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ドイツで学んだ研究の方法と働き方
(2018)
Umwelt: Technologien, um die Folgen des Klimawandels zu begrenzen, gibt es. Die soziale und politische Dimension ist der Hemmschuh, so dass sie teils nur zögernd zum Einsatz kommen.
Die Redaktion der VDI nachrichten betreute drei Studierende, die aktuell von jedem Vortrag einen Artikel für unser Ingenieurportal www.ingenieur.de schrieben sowie eine Meldung für die VDI-nachrichten-E-Paper-App. Dieser Artikel ist das Resümee der drei zur Ringvorlesung, aber keine inhaltlich komplette Zusammenfassung. Alle Artikel lesen Sie online unter: www.ingenieur.de/Ringvorlesung2018
Mit dem Anspruch, die Qualität in der medizinischen Rehabilitation weiterzuentwickeln, haben sich im Jahr 2007 13 Kliniken von acht Trägern zusammengeschlossen. Heute, ein gutes Jahrzehnt später, vereint der Qualitätsverbund Gesundheit rund 30 Reha-Kliniken von elf Trägern, darunter kommunale und kirchliche Institutionen, Privatunternehmen und die Rehazentren der Deutschen Rentenversicherung Baden-Württemberg.
Wird eine Klage auf Feststellung von Unfallfolgen rechtskräftig abgewiesen, steht diese Rechtskraft einem Anspruch auf Rücknahme des früheren, bestandskräftigen, Unfallfolgen verneinenden Bescheides nach § 44 SGB X entgegen. Denn es steht aufgrund der Rechtskraft der gerichtlichen Entscheidung fest, dass Unfallfolgen nicht vorliegen, der frühere Bescheid also rechtmäßig ist.
Zwischen Tradition und Digitalisierung – Unternehmenskulturen sozialer Organisationen im Wandel
(2018)
Zustandsregelung für ein Mikroflugsystem zur Ansteuerung vorgegebener Wegpunkte in Innenräumen
(2018)
In der Masterarbeit Zustandsregelung für ein Mikroflugsystem zur Ansteuerung vorgegebener Wegpunkte in Innenräumen wird die Entwicklung einer Positionsregelung für ein Mikroflugsystem vorgestellt. Damit ist es möglich, sowohl in einer bekannten als auch unbekannten Umgebung vorgegebene Wegpunkte automatisch anzusteuern. Die Lokalisation des Flugsystems findet mit interner Sensorik sowie mithilfe von zwei Laserscannern statt. Steht bereits eine Karte der Umgebung zur Verfügung, ist es möglich, einen Pfad zu einem vorgegebenen Zielpunkt zu berechnen und diesen Pfad automatisch abzufliegen.
Durch die Nutzung von Qualitätsindikatoren für die Zuweisungssteuerung ge-winnt das interne QM eine zentrale Bedeutung für die Zukunftssicherung der Einrichtungen. Zusätzlich untermauert wird dies durch den strukturierten Qualitätsdialog (DRV Bund 2017), der durch eine stärkere Fokussierung auf diese Qualitätsindikatoren Revisionscharakter und zugleich Anreizfunktion für die Rehabilitationseinrichtungen hat. Vor diesem Hintergrund stellt sich für die Einrichtungen die Frage, wie geeignete interne Qualitätskennzahlen genutzt werden können, um Verbesserungsprozesse so frühzeitig zu initiieren, dass die externen Qualitätskennzahlen positiv ausfallen.
Die Bundeszentrale für gesundheitliche Aufklärung (BZgA) hat im Juni dieses Jahres ihren aktuellen Forschungsbericht zum Glücksspielverhalten und zur Glücksspielsucht in Deutschland mit Datum 15.2.2018 veröffentlicht: GLÜCKSSPIELVERHALTEN UND GLÜCKSSPIELSUCHT IN DEUTSCHLAND. Ergebnisse des Surveys 2017 und Trends. BZgA-Forschungsbericht / 15.2.2018.
Wissen schmeckt
(2018)
Wie kocht ein Physiker seine Pasta „al dente“? Welche sensorischen Wahrnehmungen gibt es, wenn wir etwas Leckeres essen? Hat gesunde Ernährung immer etwas mit Verzicht zu tun? Schmeckt Essen besser, während wir Musik hören? Was hilft beim „Männerschnupfen“ wirklich? Und hat die Digitalisierung mittlerweile auch die Küche erobert? Diese und viele weitere Fragen beantworten Wissenschaftler aus den jeweiligen Fachbereichen und stellen dazu jeweils ein passendes Rezept vor, um das Forschungsthema einer breiten Zielgruppe im wahrsten Sinne des Wortes schmackhaft zu machen. Abgerundet wird dieses Menü aus Wissenschaft und kulinarischen Köstlichkeiten mit einer Weinempfehlung von Hendrik Thoma und einem Wissenshäppchen vom „Leckerwisser“.
