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Hydrogen sulfide (H2S) is well known as a highly toxic environmental chemical threat. Prolonged exposure to H2S can lead to the formation of pulmonary edema. However, the mechanisms of how H2S facilitates edema formation are poorly understood. Since edema formation can be enhanced by an impaired clearance of electrolytes and, consequently, fluid across the alveolar epithelium, it was questioned whether H2S may interfere with transepithelial electrolyte absorption. Electrolyte absorption was electrophysiologically measured across native distal lung preparations (Xenopus laevis) in Ussing chambers. The exposure of lung epithelia to H2S decreased net transepithelial electrolyte absorption. This was due to an impairment of amiloride-sensitive sodium transport. H2S inhibited the activity of the Na+/K+-ATPase as well as lidocaine-sensitive potassium channels located in the basolateral membrane of the epithelium. Inhibition of these transport molecules diminishes the electrochemical gradient which is necessary for transepithelial sodium absorption. Since sodium absorption osmotically facilitates alveolar fluid clearance, interference of H2S with the epithelial transport machinery provides a mechanism which enhances edema formation in H2S-exposed lungs.
Simulation of thermal behavior during friction stir welding process for predicting residual stresses
(2014)
The usage of the Web has experienced a vertiginous growth in the last few years. Watching video online has been one major driving force for this growth lately. Until the appearance of the HTML5 agglomerate of (still draft) specifications, the access and consumption of multimedia content in the Web has not been standardized. Hence, the use of proprietary Web browser plugins flourished as intermediate solution. With the introduction of the HTML5 VideoElement, Web browser plugins are replaced with a standardized alternative. Still, HTML5 Video is currently limited in many respects, including the access to only file-based media. This paper investigates on approaches to develop video live streaming solutions based on available Web standards. Besides a pull-based design based on HTTP, a push-based architecture is introduced, making use of the WebSocket protocol being part of the HTML5 standards family as well. The evaluation results of both conceptual principles emphasize, that push-based approaches have a higher potential of providing resource and cost efficient solutions as their pull-based counterparts. In addition, initial approaches to instrument the proposed push-based architecture with adaptiveness to network conditions have been developed.
Service Security Revisited
(2014)
SOA-Readiness of REST
(2014)
Case Management
(2014)
Dysregulation of IL12 Signaling As a Novel Cause of an Autoimmune Lymphoproliferative like Syndrome
(2014)
After an introduction, we discuss the conflicts that occurred in a highly experimental course setting, in which we implemented a student-centered course in urban higher education with a constructivist, blended-learning design. We analyse to which extent the cultural country profiles from our Learning Culture Survey suffice to prevent intercultural conflicts in education and provide support for the design of respective interventions.
Obwohl kulturbezogene Fragestellungen eine zentrale Rolle für die erfolgreiche Implementierung von Anwendungssystemen und IKT spielen, erfolgen kulturbezogene Untersuchungen in der Disziplin oft zu unkritisch: Kulturelle Kontexte werden in der Literatur häufig nicht klar abgegrenzt, und verwendete Begriffe werden nicht oder nur unzureichend definiert. Darüber hinaus werden kulturbezogene Untersuchungen, die eigentlich Besonderheiten abgegrenzter Gesellschaften (z. B. Kundensegmente) aufdecken sollen, oft ohne weitere Prüfung auf der Ebene von Nationalkultur untersucht. Die Problematik eines zu unkritischen und bisweilen sogar unangemessenen Umgangs mit kulturbezogenen Fragestellungen ist nicht auf die Wirtschaftsinformatik begrenzt sondern zieht sich durch nahezu alle Disziplinen, die "Kultur" als eine unter vielen Einflussgrößen betrachten. In dieser Arbeit wird ein praktischer Ansatz entwickelt, mit dessen Hilfe nicht nur der eigene kulturbezogene Forschungskontext abgegrenzt werden, sondern darüber hinaus auch noch herausgefunden werden kann, ob bereits verfügbare Forschungsansätze ggf. auf den eigenen Kontext passen könnten. Als Ergebnisse der Arbeit wurde ein Schritt-für-Schritt Leitfaden erstellt und eine Vergleichsbasis geschaffen, die auf einer in ihrem Umfang bislang einzigartigen Sammlung bereits verfügbarer Kulturbeschreibungsansätze beruht.
Many e-Learning-basedoffers, such as international programs and MOOCs have long since overcome the concept of national education and are designed to attract learners distributed throughout the world. In order to cope with the differences between learners, related offers often include opportunities to support the particular learning styles and learning pace beyond the advantages, which the technology itself naturally provides. Examples arethe individual configuration of the learning platformand display of contents and the provision of stylistically diverse and supplementary learning material. Such measures are relatively easy to implement andonce established, do not generate further expenses. Just, is it appropriate to lay the full responsibility for designing a comfortable (and supportive) learning environment into the hands of the learners and do they get along with such a responsibility? We asked university students from three continents regarding their expectations towards instructor-support and found major differences.