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Human mesenchymal stem cells (hMSCs) are considered a promising cell source for regenerative medicine, because they have the potential to differentiate into a variety of lineages among which the mesoderm-derived lineages such adipo- or osteogenesis are investigated best. Human MSCs can be harvested in reasonable to large amounts from several parts of the patient’s body and due to this possible autologous origin, allorecognition can be avoided. In addition, even in allogenic origin-derived donor cells, hMSCs generate a local immunosuppressive microenvironment, causing only a weak immune reaction. There is an increasing need for bone replacement in patients from all ages, due to a variety of reasons such as a new recreational behavior in young adults or age-related diseases. Adipogenic differentiation is another interesting lineage, because fat tissue is considered to be a major factor triggering atherosclerosis that ultimately leads to cardiovascular diseases, the main cause of death in industrialized countries. However, understanding the differentiation process in detail is obligatory to achieve a tight control of the process for future clinical applications to avoid undesired side effects. In this review, the current findings for adipo- and osteo-differentiation are summarized together with a brief statement on first clinical trials.
The biological effects of bilirubin, still poorly understood, are concentration-dependent ranging from cell protection to toxicity. Here we present data that at high nontoxic physiological concentrations, bilirubin inhibits growth of proliferating human coronary artery smooth muscle cells by three events. It impairs the activation of Raf/ERK/MAPK pathway and the cellular Raf and cyclin D1 content that results in retinoblastoma protein hypophosphorylation on amino acids S608 and S780. These events impede the release of YY1 to the nuclei and its availability to regulate the expression of genes and to support cellular proliferation. Moreover, altered calcium influx and calpain II protease activation leads to proteolytical degradation of transcription factor YY1. We conclude that in the serum-stimulated human vascular smooth muscle primary cell cultures, bilirubin favors growth arrest, and we propose that this activity is regulated by its interaction with the Raf/ERK/MAPK pathway, effect on cyclin D1 and Raf content, altered retinoblastoma protein profile of hypophosphorylation, calcium influx, and YY1 proteolysis. We propose that these activities together culminate in diminished 5 S and 45 S ribosomal RNA synthesis and cell growth arrest. The observations provide important mechanistic insight into the molecular mechanisms underlying the transition of human vascular smooth muscle cells from proliferative to contractile phenotype and the role of bilirubin in this transition.
Nachhaltigkeitskonzepte sind kein selbstverständlicher Gegenstand der chemischen Hochschulausbildung. Der vorliegende Text fragt nach den Ursachen und zeigt anschließend Anschlussflächen für das Thema Nachhaltigkeit in der Chemieausbildung. Er stellt ein fachübergreifendes und zugleich fachbezogenes Konzept vor, welches Nachhaltigkeit zum Gegenstand für Chemiestudierende macht. Dieses ermöglicht den Studierenden einen subjektiv bedeutsamen Zugang zu den Fachinhalten. Es fördert Bewertungskompetenzen und Verantwortungsfähigkeit, schult die Sprachgewandtheit und erleichtert methodisch geführt die Reflexion auf Gegenstand und Selbstverständnis.
Transient up-regulation of P2 receptors influence differentiation of human mesenchymal stem cells
(2012)
Gas chromatography with simultaneous flame-ionization detection (FID) and a nitrogen-phosphorus detection (NPD) as well as gas chromatography-mass spectrometry (GC/MS) has been used to characterize some long-chain primary alkyl amines and alkyl diamines after derivatization with trifluoroacetic anhydride (TFAA).
After more than twenty years of research, the molecular events of apoptotic cell death can be succinctly stated; different pathways, activated by diverse signals, increase the activity of proteases called caspases that rapidly and irreversibly dismantle condemned cell by cleaving specific substrates. In this time the ideas that apoptosis protects us from tumourigenesis and that cancer chemotherapy works by inducing apoptosis also emerged. Currently, apoptosis research is shifting away from the intracellular events within the dying cell to focus on the effect of apoptotic cells on surrounding tissues. This is producing counterintuitive data showing that our understanding of the role of apoptosis in tumourigenesis and cancer therapy is too simple, with some interesting and provocative implications. Here, we will consider evidence supporting the idea that dying cells signal their presence to the surrounding tissue and, in doing so, elicit repair and regeneration that compensates for any loss of function caused by cell death. We will discuss evidence suggesting that cancer cell proliferation may be driven by inappropriate or corrupted tissue-repair programmes that are initiated by signals from apoptotic cells and show how this may dramatically modify how we view the role of apoptosis in both tumourigenesis and cancer therapy.