Zu jedem Beitrag kann über einen QR-Code ein Video abgerufen werden, in dem sich Argang Ghadiri mit dem Beitragsautor über dessen Wissenschaftsgebiet unterhält. Dabei wird das im Beitrag vorgestellte Rezept gekocht.
Evaluation is of crucial importance and should meet professional standards in its design. In practice, organizational peculiarities and available resources characterize the search for the "right" approach. When used as a quality development tool, internal or self-evaluation should primarily be useful. It should generate information to answer organizational questions and provide results as a basis for discussion in decision-making processes.
Im Zusammenhang mit der Rhythmisierung des Schulalltags spielen Pausen eine wichtige Rolle. Dass Pausen für die Regeneration und Wiederherstellung der Leistungsfähigkeit bedeutsam sind, scheint allgemein anerkannt. Die Autoren fassen im folgenden Beitrag zusammen, welche wissenschaftlichen Erkenntnisse es über die Effekte der Gestaltung und der Dauer von Pausen gibt.
Software development is a complex task. Merely focussing on functional requirements is not sufficient any more. Developers are responsible to take many non-functional requirements carefully into account. Security is amongst the most challenging, as getting it wrong will result in a large user-base being potentially at risk. A similar situation exists for administrators. Security defaults have been put into place here to encounter lacking security controls. As first attempts to establish security by default in software development are flourishing, the question on their usability for developers arises.
In this paper we study the effectiveness and efficiency of Content Security Policy (CSP) enforced as security default in a web framework. When deployed correctly, CSP is a valid protection mean in a defence-in-depth strategy against code injection attacks. In this paper we present a first qualitative laboratory study with 30 participants to discover how developers deal with CSP when deployed as security default. Our results emphasize that the deployment as security default has its benefits but requires careful consideration of a comprehensive information flow in order to improve and not weaken security. We provide first insights to inform research about aiding developers in the creation of secure web applications with usable security by default.
Dementia not only affects the cognitive capabilities, especially memory and orientation, but also physical capabilities, which are associated with a decrease of physical activities. Here, ICT can play a major role to improve health, quality of life and wellbeing in older adults suffering from dementia and related stakeholders, such as relatives, professional and informal caregivers. The aim of the presented system is to increase physical and cognitive capabilities of people with dementia and their caregivers to support them in daily life activities, reduce the strain of the caregivers and improve both their wellbeing.
Die im Jahre 2013 begonnene Workshop-Reihe „Usability in der betrieblichen Praxis“ auf der Mensch und Computer wird mit diesem Workshop als Aktivität des Mittelstand 4.0-Kompetenzzentrums Usability des BMWi fortgesetzt. Unter dem Stichwort „Digitalisierung“ ergeben sich neue Herausforderungen der Umsetzung von Usability und positiver User Experience (UUX) in der betrieblichen Praxis kleiner und mittelständischer Unternehmen (UUX-Praxis). Diese werden in vier Schwerpunktthemen im Workshop behandelt: „UUX - Erfolgsfaktor für Innovation und Zukunft der Arbeit“, „UUX und digitale Nutzerforschung“, „UUX und Agilität“ sowie „UUX - Unterstützung mittelständischer Unternehmensnetzwerke“. Der Workshop richtet sich an Entwicklungs- und UUX-Praktiker aus Softwareentwicklungs-, Anwendungs- und UUX-Beratungsunternehmen sowie Wissenschaftler, die sich mit Umsetzung der UUX-Praxis in Unternehmen beschäftigen.
Once aberrantly activated, the Wnt/βcatenin pathway may result in uncontrolled proliferation and eventually cancer. Efforts to counter and inhibit this pathway are mainly directed against βcatenin, as it serves a role on the cytoplasm and the nucleus. In addition, speciallygenerated lymphocytes are recruited for the purpose of treating liver cancer. Peripheral blood mononuclear lymphocytes are expanded by the timely addition of interferon γ, interleukin (IL)1β, IL2 and anticluster of differentiation 3 antibody. The resulting cells are called cytokineinduced killer (CIK) cells. The present study utilised these cells and combine them with drugs inhibiting the Wnt pathway in order to examine whether this resulted in an improvement in the killing ability of CIK cells against liver cancer cells. Drugs including ethacrynic acid (EA) and ciclopirox olamine (CPX) were determined to be suitable candidates, as determined by previous studies. Drugs were administered on their own and combined with CIK cells and then a cell viability assay was performed. These results suggest that EAtreated cells demonstrated apoptosis and were significantly affected compared with untreated cells. Unlike EA, CPX killed normal and cancerous cells even at low concentrations. Subsequent to combining EA with CIK cells, the potency of killing was increased and a greater number of cells died, which proves a synergistic action. In summary, EA may be used as an antihepatocellular carcinoma drug, while CPX possesses a high toxicity to cancerous as well as to normal cells. It was proposed that EA should be integrated into present therapeutic methods for cancer.
Scientific or statistical research has long been the domain of dedicated programming languages such as R, SPSS or SAS. A few years other competitors entered the arena, among them Python with its powerful SciPy package. The following article introduces SciPy by applying a small subset of its functionality to a well-known dataset.
