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Risk-based authentication (RBA) aims to strengthen password-based authentication rather than replacing it. RBA does this by monitoring and recording additional features during the login process. If feature values at login time differ significantly from those observed before, RBA requests an additional proof of identification. Although RBA is recommended in the NIST digital identity guidelines, it has so far been used almost exclusively by major online services. This is partly due to a lack of open knowledge and implementations that would allow any service provider to roll out RBA protection to its users.
To close this gap, we provide a first in-depth analysis of RBA characteristics in a practical deployment. We observed N=780 users with 247 unique features on a real-world online service for over 1.8 years. Based on our collected data set, we provide (i) a behavior analysis of two RBA implementations that were apparently used by major online services in the wild, (ii) a benchmark of the features to extract a subset that is most suitable for RBA use, (iii) a new feature that has not been used in RBA before, and (iv) factors which have a significant effect on RBA performance. Our results show that RBA needs to be carefully tailored to each online service, as even small configuration adjustments can greatly impact RBA's security and usability properties. We provide insights on the selection of features, their weightings, and the risk classification in order to benefit from RBA after a minimum number of login attempts.
A series of reactive binaphthyl‐diimine‐based dopants is prepared and investigated with respect to their potential for the chiral induction of structural coloration in nematic liquid crystal mixture E7 and the selective photonic sensing of nitrogen dioxide (NO2). Studies of the helical twisting power (HTP) in 4‐cyano‐4′‐pentylbiphenyl (5CB) reveal HTP values as high as 375 µm‐1 and the tremendous impact of structural compatibility and changes of the dihedral binaphthyl angle on the efficiency of the chiral transfer. Detailed investigation of the sensing capabilities of the systems reveals an extraordinarily high selectivity for NO2 and a response to concentrations as low as 100 ppm. The systems show a direct response to the analyte gas leading to a concentration‐dependent shift of the reflectance wavelength of up to several hundred nanometers. Incorporation of copper ions remarkably improves the sensor's properties in terms of sensitivity and selectivity, enabling the tailored tweaking of the system's properties.
In thyroid carcinoma cells, the soluble βgalactosidespecific lectin, galectin3, is extra and intracellularly expressed and plays a significant role in thyroid cancer diagnosis. The functional relevance of this molecule, particularly in its extracellular environment however, warrants further elucidation. To gain insight into this topic, the present study characterized principal functional properties of galectin3 in 3 commonly used thyroid carcinoma cell lines (BCPAP, Cal62 and FTC133) that express the molecule intra and extracellulary. Cellintrinsic galectin3 harbors a functional carbohydrate recognition domain as determined by affinity purification. Moreover, cell surface expressed galectin3 can be partially removed by treatment with lactose or asialofetuin, but not with sucrose. Thyroid carcinoma cells adhere to substratebound galectin3 in a βgalactosidespecific manner, whereby only cell adhesion, but not cell migration is promoted. Thus, thyroid tumor cells harbor functional active galectin3 that, inter alia, specifically interacts with cell surfaceexpressed molecular ligands in a βgalactosidedependent manner, whereby the molecule can at least interfere with cell adhesion. The modulation of galectin3 expression level or its ligands in such tumor cells could be of therapeutic interest and needs further experimental clarification.
With the digital transformation, software systems have become an integral part of our society and economy. In every part of our life, software systems are increasingly utilized to, e.g., simplify housework or to optimize business processes. All these applications are connected to the Internet, which already includes millions of software services consumed by billions of people. Applications which process such a magnitude of users and data traffic requires to be highly scalable and are therefore denoted as Ultra Large Scale (ULS) systems. Roy Fielding has defined one of the first approaches which allows designing modern ULS software systems. In his doctoral thesis, Fielding introduced the architectural style Representational State Transfer (REST) which builds the theoretical foundation of the web. At present, the web is considered as the world's largest ULS system. Due to a large number of users and the significance of software for society and the economy, the security of ULS systems is another crucial quality factor besides high scalability.
