explainable behavior generation architectures and propose a socio-interactive framework for behavior explanations in social human-robot interactions that enables explaining and elaborating according to users' needs for explanation that emerge within an interaction. Consequently, we introduce an interactive explanation dialog flow concept that incorporates empirically validated explanation types. These concepts are realized within the interaction architecture of a social robot, and integrated with its dialog processing modules. We present the components of this interaction architecture and explain their integration to autonomously generate social behaviors as well as verbal self-explanations. Lastly, we report results from a qualitative evaluation of a working prototype in a laboratory setting, showing that (1) the robot is able to autonomously generate naturalistic social behavior, and (2) the robot is able to verbally self-explain its behavior to the user in line with users' requests.
Introduction. The experience of pain is regularly accompanied by facial expressions. The gold standard for analyzing these facial expressions is the Facial Action Coding System (FACS), which provides so-called action units (AUs) as parametrical indicators of facial muscular activity. Particular combinations of AUs have appeared to be pain-indicative. The manual coding of AUs is, however, too time- and labor-intensive in clinical practice. New developments in automatic facial expression analysis have promised to enable automatic detection of AUs, which might be used for pain detection. Objective. Our aim is to compare manual with automatic AU coding of facial expressions of pain. Methods. FaceReader7 was used for automatic AU detection. We compared the performance of FaceReader7 using videos of 40 participants (20 younger with a mean age of 25.7 years and 20 older with a mean age of 52.1 years) undergoing experimentally induced heat pain to manually coded AUs as gold standard labeling. Percentages of correctly and falsely classified AUs were calculated, and we computed as indicators of congruency, "sensitivity/recall," "precision," and "overall agreement (F1)." Results. The automatic coding of AUs only showed poor to moderate outcomes regarding sensitivity/recall, precision, and F1. The congruency was better for younger compared to older faces and was better for pain-indicative AUs compared to other AUs. Conclusion. At the moment, automatic analyses of genuine facial expressions of pain may qualify at best as semiautomatic systems, which require further validation by human observers before they can be used to validly assess facial expressions of pain.
IT-Governance, Prüfung & Revision mal agil gedacht! Herausforderungen und Notwendigkeit eines Perspektivwechsels für IT-Governance, Prüfung & Revision viele Fallbeispiele zeigen die praktische Umsetzbarkeit auf Agilität und der Einsatz agiler Methoden sind heute nicht mehr nur auf IT-Projekte begrenzt, sondern prägen zunehmend ganze Organisationen. Dieses Buch zeigt auf, wie sich IT-Governance, Prüfung & Revision erfolgreich dem durch Agilität ausgelösten Wandel stellen können und wie sich der Umgang mit den Kernthemen Risiko & Unsicherheit verändert. Zum einen werden Ansätze für eine agile IT-Governance und eine agile Prüfung & Revision beschrieben, indem sie sich agile Werte und Vorgehensweisen zu eigen machen. Zum anderen werden IT-Governance, Prüfung & Revision befähigt, agile Projekte angemessen steuern und wirksam prüfen zu können.
Die soziale Netzwerkanalyse versucht menschliche Interaktion in einen analytischen und auswertbaren Zusammenhang zu bringen. Sie hat sich als Methode in den letzten Jahrzehnten über die Sozialwissenschaften hinaus in die Geschichtswissenschaften, Archäologie und Religionswissenschaften verbreitet. Dabei fanden verschiedene Paradigmenwechsel statt, zum Beispiel vom statischen Netzwerken mit dem Schwerpunkt auf quantitativ-struktureller Analyse hin zu heterogenen Handlungsnetzwerken wie zum Beispiel in der der Actor Network Theory (ANT) gewandelt. Der Fokus liegt aktuell eher auf der Frage des Informationsaustauschs und der Dynamik nicht statischer Netzwerke.
This paper gives an overview of how we can benefit from using container technology in our academic work. It aims to be a starting point for fellow researchers which also think about applying these technologies. Hence, we focus on decribing our own experiences and motivations instead of proving hard scientific facts.