Kontemporäre Service-orientierte Systeme sind hochgradig vernetzt und haben zudem die Eigenschaft massiv-skalierbar zu sein. Diese Charakteristiken stellen im besonderen Maße Anforderungen an die Datensicherheit der Anwender solcher Systeme und damit primär an alle Stakeholder der Softwareentwicklung, die in der Verantwortung sind, passgenaue Sicherheitsmechanismen effektiv in die Softwareprodukte zu bringen. Die Effektivität von Sicherheitsarchitekturen in service-orientierten Systemen hängt maßgeblich von der richtigen Nutzung und Integration von Security-APIs durch eine heterogene Gruppe von Softwareentwicklern ab, bei der nicht per se ein fundiertes Hintergrundwissen über komplexe digitale Sicherheitsmechanismen vorausgesetzt werden kann. Die Diskrepanz zwischen komplexen und in der Anwendung fehleranfälligen APIs und einem fehlenden Verständnis für die zugrundeliegenden Sicherheitskonzepte auf Seiten der Nutzer begünstigt in der Praxis unsichere Softwaresysteme. Aus diesem Grund ist die Gebrauchstauglichkeit von Security-APIs besonders relevant, damit Programmierer den benötigten Funktionsumfang effektiv, effizient und zufriedenstellend verwenden können. Abgeleitet von dieser Problemstellung, konzentriert sich das Dissertationsvorhaben auf die gebrauchstaugliche Ausgestaltung von Security-APIs und den Herausforderungen die sich aus den Methoden zur Evaluation der Usability in typischen Umgebungen der Softwareentwicklung ergeben.
Untersuchungen zur Hydrophobierung von Miscanthus X giganteus für den Einsatz in Dämmstoffsystemen
(2018)
Untersuchungen zum Einfluss von chemischen Aktivatoren und Templaten auf die Zementhydratation
(2018)
Polyurethane (PU) coatings were successfully produced using unmodified kraft lignin (KL) as an environmentally benign component in contents of up to 80 wt%. Lignin samples were precipitated from industrial black liquor in aqueous solution working at room temperature and different pH levels (pH 2 to pH 5). Lignins were characterized by UV-Vis, FTIR, pyrolysis-GC/MS, SEC and 31P-NMR. Results show a correlation between pH level, OH number and molecular weight Mw of isolated lignins. Lignin-based polyurethane coatings were prepared in an efficient one step synthesis dissolving lignin in THF and PEG425 in an ultrasonic bath followed by addition of 4,4-diphenylmethanediisocyanate (MDI) and triethylamine (TEA). Crosslinking was achieved under very mild conditions (1 hour at room temperature followed by 3 hours at 35 °C). The resulting coatings were characterized regarding their physical properties including ATR-IR, TGA, optical contact angle, light microscopy, REM-EDX and AFM data. Transparent homogeneous films of high flexibility resulted from lignins isolated at pH 4, possessing a temperature resistance up to 160 °C. Swelling tests revealed a resistance against water. Swelling in DMSO depends on index, pH of precipitation and catalyst utilization for PU preparation. According to AFM studies, surface roughness is between 10 and 28 nm.
Multidisciplinary, multicultural, and multitasking has taken center stage in the global educational debate. Globalization and improvement in communication have affected the way organisations operate and hence influenced whom they hire. Today, it is common practice to work with people from diverse backgrounds and it requires competencies that go beyond general project management. Intercultural awareness, networking in different global communities, and learning to develop specific communication strategies for different stakeholders is all part of the package of skills and competencies that are required in today's interconnected world. This has indirect implication on the nature of skills and competencies institutions/universities must equip their students with to enable them to compete successfully in the working world.
The formulation of transport network problems is represented as a translation between two domain specific languages: from a network description language, used by network simulation community, to a problem description language, understood by generic non-linear solvers. A universal algorithm for this translation is developed, an estimation of its computational complexity given, and an efficient application of the algorithm demonstrated on a number of realistic examples. Typically, for a large gas transport network with about 10K elements the translation and solution of non-linear system together require less than 1 sec on the common hardware. The translation procedure incorporates several preprocessing filters, in particular, topological cleaning filters, which accelerate the solution procedure by factor 8.
Innovations in the mobility industry such as automated and connected cars could significantly reduce congestion and emissions by allowing the traffic to flow more freely and reducing the number of vehicles according to some researchers. However, the effectiveness of these sustainable product and service innovations is often limited by unexpected changes in consumption: some researchers thus hypothesize that the higher comfort and improved quality of time in driverless cars could lead to an increase in demand for driving with autonomous vehicles. So far, there is a lack of empirical evidence supporting either one or other of these hypotheses. To analyze the influence of autonomous driving on mobility behavior and to uncover user preferences, which serve as indicators for future travel mode choices, we conducted an online survey with a paired comparison of current and future travel modes with 302 participants in Germany. The results do not confirm the hypothesis that ownership will become an outdated model in the future. Instead they suggest that private cars, whether conventional or fully automated, will remain the preferred travel mode. At the same time, carsharing will benefit from full automation more than private cars. However, the findings indicate that the growth of carsharing will mainly be at the expense of public transport, showing that more emphasis should be placed in making public transport more attractive if sustainable mobility is to be developed.
