Refine
Departments, institutes and facilities
- Fachbereich Informatik (68)
- Fachbereich Wirtschaftswissenschaften (62)
- Fachbereich Angewandte Naturwissenschaften (33)
- Fachbereich Ingenieurwissenschaften und Kommunikation (33)
- Institute of Visual Computing (IVC) (25)
- Institut für funktionale Gen-Analytik (IFGA) (22)
- Institut für Verbraucherinformatik (IVI) (20)
- Institut für Cyber Security & Privacy (ICSP) (18)
- Präsidium (17)
- Fachbereich Sozialpolitik und Soziale Sicherung (16)
Document Type
- Conference Object (111)
- Article (102)
- Part of a Book (62)
- Book (monograph, edited volume) (19)
- Part of Periodical (17)
- Report (10)
- Contribution to a Periodical (6)
- Conference Proceedings (5)
- Patent (4)
- Working Paper (4)
Year of publication
- 2014 (351) (remove)
Keywords
- Nachhaltigkeit (8)
- Lehrbuch (7)
- Corporate Social Responsibility (3)
- FPGA (3)
- Unternehmen (3)
- education (3)
- parallel breadth-first search (3)
- BFS (2)
- Betriebswirtschaftslehre (2)
- Controlling (2)
- Exchangeable pairs (2)
- Formelsammlung (2)
- Garbage collection (2)
- Human Factors In Software Design (2)
- Java virtual machine (2)
- NUMA (2)
- Simulation (2)
- Stein’s method (2)
- Sustainability (2)
- apoptosis (2)
- data locality (2)
- energy awareness (2)
- low power (2)
- memory bandwidth (2)
- path planning (2)
- sustainability (2)
- 1-MCP (1)
- ARRs (1)
- Ad Hoc Kommunikation (1)
- Adaptive Case Management (1)
- Adaptive Streaming (1)
- Africa (1)
- Algebra (1)
- Analytical Chemistry (1)
- Antibody Induced Arthritis (1)
- Application Software (1)
- Applied and Practice-Oriented Research (1)
- Arbeitsplatz (1)
- Area under the curve (1)
- Aufmerksamkeitsprofile (1)
- Augmented reality (1)
- Automation (1)
- Automatisierungstechnik (1)
- B-cell leukemia (1)
- Barriers (1)
- Behälterbau (1)
- Bilanzanalyse (1)
- Bildung (1)
- Biotin (1)
- Blasformen (1)
- Blume–Capel model (1)
- Blume–Emery–Griffith model (1)
- Business Sector (1)
- Business buying (1)
- CAS (1)
- CSR-Controlling (1)
- CYP2C19 (1)
- CYP2C9 (1)
- CYP2D6 (1)
- Chancengleichheit (1)
- Change-Prozess (1)
- Chemie (1)
- Chromatography (1)
- Cloud (1)
- Cloud Computing (1)
- Cloud Security (1)
- Collagen (1)
- Composite resin (1)
- Computer Aided Software Engineering (1)
- Computer Security (1)
- Computer science (1)
- Consulting (1)
- Context (1)
- Control (1)
- Convexity (1)
- Corporate Social Responsibility (CSR) (1)
- Corporate social responsibility (1)
- Corporate sustainability (1)
- Corrosion protction (1)
- Critical temperature (1)
- Cultural Distance (1)
- Culture (1)
- Curie–Weiss–Potts models (1)
- Curing behavior (1)
- Curing depth (1)
- Curing kinetics (1)
- DASH (1)
- Data collection (1)
- Declarative Process Modeling (1)
- Demographischer Übergang (1)
- Dental composites (1)
- Dental material (1)
- Deployment (1)
- Deutschland (1)
- Dielectric analysis (1)
- Dielectric analysis (DEA) (1)
- Distortion (1)
- Domain Expert (1)
- Domain-Specific Language (1)
- Duroplast (1)
- Dynamic Case Management (1)
- E-Learning (1)
- EEG-basierte Erfassung (1)
- ERP (1)
- ETV6-RUNX1 (1)
- Eclipse Modeling Framework (1)
- Ecosystems (1)
- Educational Culture (1)
- Elementare Zahlentheorie (1)
- Employment (1)
- Enterprise Resource Planning Software (1)
- Enterprise Resource Planning System (1)
- Erdgasgewinnung (1)
- Escape analysis (1)
- Ethik (1)
- Europe (1)
- Evaluation (1)
- Evaluation als Kommunikationsanlass (1)
- External faults (1)
- FIVIS (1)
- FSW (1)
- Fahrradfahrsimulator (1)
- Fahrsimulator (1)
- Fair Trade (1)
- Fault handling (1)
- Female (1)