Open-Source Software spielt sowohl zur Ausgestaltung von Lehr- und Lernszenarien (bspw. Organisation mit Editoren und Groupware, Kollaboration und Kommunikation via Chats und Webblogs), als auch für die Umsetzung von Forschunsprojekten (zum Beispiel Auswertung großer Datenbestände, Erprobung realer Situationen in vituellen Laboren, Evaluation neuer Oberflächenentwicklungen) eine wichtige Rolle. Um eine bestmögliche Passung der Software herzustellen, erfolgt Softwareentwicklung im Hochschulbereich entweder forschungsprojektbezogen oder Disziplin- und Einrichtungsübergreifend.
Das Kernanliegen des Datenschutzes ist es, natürliche Personen vor nachteiligen Effekten der Speicherung und Verarbeitung der sie betreffenden Daten zu schützen. Aber viele Personen scheinen gar nicht geschützt werden zu wollen. Im Gegenteil, viele Endanwender willigen “freiwillig“ – bewusst oder unbewusst – in eine umfassende Verarbeitung ihrer personenbezogenen Daten ein. Warum tun Menschen dies? Es werden verschiedene Ursachen diskutiert (beispielsweise in [79]), hierzu gehören Uninformiertheit, mangelnde Sensibilität, das Gefühl der Hilflosigkeit, mangelnde Zahlungsbereitschaft und mangelnde Alternativen. Auch wenn dies in Einzelfällen zutrifft, so gibt es oft sehr wohl datenschutzfreundliche Alternativen. Beispielsweise existiert zu WhatsApp (als Instant Messaging App) die Alternative Threema. Threema gilt als EU-DS-GVO-konform und funktional durchaus mit WhatsApp vergleichbar [62]. Allerdings ist inzwischen die aktuelle Netzwerkgröße ein entscheidendes Auswahlkriterium: Im Januar 2018 hatte Threema 4,5 Millionen Nutzer [172], WhatsApp dagegen 1,5 Milliarden [171]. Dies ist ein Indiz dafür, dass WhatsApp sich quasi zum De-facto-Standard entwickelt hat und es für die einzelne Person nur schwer möglich ist, viele andere “zum Wechsel auf ein anderes Produkt zu bewegen. [. . . ] Bei Diensten mit Nutzerzahlen im Milliardenbereich kann von ’Freiwilligkeit’ nur noch bedingt gesprochen werden.“ [9]
Experience made with free and open source software (FOSS) in the public research is shared with the community. The motivation for using and publishing FOSS is to increase visibility, transparancy and feedback quality while at the same time lowering software licensing costs. Also, the idea of giving back and returning a value plays a role. The most frequently given counter arguments are discussed. In the end, it’s important to embed FOSS publishing into the company’s strategy for the exploitation of scientific research results. To help with this, a checklist of criteria to indicate FOSS publishing is suggested. On the backround of wireless sensor networks, some case studies of FOSS contribution are detailed. The emphasis is on checking the original motivation and the spirit of FOSS back with the reality. Finally, further potential of publishing FOSS in the context of scientific research is identified.
Cancer is one of the leading causes of death worldwide [183], with lung tumors being the most frequent cause of cancer deaths in men as well as one of the most common cancers diagnosed in woman [40]. As symptoms often arise in advanced stages, an early diagnosis is especially important to ensure the best and earliest possible treatment. In order to achieve this, Computed Tomography (CT) scans are frequently used for tumor detection and diagnosis. We will present examples of publicly available CT image data of lung cancer patients and discuss possible methods to realize an automatic system for automated cancer diagnosis. We will also look at the recent SPIE-AAPM Lung CT Challenge [10] data set in detail and describe possible methods and challenges for image segmentation and classification based on this data set.
Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (NEDDFL), defined primarily by developmental delay/intellectual disability, speech delay, postnatal microcephaly, and dysmorphic features, is a syndrome resulting from heterozygous variants in the dosage-sensitive bromodomain PHD finger chromatin remodeler transcription factor BPTF gene. To date, only 11 individuals with NEDDFL due to de novo BPTF variants have been described. To expand the NEDDFL phenotypic spectrum, we describe the clinical features in 25 novel individuals with 20 distinct, clinically relevant variants in BPTF, including four individuals with inherited changes in BPTF. In addition to the previously described features, individuals in this cohort exhibited mild brain abnormalities, seizures, scoliosis, and a variety of ophthalmologic complications. These results further support the broad and multi-faceted complications due to haploinsufficiency of BPTF.