TREE Jahresbericht 2017
(2018)
Knapp fünf Jahre nach Gründung als Fachbereichsinstitut und zwei Jahre nach Verankerung als zentrale wissenschaftliche Einrichtung der Hochschule präsentieren wir - nicht ganz ohne Stolz - den ersten Jahresbericht des Instituts TREE. Er soll in seiner Breite als auch in seiner Tiefe die Stärken unserer gemeinschaftlichen Anstrengungen im Forschungsfeld der nachhaltigen Technologien aufzeigen: interdisziplinär, forschungsstark, nachwuchsfördernd und gesellschaftszugewandt. TREE ist weiterhin ein im Aufbruch begriffenes Institut, aber gerade das Jahr 2017 zeigt auch, dass wir uns schon in der Wissenschaftslandkarte einen Namen machen konnten: nach NaWETec konnte mit dem Themenkomplex "Effiziente Transportalternativen" ein zweiter Forschungsschwerpunkt drittmittelgefördert etabliert werden. Erste Promotionen im Rahmen des TREE konnten erfolgreich abgeschlossen und interessante Nachwuchswissenschaftler für "FHKarrierewege" gewonnen werden.
Transition point prediction in a multicomponent lattice Boltzmann model: Forcing scheme dependencies
(2018)
Large, high-resolution displays are highly suitable for creation of digital environments for co-located collaborative task solving. Yet, placing multiple users in a shared environment may increase the risk of interferences, thus causing mental discomfort and decreasing efficiency of the team. To mitigate interferences coordination strategies and techniques were introduced. However, in a mixed-focus collaboration scenarios users switch now and again between loosely and tightly collaboration, therefore different coordination techniques might be required depending on the current collaboration state of team members. For that, systems have to be able to recognize collaboration states as well as transitions between them to ensure a proper adjustment of the coordination strategy. Previous studies on group behavior during collaboration in front of large displays investigated solely collaborative coupling states, not transitions between them though. To address this gap, we conducted a study with 12 participant dyads in front of a tiled display and let them solve two tasks in two different conditions (focus and overview). We looked into group dynamics and categorized transitions by means of changes in proximity, verbal communication, visual attention, visual interface, and gestures. The findings can be valuable for user interface design and development of group behavior models.
Towards explaining deep learning networks to distinguish facial expressions of pain and emotions
(2018)
Deep learning networks are successfully used for object and face recognition in images and videos. In order to be able to apply such networks in practice, for example in hospitals as a pain recognition tool, the current procedures are only suitable to a limited extent. The advantage of deep learning methods is that they can learn complex non-linear relationships between raw data and target classes without limiting themselves to a set of hand-crafted features provided by humans. However, the disadvantage is that due to the complexity of these networks, it is not possible to interpret the knowledge that is stored inside the network. It is a black-box learning procedure. Explainable Artificial Intelligence (AI) approaches mitigate this problem by extracting explanations for decisions and representing them in a human-interpretable form. The aim of this paper is to investigate the explainable AI method Layer-wise Relevance Propagation (LRP) and apply it to explain how a deep learning network distinguishes facial expressions of pain from facial expressions of emotions such as happiness and disgust.
Digitisation has brought a major upheaval to the mobility sector, and in the future, self-driving cars will probably be one of the transport modes. This study extends transport and user acceptance research by analysing in greater depth how the new modes of autonomous private cars, autonomous carsharing and autonomous taxis fit into the existing traffic mix from today's perspective. It focuses on accounting for relative added value. For this purpose, user preference theory was used as a base for an online survey (n=172) on the relative added value of the new autonomous traffic modes. Results show that users see advantages in the autonomous modes for driving comfort and time utilization whereas, in comparison to conventional cars, in many other areas – especially in terms of driving pleasure and control – they see no advantages or even relative disadvantages. Compared to public transport, the autonomous modes offer added values in almost all characteristics. This analysis at the partwor th level provides a more detailed explanation for user acceptance of automated driving.
We present the performance of the upGREAT heterodyne array receivers on the SOFIA telescope after several years of operations. This instrument is a multi-pixel high resolution (R≳107) spectrometer for the Stratospheric Observatory for Far-Infrared Astronomy (SOFIA). The receivers use 7-pixel subarrays configured in a hexagonal layout around a central pixel. The low frequency array receiver (LFA) has 2×7 pixels (dual polarization), and presently covers the 1.83–2.07THz frequency range, which allows to observe the [CII] and [OI] lines at 158μm and 145μm wavelengths. The high frequency array (HFA) covers the [OI] line at 63μm and is equipped with one polarization at the moment (7 pixels, which can be upgraded in the near future with a second polarization array). The 4.7THz array has successfully flown using two separate quantum-cascade laser local oscillators from two different groups. NASA completed the development, integration and testing of a dual-channel closed-cycle cryocooler system, with two independently operable He compressors, aboard SOFIA in early 2017 and since then, both arrays can be operated in parallel using a frequency separating dichroic mirror. This configuration is now the prime GREAT configuration and has been added to SOFIA’s instrument suite since observing cycle 6.