Sicherheit im Fährverkehr
(2012)
People with type 2 Diabetes have an elevated risk for developing cardiovascular disease (CVD) for which dyslipidemia is the major contributor. Diabetic patients have characteristic pattern of dyslipidemia with decreased level of high density lipoprotein cholesterol (HDL-C) and elevated triglycerides (TG) level. However, in diabetes mellitus, low density lipoprotein cholesterol (LDL-C) which is used as one of the markers for the risk of CVD, is underestimated so in such cases the levels of non-High density lipoprotein cholesterol (non-HDL-C) can be a stronger predictor of CVD as it strongly correlates with atherogenic lipoproteins. Therefore, an attempt has been made to evaluate the level of non-HDL-C as a newer marker for the risk of cardiovascular disease and to fi nd out the pattern of dyslipidemia in diabetes mellitus. The present study comprised of 82 type 2 Diabetic cases and 81 non-diabetic controls. Among the diabetics, the majority of the subjects (61.0%) were HDL-C dyslipidemic. However, among the controls, the maximum numbers of individuals (40.7%) were TG dyslipidemic. Diabetics have signifi cantly elevated ratio of total cholesterol to high density lipoprotein cholesterol (TC/HDL-C) and the signifi cant increased levels of non-high density lipoprotein cholesterol (non-HDL-C) compared to controls which can be used as markers of dyslipidemia and can also be used to predict the risk of cardiovascular disease in type 2 Diabetes Mellitus.
Werte gelten gemeinhin als Orientierungsgrundlagen von Individuen und Gesellschaften. Führungskräfte sind für die Praxis sozialer Verantwortung wirtschaftlicher, politischer und sozialer Organisationen von herausragender Bedeutung.
Ziel des vorliegenden Bandes ist es, das Thema Werte und Werthaltungen von angehenden Führungskräften aus interdisziplinärer wissenschaftlicher sowie aus wirtschafts- und gesellschaftsbezogener Perspektive zu beleuchten. Die zentralen Themen dabei sind die Bestandsaufnahme und Erfassung von Werten und Werthaltungen, die Anforderungen an die Werthaltungen von Führungskräften aus Wirtschaft und Gesellschaft sowie die Vermittlung von Werten an die künftigen Führungskräfte. Die Thematik wird von ausgewiesenen Experten aus Wissenschaft und Praxis facettenreich behandelt und präsentiert. So werden in diesem Sammelband aktuelle und zukunftsweisende wirtschaftsethische Themen einer vielfältigen Analyse unterzogen und Antworten auf brennende Fragen gegeben.
BWL-Formeln für Dummies
(2012)
Anfang Januar 2007 trat in Nordrhein-Westfalen (NRW) das Hochschulfreiheitsgesetz (HFG) in Kraft. Mit dem HFG hat sich die Landesregierung in NRW weit aus der Detailsteuerung der Hochschulen zurückgezogen und tritt lediglich noch für existenzielle Schadensereignisse ein. So sind die Hochschulen – Universitäten und Fachhochschulen – in NRW keine staatlichen Einrichtungen mehr, sondern Körperschaften des öffentlichen Rechts in staatlicher Trägerschaft. Hiermit folgt das neue Hochschulgesetz dem hochschulpolitischen Paradigmenwechsel von einem staatlich geplanten, weitgehend einheitlich gestalteten System zu einem durch Profilbildung und Wettbewerb geprägten Hochschulsystem. In diesem Artikel werden die damit verbundenen Problemstellungen und Lösungsoptionen aufgezeigt und als Empfehlung die Einführung eines Chancen- und Risikomanagements beschrieben.
Für die Entwicklung steuerungstechnischer Sicherheitsfunktionen muss ab 2012 die Normen EN ISO 13849-1 oder EN 62061 befolgt werden, die sowohl Anforderungen an die Hardware als auch Anforderungen an die Software beschreibt. Die Anforderungen an die Software spielten bis vor einigen Jahren kaum eine Rolle, da Sicherheitsfunktionen vorzugsweise in Hardware realisiert wurden. Heutzutage ist es jedoch sehr häufig üblich, Sicherheitsfunktionen mit einer dafür geeigneten programmierbaren SPS zu realisieren. Die neuen Normen bzgl. der sicheren Steuerung von Maschinen verlangen neben der Quantifizierung der Hardware-Ausfallraten von Sicherheitsfunktionen noch ein Management der Sicherheitsfunktionen. Dazu gehört auch ein Management der Softwareentwicklung für Sicherheitsfunktionen, um systematische Fehler zu minimieren. Dieses Management der Softwareentwicklung wird im Wesentlichen durch das V-Modell repräsentiert. Für die Maschinebauindustrie darf dieser Managementprozess nicht zu aufwendig sein, ansonsten wird dieser in der Praxis nur schwer angenommen. Eine Möglichkeit der Abarbeitung des V-Modells wird vorgestellt. Wahrscheinlich ist diese aufgezeigte Möglichkeit für die Industrie noch zu aufwendig.