BACKGROUND
Biallelic loss-of-function variants in NCF1 lead to reactive oxygen species deficiency and chronic granulomatous disease (CGD). Heterozygosity for the p.Arg90His variant in NCF1 has been associated with susceptibility to systemic lupus erythematosus, rheumatoid arthritis, and Sjögren's syndrome in adult patients. This study demonstrates the association of the homozygous p.Arg90His variant with interferonopathy with features of autoinflammation and autoimmunity in a pediatric patient.
CASE PRESENTATION
A 5-year old female of Indian ancestry with early-onset recurrent fever and headache, and persistently elevated antinuclear, anti-Ro, and anti-La antibodies was found to carry the homozygous p.Arg90His variant in NCF1 through exome sequencing. Her unaffected parents and three other siblings were carriers for the mutant allele. Because the presence of two NCF1 pseudogenes, this variant was confirmed by independent genotyping methods. Her intracellular neutrophil oxidative burst and NCF1 expression levels were normal, and no clinical features of CGD were apparent. Gene expression analysis in peripheral blood detected an interferon gene expression signature, which was further supported by cytokine analyses of supernatants of cultured patient's cells. These findings suggested that her inflammatory disease is at least in part mediated by type I interferons. While her fever episodes responded well to systemic steroids, treatment with the JAK inhibitor tofacitinib resulted in decreased serum ferritin levels and reduced frequency of fevers.
CONCLUSION
Homozygosity for p.Arg90His in NCF1 should be considered contributory in young patients with an atypical systemic inflammatory antecedent phenotype that may evolve into autoimmunity later in life. The complex genomic organization of NCF1 poses a difficulty for high-throughput genotyping techniques and variants in this gene should be carefully evaluated when using the next generation and Sanger sequencing technologies. The p.Arg90His variant is found at a variable allele frequency in different populations, and is higher in people of South East Asian ancestry. In complex genetic diseases such as SLE, other rare and common susceptibility alleles might be necessary for the full disease expressivity.
Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS
(2021)
The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessively inherited disease that has undergone extensive phenotypic expansion since being first described in patients with fevers, recurrent strokes, livedo racemosa, and polyarteritis nodosa in 2014. It is now recognized that patients may develop multisystem disease that spans multiple medical subspecialties. Here, we describe the findings from a large single center longitudinal cohort of 60 patients, the broad phenotypic presentation, as well as highlight the cohort's experience with hematopoietic cell transplantation and COVID-19. Disease manifestations could be separated into three major phenotypes: inflammatory/vascular, immune dysregulatory, and hematologic, however, most patients presented with significant overlap between these three phenotype groups. The cardinal features of the inflammatory/vascular group included cutaneous manifestations and stroke. Evidence of immune dysregulation was commonly observed, including hypogammaglobulinemia, absent to low class-switched memory B cells, and inadequate response to vaccination. Despite these findings, infectious complications were exceedingly rare in this cohort. Hematologic findings including pure red cell aplasia (PRCA), immune-mediated neutropenia, and pancytopenia were observed in half of patients. We significantly extended our experience using anti-TNF agents, with no strokes observed in 2026 patient months on TNF inhibitors. Meanwhile, hematologic and immune features had a more varied response to anti-TNF therapy. Six patients received a total of 10 allogeneic hematopoietic cell transplant (HCT) procedures, with secondary graft failure necessitating repeat HCTs in three patients, as well as unplanned donor cell infusions to avoid graft rejection. All transplanted patients had been on anti-TNF agents prior to HCT and received varying degrees of reduced-intensity or non-myeloablative conditioning. All transplanted patients are still alive and have discontinued anti-TNF therapy. The long-term follow up afforded by this large single-center study underscores the clinical heterogeneity of DADA2 and the potential for phenotypes to evolve in any individual patient.