In 2018, in the US alone, it is estimated that 268,670 people will be diagnosed with breast cancer, and that 41,400 will die from it. Since breast cancers often become resistant to therapies, and certain breast cancers lack therapeutic targets, new approaches are urgently required. A cell-stress response pathway, the unfolded protein response (UPR), has emerged as a promising target for the development of novel breast cancer treatments. This pathway is activated in response to a disturbance in endoplasmic reticulum (ER) homeostasis but has diverse physiological and disease-specific functions. In breast cancer, UPR signalling promotes a malignant phenotype and can confer tumours with resistance to widely used therapies. Here, we review several roles for UPR signalling in breast cancer, highlighting UPR-mediated therapy resistance and the potential for targeting the UPR alone or in combination with existing therapies.
Through the “Act to Strengthen the Non-financial Reporting by Corporations in their Management and Group Management Reports” (Gesetz zur Stärkung der nichtfinanziellen Berichterstattung der Unternehmen in ihren Lage- und Konzernlageberichten) (CSR Directive Transposition Act, „CSR-RUG“) of 11 April 2017[1], the German Bundestag implemented Directive 2014/95/EU (“CSR Directive”)[2] into German law. Following the European impetus, the CSR-RUG enriches the traditional repertoire of forms of action under environmental law by a further instrument. Already the regulatory context gives an idea of its atypical nature: The centrepiece of the CSR-RUG is the amendment of and addition to the Third Book of the German Commercial Code (Handelsgesetzbuch, “HGB”), which deals with the “trading books” of undertakings, i.e., accounting and reporting requirements. Since the reporting year 2017, large capital market-oriented corporations must report extensively within the framework of their annual management reports on their activities and effects in certain areas of “Corporate Social Responsibility”. This also includes environmental matters. The transparency and publicity this entails is intended to generate positive stimuli for more responsible, sustained and not least of all environmentally friendly entrepreneurial action.
Following a brief presentation of the European legal bases and their implementation in Germany (I.), we will classify the provisions within the underlying concept of Corporate Social Responsibility (II.) and analyse and systemise the governance effects of non-financial reporting (III.). A few remarks on selected aspects of the chosen approach and its implementation (IV.) as well as an outlook summarising our conclusions (V.) will complete this article. By detailing the German approach to transposing the CSR Directive, this paper intends to provide an example of the challenges member state legislators face when complying with modern governance concepts such as Corporate Social Responsibility by way of non-financial reporting obligations.
[1] Federal Law Gazette, Part I 2017, 802 et seq.
[2] Directive 2014/95/EU of the European Parliament and of the Council 22 October 2014 amending Directive 2013/34/EU as regards disclosure of non-financial and diversity information by certain large undertakings and groups, OJ EU No. L 330, p. 1.
Maintaining orientation in an environment with non-Earth gravity (1 g) is critical for an astronaut's operational performance. Such environments present a number of complexities for balance and motion. For example, when an astronaut tilts due to ascending or descending an inclined plane on the moon, the gravity vector will be tilted correctly, but the magnitude will be different from on earth. If this results in a mis-perceived tilt, then that may lead to postural and perceptual errors, such as mis-perceiving the orientation of oneself or the ground plane and corresponding errors in task judgment.
Die Diskussion um die Nachhaltigkeit von Dienstleistungen im öffentlichen Sektor steht in einem engen Zusammenhang mit der Frage, ob sich der Einsatz finanzieller Mittel für die Beteiligten lohnt. Daher besteht ein breites Interesse, herauszufinden, ob der Nutzen von Rehabilitationsarbeit auch finanziell messbar ist, und falls ja, wie hoch das ökonomische Potential der Investitionen ist. Um diese Frage zu beantworten, ist es notwendig Leistungen sowie die dadurch anfallenden Ausgaben statistisch zu erfassen und in einem ökonomischen Modell zu bewerten.
The paper contributes to the debate on the political economy of implementation of propoor social policy. It argues for a broadening of the debate, which is dominated by technocratic arguments, emphasizing the lack of financial resources, technology or skills as the major barriers for effective implementation. Describing the dynamic interplay of ‘formal’ operational programme structures and ‘informal’ traditional institutions in delivering the CT-OVC – the largest and oldest cash transfer programme in Kenya – it argues for the need to look more closely into the local political economy as an important mediating arena for implementing social policies. Implementation is heavily contingent upon the local social, political and institutional context that influences and shapes its outcomes. These processes are highly dynamic and ambivalent evolving between ‘formal’ and ‘informal’ structures and institutions. They may change over time and place, challenging the implicit assumption that programmes are evenly implemented across geographic and political entities.