Off-lattice Boltzmann methods increase the flexibility and applicability of lattice Boltzmann methods by decoupling the discretizations of time, space, and particle velocities. However, the velocity sets that are mostly used in off-lattice Boltzmann simulations were originally tailored to on-lattice Boltzmann methods. In this contribution, we show how the accuracy and efficiency of weakly and fully compressible semi-Lagrangian off-lattice Boltzmann simulations is increased by velocity sets derived from cubature rules, i.e. multivariate quadratures, which have not been produced by the Gauss-product rule. In particular, simulations of 2D shock-vortex interactions indicate that the cubature-derived degree-nine D2Q19 velocity set is capable to replace the Gauss-product rule-derived D2Q25. Likewise, the degree-five velocity sets D3Q13 and D3Q21, as well as a degree-seven D3V27 velocity set were successfully tested for 3D Taylor-Green vortex flows to challenge and surpass the quality of the customary D3Q27 velocity set. In compressible 3D Taylor-Green vortex flows with Mach numbers Ma={0.5;1.0;1.5;2.0} on-lattice simulations with velocity sets D3Q103 and D3V107 showed only limited stability, while the off-lattice degree-nine D3Q45 velocity set accurately reproduced the kinetic energy provided by literature.
Hintergrund: Empirische Studien zeigen, dass mehr als zwei Drittel der Beschäftigten trotz Krankheit zur Arbeit gehen. Dieser sog. Präsentismus bringt sowohl gesundheitliche und motivationale Risiken für die Mitarbeiter als auch wirtschaftliche Risiken für die Organisation mit sich.
Ziel der Arbeit: Die durchgeführten Studien fokussieren Möglichkeiten zur Verringerung der negativen gesundheitlichen Effekte und entwickeln Maßnahmen zur generellen Vermeidung von Präsentismus am spezifischen Setting Hochschule.
Methode: An einer deutschen Hochschule erfolgte eine quantitative Befragung (n = 308) zur Prävalenz von Präsentismus, dessen Zusammenhang mit körperlichen Beschwerden untersucht wurde. Weiterhin wurden potenziell moderierende Effekte der Ressourcen Erholung, Achtsamkeit und Work-Life-Balance (WLB) betrachtet. Eine qualitative Studie explorierte auf Grundlage von Interviews (n = 11, qualitative Inhaltsanalyse) Gründe für Präsentismus und potenzielle Maßnahmen, um diesem entgegenzuwirken.
Ergebnisse: Die quantitativen Ergebnisse zeigen, dass Präsentismus im Hochschulkontext vertreten ist und körperliche Beschwerden begünstigt. Die Ressourcen Erholung, Achtsamkeit und WLB können bei hoher Ausprägung die negativen gesundheitlichen Effekte von Präsentismus abschwächen. Bei niedriger Ausprägung verstärken sie die Effekte. Die qualitative Analyse machte deutlich, dass quantitative Arbeitsbelastung, Pflichtgefühl sowie das Gefühl, noch leistungsfähig zu sein, zentrale Gründe für Präsentismus sind und zum Beispiel die Unterstützung eines gesundheitsförderlichen Organisationsklimas oder Vertretungsregelungen geeignete Gegenmaßnahmen darstellen.
Diskussion: Die Ergebnisse werden vor dem Hintergrund verhaltens- und verhältnispräventiver Maßnahmen diskutiert und praktische Implikationen abgeleitet.
