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Die Zukunft der CCS-Technologie ist maßgeblich von den Entwicklungsmöglichkeiten abhängig, die ihr der Gesetzgeber einräumt. Der von der Bundesregierung am 13.4.2011 beschlossene Gesetzentwurf geht mit großer Vorsicht an den Einsatz der CCS-Technologie heran. Die Entwicklung sowie die Planungs- und Investitionssicherheit haben gegenüber den Bedenken gegen die kurz- und langfristige Sicherheit der CO2-Speicherung zurückstecken müssen. Der nachfolgende Beitrag erläutert Rechtsprobleme der Genehmigung von CO2-Abscheidungsanlagen, Transportleitungen und Speichern sowie der Gefahrenvorsorge, -nachsorge und Haftung.
A deployment of the Vehicle-2-Vehicle communication technology according to ETSI is in preparation in Europe. Currently, a policy for a necessary Public Key Infrastructure to enrol cryptographic keys and certificates for vehicles and infrastructure component is in discussion to enable an interoperable Vehicle-2-Vehicle communication. Vehicle-2-Vehicle communication means that vehicles periodically send Cooperative Awareness Messages. These messages contain the current geographic position, driving direction, speed, acceleration, and the current time of a vehicle. To protect privacy (location privacy, “speed privacy”) of vehicles and drivers ETSI provides a specific pseudonym concept. We show that the Vehicle-2-Vehicle communication can be misused by an attacker to plot a trace of sequent Cooperative Awareness Messages and to link this trace to a specific vehicle. Such a trace is non-disputable due to the cryptographic signing of the messages. So, the periodically sending of Cooperative Awareness Messages causes privacy problems even if the pseudonym concept is applied.
The combination of Software-Defined Networking (SDN) and Wireless Mesh Network (WMN) is challenging due to the different natures of both concepts. SDN describes networks with homogeneous, static and centralized controlled topologies. In contrast, a WMN is characterized by a dynamic and distributed network control, and adds new challenges with respect to time-critical operation. However, SDN and WMN are both associated with decreasing the operational costs for communication networks which is especially beneficial for internet provisioning in rural areas. This work surveys the current status for Software-Defined Wireless Mesh Networking. Besides a general overview in the domain of wireless SDN, this work focuses especially on different identified aspects: representing and controlling wireless interfaces, control-plane connection and topology discovery, modulation and coding, routing and load-balancing and client handling. A complete overview of surveyed solutions, open issues and new research directions is provided with regard to each aspect.
Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases
(2017)
ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. As few ETV6-RUNX1 carriers develop precursor B cell acute lymphocytic leukemia (pB-ALL), the underlying genetic basis for development of full-blown leukemia remains to be identified, but the appearance of leukemia cases in time-space clusters keeps infection as a potential causal factor. Here we present in vivo genetic evidence mechanistically connecting preleukemic ETV6-RUNX1 expression in hematopoetic stem cells/peripheral cells (HSC/PC) and postnatal infections for human-like pB-ALL. In our model, ETV6-RUNX1 conferred a low risk of developing pB-ALL after exposure to common pathogens, corroborating the low incidence observed in humans. Murine preleukemic ETV6-RUNX1 pro/preB cells showed high Rag1/2 expression, known for human ETV6-RUNX1 pB-ALL. Murine and human ETV6-RUNX1 pB-ALL revealed recurrent genomic alterations, with a relevant proportion affecting genes of the lysine demethylase (KDM) family. KDM5C loss-of-function resulted in increased levels of H3K4me3, which co-precipitated with RAG2 in a human cell line model, laying the molecular basis for recombination activity. We conclude that alterations of KDM family members represent a disease-driving mechanism and an explanation for RAG off-target cleavage observed in humans. Our results explain the genetic basis for clonal evolution of an ETV6-RUNX1 preleukemic clone to pB-ALL after infection exposure and offer the possibility of novel therapeutic approaches.
Wissenschaft trifft Praxis
(2017)
I. Einleitung II. Soziale Sicherung als Bestandteil entwicklungspolitischer Agenden – Eine internationale Perspektive III. Internationale Politikdiffusion und nationaler Politikwandel – Konzeptionelle Grundlagen IV. Die Rolle internationaler Politikdiffusion für den Wandel sozialer Sicherungssysteme – Empirische Evidenz V. Schlussfolgerungen
Exosomes derived from human autologous conditioned serum are nanocarriers for IL-6 and TNF-alfa
(2017)
Der Trend zum CTA-Model basiert auf Überlegungen zur Insolvenzsicherung, zur Verbesserung des Bilanzbilds und zur Steuerung des Risikos. Das Argument der Insolvenzsicherung ist nicht schlüssig, da einerseits die Sicherung der Verpflichtungen umfassender Personalbestände nicht im Vordergrund steht und andererseits potenzielle Konkursmasse verloren geht. Auch das Bilanz-, GuV- und Cash Flow-Bild wird bei einer sorgfältigen Arbeit der Analysten nur vordergründig beeinflusst. Bei Vorhandensein und Erkennbarkeit der potenziellen Auslagerungsmittel ändert sich die Effektivverschuldung nicht und im Fall der Notwendigkeit der Aufnahme von Fremdmitteln entsteht ein Passivtausch von zweifelhafter Wirkung. Insgesamt sei aber darauf hingewiesen, dass die Kombination von CTA-Modellen zusammen mit anderen externen Durchführungswegen, insbesondere dem Pensionsfonds, je nach unternehmerischer Präferenz der Grad der Zeilerreichung durchaus erhöht werden kann.