This policy brief investigates the costs of child poverty in the Balkans, including deprivation in terms of education, health, and social mobility. It then lays out the potential of social protection, most notably in terms of building resilence and fostering development. Set against recent case studies from around the world, including Cambodia and Uganda, the brief gives policy recommendations on various critical issues including transfer schemes, transformative measures, and (alternative) care for children with disabilities.
This policy brief is part of a wider research project entitled ‘Building the Economic Case for Investments in Social Protection’. The research aims at demonstrating the potential impacts of social protection on inclusive growth. The project is a collaborative effort between the Maastricht Graduate School of Governance at the University of Maastricht and United Nations University-MERIT, NL; the Global Development Institute at the University of Manchester, UK; the School of Social Science at the University of Makerere, Uganda; and the Expanding Social Protection Programme of the Ugandan Ministry of Gender, Labour and Social Development. This project is part of the research agenda of the Knowledge Platform Inclusive Development Policies and funded by the Ministry of Foreign Affairs of the Netherlands through the NWO-WOTRO programme.
Amaç: Keton cisim oluşumu (ketogenez) bozuklukları; mitokondriyel 3-hidroksi-3metil glutaril CoA sentaz (Mhs) ve 3-hidroksi-3-metil glutaril CoA liyaz (HL) enzim eksiklikleri sonucu oluşur. Keton cisim yıkımı (ketoliz) bozuklukları ise suksinil CoA: 3 oksoasit CoA transferaz (SCOT) ve asetoasetil CoA thiolaz-beta ketotiolaz (MAT) enzim eksiklikleri sonucu oluşmaktadır. Keton metabolizma bozukluğu tanısıyla izlenen hastaların klinik ve laboratuvar bulguları ile değerlendirilmesi amaçlandı.
Yöntem: Keton metabolizması bozukluğu tanısıyla izlenen hasta verileri retrospektif olarak incelendi.
Bulgular: Dört hastada HL eksikliği, 3 hastada MAT eksikliği ve 2 hastada SCOT eksikliği tanısı mevcuttu. Hastaların ortanca yaşı 5 yıl (6 ay-15,5 yıl), ilk metabolik dekompanzasyon atak yaşı ortalama 7,7 ay (22 gün-19 ay) idi. MAT eksikliği olan bir hasta, kardeş taraması ile asemptomatik dönemde tanı aldı. İki hastada spastik tetraparezi gibi ağır nörolojik defisit gelişti. Dekompanzasyon ataklarının beslenememe, kusma ve gastroenterit gibi infeksiyon sonrası geliştiği görüldü.
Sonuç: Açıklanamayan metabolik asidoz atakları durumunda keton metabolizma bozuklukları akılda tutulmalıdır. Akut dekompanzasyon değişik yaşlarda ortaya çıkabilir, klinik şiddeti değişken olabilir. Erken tanı ve uygun tedavi mortalite ve morbidite açısından çok önemlidir.
Ob im Studium oder in der Praxis - bei der technischen Chemie kommt man schnell an seine Grenzen. Aber keine Sorge, "Technische Chemie für Dummies" hilft Ihnen, bei diesem komplexen Thema den Durchblick zu behalten. Nach einem allgemeinen Überblick über die Entwicklungen, Herausforderungen und Konzepte der technischen Chemie und einer verständlichen Übersicht über die nötige Mathematik lernen Sie, was man bei der praktischen und theoretischen Vorarbeit beachten muss, um die chemische Reaktion später in einem größeren Maßstab durchführen zu können. Anschließend erfahren Sie alles über Reaktionsmodellierung, Katalysatoren und chemische Reaktoren. Idealisierte Modelle helfen Ihnen dabei, aber auch die Umsetzung unter realen Bedingungen kommt nicht zu kurz. Der Verfahrenstechnik ist ein eigener Teil gewidmet, damit auch Trenntechnik, Strömungsmechanik, Fluidströmungen, Dimensionierung und Co. bald kein Problem mehr für Sie sind.
We present a novel forearm-and-glove tactile interface that can enhance 3D interaction by guiding hand motor planning and coordination. In particular, we aim to improve hand motion and pose actions related to selection and manipulation tasks. Through our user studies, we illustrate how tactile patterns can guide the user, by triggering hand pose and motion changes, for example to grasp (select) and manipulate (move) an object. We discuss the potential and limitations of the interface, and outline future work.
Die Optimierung von Produktionsprozessen steht im Vordergrund jedes Produzenten, vor allem im Hinblick auf den optimalen Erntezeitpunkt. Zur Pflückreife sollen Kirschen als nicht-klimakterische Früchte eine optimale und hochwertige Fruchtqualität aufweisen, eine ausreichende Anzahl an Erntehelfern, Pflückhilfen, Transportkisten, Sortier- und Lagereinrichtungen sowie Absatzwege vorhanden sein. Aus diesem Grund entwickelten Wissenschaftler in der Vergangenheit diverse Reifeindices und Erntemodelle zur Bestimmung des optimalen Erntezeitpunkts von Früchten, erst an Äpfeln, dann für Steinobst.