Ghana suffers from frequent power outages, which can be compensated by off-grid energy solutions. Photovoltaic-hybrid systems become more and more important for rural electrification due to their potential to offer a clean and cost-effective energy supply. However, uncertainties related to the prediction of electrical loads and solar irradiance result in inefficient system control and can lead to an unstable electricity supply, which is vital for the high reliability required for applications within the health sector. Model predictive control (MPC) algorithms present a viable option to tackle those uncertainties compared to rule-based methods, but strongly rely on the quality of the forecasts. This study tests and evaluates (a) a seasonal autoregressive integrated moving average (SARIMA) algorithm, (b) an incremental linear regression (ILR) algorithm, (c) a long short-term memory (LSTM) model, and (d) a customized statistical approach for electrical load forecasting on real load data of a Ghanaian health facility, considering initially limited knowledge of load and pattern changes through the implementation of incremental learning. The correlation of the electrical load with exogenous variables was determined to map out possible enhancements within the algorithms. Results show that all algorithms show high accuracies with a median normalized root mean square error (nRMSE) <0.1 and differing robustness towards load-shifting events, gradients, and noise. While the SARIMA algorithm and the linear regression model show extreme error outliers of nRMSE >1, methods via the LSTM model and the customized statistical approaches perform better with a median nRMSE of 0.061 and stable error distribution with a maximum nRMSE of <0.255. The conclusion of this study is a favoring towards the LSTM model and the statistical approach, with regard to MPC applications within photovoltaic-hybrid system solutions in the Ghanaian health sector.
Validierung einer Web-Applikation zum Fern-Monitoring von Belastungs- und Erholungsparametern
(2020)
Simultan zur agilen Entwicklung einer Web-Applikation, die Parameter der Belastungs- und Beanspruchungssteuerung erfasst, wurden die implementierten Belastungs- und Erholungs-parameter an freiwilligen Testern/innen in der Praxis überprüft. Um sowohl die Applikation als auch die z.T. selbst entwickelten Kenngrößen auf ihre externe Validität hin zu bewerten, werden diese regressionsanalytisch bearbeitet.
Due to the use of fossil fuel resources, many environmental problems have been increasingly growing. Thus, the recent research focuses on the use of environment friendly materials from sustainable feedstocks for future fuels, chemicals, fibers and polymers. Lignocellulosic biomass has become the raw material of choice for these new materials. Recently, the research has focused on using lignin as a substitute material in many industrial applications. The antiradical and antimicrobial activity of lignin and lignin-based films are both of great interest for applications such as food packaging additives. DPPH assay was used to determine the antioxidant activity of Kraft lignin compared to Organosolv lignins from different biomasses. The purification procedure of Kraft lignin showed that double-fold selective extraction is the most efficient confirmed by UV-Vis, FTIR, HSQC, 31PNMR, SEC, and XRD. The antioxidant capacity was discussed regarding the biomass source, pulping process, and degree of purification. Lignin obtained from industrial black liquor are compared with beech wood samples: Biomass source influences the DPPH inhibition (softwood > grass) and the TPC (softwood < grass). DPPH inhibition affected by the polarity of the extraction solvent. Following the trend: ethanol > diethylether > acetone. Reduced polydispersity has positive influence on the DPPH inhibition. Storage decreased the DPPH inhibition but increased the TPC values. The DPPH assay was also used to discuss the antiradical activity of HPMC/lignin and HPMC/lignin/chitosan films. In both binary (HPMC/lignin) and ternary (HPMC/lignin/chitosan) systems the 5% addition showed the highest activity and the highest addition had the lowest. Both scavenging activity and antimicrobial activity are dependent on the biomass source; Organosolv of softwood > Kraft of softwood > Organosolv of grass. Lignins and lignin-containing films showed high antimicrobial activities against Gram-positive and Gram-negative bacteria at 35 °C and at low temperatures (0-7 °C). Purification of Kraft lignin has a negative effect on the antimicrobial activity while storage has positive effect. The lignin leaching in the produced films affected the activity positively and the chitosan addition enhances the activity for both Gram-positive and Gram-negative bacteria. Testing the films against food spoilage bacteria that grow at low temperatures revealed the activity of the 30% addition on HPMC/L1 film against both B. thermosphacta and P. fluorescens while L5 was active only against B. thermosphacta. In HPMC/lignin/chitosan films, the 5% addition exhibited activity against both food spoilage bacteria.