One of the biggest challenges faced by many tech start-ups from developed markets is to have validated market-fit products/services and to see their solutions implemented. In several sectors, stringent regulations, and the law of handicap of head start at home can be hurdles that limit the development and even the survival potential of theses start-ups. Tech start-ups seeking implementation, learning, and legitimacy may have a solution in expanding into emerging markets. Emerging markets offer both business opportunities in sectors in need of new technologies as they are “fertile grounds” for developing and testing internationalisation business models. We present here a process designed to help tech start-ups to identify, access, shape and seize these opportunities and to overcome their own specificities and emerging markets specificities. The three phases of the proposed process cover entry node concept, partnership, and business, operating and revenue joint models’ development. DesignScience Research Paradigm is used for the design and evaluation of the process. To show the relevance of this process, a case study on the expansion in Morocco of a Dutch start-up active in e-health is used. The study shows the importance of the process for the embeddedness in a local relevant value network with a relevant adopter’s system, a key enabler to achieve time and cost-effective expansion in that specific business and institutional contexts. A pilot to assess the proposed models and evidence of benefits is under development. To boost their chances of growth tech start-ups from developed markets should consider expansion into emerging markets in their strategy. It would be beneficial that policy makers adopt a strategy by which to assist tech start-ups in accessing value networks in emerging markets. It is also important for policy makers from emerging markets to consider developing schemes to attract tech start-ups from developed markets.
Research on entrepreneurial eco-systems is evolving with exhortations for empirical studies at regional and local levels to augment national surveys. The study, therefore, sought to explore the entrepreneurial eco-system of the Central Region, which is relatively well-endowed with natural resources but lags behind in economic advancement in Ghana. Through descriptive research design, quantitative data were collected using self-administered questionnaires from a convenience sample of 44 entrepreneurs under the presidential business support programme in the Central Region of Ghana, in 2019. Data were analysed, by conducting descriptive analysis such as means (M) and percentages and by exploratory factor analysis, with the IBM SPSS Version 25. Descriptive results of 37 valid responses showed that the respondents were satisfied, in varying degrees (M = 4.19-5.65), with 11 factors within the eco-system; the top three factors were demand, security and availability of raw materials. Respondents were, however, not satisfied with access to business development services, access to finance, rent charges and access to repairers of equipment and thus, pose as challenges to their entrepreneurial pursuits. Principal component analysis revealed inter-connectedness among the factors in the eco-system with strong loadings of measures of institutions and resource endowment under the two components of the solution. Based on the findings, it is concluded that the entrepreneurs surveyed were satisfied with more factors in the EES of the Central Region while they were dissatisfied with relatively few but critical factors in the EES, thereby posing as major challenges to their entrepreneurial activities. As an exploratory study, the findings suggest that the entrepreneurial eco-system of the Central Region of Ghana is, to some extent, supportive of entrepreneurial activities but has key challenges. To achieve maximum outcomes, policy interventions should collectively address, at a time, factors that interact strongly to influence entrepreneurship within the system.
Developing the Circular Economy in Uganda: Prospects for Academia-Public-Private-Partnerships
(2021)
Issues: Circular economy is a production system that optimizes the reusability of by-products/waste as raw materials. As the global population threatens to reach 9 billion by 2050, consumption levels grow proportionally, raising food, material, and energy demands. In Uganda, soil nutrient depletion and energy poverty are key challenges faced by urban and rural communities. Rampart depletion of natural resources calls for transit from the linear economic models towards sustainable production/consumption technologies. This study investigated prospects for APPP to optimize the reusability of by-products/waste as raw materials. Approach: Quantitative and qualitative tools were used to collect data via document analysis, interviews, and participant observations. The tools were administered to municipal authorities, private waste-collecting agencies in cities and municipalities; officials in Ministries of energy and Agriculture; officials in universities research units and entrepreneurs that deal in agricultural and energy products; officials from civil society organizations. Findings: there are a number of sustainability projects being undertaken by Universities and High schools, Government agencies, companies, and civil society organization isolation. Singlehandedly, individual agencies lack the requisite capacity to develop closed-loop production/consumption models. Analysis of a few successful RRR projects suggests that APPP is positioned to promote CE. Transiting towards a circular economy requires joint ventures to optimize human, technological, and financial resources and develop policy and institutional frameworks. In Uganda, recycling biotic by-products can promote environmental sustainability; reduce stress on natural resources; enable cost savings; promote green entrepreneurship, and create jobs/livelihoods. Conclusion: working jointly, CE could be enhanced via technical and business models by the academia, private capital investment by companies, community engagement by CSOs, and development of supportive policy and institutional frameworks to facilitate decision-making processes. The APPPs are positioned to use interactive platforms for creating awareness and promote sensitization about green values through education and multimedia communication platforms.