Die vergangene Forschung zeigte, dass Werte und Persönlichkeitseigenschaften von (potentiellen) Arbeitnehmern die wahrgenommene Attraktivität bestimmter Arbeitgebermerkmale wie der Corporate Social Responsibility (CSR) beeinflussen. Weitere Forschung wird hingegen benötigt, um die in diesem Zusammenhang relevanten Persönlichkeitsmerkmale zu identifizieren. Diese Studie zielt darauf ab, die Werte und Persönlichkeitseigenschaften zu ermitteln, welche die unterschiedliche Attraktivität von CSR und weiteren Arbeitgebermerkmalen, die sich nicht auf die CSR beziehen, erklären können. Dazu bewerteten (potentielle) Arbeitnehmer (N = 145) auf zwei eigenentwickelten Skalen sowohl CSR-basierte Faktoren der Arbeitgeberattraktivität (z.B. Wassersparen) als auch Nicht-CSR-basierte Faktoren der Arbeitgeberattraktivität (z.B. erwünschte Unternehmenslage) hinsichtlich ihrer Wichtigkeit. Für die CSR-basierte Arbeitgeberattraktivität konnten unter Kontrolle der Big-Five hypothesenkonform die Wertedimension Selbst-Überwindung, die Persönlichkeitsdimension Communion und die prosoziale Persönlichkeit als Prädiktoren identifiziert werden. Die Wertedimensionen Selbst-Erhöhung und Selbst-Überwindung sowie die Persönlichkeitsdimensionen Agency und Communion leisten – ebenfalls über die Big-Five hinaus – einen bedeutenden Beitrag zur Vorhersage der Nicht-CSR-basierten Arbeitgeberattraktivität.
Softwarenutzung im Umbruch: Von der Software-Lizenz zum Cloudbasierten Business Process Outsourcing
(2018)
This book is about how computer systems might be designed to serve their users rather better. It deals with how to study the natural behaviour of users to see how computer systems might best help them, and how one might also involve them in the design of computer systems that will assist them in their everyday practices.
This paper analyzes the complex effects and risks of social protection programmes in Ghana and Kenya on poor people’s human wellbeing, voice and empowerment and interactions with the social protection regulatory framework and policy instruments. For this purpose, it adopts a comprehensive Inclusive Development framework to systematically explore the complex effects of cash transfers and health insurance at the individual, household and community level. The findings highlight the positive provisionary and preventive effects of social protection, but also illustrate that the poorest are still excluded and that promotive effects, in the form of enhanced productivity, manifest themselves mainly for the people who are less resource poor. They can build more effectively upon an existing asset base, capabilities, power and social relations to counter the exclusionary mechanisms of the system, address inequity concerns and offset the transaction costs of accessing and benefitting from social protection. The inclusive development framework enables to lay these complex effects and interactions bear, and points to areas that require more longitudinal and mixed methodology research.
Social Insurance
(2018)
Extending coverage through contributory social insurance or other contributory programs is tempting for governments as a potential avenue for mobilizing new resources and creating new fiscal space. Such extension has clear limits, however: it applies only to those in the labor market who have employment status with high degree of formality and whose incomes are significantly above subsistence level and received regularly. It also requires administrative structures with capacity to regularly register incomes of those covered, and to collect contributions.
This chapter analyzes the potential of social insurance (also called contributory social protection) in the 16 Asian countries reviewed in this publication to fill the protection and coverage gaps in income security. It focuses on pensions, but also reviews other benefits temporarily replacing lost labor income due to events such as sickness, maternity, and unemployment. As current labor market structures largely determine the chances of extending coverage through these means, this chapter also examines their characteristics and analyzes coverage by the different forms of social insurance and assesses the potential for extension.
Social Assistance
(2018)
If the first Sustainable Development Goal (SDG) to “End poverty in all its forms everywhere” is to be taken seriously, most low- and middle-income countries face a huge challenge. An estimated 1 billion people have indeed escaped extreme poverty since the early 1990s, and the global poverty rate fell from 35% in 1990 to 10.7% in 2013, but the absolute number of people living below the international poverty line of $1.90 at purchasing power parity has hardly changed. Countries in Asia contributed greatly to the overall decline in poverty rates: from 2012 to 2013, over 100 million people in Asia left extreme poverty behind, notably in India, Indonesia, and the People’s Republic of China (PRC) (World Bank 2016). Yet the living standards of those still below that line have hardly improved (Ravallion 2016). The achievement of the first SDG requires additional efforts at global and national levels, particularly on policies that address chronic poverty traps and that improve the outcomes of poor and vulnerable populations.