Advances in computer graphics enable us to create digital images of astonishing complexity and realism. However, processing resources are still a limiting factor. Hence, many costly but desirable aspects of realism are often not accounted for, including global illumination, accurate depth of field and motion blur, spectral effects, etc. especially in real‐time rendering. At the same time, there is a strong trend towards more pixels per display due to larger displays, higher pixel densities or larger fields of view. Further observable trends in current display technology include more bits per pixel (high dynamic range, wider color gamut/fidelity), increasing refresh rates (better motion depiction), and an increasing number of displayed views per pixel (stereo, multi‐view, all the way to holographic or lightfield displays). These developments cause significant unsolved technical challenges due to aspects such as limited compute power and bandwidth. Fortunately, the human visual system has certain limitations, which mean that providing the highest possible visual quality is not always necessary. In this report, we present the key research and models that exploit the limitations of perception to tackle visual quality and workload alike. Moreover, we present the open problems and promising future research targeting the question of how we can minimize the effort to compute and display only the necessary pixels while still offering a user full visual experience.
Mobilitäts- und Nachhaltigkeitsforscher sehen sich bei der Erforschung des Mobilitätsverhaltens von Personen mit einer bunten Palette an Erhebungsmethoden konfrontiert. Erweitert wird diese Vielfalt in der letzten Zeit durch die Möglichkeit, dieses Verhalten direkt über die Smartphones der Probanden zu erfassen. Um die Auswahl geeigneter Methoden zu erleichtern, liefert die vorliegende Literaturstudie einen detaillierten Überblick zu Fragestellungen, Daten und Erhebungsmethoden, die im Bereich der Mobilitätsforschung zur Erfassung von Alltagsmobilität eingesetzt werden.
This paper introduces our robotic system named UGAV (Unmanned Ground-Air Vehicle) consisting of two semi-autonomous robot platforms, an Unmanned Ground Vehicle (UGV) and an Unmanned Aerial Vehicles (UAV). The paper focuses on three topics of the inspection with the combined UGV and UAV: (A) teleoperated control by means of cell or smart phones with a new concept of automatic configuration of the smart phone based on a RKI-XML description of the vehicles control capabilities, (B) the camera and vision system with the focus to real time feature extraction e.g. for the tracking of the UAV and (C) the architecture and hardware of the UAV.
Multiple myeloma is the second most common hematological malignancy. Despite all the progress made in treating multiple myeloma, it still remains an incurable disease. Patients are left with a median survival of 4-5 years. The combined treatment of multiple myeloma with histone deacetylase inhibitors and cytokine-induced killer cells provides a promising targeted treatment option for patients. This study investigated the impact of a combined treatment compared to treatment with histone deacetylase inhibitors. The experiments revealed that a treatment with histone deacetylase (HDAC) inhibitors could reduce cell viability to 59% for KMS 18 cell line and 46% for the U-266 cell line. The combined treatment led to a decrease of cell viability to 33% for KMS 18 and 27% for the U-266 cell line, thus showing a significantly better efficacy than the single treatment.
This study contributes to the growing body of research concerning management consultancies by linking two previously disparate fields of study: (1) the examination of the effectiveness of consulting interventions and (2) the examination of the social processes that aim to create and legitimize the insights, knowledge and capabilities of management consultancies. We propose that consulting firms accumulate social authority in the course of pre-intervention discourse processes that is reflected in their reputation and celebrity. With respect to intervention, this social authority affects change recipients’ commitment to and compliance with the requirements of change implementation. We test the proposed relationships by conducting a measured variable path analysis of 117 change initiatives in German companies that were set up and implemented with the assistance of external consultancies. Our findings indicate that a consulting firm’s levels of both celebrity and reputation affect the change recipients’ commitment to proposed change strategies and thus, indirectly affect their behavioral compliance with the explicit requirements of change implementation.
Die Forschung zur kontrovers diskutierten Robotik in der Pflege und Begleitung von Personen mit Demenz steht noch am Anfang, wenngleich bereits erste Systeme auf dem Markt sind. Der Beitrag gibt entlang beispielhafter, fallbezogener Auszüge Einblicke in das laufende multidisziplinäre Projekt EmoRobot, das sich explorativ und interpretativ mit der Erkundung des Einsatzes von Robotik in der emotionsorientierten Pflege und Versorgung von Personen mit Demenz befasst. Fokussiert werden dabei die je eigenen Relevanzen der Personen mit Demenz.