This study sought to apply the Structure Conduct Performance paradigm to Africa´s air transport landscape in general. To do that, it examines the past, present, and future expectations of four of Sub-Saharan Africa’s biggest aviation economies, namely South Africa, Kenya, Ethiopia, and Nigeria. Secondary data containing historical passenger traffic was analysed, and predictions for growth in the next ten years were proposed. The findings suggest that the experience of the existing liberalization initiatives, such as the Yamoussoukro Declaration (YD), has produced less than expected benefits. However, the future of aviation in Africa is somewhat positive, with a growth trajectory expected to follow a linear and gradual path supported by various initiatives, including the Single African Air Transport Market (SAATM) and the African Continental Free Trade Area (AFCTA). The study’s contribution is to illuminate the current discourse on the aviation sector in Africa through the Structure-Conduct-Performance theory paradigm and suggests a conceptual model that could be applied to future studies relating to aviation in Africa.
Personal values and electronic waste disposal behaviours among households in Cape Coast Metropolis
(2021)
The study examined social values that accounted for electronic waste recycling and reuse behaviours. Via a crosscommunity survey of 193 of households in the Cape Coast Metropolis, a correlational design was employed in the study. Partial Least Squares-Structural equation modelling was used to analyse the data. Results from the analysis showed the influence of altruistic values (β = 0.275, p < 0.05) on reuse behaviour. Similarly, environmental awareness (β = 0.213, p<0.05) also showed significant influence on participation in recycling, whereas psychological ownership significantly influenced both reuse (β = 0.319, p < 0.05), and participation in recycling (β = 0.339, p < 0.05), The joint significance of altruistic values, environmental awareness and psychological ownership to explaining recycling participation was 21.3% (R2 = 0.213, p < 0.05) and that of reuse was 24.6% (R2 = 0.246, p < 0.05). The results of the study showed that individuals who are knowledgeable about the state of their environment were more likely to participate in recycling. On the other hand, individuals with altruistic values preferred giving unwanted electronic equipment to others for reuse. Altruistic values are particularly true of collectivist cultural orientation. Psychological ownership was significant in predicting both behaviours, however, the effect size on reuse was moderate. Psychological ownership due to waste aversion and frugality lead consumers to keep, and subsequently give to close relatives in their social network. It was recommended that individuals should be encouraged to patronize formal recycling services. as a way to show concern for the well-being of others by reducing pollution due to improper waste treatment. Again, like in developed economies, second-hand collection systems for unwanted electronic products can be developed, and made convenient for individuals with reusable items, who may be willing to donate or even resell.
There is severe clinical vitamin A deficiency (VAD) prevalence among Ghanaians and many African countries. Foodbased diets has been suggested as a more sustainable approach to solving the VAD situation in Africa. In this study, A participatory action research between orange flesh sweet potato farmers, gari processors within central region and academia was adopted to develop gari containing provitamin A beta-carotene. Gari is a major staple for Ghanaians and people in the West African subregion due to its affordability and swelling capacity. It is mainly eaten raw with water, sugar, groundnut and milk as gari-soakings or with hot water to prepare gelatinized food called gari-kai in Ghana or “eba” among Nigerians. However, gari is limited in provitamin A carotenoids. Orange fleshed sweet potato (OFSP) is known to contain large amount of vitamin A precursor. Therefore, addition of OFSP to gari would have the potential to fight the high prevalence rate of vitamin A deficiency amongst less developed regions of Africa. To develop this, different proportions of orange fleshed sweet potatoes (OFSP) was used to substitute cassava mash and fermented spontaneously to produce composite gari - a gritty-crispy ready-to-eat food product. Both the amount of OFSP and the fermentation duration caused significant increases in the β-carotene content of the composite gari. OFSP addition reduced the luminance while roasting made the composite gari yellower when compared with the cake used. Addition of OFSP negatively affected the swelling capacity of the gari although not significant. The taste, texture, flavour and the overall preferences for the composite gari decreased due to the addition of the OFSP but fermentation duration (FD) improved them. The sample with 10% OFSP and FD of 1.81 days was found to produce the optimal gari. One-portion of the optimal gari would contribute to 34.75, 23.2, 23.2, 27, 17 and 16% of vitamin A requirements amongst children, adolescent, adult males, adult females, pregnant women and lactating mothers respectively. The study demonstrated that partial substitution of cassava with OFSP for gari production would have the potential to fight the high prevalence rate of vitamin A deficiency amongst less developed regions of Africa while involvement of farmers and processors prior to the design of research phase enhanced the adoption of intervention strategies.