- File carving (1)
- First-order phase transition (1)
- Food Process Quality (1)
- Food Safety and Security (1)
- Food allergy (1)
- Force field parameters (1)
- Fragmented files (1)
- Full-text Search (1)
- Functional Safety Management (1)
- Führungskräfteentwicklung (1)
- GC/MS (1)
- GDDL (1)
- Gas Chromatography (1)
- Gebäudemanagement (1)
- Gefahrenprävention (1)
- Gelatin Zymography (1)
- Gene expression (1)
- Genetic Predisposition to Disease (1)
- Genomics (1)
- German housing market (1)
- German real estate industry (1)
- Germany (1)
- Gesamt-Exom-Sequenzierung (1)
- Gestaltungsorientierte Forschung (1)
- Global Reporting Initiative (GRI) (1)
- Global Software Engineering (1)
- Glücksspiel (1)
- Glücksspielmarkt (1)
- Graphene (1)
- Grasp Domain Definition Language (1)
- Grasp Planner (1)
- Grasping (1)
- HCI (1)
- HTML5 (1)
- Hands-On Learning/Manipulatives (1)
- Handzeichenerkennung (1)
- Head-Mounted Displays (1)
- Histamine (1)
- Histamine receptors (1)
- Host-Based Code Injection Attacks (1)
- Housing finance (1)
- Humanoid Robot (1)
- Humans (1)
- Hyperammonemia (1)
- IEEE 802.11n (1)
- Identification and control methods (1)
- Immersive Virtual Environments (1)
- Information Systems (1)
- Informationstechnik (1)
- Infrastruktur (1)
- Innovation (1)
- Instructor Support (1)
- Integrate Development Environment (1)
- Intellectual disability (1)
- Interactive Smart Card Applications (1)
- Interaktion (1)
- International Standard ISO 13849-1 (1)
- Interpersonale Kommunikation (1)
- Interviews (1)
- Intracellular Ca2+ (1)
- Ion viscosity (1)
- JPEGs (1)
- Jahresabschluss (1)
- K/BxN (1)
- KID (1)
- Kinetic inductance detector (1)
- Klein- und Mittelbetrieb (1)
- Knowledge Worker (1)
- Knowledge-intensive Process (1)
- Kognitive Belastung am Arbeitsplatz (1)
- Konzeptionelle Kulturmodelle (1)
- Kriminalistik (1)
- Kultur (1)
- Kulturbeschreibungsmodelle (1)
- Kulturerfassungsansätze (1)
- Kulturforschung (1)
- Learner’s Preferences (1)
- Learning Culture Survey (1)
- Life Cycle Model (1)
- Light attenuation (1)
- Live Streaming (1)
- Long-distance (1)
- Low temperature detectors (1)
- MIMO (1)
- MKID (1)
- MMP-9 (1)
- Mal d 1 (1)
- Male (1)
- Malware Detection (1)
- Management information systems (1)
- Managementsystem (1)
- Manipulator (1)
- Mass Spectrometry (1)
- Mast cells (1)
- Mathematisches Modell (1)
- Memory management (1)
- Metabolic stroke (-like event) (1)
- Metabolicdecompensation (1)
- Methylmalonic acidemia (1)
- Methylmalonic aciduria (1)
- Methylmalonyl-CoAmutase (1)
- Mining software repositories (1)
- Mixed methods (1)
- Mobiltelefone (1)
- Modelica (1)
- Modeling (1)
- Molecular Dynamics (1)
- Molecular modeling (1)
- Molecular simulation (1)
- Motion Control Systems (1)
- Movement disorder (1)
- Multidimensional Z-transforms (1)
- Multimedia forensics (1)
- Nachhaltige Energieversorgung (1)
- Nachhaltige Entwicklung (1)
- Nachhaltiges Bauen (1)
- Nachhaltigkeit im Lebensmittelhandel (1)
- Naive physics (1)
- Nano-Systems (1)
- Nickel-based superalloy (1)
- Non-zero external field (1)
- Nonlinear sampled-data system (1)
- Normung (1)
- OER (1)
- Open Educational Resources (1)
- Optimization (1)
- Organizations (1)
- Osteogenesis (1)
- Pain Reduction (1)
- Pedigree (1)
- Personalmanagement (1)
- Point Clouds (1)
- Polymer Chemistry (1)
- Polymorphism, Single Nucleotide (1)
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics (1)
- Process Automation (1)
- Programmer Workbench (1)
- Propionic acidemia (1)
- Propionic aciduria (1)
- Propionyl-CoA carboxylase (1)
- Prosumer Model (1)
- Prozessautomation (1)
