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Wesch D, Miranda P, Afonso-Oramas D, Althaus M, Castro-Hernandez J, Dominguez J, Morty RE, Clauss W, Gonzalez-Hernandez T, Alvarez de la Rosa D, Giraldez T. The neuronalspecific SGK1.1 kinase regulates delta-epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling. Am J Physiol Cell Physiol 299: C779-C790, 2010. First published July 14, 2010; doi:10.1152/ajpcell.00184.2010.-The delta-subunit of the epithelial Na+ channel (ENaC) is expressed in neurons of the human and monkey central nervous system and forms voltage-independent, amiloride-sensitive Na+ channels when expressed in heterologous systems. It has been proposed that delta-ENaC could affect neuronal excitability and participate in the transduction of ischemic signals during hypoxia or inflammation. The regulation of delta-ENaC activity is poorly understood. ENaC channels in kidney epithelial cells are regulated by the serum-and glucocorticoid-induced kinase 1 (SGK1). Recently, a new isoform of this kinase (SGK1.1) has been described in the central nervous system. Here we show that delta-ENaC isoforms and SGK1.1 are coexpressed in pyramidal neurons of the human and monkey (Macaca fascicularis) cerebral cortex. Coexpression of delta beta gamma-ENaC and SGK1.1 in Xenopus oocytes increases amiloride-sensitive current and channel plasma membrane abundance. The kinase also exerts its effect when delta-subunits are expressed alone, indicating that the process is not dependent on accessory subunits or the presence of PY motifs in the channel. Furthermore, SGK1.1 action depends on its enzymatic activity and binding to phosphatidylinositol(4,5)-bisphosphate. Physiological or pharmacological activation of phospholipase C abrogates SGK1.1 interaction with the plasma membrane and modulation of delta-ENaC. Our data support a physiological role for SGK1.1 in the regulation of delta-ENaC through a pathway that differs from the classical one and suggest that the kinase could serve as an integrator of different signaling pathways converging on the channel.
Die Debatte um muslimische Einwandernde in Deutschland, die in jüngster Zeit neuen Auftrieb erhalten hat (1), offenbart immer wieder simplifizierende Sichtweisen vom Islam als einer homogenen Religion. Dabei beweist bereits ein Blick auf die vielfältige muslimische Organisationslandschaft in Deutschland: Es gibt nicht den Islam, sondern stattdessen eine Vielzahl unterschiedlicher islamischer Strömungen, welche mitunter in Konkurrenz zu einander stehen und sich mal mehr, mal weniger deutlich voneinander abgrenzen. Diese Vielfalt der MuslimInnen in Deutschland sowie ihr eher geringer Organisationsgrad erschwert die Bildung eines zentralen islamischen Ansprechpartners, der für sich in Anspruch nehmen könnte, für die Mehrheit der MuslimInnen in Deutschland zu sprechen.
Usable Security und Privacy
(2010)
When entering a password (or other secrets) the typed input is most commonly masked, i.e. the characters are hidden behind bullets or asterisks. This, however, complicates the input and highly decreases the user's confident causing several issues such as login failure attempts. On the other hand, password masking is an important security requirement for a lot of applications and contexts to prevent a third person to read the password. Thus, simply dropping password masking is not feasible in general. A common solution provides the user with the choice of toggling password masking on and off, but due to distinct defaults (in dependency of the application and context) this is rather complex and confusing. Enhanced password visualization technologies beyond the simple masking of passwords can provide more sophisticated solutions from both a usability and security perspective. In this paper, available password visualization technologies are presented and discussed. Furthermore a novel password visualization approach is introduced, the TransparentMask, which provides unique properties in comparison to the existing schemes. Amongst these are the ability to detect mistakes while typing and being able to localize and correct the typo within a certain range. Finally, a security analysis of the TransparentMask shows that the protection level given by a certain password length is slightly decreased in comparison to the fully masked approach.
In this paper, we present a solution how to test cultural influences on E-Learning in a global context. Based on a metadata approach, we show how specifically cultural influence factors can be determined to transfer and adapt learning environments. We present a method how those influence factors can be validated for both, to improve the dynamical meta-data specification and to be used in the development of (international) E-Learning scenarios.
In an explorative study, we investigated on German schoolteachers how they use, reuse, produce and manage Open Educational Resources. The main questions in this research have been, what their motivators and barriers are in their use of Open Educational Resources, what others can learn from their Open Educational Practices, and what we can do to raise the dissemination level of OER in schools.
Eine internationale Verbreitung von OER ist u. a. davon abhängig, ob bereitstehende Inhalte an den jeweiligen Kontext angepasst werden können. Dieser Beitrag befasst sich mit studierendenspezifischen, kulturell motivierten Einflussfaktoren auf Lernsituationen, die neben u. a. inhaltlichen, technischen, didaktischen und rechtlichen Fragen für eine erfolgreiche Wiederverwendung von bereits etablierten Lernressourcen prüfend berücksichtigt werden sollten.
Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients
(2010)
Dihydropyrimidine Dehydrogenase Deficiency Caused by a Novel Genomic Deletion c.505_513del of DPYD
(2010)
Changes in plasma amino acid concentrations with increasing age in patients with propionic acidemia
(2010)
The aim of the study was to develop a method for fast and reliable diagnosis of peroxisomal diseases and to facilitate differential diagnosis of cholestatic hepatopathy. For the quantification of bile acids and their conjugates as well as C(27) precursors di- and trihydroxycholestanoic acid (DHCA, THCA), in small pediatric blood samples we combined HPLC separation on a reverse-phase C18 column with ESI-MS/MS analysis in the negative ion mode. Analysis was done with good precision (CV 3,7%-11.1%) and sufficient sensitivity (LOQ: 11-91 nmol/L) without derivatization. Complete analysis of 17 free and conjugated bile acids from dried blood spots and 10 microL serum samples, respectively, was performed within 12 min. Measurement of conjugated primary bile acids plus DHCA and THCA as well as ursodeoxycholic acid was done in 4.5 min. In blood spots of healthy newborns, conjugated primary bile acids were found in the range of 0.01 to 2.01 micromol/L. Concentrations of C(27) precursors were below the detection limit in normal controls. DHCA and THCA were specifically elevated in cases of peroxysomal defects and one Zellweger patient.