In times of climatic or political grievances that affect not only human life worldwide, but also the environment and the economic situation of a country, a change in the way of thinking about tourism is beginning and the sector of ecotourism is also becoming increasingly important in Germany. The applicability of this form of tourism in the East African destination Kenya in the form of a travel package that is both partly unique and can be designed individually describes the subject matter of this elaboration and is illustrated using the example of the charitable organization Mully Children's Family and the related registered tourism company, MCF Africa Safaris. The underlying research aims to determine how to transform the organisation's own tree planting initiative into a niche tourist market and how this must be geared to gain the interest of the German eco-tourist. Based on the evaluation of the research results, there is high potential, which is dedicated to the implementation of a form of travel consisting of the active support of the named charity and its initiative as well as individually selectable holiday activities in the target market Kenya. As a result, there are basic prerequisites, the consideration of which is essential for the successful integration of the so-called niche market tree planting and the branch-specific nature of ecotourism in the Kenyan travel market.
Most economies across the globe rely on entrepreneurship for growth. There is evidence to suggest that entrepreneurship creates job opportunities and spurs economic growth and development (Pacheco, Dean, & Payne, 2010; Mojica, Gebremedhin, & Schaeffer, 2010, and Solomon, 2007). Even though entrepreneurship is one of the fastest growing education disciplines globally, researchers are still divided on what should be taught and how it should be taught in institutions of higher learning. Entrepreneurial decision-making is laced with uncertainty and drawbacks. Hence, entrepreneurship learners must be taught using practical and conceptual methodologies to equip them with the requisite knowledge and skill that will enable them to confront such challenges in their entrepreneurial activities. This calls for entrepreneurship teachers to be innovative and to also encourage their learners to be innovative as entrepreneurship involves the generation of new business ideas. This paper sought to examine teaching methodologies for entrepreneurship education in institutions of higher learning in Kenya. A mixed-method approach that involved triangulation as the main data collection technique was used. Interviews were administered with teachers and learners of entrepreneurial education in Kenya, with a view to identifying the most commonly used teaching methodologies of entrepreneurial education and their shortcomings. Course outlines and curricula borrowed from twenty (20) institutions of higher learning in Kenya were reviewed. Results indicate that entrepreneurial education in Kenya is largely theoretical and does not meet the needs of the modern entrepreneur. The paper therefore recommends innovative teaching methodologies of entrepreneurial education that can be utilised by the teacher to prepare students adequately to generate entrepreneurial ideas and to identify entrepreneurial opportunities. For this reason, the paper recommends the use of such methodologies as business plan generation, idea generation, innovation, creativity, networking, opportunity recognition, expecting and embracing failure, and adapting to change.