- Prozessoptimierung (1)
- Psychische Belastung (1)
- Pulse-width modulation (1)
- Pyrolysis GC/MS (1)
- Qualitative Analysis (1)
- Qualitative research (1)
- Quality (1)
- Quality Concept (1)
- Quality management (1)
- Qualitätspakt Lehre (1)
- RGB-D (1)
- Radfahren (1)
- Rapid Prototyping (1)
- Real estate (1)
- Real-time measurement (1)
- Regulierung (1)
- Rental market (1)
- Research methods (1)
- Resilienz (1)
- Ressourcenökonomie (1)
- Restorative Virtual Environments (1)
- Restorative composite (1)
- Robotics (1)
- Robustness (1)
- Safety PLC (1)
- Satisfaction (1)
- Schiefergas (1)
- Schwarzmarkt (1)
- Second-Year Undergraduate (1)
- Second-order phase transition (1)
- Secure Cloud Storage (1)
- Segmentation (1)
- Seizures (1)
- Smart Card (1)
- Social Software (1)
- Social cash transfers (1)
- Software (1)
- Software Development Process (1)
- Solution (1)
- Soziale Kosten (1)
- Soziale Marktwirtschaft (1)
- Sozialer Wandel (1)
- Sozialpsychologie (1)
- Spatial Proximity (1)
- Spectral Analysis (1)
- Spectral Clustering (1)
- Spielsucht (1)
- Stakeholder-Management (1)
- Statistische Methodenlehre (1)
- Stem cells (1)
- Strategisches Management (1)
- Stress Management (1)
- Submucosal plexus (1)
- Sucht (1)
- Supply Chain (1)
- Sustainability in food retailing (1)
- TEL (1)
- TEL-AML1 (1)
- Teaching Quality Pact (1)
- Technology Enhanced Learning (1)
- Translocation (1)
- Transmission of monetary policy (1)
- Tricritical point (1)
- UI design (1)
- Umweltökonomie (1)
- Unternehmensgründung (1)
- Usage Experience (1)
- User Interface Design (1)
- User-Centered Approach (1)
- Value-Added Chain (1)
- Verantwortung (1)
- Verbraucherschutz (1)
- Verkehrserziehung (1)
- Vertrauen (1)
- Video (1)
- Virtuelle Realität (1)
- Visible light curing (1)
- Visible light-curing (1)
- Vitamin B12/adenosylcobalamin (1)
- Volterra-Wiener series (1)
- WebSockets (1)
- Weibliche Führungskräfte (1)
- Wettbewerb (1)
- Wettbewerbsverzerrung (1)
- Wireless back-haul (1)
- Wirkungsanalyse (1)
- Wirtschaftsinformatik (1)
- Wirtschaftsmathematik (1)
- Wirtschaftsstatistik (1)
- Zahnfüllung (1)
- Zambia (1)
- accelerometer (1)
- adaptive agents (1)
- adaptive fault thresholds (1)
- agri-food chains (1)
- alkyl amines (1)
- allergenicity (1)
- anthocyanins (1)
- apple (Malus domestica Borkh.) (1)
- apple allergy (1)
- atomic operation (1)
- basic needs (1)
- battery charging (1)
- biomaterial (1)
- biopolymer (1)
- blood vessel (1)
- bond graph modelling (1)
- camera (1)
- carotenoids (1)
- cash transfers (1)
- caspase (1)
- caspases (1)
- cell death (1)
- chain and network (1)
- change process (1)
- childhood cancer syndrome (1)
- classical dance (1)
- climate change (1)
- coaching (1)
- coaching framework (1)
- coaching psychology (1)
- collagen (1)
- colouration (1)
- community-based targeting (1)
- computer vision (1)
- constitutional mismatch repair syndrome (1)
- consumption expenditure (1)
- contribution ratio (1)
- coordinated charging (1)
- cross-linking (1)
- cysteine proteases (1)
- dc electric drive (1)
- demi-plié (1)
- differentiation (1)
- diffuse reflection (1)
- disabled people (1)
- eco-driving (1)
- electron backscatter diffraction (EBSD) (1)
- embedded systems (1)
- empirical studies in interaction design (1)
- endothelial cell (1)
- energy efficient transportation (1)
- energy optimal driving (1)
- erbliche Krebssyndrome (1)
- evaluation as a mean to communication (1)
- evolution strategies (1)
- evolved neural network controller (1)
- evolving look ahead controllers (1)
- fault detection (1)
- faults in robotics (1)
- feature (1)