Data emerged as a central success factor for companies to benefit from digitization. However, the skills in successfully creating value from data – especially at the management level – are not always profound. To address this problem, several canvas models have already been designed. Canvas models are usually created to write down an idea in a structured way to promote transparency and traceability. However, some existing data science canvas models mainly address developers and are thus unsuitable for decision-makers and communication within interdisciplinary teams. Based on a literature review, we identified influencing factors that are essential for the success of data science projects. With the information gained, the Data Science Canvas was developed in an expert workshop and finally evaluated by practitioners to find out whether such an instrument could support data-driven value creation.
Bei untypischen Verhaltensweisen am Unfalltag ist allein aus dem objektiven Zurücklegen des Heimweges kein zweifelsfreier Rückschluss auf die erforderliche subjektive Handlungstendenz möglich. Den Zweifeln an einer den Versicherungsschutz rechtfertigenden Handlungstendenz kann im Falle eines untypischen Verlaufs nicht mit einer Beweiserleichterung begegnet werden.
The actomyosin system generates mechanical work with the execution of the power stroke, an ATP-driven, two-step rotational swing of the myosin-neck that occurs post ATP hydrolysis during the transition from weakly to strongly actin-bound myosin states concomitant with Pi release and prior to ADP dissociation. The activating role of actin on product release and force generation is well documented; however, the communication paths associated with weak-to-strong transitions are poorly characterized. With the aid of mutant analyses based on kinetic investigations and simulations, we identified the W-helix as an important hub coupling the structural changes of switch elements during ATP hydrolysis to temporally controlled interactions with actin that are passed to the central transducer and converter. Disturbing the W-helix/transducer pathway increased actin-activated ATP turnover and reduced motor performance as a consequence of prolonged duration of the strongly actin-attached states. Actin-triggered Pi release was accelerated, while ADP release considerably decelerated, both limiting maximum ATPase, thus transforming myosin-2 into a high-duty-ratio motor. This kinetic signature of the mutant allowed us to define the fractional occupancies of intermediate states during the ATPase cycle providing evidence that myosin populates a cleft-closure state of strong actin interaction during the weak-to-strong transition with bound hydrolysis products before accomplishing the power stroke.
Kommunikation gilt nicht ohne Grund als die Königsdisziplin im BGM. Hier gilt es, Mitarbeiter in einem ersten Schritt für das Thema Gesundheit zu sensibilisieren und mit relevanten Materialien zu informieren, um sie letztendlich zur Teilnahme an Gesundheitsangeboten zu motivieren. Diese drei Schritte empfehlen sich ebenfalls für die Kommunikation in digitalen Zeiten. Gesundheitsplattformen und/oder Gesundheits-Apps können die Kommunikation unterstützen. Das richtige Maß an Kommunikation stellt eine weitere Herausforderung in digitalen Zeiten dar, da Informationen in der Flut an E-Mails durchaus untergehen können. Eine Kombination aus Push- und Pull-Kommunikation hat sich hierbei bewährt, um bei Mitarbeitern das nötige Interesse für Gesundheit anzustoßen, damit diese dann eigenständig aus bestehenden Angeboten (Informationen, Kurse usw.) wählen.
Describing the elephant: a foundational model of human needs, motivation, behaviour, and wellbeing
(2020)
Models of basic psychological needs have been present and popular in the academic and lay literature for more than a century yet reviews of needs models show an astonishing lack of consensus. This raises the question of what basic human psychological needs are and if this can be consolidated into a model or framework that can align previous research and empirical study. The authors argue that the lack of consensus arises from researchers describing parts of the proverbial elephant correctly but failing to describe the full elephant. Through redefining what human needs are and matching this to an evolutionary framework we can see broad consensus across needs models and neatly slot constructs and psychological and behavioural theories into this framework. This enables a descriptive model of drives, motives, and well-being that can be simply outlined but refined enough to do justice to the complexities of human behaviour. This also raises some issues of how subjective well-being is and should be measured. Further avenues of research and how to continue building this model and framework are proposed.