Rural Social Entrepreneurship (RSE) is considered an essential factor for achieving Sustainable Rural Development (SRD) and improving rural people's socio-economic status through increasing production, productivity, reducing unemployment, and accelerating the progress in achieving SDGs. The paper aims at examining the role of social entrepreneurship in achieving (SRD) in Sudan with reference to Wad Balal Project for investment and rural development in Gezira State, which established in 2005 in small villages in Gezira State through mobilizing of local savings and resources for creating job opportunities, sponsoring poor households, improving the infrastructures, and reducing poverty. The study depends on cross-sectional data collected through a questionnaire and focus group discussion from 100 head of households in the village under research. A questionnaire is internally consistent, and its questions are stable. Frequencies and percentages have been used for describing the basic characteristics of the respondents. Statistical t-test was adopted to test the opinions of respondents about the role of the project based on the Likert scale. The results revealed that the project has significantly increased the opportunities of job and training as well as household income, the results also confirmed that the project has improved the status of education and health services in the village. The project has extended and established many branches; the project also diversified its investment to cover more kinds of investments, the project reinvested 50% of its profits and directed the rest to charity, and social services in the village, many lessons can be learned from the project story. The research recommended that a similar social entrepreneurship project can be generalized to more villages in Sudan and other developing countries to accelerate sustainable rural development. Local communities have to support similar initiatives for developing their villages.
A school leader’s achievement is not what they study in learning institutions but the way they organize themselves into problem solving and realistic decision making. While this includes some taught hard skills, the bulk of school activities rely on soft skills. Soft skills, however, are frequently neglected, although they play an important role in school principals’ daily operations as an instructional supervisor. This study aimed to examine the relationship between soft skills training and Principals' performance. The study adopted a cross-sectional mixed survey design. Using Yamane formulae, the sample comprised of 167 principals from 286 public secondary schools in Kiambu County. These were spread proportionally across all the 12 sub-counties in the County. The principal research instrument was primarily a questionnaire. The reliability of the instrument using the Cronbach Alpha coefficient was deemed reasonable at.73. The findings showed that a substantial relationship exists between the training of the principal on soft skills and their good performance of the duties. The study suggests routine in-service training should be undertaken in the county to improve the development of soft skills. It is also advisable that undergraduate, postgraduate, or in-service training include soft skills as a unit, to build knowledge of the value of soft skills.
Studies in entrepreneurship education in hospitality and tourism has indicated that further attention could be given toward helping students to develop creativity and critical thinking skills, engage in deeper self-discovery experiences, and understand tourism more fully to help prepare them for entrepreneurial roles. This study aims at evaluating Hospitality entrepreneurial modules offered in Tourism programs in Ghanaian institutions. The curriculum of Tourism in two tertiary institutions in Ghana offering Tourism is studied. The research highlights on the need to integrate hospitality technical skills into Tourism education to create a culture that will enhance the growth of entrepreneurial hospitality into Tourism as culinary Tourism is becoming common. Some of the challenges faced by tourism students and entrepreneurship educators are highlighted. Structured interview technique was used to collect data from 20 purposive sampled students of the selected institutions. The results revealed that the level of importance and attention given to hospitality skills in tourism and the perception of students on acquisition of the required competencies is minimal. It is therefore recommended that more skills and competences in hospitality operation, food and beverage production and service be introduced in tourism education in a more holistic manner with emphasis on skill acquisition in order to make the tourism graduate more creative and critical thinker in today’s global competitive environment.
Datenschutz und informationelle Selbstbestimmung sind Bestandteile aktueller Leitbilder einer Digitalen Bildung in der Schule. Im Kontext der Schulschließungen und der vorrangigen Nutzung digitaler Medien zeigte sich jedoch, dass Datenschutz weder als Thema noch als Gestaltungsprinzip digitaler Lernumgebungen in der bildungsadministrativen und pädagogisch-praktischen Schulwirklichkeit systematisch verankert ist. Die Diskrepanz zwischen aktuellen Leitbildern einer digitalen Bildung und der sichtbar problematischen Praxis des digitalen Notfalldistanzunterrichts markiert den Ausgangspunkt des Beitrages, der sich der übergeordneten Frage widmet, welche Herausforderungen sich bei der Realisierung von Datenschutz in der Schul- und Unterrichtswirklichkeit in einer digital geprägten Welt stellen. Im Sinne einer Problemfeldanalyse werden prototypische Handlungsprobleme der Schule herausgearbeitet. Fokussiert betrachtet werden exemplarische Herausforderungen und Anforderungen an Technologien und Akteur:innen der inneren und äußeren Schulentwicklung auf den Ebenen der Unterrichtsentwicklung, der Personalentwicklung, der Technologieentwicklung und der Organisationsentwicklung.