- fiducial marker (1)
- field experiment (1)
- first position (1)
- flavonoids (1)
- fractional activity (1)
- fruit quality (1)
- genetic polymorphism (1)
- genetic testing (1)
- genetische Testung (1)
- hail net (1)
- health (1)
- heat shock proteins (1)
- heat shock response (1)
- heuristics (1)
- hierarchical clustering (1)
- human cathepsins (1)
- hybrid system models (1)
- immersive Visualisierung (1)
- impact (1)
- in-home charging (1)
- incremental bond graphs (1)
- individualized therapy (1)
- information display methods (1)
- infrared pattern (1)
- internal drug exposure (1)
- intrinsic pathway (1)
- issue tracker (1)
- long-term storage (1)
- mathematics (1)
- mininig software repositories (1)
- mobile robots (1)
- motion control (1)
- motion estimation (1)
- motivation (1)
- myogenesis (1)
- naive physics (1)
- neuropsychotherapy (1)
- nitrile inhibitors (1)
- non-apoptotic roles (1)
- odds-weighted regression (1)
- optical tracking (1)
- optimal control (1)
- optimal control problem (1)
- organizational management and coordination (1)
- parallel work queue (1)
- performance optimizations (1)
- peripheral visual field (1)
- pervasive computing (1)
- plug-in electric vehicle (1)
- power electronic systems (1)
- power industry (1)
- preprocessing (1)
- process infrastructure (1)
- project management (1)
- proliferation (1)
- propensity score matching (1)
- recycling (1)
- redundant work (1)
- reflective mulch (1)
- renewable energy (1)
- requirements management (1)
- risk management (1)
- robot dynamics (1)
- robot kinematics (1)
- robotic arm (1)
- robotic evaluation (1)
- scaffold (1)
- scalability (1)
- screening (1)
- see-through head-mounted displays (1)
- serious games (1)
- shared memory (1)
- smooth muscle cell (1)
- software engineering (1)
- steady-state concentration (1)
- stem cell (1)
- surface modification (1)
- sway (1)
- system modes (1)
- targeting preferences (1)
- teaching topics (1)
- titanium-matrix composite (1)
- unexpected situations (1)
- unstructured data (1)
- user documentation (1)
- user input (1)
- user interaction (1)
- user studies (1)
- video (1)
- whole-exome sequencing (1)
- youBot (1)
- öffentlicher Personennahverkehr (1)
- β-amino acids (1)
Exposure to microgravity conditions causes cardiovascular deconditioning in astronauts during spaceflight. Until now, no specific drugs are available for countermeasure, since the underlying mechanism is largely unknown. Endothelial cells (ECs) and smooth muscle cells (SMCs) play key roles in various vascular functions, many of which are regulated by purinergic 2 (P2) receptors. However, their function in ECs and SMCs under microgravity conditions is still unclear. In this study, primary ECs and SMCs were isolated from bovine aorta and verified with specific markers. We show for the first time that the P2 receptor expression pattern is altered in ECs and SMCs after 24 h exposure to simulated microgravity using a clinostat. However, conditioned medium compensates this change in specific P2 receptors, for example, P2X7. Notably, P2 receptors such as P2X7 might be the important players during the paracrine interaction. Additionally, ECs and SMCs secreted different cytokines under simulated microgravity, leading into a pathogenic proliferation and migration. In conclusion, our data indicate P2 receptors might be important players responding to gravity changes in ECs and SMCs. Since some artificial P2 receptor ligands are applied as drugs, it is reasonable to assume that they might be promising candidates against cardiovascular deconditioning in the future.