People have dreamed of machines, which would free them from unpleasant, dull, dirty and dangerous tasks and work for them as servants, for centuries if not millennia. Service robots seem to finally let these dreams come true. But where are all these robots that eventually serve us all day long, day for day? A few service robots have entered the market: domestic and professional cleaning robots, lawnmowers, milking robots, or entertainment robots. Some of these robots look more like toys or gadgets rather than real robots. But where is the rest? This is a question, which is asked not only by customers, but also by service providers, care organizations, politicians, and funding agencies. The answer is not very satisfying. Today’s service robots have their problems operating in everyday environments. This is by far more challenging than operating an industrial robot behind a fence. There is a comprehensive list of technical and scientific problems, which still need to be solved. To advance the state of the art in service robotics towards robots, which are capable of operating in an everyday environment, was the major objective of the DESIRE project (Deutsche Service Robotik Initiative – Germany Service Robotics Initiative) funded by the German Ministry of Education and Research (BMBF) under grant no. 01IME01A. This book offers a sample of the results achieved in DESIRE.
Open Source ERP-Systeme
(2012)
Mit Free and Open Source Software können die IT-Kosten in erheblichem Umfang gesenkt werden. Wegen ihres hohen Durchdringungsgrades in Unternehmen und des damit verbundenen Kostenblocks gilt dies insbesondere für Free and Open Source (FOS-) ERP-Systeme. Zwar sind die Verbreitung und die Akzeptanz von FOS-ERP-Systemen in den letzten Jahren schon stark angewachsen, durch eine verbesserte Markttransparenz lassen sich aber noch weitere Potenziale erschließen. Bestehende Marktübersichten für FOS-ERP-Systeme sind jedoch wenig umfassend. Vor diesem Hintergrund wurde ein Marktspiegel mit detaillierten Angaben zu den verschiedenen FOS-ERP-Systemen erstellt.
ERP systems are being used throughout the whole enterprise and are therefore responsible for a high percentage of IT expenses. The use of Free and Open Source ERP systems (FOS ERP systems) can help to reduce these IT costs. Though the acceptance of FOS ERP systems has increased enormously in the last years, even more entreprises would use FOS ERP systems to support their order processing, if the FOS ERP market was more transparent. Existing market surveys are less comprehensive. Therefore, a detailed market guide was developed.
We present our approach to extend a Virtual Reality software framework towards the use for Augmented Reality applications. Although VR and AR applications have very similar requirements in terms of abstract components (like 6DOF input, stereoscopic output, simulation engines), the requirements in terms of hardware and software vary considerably. In this article we would like to share the experience gained from adapting our VR software framework for AR applications. We will address design issues for this task. The result is a VR/AR basic software that allows us to implement interactive applications without fixing their type (VR or AR) beforehand. Switching from VR to AR is a matter of changing the configuration file of the application. We also give an example of the use of the extended framework: Augmenting the magnetic field of bar magnets in physics classes. We describe the setup of the system and the real-time calculation of the magnetic field, using a GPU.
Using virtual environment systems for road safety education requires a realistic simulation of road traffic. Current traffic simulations are either too restricted in their complexity of agent behavior or focus on aspects not important in virtual environments. More importantly, none of them are concerned with modeling misbehavior of traffic participants which is part of every-day traffic and should therefore not be neglected in this context. We present a concept for a traffic simulation that addresses the need for more realistic agent behavior with regard to road safety education. The two major components of this concept are a simulation of persistent agents which minimizes computational overhead and a model of cognitive processes of human drivers combined with psychological personality profiles to allow for individual behavior and misbehavior.
This paper compares the memory allocation of two Java virtual machines, namely Oracle Java HotSpot VM 32-bit (OJVM) and Jamaica JamaicaVM (JJVM). The basic difference of the architectures in both machines is that the JamaicaVM uses fixed-size blocks for allocating objects on the heap. The basic difference of the architectures is that the JJVM uses fixed size block allocation on the heap. This means that objects have to be split into several connected blocks if they are bigger than the specified block-size. On the other hand, for small objects a full block must be allocated. The paper contains both theoretical and experimental analysis on the memory-overhead. The theoretical analysis is based on specifications of the two virtual machines. The experimental analysis is done with a modified JVMTI Agent together with the SPECjvm2008 Benchmark.
This paper describes adaptive time frequency analysis of EEG signals, both in theory as well as in practice. A momentary frequency estimation algorithm is discussed and applied to EEG time series of test persons performing a concentration experiment. The motivation for deriving and implementing a time frequency estimator is the assumption that an emotional change implies a transient in the measured EEG time series, which again are superimposed by biological white noise as well as artifacts. It will be shown how accurately and robustly the estimator detects the transient even under such complicated conditions.