Smallholder farmers as a backbone for the implementation of the Sustainable Development Goals
(2018)
Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells
(2018)
The need for bone grafts is high, due to age-related diseases, such as tumor resections, but also accidents, risky sports, and military conflicts. The gold standard for bone grafting is the use of autografts from the iliac crest, but the limited amount of accessible material demands new sources of bone replacement. The use of mesenchymal stem cells or their descendant cells, namely osteoblast, the bone-building cells and endothelial cells for angiogenesis, combined with artificial scaffolds, is a new approach. Mesenchymal stem cells (MSCs) can be obtained from the patient themselves, or from donors, as they barely cause an immune response in the recipient. However, MSCs never fully differentiate in vitro which might lead to unwanted effects in vivo. Interestingly, purinergic receptors can positively influence the differentiation of both osteoblasts and endothelial cells, using specific artificial ligands. An overview is given on purinergic receptor signaling in the most-needed cell types involved in bone metabolism-namely osteoblasts, osteoclasts, and endothelial cells. Furthermore, different types of scaffolds and their production methods will be elucidated. Finally, recent patents on scaffold materials, as wells as purinergic receptor-influencing molecules which might impact bone grafting, are discussed.
The elucidation of conformations and relative potential energies (rPEs) of small molecules has a long history across a diverse range of fields. Periodically, it is helpful to revisit what conformations have been investigated and to provide a consistent theoretical framework for which clear comparisons can be made. In this paper, we compute the minima, first- and second-order saddle points, and torsion-coupled surfaces for methanol, ethanol, propan-2-ol, and propanol using consistent high-level MP2 and CCSD(T) methods. While for certain molecules more rigorous methods were employed, the CCSD(T)/aug-cc-pVTZ//MP2/aug-cc-pV5Z theory level was used throughout to provide relative energies of all minima and first-order saddle points. The rPE surfaces were uniformly computed at the CCSD(T)/aug-cc-pVTZ//MP2/aug-cc-pVTZ level. To the best of our knowledge, this represents the most extensive study for alcohols of this kind, revealing some new aspects. Especially for propanol, we report several new conformations that were previously not investigated. Moreover, two metrics are included in our analysis that quantify how the selected surfaces are similar to one another and hence improve our understanding of the relationship between these alcohols.
Sind kleinere und mittlere Unternehmen (KMU) bereits auf die Digitale Transformation vorbereitet?
(2018)
Eine von den Autoren durchgeführte Untersuchung konnte deutliche Indizien dafür ausmachen, dass viele kleinere und mittlere Unternehmen (KMU) aktuell noch keine ausreichende Reife zur Digitalen Transformation haben. Zur Lösung des Problems wird vorgeschlagen, ein agiles IT-Management-Konzept zu entwickeln, um den IT-Bereich dynamisch und ohne formalen Ballast des klassischen IT-Managements zu steuern.
Companies investing in the occupied Palestinian territories are faced with a dilemma. Undoubtedly, the creation of jobs helps to put young Palestinians to work. Experience shows that especially young males are less likely to radicalise and commit crimes when having an occupation. However, negative press coverage due to the disputed status of the territory can force companies to withdraw. CSR activities can help to demonstrate that a company has a genuine interest in its employees and community at large. Our article looks into one particular case of an Israeli company that had to withdraw their operation due to public pressure, mainly Western media. We give recommendations how such failure could have been avoided by using the right kind of CSR activities that address the needs of the Palestinians.
Shared Autonomous Vehicles: Potentials for a Sustainable Mobility and Risks of Unintended Effects
(2018)
Automated and connected cars could significantly reduce congestion and emissions through a more efficient flow of traffic and a reduction in the number of vehicles. An increase in demand for driving with autonomous vehicles is also conceivable due to higher comfort and improved quality of time using driverless cars. So far, empirical evidence supporting this hypothesis is missing. To analyze the influence of autonomous driving on mobility behavior and to uncover user preferences, which serve as an indicator for future travel mode choices, we conducted an online survey with a paired comparison of current and future travel modes with 302 German participants. The results do not confirm the hypothesis that ownership will become an outdated model in the future. Instead they suggest that private cars, whether traditional or fully automated, will remain the preferred travel mode. At the same time, carsharing will benefit from full automation more than private cars. However, findings indicate that the growth of carsharing will mainly be at the expense of public transport, showing that more effort should be placed in making public transportation more attractive if sustainable mobility is to be developed.
Science Track FrOSCon 2016
(2018)
Im Jahre 2015 feierte die Free and Open Source Software Conference ihr 10 Jähriges Bestehen. Entstanden aus einer Idee von Studierenden, wissenschaftlichen Mitarbeitern und Professoren des Fachbereichs Informatik entwickelte sich eine der wichtigsten Konferenzen im Bereich der freien und quelloffenen Software in Deutschland.
Social protection measures require sustainable financing – creating and maintaining adequate fiscal space at the national level. Good governance of social protection at all stages – planning policies, policy reforms, and implementation – requires continuous monitoring of its performance and finances, including long-term projections and simulations of cost and benefits of different social protection programs and overall social protection systems. These projections and simulations should take into account demographic trends, including demographic ageing.