During space missions astronauts suffer from cardiovascular deconditioning, when they are exposed to microgravity conditions. Until now, no specific drugs are available for effective countermeasures, since the underlying mechanism is not completely understood. Endothelial cells (ECs) and smooth muscle cells (SMCs) play crucial roles in a variety of cardiovascular functions, many of which are regulated via P2 receptors. However, their function in ECs and SMCs under microgravity condition is still unknown. In this study, ECs and SMCs were isolated from bovine aorta and differentiated from human mesenchymal stem cells (hMSCs), respectively. Subsequently, the cells were verified based on specific markers. An altered P2 receptor expression pattern was detected during the commitment of hMSC towards ECs and SMCs. The administration of natural and artificial P2 receptor agonists and antagonists directly affected the differentiation process. By using EC growth medium as conditioned medium, a vessel cell model was created to culture SMCs and vice versa. Within this study, we were able to show for the first time that the expression of some P2 receptors were altered in ECs and SMCs grown for 24h under simulated microgravity conditions. On the other hand, in some P2 receptor expressions such as P2X7 conditioned medium compensated this change.
In conclusion, our data show that P2 receptors play an important functional role in hMSC differentiation towards ECs and SMCs. Since some P2 receptor artificial ligands are already used as drugs for patients with cardiovascular diseases, it is reasonable to assume that in the future they might be promising candidates for treating cardiovascular deconditioning.
Structure-activity relationships of thiostrepton derivatives: implications for rational drug design
(2014)
The Project SupraMetall: Towards Commercial Fabrication of High-Temperature Superconducting Tapes
(2014)
Informatikerinnen und Informatiker aller Fachrichtungen müssen die grundlegenden Konzepte, Methoden und Verfahren, die der Entwicklung und dem Einsatz von Informations- und Kommunikationstechnologien zugrunde liegen, verstehen und bei der Lösung von Problemen anwenden können. Das Buch stellt die algebraischen und zahlentheoretischen Grundlagen dafür vor und wendet diese bei der Lösung praktischer Problemstellungen, wie modulare Arithmetik, Primzahltests und Verschlüsselung an. Das Verständnis der Begriffe und deren Zusammenhänge und Zusammenwirken wird u.a. durch Lernziele, integrierte Übungsaufgaben mit Musterlösungen und Marginalien unterstützt. Das Buch ist zum Selbststudium gut geeignet.
Improving the study entry supports students in a decisive phase of their university education. Implementing improvements is a change process and can only be successful if the relevant stakeholders are addressed and convinced. In the described Teaching Quality Pact project evaluation data is used as a mean to discuss in the university the situation of the study programs. As these discussions were based on empirical data rather than on opinion, it was possible to achieve an open discussion about measures that are implemented. The open discussion is maintained during the project when results of the measures taken are analyzed.
Low power dissipation is a current topic in digital design, and therefore, it should be covered in a state-of-the-art electrical engineering curriculum. This paper describes how low-power design can be addressed within a digital design course. Doing so would be beneficial for both topics because low-power design is not detached from the systems perspective, and the digital design course would be enriched by references to current challenges and applications. Thus, the presented course should serve as an example of how a course can be developed to also teach students about sustainable engineering.
Das Management von Sicherheit und Gesundheit bei der Arbeit beinhaltet die Praevention psychischer Fehlbelastungen und psychischer Erkrankungen. Die gesetzliche Grundlage der Praeventionsaktivitaeten der gesetzlichen Unfallversicherung wird aufgefuehrt. Anschliessend wird verdeutlicht, in welchen Handlungsfeldern und mit welchen Instrumenten die gesetzliche Unfallversicherung die Praevention psychischer Erkrankungen in den Betrieben unterstuetzt. Als theoretischer Rahmen fuer Praeventionsmassnahmen werden das Dreiebenenmodell psychischer Belastungen (Mitarbeiter, Unternehmen, Gesellschaft) und das Dreiebenen-Interventionsmodell psychischer Erkrankungen skizziert. Die betriebliche Praevention erfolgt im Idealfall auf der Basis konkreter innerbetrieblicher Regelungen. Dies wird beispielhaft fuer den Umgang mit E-Mails und die Regelungen zur Erreichbarkeit naeher beschrieben.