The role of tourism entrepreneurship in rural development continues to be a subject of interest and debate among academia and practitioners. Theoretically, it is anticipated that tourism entrepreneurship will lead to livelihood diversification, enhancement and ultimately a revitalization of the rural economy. While tourism is posited as an accessible entrepreneurship pathway, there is a dearth of information regarding rural dwellers’ actual experiences with it, especially within the Ghanaian context. Using a case study approach and qualitative data from Wli; a rural tourism destination in Ghana, this paper delves into the opportunities and concerns associated with tourism entrepreneurship in rural areas. Data was obtained between November and December 2016 from 27 persons who were either tourism enterprise owners or employees. Findings from the study showed that entrepreneurial activities centred on the provision of accommodation, food and beverage, souvenir and guiding services. The nature of the activities enabled easy transfer of existing skills and knowledge. Further, entry into tourism entrepreneurship was perceived to be easy by the majority of study participants. These findings confirm the potential for tourism to be employed in boosting entrepreneurial activities in rural areas. Nevertheless, there were concerns regarding access to credit, institutional support, unhealthy competitions, low incomes, unguaranteed pensions, and seasonality and skewness of demand. These concerns threatened the growth and sustainability of tourism entrepreneurship within the community. From a policy perspective, there is a need for institutional recognition and support for tourism entrepreneurial intentions and activities in rural areas. Practice-wise, credit facilities need to be designed specifically for tourism-related rural enterprises. Further, periodic skills and knowledge augmentation programmes must be initiated to help expand the skill sets for the rural entrepreneurs. Finally, there is a need for the formation of traderelated networks to provide a platform for knowledge and experience sharing among the entrepreneurs.
Kenya as a touristic destination is well known as an exotic country offering many different landscapes as well as the diversity of wildlife; this is typical for several African countries. To ensure a sustainable tourism development, different forms of tourism have to be considered. One of these forms could be eco-mountain bike cycling tours, as these tours are gaining in popularity, for example in Germany. The aim of this study was to obtain results regarding the market potential for mountain bike eco-tourism in Kenya. The up-and-coming tourism branch of mountain biking was examined in connection with the increasing demand for long-distance travel. The results of this study showed that mountain biking in exotic countries like Kenya has market potential in principle. However, it was also found that mountain biking alone is not a sufficient pull factor for tourists. The combination with other activities turned out to be promising. It was found that tourist packages that include mountain biking as an activity are perceived as attractive. Moreover, it was obtained that not only tourists who ride a mountain bike regularly are addressed as a target group. Even "regular" tourists find mountain biking an attractive (touristic) activity, especially in combination with game drives. Experts also assess the market potential for eco-mountain bike tourism as positive and find existing routes and accommodation attractive. The findings are giving indications for the possibilities to develop eco-mountain bike tourism as a touristic alternative and addition to existing touristic products.
Hinreichende Datensouveränität gestaltet sich für Verbraucher:innen in der Praxis als äußerst schwierig. Die Europäische Datenschutzgrundverordnung garantiert umfassende Betroffenenrechte, die von verwantwortlichen Stellen durch technisch-organisatorische Maßnahmen umzusetzen sind. Traditionelle Vorgehensweisen wie die Bereitstellung länglicher Datenschutzerklärungen oder der ohne weitere Hilfestellungen angebotene Download von personenbezogenen Rohdaten werden dem Anspruch der informationellen Selbstbestimmung nicht gerecht. Die im Folgenden aufgezeigten neuen technischen Ansätze insbesondere KI-basierter Transparenz- und Auskunftsmodalitäten zeigen die Praktikabilität wirksamer und vielseitiger Mechanismen. Hierzu werden die relevanten Transparenzangaben teilautomatisiert extrahiert, maschinenlesbar repräsentiert und anschließend über diverse Kanäle wie virtuelle Assistenten oder die Anreicherung von Suchergebnissen ausgespielt. Ergänzt werden außerdem automatisierte und leicht zugängliche Methoden für Auskunftsersuchen und deren Aufbereitung nach Art. 15 DSGVO. Abschließend werden konkrete Regulierungsimplikationen diskutiert.