Mobbing
(2014)
Stress
(2014)
Over the past two decades social protection has gained importance at the international and the national level of many low and middle income countries. Despite reforms in this sector being a global phenomenon, they differ from country to country. Traditional efforts to explain these dif- ferences focus on domestic factors. Yet it remains unclear how international influences and interdependencies contrib- ute to policy change. The study ‘International Policy Learn- ing and Policy Change’ aims at providing an answer to this question, by focusing on ‘soft governance’ via horizontal processes, meaning processes between equal actors. The studie was carried out in two parts. While in Part I the cur- rent state of the art in relevant research fields was assessed, in Part II the findings from Part I were used to conduct a survey which analyses the role of policy networks.
Nachhaltigkeit als Megatrend. Die Arbeit der Weltkommission für Umwelt und Entwicklung unter Vorsitz von Brundtland machte bereits 1987 deutlich, dass v.a. das Management von Gemeingütern wie Ozeanen und der Atmosphäre, die Erhaltung des Weltfriedens, die weltweite Bevölkerungsentwicklung, die globale Ernährungssicherheit, die begrenzten Energieressourcen sowie die Folgen des Wirtschaftswachstums globale Herausforderungen darstellen, die nur durch eine nachhaltige Entwicklung gemeistert werden können.
Kriminalistik
(2014)
Rendering techniques for design evaluation and review or for visualizing large volume data often use computationally expensive ray-based methods. Due to the number of pixels and the amount of data, these methods often do not achieve interactive frame rates. A view direction based rendering technique renders the users central field of view in high quality whereas the surrounding is rendered with a level of detail approach depending on the distance to the users central field of view thus giving the opportunity to increase rendering efficiency. We propose a prototype implementation and evaluation of a focus-based rendering technique based on a hybrid ray tracing/sparse voxel octree rendering approach.
In contrast to projection-based systems, large, high resolution multi-display systems offer a high pixel density on a large visualization area. This enables users to step up to the displays and see a small but highly detailed area. If the users move back a few steps they don't perceive details at pixel level but will instead get an overview of the whole visualization. Rendering techniques for design evaluation and review or for visualizing large volume data (e.g. Big Data applications) often use computationally expensive ray-based methods. Due to the number of pixels and the amount of data, these methods often do not achieve interactive frame rates.
A view direction based (VDB) rendering technique renders the user's central field of view in high quality whereas the surrounding is rendered with a level-of-detail approach depending on the distance to the user's central field of view. This approach mimics the physiology of the human eye and conserves the advantage of highly detailed information when standing close to the multi-display system as well as the general overview of the whole scene. In this paper we propose a prototype implementation and evaluation of a focus-based rendering technique based on a hybrid ray tracing/sparse voxel octree rendering approach.
True Fruits
(2014)
The latest advances in the field of smart card technologies allow modern cards to be more than just simple security tokens. Recent developments facilitate the use of interactive components like buttons, displays or even touch-sensors within the cards body thus conquering whole new areas of application. With interactive functionalities the usability aspect becomes the most important one for designing secure and popularly accepted products. Unfortunately the usability can only be tested fully with completely integrated hence expensive smart card prototypes. This restricts application specific research, case studies of new smart card user interfaces, concerning applications and the performance of useability tests in smart card development. Rapid development and simulation of smart card interfaces and applications can help to avoid this restriction. This paper presents SCUIDtextsuperscript{Sim} a tool for rapid user-centric development of new smart card interfaces and applications based on common smartphone technology.
Gene expression and cell growth rely on the intracellular concentration of amino acids, which in metazoans depends on extracellular amino acid availability and transmembrane transport. To investigate the impact of extracellular amino acid concentrations on the expression of a concentrative amino acid transporter, we overexpressed the main kidney proximal tubule luminal neutral amino acid transporter B0AT1-collectrin (SLC6A19-TMEM27) in MDCK cell epithelia. Exogenously expressed proteins co-localized at the luminal membrane and mediated neutral amino acid uptake. However, the transgenes were lost over few cell culture passages. In contrast, the expression of a control transgene remained stable. To test whether this loss was due to inappropriately high amino acid uptake, freshly transduced MDCK cell lines were cultivated either with physiological amounts of amino acids or with the high concentration found in standard cell culture media. Expression of exogenous transporters was unaffected by physiological amino acid concentration in the media. Interestingly, mycoplasma infection resulted in a significant increase in transgene expression and correlated with the rapid metabolism of L-arginine. However, L-arginine metabolites were shown to play no role in transgene expression. In contrast, activation of the GCN2 pathway revealed by an increase in eIF2α phosphorylation may trigger transgene derepression. Taken together, high extracellular amino acid concentration provided by cell culture media appears to inhibit the constitutive expression of concentrative amino acid transporters whereas L-arginine depletion by mycoplasma induces the expression of transgenes possibly via stimulation of the GCN2 pathway.
Abstract Classical ballet requires dancers to exercise significant muscle control and strength both while stationary and when moving. Following the Royal Academy of Dance (RAD) syllabus, 8 male and 27 female dancers (aged 20.2 + 1.9 yr) in a full-time university undergraduate dance training program were asked to stand in first position for 10 seconds and then perform 10 repeats of a demi-plié exercise to a counted rhythm. Accelerometer records from the wrist, sacrum, knee and ankle were compared with the numerical scores from a professional dance instructor. The sacrum mounted sensor detected lateral tilts of the torso in dances with lower scores (Spearman’s rank correlation coefficient r = -0.64, p < 0.005). The 5RMS6 acceleration amplitude of wrist mounted sensor was linearly correlated to the movement scores (Spearman’s rank correlation coefficient r = 0.63, p < 0.005). The application of sacrum and wrist mounted sensors for biofeedback during dance training is a realistic, low cost option.
Sustainability is a key issue in current research activities and programs. In this conjunction three major functions of research have been identified: Basic research, knowledge reservoirs, and knowledge transfer. With regard to a transmission to the private sector, knowledge transfer is the most important factor. In this process, universities of applied sciences can play an important part as they typically have a long-standing experience in linking science and business in their teaching and research. Another important agent in the process of knowledge transfer are networks and clusters. Their strength lies integrating the different competencies of its partners and using them to a mutual benefit.
The International Centre for Sustainable Development (IZNE) – with a major focus on responsible business and sustainable food – takes the advantage of being part of a University of Applied Sciences (Bonn-Rhein-Sieg, BRSU), and being a member of several regional and international clusters and networks. These co-operations aim to establish and strengthen linkages between science and business, in particular by investigating research needs for business and business relevant research activities. Moreover, IZNE established and expanded regional and international co-operations of its own to get more transparency about regional and international value-added chains in the food sector and the issue of responsible business.
Social cash transfers (SCTs) are considered a priority in least-developed countries, where the gap between the need for basic social protection and existing provisions is greatest. This study represents one of the first comprehensive treatments of the impact of social cash transfers in low-income sub-Saharan Africa, and the first for Zambia's oldest SCT scheme. The results, based on propensity score matching and fully efficient odds-weighted regression, and data from the Kalomo SCT pilot scheme, confirm positive SCT effects on per capita consumption expenditure. We also discover threshold effects with SCT mostly impacting food expenditure among poorer beneficiary households and non-food expenditure among wealthier beneficiaries.
Bauen für die Umwelt?
(2014)
In den letzten Jahren ist das Thema Nachhaltigkeit zu einem Schlüsselthema in vielen wissenschaftlichen und gesellschaftlichen Diskursen geworden. Ausgehend von natur-, technik-, politik- und zunehmend wirtschaftswissenschaftlichen Auseinandersetzung mit Fragestellungen im Kontext von Nachhaltigkeit, sind diese in den Mittelpunkt gesellschaftlicher und politischer Wahrnehmung gerückt.
GRI4-Guidelines
(2014)
In diesem Beitrag wird gezeigt, dass das Corporate Social Responsibility-Controlling (CSR-Controlling) im Zuge der neuen Berichterstattungsvorgaben der Global Reporting Initiative (GRI) vor neuen Herausforderungen steht. Die neue GRI-4-Version fordert über erweiterte und neue Pflichtstandardangaben die CSR-Umsetzung in höchster Niveauausprägung ein und setzt neue Maßstäbe an die CSR-Gütekriterien „Transparenz“ und „Rechenschaftslegung“ in der gesamten Supply Chain. In der Analyse werden die für den zukünftigen GRI-4-Berichtseinstieg erforderlichen Anpassungsschritte dargestellt und in einem GRI-3.1-versus-GRI-4-Vergleich indikatorenbezogen erläutert.